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ABC

The ATP-binding cassette transporters (ABC transporters) are a transport system superfamily that is one of the largest and possibly one of the oldest gene families. It is represented in all extant phyla, from prokaryotes to humans. ABC transporters often consist of multiple subunits, one or two of which are transmembrane proteins and one or two of which are membrane-associated AAA ATPases. The ATPase subunits utilize the energy of adenosine triphosphate (ATP) binding and hydrolysis to provide the energy needed for the translocation of substrates across membranes, either for uptake or for export of the substrate.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
TN7124 5-Hydroxy-2′,3,4′,7-tetramethoxyflavone 19056-75-8 98.50%
5-Hydroxy-2′,3,4′,7-tetramethoxyflavone
5-Hydroxy-2′,3,4′,7-tetramethoxyflavone shows weak ABCG2 inhibitory potency with IC50s of 3.27 and 3.89 µM in the Hoechst 33342 and pheophorbide A assays.
TN3150 6,8-Diprenylnaringenin 68236-11-3 98%
6,8-Diprenylnaringenin
6,8-Diprenylnaringenin (Senegalensin) is a natural product from hop Humulus lupulus. 6,8-Diprenylnaringenin is a breast cancer resistance protein(BCRP) inhibitor...
T15355 Fumitremorgin C 118974-02-0 98%
Fumitremorgin C
Fumitremorgin C (12α-Fumitremorgin C) is a mycotoxin and inhibits ABCG2/BRCP.
T16122 MMAF sodium 1799706-65-2 98%
MMAF sodium
MMAF sodium is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as Vorsetuzumab mafodotin and SGN-CD19A. MMAF sodium is an effective ...
T2590 Vismodegib 879085-55-9 99.99%
Vismodegib
Vismodegib (GDC-0449) is a hedgehog pathway inhibitor (IC50: 3 nM). It also inhibits P-gp (IC50: 3.0 μM), ABCG2 (IC50: 1.4 μM).
T0254 Probucol 23288-49-5 99.99%
Probucol
Probucol (DH-581), an anti-hyperlipidemic drug, can lower the level of cholesterol in the bloodstream by increasing the LDL catabolic rate.
T1050 Prazosin hydrochloride 19237-84-4 99.87%
Prazosin hydrochloride
Prazosin hydrochloride (Vasoflex) reduces peripheral resistance and relaxes vascular smooth muscles as a selective adrenergic alpha-1 antagonist by a mechanism n...
T20003 Acridone 578-95-0 99.57%
Acridone
Acridone could induce cell apoptosis, inhibited ABCG2 (ATP-binding cassette sub-family G member 2) protein, and adjusted hormone level.
T8165 Erythrodiol 545-48-2 99.52%
Erythrodiol
Erythrodiol, an olive oil component, promotes Cholesterol efflux (ChE) by selectively inhibiting the degradation of ABCA1 protein.
T0128 Vigabatrin 60643-86-9 99.47%
Vigabatrin
Vigabatrin (Sabril), an analogue of gamma-aminobutyric acid, is an irreversible inhibitor of 4-aminobutyrate Transaminase responsible for the catabolism of γ-ami...
T18975 DIDS sodium salt 67483-13-0 99.34%
DIDS sodium salt
DIDS sodium salt (MDL101114ZA) is a dual inhibitor of ABCA1 and VDAC1.
T0974 Novobiocin Sodium 1476-53-5 99.1%
Novobiocin Sodium
Novobiocin Sodium (Albamycinsodium) binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity. Novobiocin sodium is an antibiotic compound derive...
T17072 Thiethylperazine dimaleate 1179-69-7 99.07%
Thiethylperazine dimaleate
Thiethylperazine dimaleate (Thiethylperazine maleate) is an antagonist of the D2 receptor and H1 receptor. Thiethylperazine dimaleate is an activator of ABCC1 an...
T9587 CCTA-1523 1616271-41-0 99.03%
CCTA-1523
CCTA-1523 is an efflux function of ABCG2 inhibitor. CCTA-1523 selectively reverses ABCG2-mediated MDR in cancer cells.
T0490 Chlorpropamide 94-20-2 99.01%
Chlorpropamide
Chlorpropamide (Diabinese) is a sulfonylurea hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modifi...
TQ0186 Ko 143 461054-93-3 98.91%
Ko 143
Ko 143 is a selective inhibitor of ATP-binding cassette sub-family G member 2 (ABCG2; BCRP).
T1603 Glipizide 29094-61-9 98.66%
Glipizide
Glipizide (CP 28720) is a short-acting, second-generation sulfonylurea with hypoglycemic activity.
T0055L Glafenine Hydrochloride 65513-72-6 98%
Glafenine Hydrochloride
Glafenine Hydrochloride is an anti-inflammatory agent.
TN1804 Isosilybin A 142796-21-2 98%
Isosilybin A
Isosilybin A is a partial PPARγ agonist, it significantly induced ABCA1 protein expression, it inhibited both monophenolase (IC50=1.7-7.6μM) and diphenolase (IC5...
T9601 Tepotinib hydrochloride(1 : x) 1103508-80-0 98%
Tepotinib hydrochloride(1 : x)
Tepotinib hydrochloride(1 : x) is an orally bioavailable, mesenchymal-epithelial transition (MET) TKI developed mainly for selected NSCLC patients with METex14 s...
5-Hydroxy-2′,3,4′,7-tetramethoxyflavone
TN7124
5-Hydroxy-2′,3,4′,7-tetramethoxyflavone shows weak ABCG2 inhibitory potency with IC50s of 3.27 and 3.89 µM in the Hoechst 33342 and pheophorbide A assays.
6,8-Diprenylnaringenin
TN3150
6,8-Diprenylnaringenin (Senegalensin) is a natural product from hop Humulus lupulus. 6,8-Diprenylnaringenin is a breast cancer resistance protein(BCRP) inhibitor...
Fumitremorgin C
T15355
Fumitremorgin C (12α-Fumitremorgin C) is a mycotoxin and inhibits ABCG2/BRCP.
MMAF sodium
T16122
MMAF sodium is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as Vorsetuzumab mafodotin and SGN-CD19A. MMAF sodium is an effective ...
Vismodegib
T2590
Vismodegib (GDC-0449) is a hedgehog pathway inhibitor (IC50: 3 nM). It also inhibits P-gp (IC50: 3.0 μM), ABCG2 (IC50: 1.4 μM).
Probucol
T0254
Probucol (DH-581), an anti-hyperlipidemic drug, can lower the level of cholesterol in the bloodstream by increasing the LDL catabolic rate.
Prazosin hydrochloride
T1050
Prazosin hydrochloride (Vasoflex) reduces peripheral resistance and relaxes vascular smooth muscles as a selective adrenergic alpha-1 antagonist by a mechanism n...
Acridone
T20003
Acridone could induce cell apoptosis, inhibited ABCG2 (ATP-binding cassette sub-family G member 2) protein, and adjusted hormone level.
Erythrodiol
T8165
Erythrodiol, an olive oil component, promotes Cholesterol efflux (ChE) by selectively inhibiting the degradation of ABCA1 protein.
Vigabatrin
T0128
Vigabatrin (Sabril), an analogue of gamma-aminobutyric acid, is an irreversible inhibitor of 4-aminobutyrate Transaminase responsible for the catabolism of γ-ami...
DIDS sodium salt
T18975
DIDS sodium salt (MDL101114ZA) is a dual inhibitor of ABCA1 and VDAC1.
Novobiocin Sodium
T0974
Novobiocin Sodium (Albamycinsodium) binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity. Novobiocin sodium is an antibiotic compound derive...
Thiethylperazine dimaleate
T17072
Thiethylperazine dimaleate (Thiethylperazine maleate) is an antagonist of the D2 receptor and H1 receptor. Thiethylperazine dimaleate is an activator of ABCC1 an...
CCTA-1523
T9587
CCTA-1523 is an efflux function of ABCG2 inhibitor. CCTA-1523 selectively reverses ABCG2-mediated MDR in cancer cells.
Chlorpropamide
T0490
Chlorpropamide (Diabinese) is a sulfonylurea hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modifi...
Ko 143
TQ0186
Ko 143 is a selective inhibitor of ATP-binding cassette sub-family G member 2 (ABCG2; BCRP).
Glipizide
T1603
Glipizide (CP 28720) is a short-acting, second-generation sulfonylurea with hypoglycemic activity.
Glafenine Hydrochloride
T0055L
Glafenine Hydrochloride is an anti-inflammatory agent.
Isosilybin A
TN1804
Isosilybin A is a partial PPARγ agonist, it significantly induced ABCA1 protein expression, it inhibited both monophenolase (IC50=1.7-7.6μM) and diphenolase (IC5...
Tepotinib hydrochloride(1 : x)
T9601
Tepotinib hydrochloride(1 : x) is an orally bioavailable, mesenchymal-epithelial transition (MET) TKI developed mainly for selected NSCLC patients with METex14 s...
TargetMol