snc

SNC 80 (NIH 10815) is a potent, highly selective and non-peptide δ-opioid receptor agonist, Ki = 1.78 nM, IC50 = 2.73 nM. SNC80 also selectively activates μ-δ heteromer in HEK293 cells with an EC50 of 52.8 nM. SNC80 shows antinociceptive, antihyperalgesic and antidepressant‐like effects. SNC80 has the potential for multiple headache disorders treatment.

SNC 162 is a potent and selective delta-opioid receptor (DOR, δ-opioid) agonist with an IC50 value of 0.94 nM with analgesic, antidepressant and antiarrhythmic effects.

SB-200646 is a selective and potent antagonist of 5-HT2B/5-HT2C receptor

(Rac)-SNC80, a racemate of SNC80 (NIH 10815), is a potent, highly selective non-peptide δ-opioid receptor agonist, characterized by a K_i of 1.78 nM and an IC_50 of 2.73 nM. Demonstrating antinociceptive, antihyperalgesic, and antidepressant-like effects, SNC80 holds potential for the treatment of multiple headache disorders [1] [2] [3] [4] [5] [6].

PSNCBAM-1 (PSNCBAM 1) is a CB1 receptor negative allosteric modulator (EC50 = 0.1 μM) with hypophagic effects in vivo. PSNCBAM-1 can be used for obesity studies.

Synucleozid is a potent the SNCA mRNA inhibitor that encodes α-synuclein protein (IC50=1.5 μM), has the potential for the investigation of Parkinson's disease.

Synucleozid hydrochloride inhibits the translation of the intrinsically disordered protein α-synuclein by targeting its structured mRNA. Synucleozid hydrochloride targets the IRE structure and inhibits SNCA translation in cells, and can be used to study Alzheimer's disease.

Felypressin (Octapressin) is a synthetic analog of LYPRESSIN with a PHENYLALANINE substitution at residue 2. Felypressin is a vasoconstrictor with reduced antidiuretic activity.

Felypressin acetate (PLV-2) is an agonist of vasopressin 1 and acts on all arginine vasopressin receptors 1AS. Felypressin acetate can be used in dental procedures.

N-trans-caffeoyltyramine (Trans-N-Caffeoyltyramine) is a modulator of inflammatory responses and can be used in studies about treatment for chronic inflammatory diseases.

c(Bua-Cpa-Thi-Val-Asn-Cys)-Pro-d-Arg-NEt2 acetate is a potent, selective and short-acting peptidic V2 receptor (V2R) agonist with EC50s of 0.07 and 0.02 nM for hV2R and rV2R, respectively.

c(Bua-Cpa-Thi-Val-Asn-Cys)-Pro-d-Arg-NEt2 is a selective and short-acting peptidic V2 receptor (V2R) agonist with EC50s of 0.07nM and 0.02 nM for hV2R and rV2R, respectively.

c(Bua-Cpa-Thi-Val-Asn-Cys)-Pro-Agm is a highly efficient, selective, and short-acting peptide V2 receptor agonist (V2R), with EC50s of hV2R and rV2R being 0.25 and 0.05 nM, respectively.

AR-M 1000390 hydrochloride (ARM-390 HCl) , also known as ARM-390, is a low-internalizing nonpeptidic δ-selective opioid receptor agonist; derivative of SNC 80. Does not trigger acute desensitization of the analgesic response; reduces CFA-induced hyperalgesia. Brain penetrant following systemic administration.

TXB4 is a human monoclonal antibody (mAb) that penetrates the brain and targets CD71. In a mouse model of Parkinson's disease (PD) induced by 6-OHDA, TXB4 prevents 6-OHDA-induced death of TH-positive neurons in the SNc. TXB4 can be utilized for studies on neurodegenerative diseases, acute brain and spinal cord injuries, and depression.

(S)-(-)-Canadine (tetrahydroberberine) is a naturally occurring isoquinoline alkaloid, acting as a D2 receptor antagonist and 5-HT1A receptor agonist, capable of blocking dopamine-stimulated adenylate cyclase activity. (S)-(-)-Canadine also enhances gastrointestinal motility, blocks K(ATP) channels in substantia nigra pars compacta (SNc) dopaminergic neurons, and exerts neuroprotective effects.