retinol

Retinol (Alphalin) and derivatives of retinol that play an essential role in metabolic functioning of the retina, the growth of and differentiation of epithelial tissue, the growth of bone, reproduction, and the immune response. Dietary vitamin A is derived from a variety of CAROTENOIDS found in plants. It is enriched in the liver, egg yolks, and the fat component of dairy products.

All-trans-Anhydro Retinol (Anhydrovitamin A) is a Vitamin A metabolite commonly employed in the synthesis of multivitamin preparations[1].

11-cis Retinol is an isomer of vitamin A, serving as an agonist for red rod optochromin and an inverse agonist for red cone optochromin.

Retinyl acetate (Vitamin A acetate) is a group of unsaturated nutritional hydrocarbons, that contains retinal, retinol, retinoic acid, and several provitamins A carotenoids, among which beta-carotene is the most important.

Retinyl palmitate (Vitamin A palmitate) is a naturally-occurring phenyl analogue of retinol, with potential antineoplastic and chemopreventive activities.

Vitamin A-D4 is a deuterated compound of Vitamin A. Vitamin A has a CAS number of 68-26-8. Retinol and derivatives of retinol that play an essential role in metabolic functioning of the retina, the growth of and differentiation of epithelial tissue, the growth of bone, reproduction, and the immune response. Dietary vitamin A is derived from a variety of CAROTENOIDS found in plants. It is enriched in the liver, egg yolks, and the fat component of dairy products.

Vitamin A-D5 Acetate is a deuterated compound of Vitamin A Acetate. Vitamin A Acetate (T0685) has a CAS number of 127-47-9. Vitamin A is a group of unsaturated nutritional hydrocarbons, that contains retinal, retinol, retinoic acid, and several provitamins A carotenoids, among which beta-carotene is the most important.

Vitamin A-4,4,18,18,18-[D5] (Standard) is a reference standard of Vitamin A-4,4,18,18,18-[D5] intended for quantitative analysis, quality control, and related biochemical research applications.

Retinol (Standard) is the standard substance of Retinol, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Retinol (Vitamin A) is a natural vitamin that is fat soluble. Retinol plays an important role in the metabolic functions of the retina, growth and differentiation of epithelial tissues, bone growth, reproduction and immune response.

All-trans-13,14-Dihydroretinol, a metabolite of all-trans-retinoic acid, is synthesized through the enzymatic action of retinol saturase on all-trans-retinoic acid.

Zuretinol is a oral retinoid.

K-80003(TX-803) is a potent retinol-like X-receptor-alpha regulator that inhibits TRxrα-dependent Akt activation and tumor cell growth.

β-Carotene (Provitamin A) is a naturally-occurring retinol (vitamin A) precursor obtained from certain fruits and vegetables with potential antineoplastic and chemopreventive activities. As an anti-oxidant, beta carotene inhibits free-radical damage to DNA.

BPN-14136 is a potent antagonist of retinol-binding protein 4 (RBP4), utilized in mechanistic studies of retinoid transport, metabolic disorders BPN-14136 is used in the research for RBP4-driven pathophysiology, particularly in the context of insulin resistance and metabolic disease models.

Retinyl oleate is A fatty acid ester formed from oleic acid and all-trans retinol (vitamin A) that is used in the preparation of oily acne treatment preparations.

A 1120 is a nonretinoid retinol-binding protein 4 (RBP4) antagonist (Ki: 8.3 nM), which disrupts the interaction between RBP4 and its binding partner transthyretin.

Emixustat hydrochloride (ACU-4429 hydrochloride) strongly inhibits 11-cis-retinol production with IC50 values of 232 ± 3 nM. 11-cis-retinol Emixustat hydrochloride is a novel visual cycle modulator.

9-cis-Retinal is a retinoid with Kd of 8 nM and 5 nM for cellular retinol binding protein-I (CRBP-1) and CRBP-II, respectively. 9-cis-Retinal accelerates the differentiation and maturation of rod photoreceptors in retinal organoids, reduces the toxicity of unliganded opsins, and can be used to study congenital stationary night blindness caused by G90D rhodopsin.

LRAT-IN-1 (compound 1) is an inhibitor of lecithin retinol acyltransferase (LRAT) with an IC50 value of 21.1 μM. This compound works by inhibiting the esterification of retinol to form retinyl esters, thereby increasing the availability of retinol in the skin to deliver anti-aging benefits. LRAT-IN-1 is under investigation for its potential use as an anti-aging ingredient in cosmetics.

STG-001 is an antagonist of retinol-binding protein 4 (RBP4). By inhibiting RBP4, STG-001 reduces the synthesis of retinaldehyde and bis-retinoids, thereby preventing photoreceptor degeneration. This compound is applicable in studies related to sex-linked hereditary retinopathies such as Stargardt disease (STGD).

Retinyl formyl aspartamate is a novel synthesized retinol derivative with higher photostability.

RBP4 inhibitor 1 (compound 43b) is an orally active and potent inhibitor of retinol-binding protein 4 (RBP4) with IC50 values of 28 nM and 110 nM for human and mouse RBP4, respectively. It effectively reduces blood RBP4 levels in mice, providing a long-lasting effect [1].

RBP4 ligand-1 is a non-retinoid ligand for retinol-binding protein 4 (RBP4). It exhibits hRBP4SPA IC50 and RBP4-TTR FRET IC50 values of 0.23±0.11 μM and 0.13±0.12 μM, respectively, in radioligand binding and FRET assays. The measured concentration was 0.12 μM.

RORγt modulator 3 is a modulator of retinol-related orphan receptor γt (RORγt) and can be used to study RORγt-mediated diseases such as pain, COPD, inflammation, asthma, colitis, multiple sclerosis, rheumatoid arthritis, psoriasis, neurodegenerative diseases and cancer.