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Acetyl-CoA Carboxylase

Acetyl-CoA carboxylase (ACC) is a biotin-dependent enzyme that catalyzes the irreversible carboxylation of acetyl-CoA to produce malonyl-CoA through its two catalytic activities, biotin carboxylase (BC) and carboxyltransferase (CT).

  • Moiramide B
    T73054155233-31-1In house
    Moiramide B is a potent acetyl coenzyme A carboxylase (ACC) inhibitor (IC50:6 nM) with antimicrobial activity, strongly inhibiting Gram-positive bacteria but weakly inhibiting Gram-negative bacteria.
    • $748 TargetMol
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  • Tralkoxydim
    T1998287820-88-0
    Tralkoxydim (Tralkoxydime) is an alkyl ketone herbicide. Tralkoxydim works as an ACCase inhibitor.
    • $50
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  • Firsocostat
    T71841434635-54-7
    Firsocostat (GS-0976) is an inhibitor of acetyl-CoA carboxylase (ACC) dimerization that inhibits human ACC1 and ACC2 activity (IC50s of 2.1 and 6.1 nM, respectively)
    • $88
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    TargetMol | Citations Cited
  • Quizalofop-P
    T8131994051-08-8
    Quizalofop-P, a selective herbicide, is absorbed by weed stems and leaves before translocating both upward and downward within the plant, concentrating in apical and intercalary meristems. It inhibits fatty acid synthesis at the cellular level, leading to weed necrosis, and exhibits high selectivity between grass weeds and dicotyledonous crops [1].
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    TargetMol | Inhibitor Sale
  • CP-640186
    T1889591778-68-6
    CP-640186 is an isozyme-nonselective Acetyl-CoA carboxylase (ACCase) inhibitor. The IC50s of CP-640186(CP 640186) is 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively.
    • $41
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  • CMS-121
    T149911353224-53-9
    CMS-121, a quinolone derivative, is an orally active acetyl-CoA carboxylase 1 (ACC1) inhibitor. CMS-121 protects HT22 cells against ischemia and oxidative damage (EC50: 7 nM and 200 nM). CMS-121 shows strong neuroprotective, antioxidative, anti-inflammatory, and renoprotective activities.
    • $37
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  • Olumacostat Glasaretil
    T35101261491-89-7
    Olumacostat glasaretil is a small molecule inhibitor of acetyl coenzyme A carboxylase (ACC). It has been used in trials studying the treatment of Acne Vulgaris.
    • $50
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  • ND-646
    TQ02431434639-57-2
    ND-646 is an orally bioavailable and allosteric inhibitor of the ACC enzymes ACC1 and ACC2(IC50s of 3.5 nM and 4.1 nM for recombinant hACC1 and hACC2, respectively)
    • $77
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  • TOFA
    T398854857-86-2
    TOFA (MDL14514) is an allosteric inhibitor of acetyl-CoA carboxylase-α (ACCA).
    • $32
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    TargetMol | Citations Cited
  • PF-05221304
    T92091370448-25-1
    PF-05221304 (NSC-170984) is an orally active, liver-targeted inhibitor of acetyl-CoA carboxylase (ACC), a rate-limiting enzymes for fatty acid synthesis.
    • $143
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  • PF-05175157
    T71631301214-47-0
    PF 05175157 is an inhibitor of acetyl-CoA carboxylase 1 (ACC1) and ACC2 (IC50s = 27, 33, 23.5, and 50.4 nM for human ACC1, human ACC2, rat ACC1, and rat ACC2, respectively
    • $61
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  • CP-640186 hydrochloride
    T3622591778-70-0
    CP-640186 hydrochloride (CP 640186 HCl) is an isozyme-nonselective acetyl-CoA carboxylase (ACC) inhibitor, including rat liver ACC1 (IC50: 53 nM) and rat skeletal muscle ACC2 (IC50: 61 nM); with higher metabolic stability than CP-610431.
    • $31
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  • Haloxyfop
    T504669806-34-4
    (±)-Haloxyfop (Haloxyfop Acid) is a herbicide.
    • $33
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