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Results for "

stat-1

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    39
    TargetMol | Inhibitors_Agonists
  • Inhibitory Antibodies
    1
    TargetMol | Inhibitory_Antibodies
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TargetMolTargetMolCompare
STAT1 Protein, Human, Recombinant
Transcription Factor ISGF-3 Components p91 p84, STAT1, Signal Transducer and Activator of Transcription 1-α β, Signal Transducer and Activator of Transcription 1-α Beta, Signal Transducer and Activator of Transcription 1-Alpha Beta
TMPJ-00961
Signal Transducer and Activator of Transcription 1-Alpha Beta (STAT1) contains one SH2 domain and belongs to the transcription factor STAT family. When tyrosine- and serine-phosphorylated, STAT1 can form a homodimer termed IFN-gamma-activated factor (GAF), migrate into the nucleus and bind to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. STAT1 functions as signal transducer and transcription activator that mediates cellular responses to interferons. Defects in STAT1 are the cause of STAT1 deficiency complete and familial candidiasis type 7.
  • Inquiry Price
7-10 days
Size
QTY
SPR-compatible buffer
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SOCS1 Protein, Human, Recombinant (His)
TIP3, Tec-interacting protein 3 (TIP-3), Suppressor of cytokine signaling 1, STAT-induced STAT inhibitor 1 (SSI-1), SSI1, SOCS-1, SOCS1, JAK-binding protein (JAB)
TMPH-02156
Expression system: P. pastoris (Yeast)
Length: 1-211, Full Length
Activity: Not Tested
  • Inquiry Price
20 days
Size
QTY
Buffer-exchangeable
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SOCS1 Protein, Mouse, Recombinant (His & Myc)
Suppressor of cytokine signaling 1, STAT-induced STAT inhibitor 1 (SSI-1), Ssi1, SOCS-1, Socs1, JAK-binding protein (JAB), Cish1
TMPH-02919
Expression system: E. coli
Length: 1-212, Full Length
Activity: Not Tested
  • Inquiry Price
20 days
Size
QTY
Buffer-exchangeable
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IL-22RA1 Protein, Cynomolgus, Recombinant (His)
zcytoR11, IL-TIF-R1, IL-22R-α-1, IL-22R-alpha-1, IL-22RA1, IL22R1, IL-22R α1, IL22R, CRF2-9
TMPK-00474
IL-22 receptor, also known as IL-22 R alpha 1 and CRF2-9, is an approximately 65 kDa transmembrane glycoprotein in the type II cytokine receptor family (CRF).Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK STAT pathways. IL22 also induces activation of MAPK1 MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation.
  • Inquiry Price
7-10 days
Size
QTY
SPR-compatible buffer
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STAT1 Protein, Human, Recombinant (His & GST)
STAT91, signal transducer and activator of transcription 1, 91kDa, ISGF-3, IMD31C, IMD31B, IMD31A, CANDF7
TMPY-02240
STAT1 is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor-associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. STAT1 can be activated by various ligands, including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. It is a signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG SCF and other cytokines and growth factors. The phosphorylated STATs dimerize, associate with ISGF3G IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon-stimulated genes, which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. STAT1 becomes activated in response to KITLG SCF and KIT signaling and may mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Defects in STAT1 can cause STAT1 deficiency complete and familial candidiasis type 7.
  • Inquiry Price
7-10 days
Size
QTY
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CCL26 Protein, Human, Recombinant
TSC-1, SCYA26, MIP-4α, MIP-4alpha, MIP-4a, IMAC, chemokine (C-C motif) ligand 26
TMPY-05353
Expression system: Baculovirus Insect Cells
Length: 1-94, Full Length
Activity: Not Tested
  • Inquiry Price
7-10 days
Size
QTY