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ABC

The ATP-binding cassette transporters (ABC transporters) are a transport system superfamily that is one of the largest and possibly one of the oldest gene families. It is represented in all extant phyla, from prokaryotes to humans. ABC transporters often consist of multiple subunits, one or two of which are transmembrane proteins and one or two of which are membrane-associated AAA ATPases. The ATPase subunits utilize the energy of adenosine triphosphate (ATP) binding and hydrolysis to provide the energy needed for the translocation of substrates across membranes, either for uptake or for export of the substrate.
Cat. No. Product name CAS No. Purity Chemical Structure
T16122 MMAF sodium 1799706-65-2 98%
MMAF sodium is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as Vorsetuzumab mafodotin and SGN-CD19A. MMAF sodium is an effective ...
TQ0186 Ko 143 461054-93-3 98%
Ko 143 is a selective inhibitor of ATP-binding cassette sub-family G member 2 (ABCG2; BCRP).
T0055L Glafenine Hydrochloride 65513-72-6 98%
Glafenine Hydrochloride is an anti-inflammatory agent.
T0490 Chlorpropamide 94-20-2 98%
Chlorpropamide is a sulfonylurea hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification.
T9587 CCTA-1523 1616271-41-0 98%
CCTA-1523 is an efflux function of ABCG2 inhibitor. CCTA-1523 selectively reverses ABCG2-mediated MDR in cancer cells.
T0974 Novobiocin Sodium 1476-53-5 98%
Novobiocin binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity. Novobiocin sodium is an antibiotic compound derived from Streptomyces niveu...
T18975 DIDS sodium salt 67483-13-0 98%
DIDS sodium salt is a dual inhibitor of ABCA1 and VDAC1.
T20003 Acridone 578-95-0 98%
Acridone is an organic compound based on the acridine skeleton. Acridone could induce cell apoptosis, inhibited ABCG2 (ATP-binding cassette sub-family G member 2...
T1603 Glipizide 29094-61-9 98%
Glipizide is a short-acting, second-generation sulfonylurea with hypoglycemic activity.
T0128 Vigabatrin 60643-86-9 98%
Vigabatrin, an analogue of gamma-aminobutyric acid, is an irreversible inhibitor of 4-aminobutyrate Transaminase responsible for the catabolism of γ-aminobutyric...
T8165 Erythrodiol 545-48-2 98%
Erythrodiol, an olive oil component, promotes Cholesterol efflux (ChE) by selectively inhibiting the degradation of ABCA1 protein.
T9601 Tepotinib hydrochloride(1 : x) 1103508-80-0 98%
Tepotinib hydrochloride(1 : x) is an orally bioavailable, mesenchymal-epithelial transition (MET) TKI developed mainly for selected NSCLC patients with METex14 s...
T1050 Prazosin hydrochloride 19237-84-4 98%
Prazosin Hydrochloride reduces peripheral resistance and relaxes vascular smooth muscles as a selective adrenergic alpha-1 antagonist by a mechanism not complete...
T0254 Probucol 23288-49-5 98%
Probucol, an anti-hyperlipidemic drug, can lower the level of cholesterol in the bloodstream by increasing the LDL catabolic rate.
T2590 Vismodegib 879085-55-9 98%
Vismodegib is a hedgehog pathway inhibitor (IC50: 3 nM). It also inhibits P-gp (IC50: 3.0 μM), ABCG2 (IC50: 1.4 μM).
T17072 Thiethylperazine dimaleate 1179-69-7 98%
Thiethylperazine dimaleate is an antagonist of the D2 receptor and H1 receptor. Thiethylperazine dimaleate is an activator of ABCC1 and possesses antimicrobial, ...
T15355 Fumitremorgin C 118974-02-0 98%
Fumitremorgin C is a potent and selective inhibitor of ABCG2/BRCP.
TN3150 6,8-Diprenylnaringenin 68236-11-3 98%
6,8-Diprenylnaringenin is a natural product from hop Humulus lupulus. 6,8-Diprenylnaringenin is a breast cancer resistance protein(BCRP) inhibitor with some estr...
TN1804 Isosilybin A 142796-21-2 98%
Isosilybin A is a partial PPARγ agonist, it significantly induced ABCA1 protein expression, it inhibited both monophenolase (IC50=1.7-7.6μM) and diphenolase (IC5...
TN7124 5-Hydroxy-2′,3,4′,7-tetramethoxyflavone 19056-75-8 98%
5-Hydroxy-2′,3,4′,7-tetramethoxyflavone shows weak ABCG2 inhibitory potency with IC50s of 3.27 and 3.89 µM in the Hoechst 33342 and pheophorbide A assays.
MMAF sodium
T16122
MMAF sodium is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as Vorsetuzumab mafodotin and SGN-CD19A. MMAF sodium is an effective ...
Ko 143
TQ0186
Ko 143 is a selective inhibitor of ATP-binding cassette sub-family G member 2 (ABCG2; BCRP).
Glafenine Hydrochloride
T0055L
Glafenine Hydrochloride is an anti-inflammatory agent.
Chlorpropamide
T0490
Chlorpropamide is a sulfonylurea hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification.
CCTA-1523
T9587
CCTA-1523 is an efflux function of ABCG2 inhibitor. CCTA-1523 selectively reverses ABCG2-mediated MDR in cancer cells.
Novobiocin Sodium
T0974
Novobiocin binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity. Novobiocin sodium is an antibiotic compound derived from Streptomyces niveu...
DIDS sodium salt
T18975
DIDS sodium salt is a dual inhibitor of ABCA1 and VDAC1.
Acridone
T20003
Acridone is an organic compound based on the acridine skeleton. Acridone could induce cell apoptosis, inhibited ABCG2 (ATP-binding cassette sub-family G member 2...
Glipizide
T1603
Glipizide is a short-acting, second-generation sulfonylurea with hypoglycemic activity.
Vigabatrin
T0128
Vigabatrin, an analogue of gamma-aminobutyric acid, is an irreversible inhibitor of 4-aminobutyrate Transaminase responsible for the catabolism of γ-aminobutyric...
Erythrodiol
T8165
Erythrodiol, an olive oil component, promotes Cholesterol efflux (ChE) by selectively inhibiting the degradation of ABCA1 protein.
Tepotinib hydrochloride(1 : x)
T9601
Tepotinib hydrochloride(1 : x) is an orally bioavailable, mesenchymal-epithelial transition (MET) TKI developed mainly for selected NSCLC patients with METex14 s...
Prazosin hydrochloride
T1050
Prazosin Hydrochloride reduces peripheral resistance and relaxes vascular smooth muscles as a selective adrenergic alpha-1 antagonist by a mechanism not complete...
Probucol
T0254
Probucol, an anti-hyperlipidemic drug, can lower the level of cholesterol in the bloodstream by increasing the LDL catabolic rate.
Vismodegib
T2590
Vismodegib is a hedgehog pathway inhibitor (IC50: 3 nM). It also inhibits P-gp (IC50: 3.0 μM), ABCG2 (IC50: 1.4 μM).
Thiethylperazine dimaleate
T17072
Thiethylperazine dimaleate is an antagonist of the D2 receptor and H1 receptor. Thiethylperazine dimaleate is an activator of ABCC1 and possesses antimicrobial, ...
Fumitremorgin C
T15355
Fumitremorgin C is a potent and selective inhibitor of ABCG2/BRCP.
6,8-Diprenylnaringenin
TN3150
6,8-Diprenylnaringenin is a natural product from hop Humulus lupulus. 6,8-Diprenylnaringenin is a breast cancer resistance protein(BCRP) inhibitor with some estr...
Isosilybin A
TN1804
Isosilybin A is a partial PPARγ agonist, it significantly induced ABCA1 protein expression, it inhibited both monophenolase (IC50=1.7-7.6μM) and diphenolase (IC5...
5-Hydroxy-2′,3,4′,7-tetramethoxyflavone
TN7124
5-Hydroxy-2′,3,4′,7-tetramethoxyflavone shows weak ABCG2 inhibitory potency with IC50s of 3.27 and 3.89 µM in the Hoechst 33342 and pheophorbide A assays.