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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T16745 | Rhosin hydrochloride | Apoptosis , Rho , Ras | |
Rhosin hydrochloride is an effective and specific RhoA subfamily Rho GTPases inhibitor, which specifically binds to RhoA to inhibit RhoA-GEF interaction (Kd: ~ 0.4 uM). Rhosin hydrochloride does not interact with Cdc42 o... | |||
T2161 | Cardiogenol C | Wnt/beta-catenin | |
Cardiogenol C is a cardiomyogenesis inducer in embryonic stem cells. | |||
T8005 | Cardiogenol C hydrochloride | Cardiogenol C HCl,Cardiogenol C | Wnt/beta-catenin |
Cardiogenol C hydrochloride (Cardiogenol C) can induces the differentiation of ESCs into cardiomyocytes (EC50= 100 nM). | |||
T7516 | ZD7288 | ICI D7288 | HCN Channel |
ZD7288 (ICI D7288), a selective hyperpolarization-activated cyclic nucleotide-gated channel blocker, inhibits hippocampal synaptic plasticity. | |||
T3597 | Cutamesine dihydrochloride | AGY94806 dihydrochloride,SA4503 (dihydrochloride),SA4503 dihydrochloride | Sigma receptor |
Cutamesine dihydrochloride (SA4503 dihydrochloride) is a selective σ1 receptor agonist (IC50: 17.4 nM). It shows selectivity for σ1 over σ2 receptors, and inhibits angiotensin II-induced cardiomyocyte hypertrophy in vitr... | |||
T70064 | PDE1-IN-1 | ||
PDE1-IN-1can enhance levels of the second messengers cAMP/cGMP leading to the expression of neuronal plasticity-related genes, neurotrophic factors, and neuroprotective molecules. These neuronal plasticity enhancement pr... | |||
T62055 | NVS-BET-1 | ||
NVS-BET-1 is a BET bromodomain inhibitor. NVS-BET-1 can regulate keratinocyte plasticity. | |||
T70032 | NCI-006 | ||
NCI-006 is a potent new inhibitor of lactate dehydrogenase (LDH) that disrupts tumor growth in mice. LDH inhibition slows tumor growth but rapidly redirects pyruvate to support mitochondrial metabolism. Inhibiting both m... | |||
T76078 | Neurogranin (48-76), mouse | ||
Neurogranin (48-76), mouse, is a peptide comprising residues 48-76 of Neurogranin, a post-synaptically exclusive calmodulin-binding protein that mediates NMDAR-driven synaptic plasticity by regulating the calcium-calmodu... | |||
T82339 | Gangliotetraose | Gg4 | |
Gangliotetraose (Gg4), a tetrasccharide, predominantly comprises GM1 and its sialylated derivatives, which play a crucial role in modulating nuclear Ca2+ efflux and maintaining lower nuclear Ca2+ levels in differentiated... | |||
T82673 | CPF-7 | Caerulein precursor fragment | |
CPF-7 (Caerulein precursor fragment), an insulinotropic peptide, promotes insulin secretion and drives epithelial-mesenchymal transition via Snai1 upregulation in PANC-1 ductal cells. Moreover, it induces exocrine plasti... | |||
T37388 | Afizagabar | ||
Afizagabar (S44819) is a first-in-class, competitive, and selective antagonist at the GABA-binding site of the α5-GABAAR, with an IC50 of 585 nM for α5β2γ2 and a Ki of 66 nM for α5β3γ2. Afizagabar enhances hippocampal sy... | |||
T62127 | AMPA-IN-1 | ||
AMPA-IN-1 is a potent inhibitor of AMPA receptors, a widely expressed receptor in the brain with a central role in the regulation of rapid excitatory synaptic transmission and synaptic plasticity. 14). | |||
T76221 | Leptin (116-130) | ||
Leptin (116-130), a bioactive fragment of leptin, enhances synaptic plasticity in the hippocampus by promoting AMPA receptor trafficking to synapses. It preserves hippocampal synapse integrity and prevents neuronal cell ... | |||
TP2157L | TAT-DEF-Elk-1 TFA (1220751-16-5 free base) | TDE TFA,TAT-DEF-Elk-1 TFA | Others |
TAT-DEF-Elk-1 TFA is a cell-penetrating peptide Elk-1 inhibitor, mimics and specifically interferes with the DEF domain of Elk-1. TAT-DEF-Elk-1 blocks Elk-1 phosphorylation and prevents Elk-1 nuclear translocation withou... | |||
T81038 | TAT-DEF-Elk-1 TFA | TDE TFA | |
TAT-DEF-Elk-1 TFA (TDE TFA) is a cell-penetrating peptide that inhibits Elk-1 by mimicking its DEF domain and disrupting its function. It effectively blocks Elk-1 phosphorylation and its subsequent nuclear translocation,... | |||
T38169 | LY 341495 disodium salt | ||
Highly potent and selective group II metabotropic glutamate receptor antagonist. Disodium salt of LY 341495 Fitzjohn et al (1998) The potent mGlu receptor antagonist LY341495 identifies roles for both cloned and novel mG... | |||
T36679 | Rp-cAMPS sodium salt | ||
Rp-cAMPS sodium salt, a cAMP analog, is a potent, competitive cAMP-induced activation of cAMP-dependent PKA I and II (Kis of 12.5 μM and 4.5 μM, respectively) antagonist. Rp-cAMPS sodium salt is resistant to hydrolysis b... | |||
T37582 | Ganglioside GM1 Mixture (ovine) (ammonium salt) | ||
Ganglioside GM1is a monosialylated ganglioside and the prototypic ganglioside for those containing one sialic acid residue.1,2It is found in a large variety of cells, including immune cells and neurons, and is enriched i... |