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Search Results for " neonatal "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T21793	CGP 35348		GABA Receptor
	CGP 35348 is a selective antagonist of GABAB receptor (EC50 = 34 μM). CGP 35348 can be used in studies of neuromuscular coordination and spatial learning after neonatal brain damage in albino mice.		GABA Receptor
T7714	Temocapil		Tyrosinase
	Temocapril is an inhibitor of tyrosine kinase.		Tyrosinase
T23283	2-Methoxyidazoxan monohydrochloride	RX 821002 hydrochloride	Adrenergic Receptor
	L-Albizziin (2-Methoxyidazoxan monohydrochloride) is a highly potent selective antagonist of the alpha 2r adrenergic receptor, with little or no antagonistic effect on imidazoline. It has a significantly higher affinity ...		Adrenergic Receptor
T6698	Temocapril hydrochloride	CS-622 HCl,Acecol,Temocapril HCl,CS-622	RAAS
	Temocapril hydrochloride (CS-622 HCl), the hydrochloride of Temocapril, is a long-acting ACE inhibitor used for the therapy of hypertension.		RAAS
T29670	ADR-925	ICRF198,ICRF-198,ADR 925,ICRF 198,ADR925	Endogenous Metabolite
	ADR-925 (ICRF 198), an active chelated iron metabolite of dexrazoxane, has the ability to protect neonatal rat cardiomyocytes from adriamycin-induced injury.		Endogenous Metabolite
T11339L	Furegrelate		PPAR
	FUREGRELATE, a thromboxane A2 (TxA2) synthase inhibitor, blunts the development of pulmonary arterial hypertension in neonatal piglets.		PPAR
T28607	Rocepafant	LAU 8080,LAU8080,BN 50730,LAU-8080,BN50730,BN-50730	Platelet aggregation
	Rocepafant (LAU8080) is a platelet-activating factor (PAF) antagonist that attenuates hypoxic-ischemic brain damage in neonatal rats.Rocepafant inhibits tumor necrosis factor-Afa-mediated cytotoxicity in mouse L929 tumor...		Platelet aggregation
T23215L	(R)-3,4-DCPG HCl	(R)-3,4-DCPG HCl(201730-10-1 Free base)	GluR
	(R)-3,4-DCPG HCl is a potent and selective mGlu8a receptor agonist that activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord.		GluR
T7578	REVERSE T3	3,3',5'-triiodo-L-thyronine	Thyroid hormone receptor(THR)
	Reverse T3 (3,3',5'-triiodo-L-thyronine) inhibits the increase of sodium current generated by other thyroid hormone analogs in neonatal rat myocytes.		Thyroid hormone receptor(THR)
T7284	Argipressin acetate (113-79-1(free base))		Others
	Vasopressin acetate is a peptide hormone with vasoconstrictive and antidiuretic activities that binds to the vascular arginine vasopressin receptor, V1, with Kd values of 1.31 and 1.44 nM in A7r5 rat aortic smooth muscle...		Others
T0005	Aspirin	Acetylsalicylate,Acetylsalicylic Acid,ASA	Mitophagy , Virus Protease , COX , Autophagy
	Aspirin (Acetylsalicylic Acid) is a potent and selective inhibitor of COX with various pharmacological activities, such as anti-inflammation and pain relief. Aspirin is a histone deacetylase inhibitors to up-regulate cel...		Mitophagy , Virus Protease , COX , Autophagy
T68123	Oxodipine		Calcium Channel
	Oxodipine, a dihydropyridine-type calcium antagonist , inhibited KCl-induced aortic contraction in rabbits and reduced cardiac force in less potent rat ventricular test-paper contractions. In rat cultured neonatal ventri...		Calcium Channel
T63715	HIgG–hFc receptor-IN-1
	hIgG-hFc receptor-IN-1 is a human immunoglobulin G - human neonatal Fc receptor (hIgG-hFcRn) protein-protein interaction inhibitor (IC50: 2 μM).
TP2012	JMV 449
	Potent, metabolically stable neurotensin receptor agonist peptide (IC50 = 0.15 nM for inhibition of [125I]-NT binding to neonatal mouse brain; EC50 = 1.9 nM for contraction of guinea pig ileum). Produces long-lasting hyp...
TP1171	Apraglutide TFA (1295353-98-8 free base)	Apraglutide TFA,FE 203799e (TFA)
	Apraglutide TFA (FE 203799 TFA), a synthetic 33-amino-acid peptide and a long-acting GLP-2 analogue, enhances adaptation and linear intestinal growth in a neonatal piglet model of short bowel syndrome with total resectio...
T79549	Antifungal agent 67
	Compound 9 (Antifungal agent 67), an imidazole class antifungal, exhibits efficacy against Candida and possesses a CC50 value of 33.6 μM in neonatal rat cardiomyoblasts [1].
T7434	Argipressin	Arg8-vasopressin,Vasopressin,AVP	Vasopressin Receptor
	Argipressin (Vasopressin) is a peptide hormone with vasoconstrictive and antidiuretic activities that binds to the vascular arginine vasopressin receptor, V1, with Kd values of 1.31 and 1.44 nM in A7r5 rat aortic smooth ...		Vasopressin Receptor
T70421	VCP746
	VCP-746 is a potent adenosine A2B receptor agonist that stimulates anti-fibrotic signalling. VCP746 reduces hypertrophy in a rat neonatal cardiac myocyte model. VCP746 is a hybrid molecule consisting of an adenosine moie...
T36336	Burnettramic Acid A
	Burnettramic acid A is a fungal metabolite originally isolated fromA. burnettiithat has diverse biological activities.1It is active againstB. subtilis,S. aureus,C. albicans, andS. cerevisiae(IC50s = 2.3, 5.9, 0.5, and 0....
T36218	19R(20S)-EpDPA
	19R(20S)-EpDPA is an oxylipin and a metabolite of docosahexaenoic acid .1,2It is formed from DHA by various cytochrome P450 (CYP) isoforms in a stereoselective manner.219R(20S)-EpDPA (30 nM) prevents calcium-induced incr...
T39717	VGSC blocker-1
	VGSC blocker-1 is a powerful small molecule that serves as a blocker for the neonatal isoform of the VGSC subtype known as Nav1.5 (nNav1.5). It effectively blocks INa peak currents by 34.9% at a concentration of 1 μM, an...
T63793	Tauro-ω-muricholic acid sodium
	Tauro-ω-muricholic acid sodium (TωMCA sodium) is an analogue of tauro-α-muricholic acid, a bile acid of hepatic origin. Tauro-ω-muricholic acid sodium can be used as a serum marker for early onset neonatal sepsis (EOS) a...
T76001	Apraglutide TFA
	Apraglutide TFA (FE 203799 TFA), a synthetic 33-amino-acid peptide functioning as a long-acting GLP-2 analogue, promotes adaptation and linear growth of the intestine in neonatal piglet models of short bowel syndrome fol...
T37409	DPC-AJ1951 (trifluoroacetate salt)	DPC-AJ1951 (trifluoroacetate salt)
	DPC-AJ1951 is a peptide agonist of the parathyroid hormone (PTH)/PTH-related peptide receptor (PPR; EC50 = 0.15 nM in HEK293 cells expressing human PPR). It induces cAMP production in SAOS-2 and UMR106 cells that endogen...
T37210	5-hydroxy Indomethacin
	5-hydroxy Indomethacin is a metabolite of indomethacin .1It is formed from indomethacin in rabbit hepatic microsomes. 1.Evans, M.A., Papazafiratou, C., Bhat, R., et al.Indomethacin metabolism in isolated neonatal and fet...
T71145	Racecadotril-d5
	Racecadotril-d5 is intended for use as an internal standard for the quantification of racecadotril by GC- or LC-MS. Racecadotril is a prodrug form of the neprilysin (NEP) inhibitor thiorphan. In vivo, racecadotril reduce...
T75868	JMV 449 acetate
	JMV 449 acetate is a potent neurotensin receptor agonist. JMV 449 acetate shows an IC 50 of 0.15 nM for inhibition of 125 I-neurotensin binding to neonatal mouse brain and an EC 50 of 1.9 nM in contracting the guinea-pig...
T64266	KR-39038
	KR-39038 is an orally active GRK5 (G protein-coupled receptor kinase 5) inhibitor (IC50: 0.02 μM). KR-39038 inhibits the HDAC5 pathway in neonatal cardiomyocytes and significantly inhibits angiotensin II-induced hypertro...
T36215	17R(18S)-EpETE
	17R(18S)-EpETE is an oxylipin and a cytochrome P450 metabolite of eicosapentaenoic acid .1,217R(18S)-EpETE is an activator of large-conductance calcium-activated potassium (BKCa) channels, increasing the potassium curren...
T36055	Nitisinone-13C6	Nitisinone-13C6
	Nitisinone-13C6is intended for use as an internal standard for the quantification of nitisinone by GC- or LC-MS. Nitisinone is an inhibitor of 4-hydroxyphenylpyruvate dioxygenase (HPPD), which converts 4-hydroxyphenylpyr...
T83766	Moexiprilat	RS 10029
	Moexiprilat, an active metabolite of the prodrug moexipril formed through side chain ester hydrolysis in vivo, functions as an angiotensin-converting enzyme (ACE; IC50 = 2.1 nM) inhibitor. At a concentration of 10 nM, it...
T83721	Hexafluoropropylene Oxide Dimer Acid	FRD-903,Perfluoro-2-propoxypropanoic Acid,PFPrOPrA,HFPO-DA
	Hexafluoropropylene oxide dimer acid (HFPO-DA), a perfluoroalkyl ether carboxylic acid (PFECA), shows diverse biological impacts across species. At 250 µM, it triggers apoptosis and enhances reactive oxygen species (ROS)...
T36418	O-Desmethyl-N-deschlorobenzoyl Indomethacin
	O-Desmethyl-N-deschlorobenzoyl indomethacin is a metabolite of the non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor indomethacin .1It is formed from indomethacin in isolated rabbit hepatocytes. O-Desmethyl-...
T37347	6'-Sialyllactose Sodium Salt	6'-Sialyllactose Sodium Salt,6'-N-Acetylneuraminyl-D-lactose
	6'-Sialyllactose consists of the monosaccharide N-acetylneuraminic acid linked to the galactosyl subunit of lactose at the 6 position. This connection is at the 3 position in the related compound, 3’-sialyllactose. Both ...

Compounds

CGP 35348

T21793

Synonym:

Target: GABA Receptor

2-Methoxyidazoxan monohydrochloride

T23283

Synonym: RX 821002 hydrochloride

Target: Adrenergic Receptor

Temocapril hydrochloride

T6698

Synonym: CS-622 HCl,Acecol,Temocapril HCl,CS-622

Target: RAAS

ADR-925

T29670

Synonym: ICRF198,ICRF-198,ADR 925,ICRF 198,ADR925

Target: Endogenous Metabolite

Synonym: LAU 8080,LAU8080,BN 50730,LAU-8080,BN50730,BN-50730

Target: Platelet aggregation

(R)-3,4-DCPG HCl

T23215L

Synonym: (R)-3,4-DCPG HCl(201730-10-1 Free base)

Target: GluR

REVERSE T3

T7578

Synonym: 3,3',5'-triiodo-L-thyronine

Target: Thyroid hormone receptor(THR)

Argipressin acetate (113-79-1(free base))

Synonym: Acetylsalicylate,Acetylsalicylic Acid,ASA

Target: Mitophagy, Virus Protease, COX, Autophagy

Oxodipine

T68123

Synonym:

Target: Calcium Channel

hIgG–hFc receptor-IN-1

Apraglutide TFA (1295353-98-8 free base)

TP1171

Synonym: Apraglutide TFA,FE 203799e (TFA)

Synonym: Arg8-vasopressin,Vasopressin,AVP

Target: Vasopressin Receptor

Tauro-ω-muricholic acid sodium

DPC-AJ1951 (trifluoroacetate salt)

T37409

Synonym: DPC-AJ1951 (trifluoroacetate salt)

Target:

5-hydroxy Indomethacin

Synonym: Nitisinone-13C6

Hexafluoropropylene Oxide Dimer Acid

T83721

Synonym: FRD-903,Perfluoro-2-propoxypropanoic Acid,PFPrOPrA,HFPO-DA

Target:

O-Desmethyl-N-deschlorobenzoyl Indomethacin

T36418

Synonym:

Target:

6'-Sialyllactose Sodium Salt

T37347

Synonym: 6'-Sialyllactose Sodium Salt,6'-N-Acetylneuraminyl-D-lactose

Target:

Cat No.	Product Name	Synonyms	Targets
T5252	Tridecanedioic acid	1,11-Undecanedicarboxylic acid,1,13-Tridecanedioic acid,Brassilic acid	Others , Endogenous Metabolite
	Tridecanedioic acid (Brassilic acid) is an unusual odd-numbered dicarboxylic acid that appears in the urines of children with neonatal adrenoleukodystrophy and Zellweger syndrome, as an additional marker of these peroxis...		Others , Endogenous Metabolite
T4762	L-Pipecolic acid	L-Homoproline,H-HoPro-OH	Endogenous Metabolite
	L-Pipecolic acid (L-Homoproline) is a breakdown product of lysine, accumulates in body fluids of infants with generalized genetic peroxisomal disorders, such as Zellweger syndrome, neonatal adrenoleukodystrophy.		Endogenous Metabolite
T82545	Disialyllacto-N-tetraose
	Disialyllacto-N-tetraose, a human milk oligosaccharide, has been shown to prevent necrotizing enterocolitis in neonatal rats [1].
T72734	3-Fucosyllactose	3-Fucosyl-D-lactose
	3-Fucosyllactose (3-Fucosyl-D-lactose), a predominant fucosylated oligosaccharide in human breast milk, exhibits prebiotic, immunomodulating, neonatal brain development, and antimicrobial functions.
TN6453	Nardoaristolone B
	Nardoaristolone B, a nor-sesquiterpenoid with an unusual fused ring system and having protective effects on the injury of neonatal rat cardiomyocytes. The novel mosquito-repellentsynthetic hydrindanesbased on noreremophi...
T36337	Burnettramic Acid A aglycone
	Burnettramic acid A aglycone is a fungal metabolite and an aglycone form of burnettramic acid A originally isolated fromA. burnettiithat has anticancer activity.1It is cytotoxic to NS-1 murine myeloma cells but not neona...

Natural Products

Tridecanedioic acid

T5252

Synonym: 1,11-Undecanedicarboxylic acid,1,13-Tridecanedioic acid,Brassilic acid

Target: Others, Endogenous Metabolite

L-Pipecolic acid

T4762

Synonym: L-Homoproline,H-HoPro-OH

Target: Endogenous Metabolite

Disialyllacto-N-tetraose

Synonym: 3-Fucosyl-D-lactose

Burnettramic Acid A aglycone

T36337

Synonym:

Target:

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-00395	Insulin Protein, Human, Recombinant	Human	Yeast
	INS (Insulin) is a Protein Coding gene. This gene encodes insulin, a peptide hormone that plays a vital role in the regulation of carbohydrate and lipid metabolism. After removal of the precursor signal peptide, proinsul...
TMPY-00117	FGF-16 Protein, Human, Cynomolgus, Recombinant	Human,Cynomolgus	Baculovirus-Insect Cells
	Fibroblast growth factor 16 (FGF16) is preferentially expressed in the heart after birth, suggesting its regulation is associated with tissue-specific chromatin remodeling and DNA-protein interactions. Mutation of the ME...
TMPJ-00071	EPO/Erythropoietin Protein, Human, Recombinant (His)	Human	Human Cells
	Erythropoietin (EPO) is a glycoprotein hormone that is principally known for its role in erythropoiesis, where it is responsible for stimulating proliferation and differentiation of erythroid progenitor cells. Erythropoi...
TMPY-00639	EPO/Erythropoietin Protein, Human, Recombinant (hFc)	Human	HEK293
	Erythropoietin is a member of the EPO / TPO family. It is a secreted, glycosylated cytokine composed of four alpha helical bundles. Erythropoietin can be found in the plasma and regulates red cell production by promoting...
TMPY-00443	EPO/Erythropoietin Protein, Mouse, Recombinant	Mouse	HEK293
	Erythropoietin is a member of the EPO / TPO family. It is a secreted, glycosylated cytokine composed of four alpha helical bundles. Erythropoietin can be found in the plasma and regulates red cell production by promoting...
TMPY-00915	Serpin A1 Protein, Human, Recombinant (His)	Human	HEK293
	SerpinA1, also known as Alpha-1 antitrypsin (AAT), is a prototype member of the Serpin superfamily of the serine protease inhibitors. This serine protease inhibitor blocks the protease, neutrophil elastase. Alpha-1 antit...
TMPK-00096	FGF-10 Protein (Primary Amine Labeling), Human, Recombinant, Biotinylated	Human	E. coli
	Fibroblast growth factor 10 (FGF10) regulates multiple stages of structural lung morphogenesis, cellular differentiation, and the response to injury. As a driver of lung airway branching morphogenesis, FGF10 signaling de...
TMPY-06802	HSV 2 (strain 333) Glycoprotein D/gD Protein (His)	HSV2	HEK293
	Herpes simplex viruses (human herpesviruses types 1 and 2) commonly cause recurrent infection affecting the skin, mouth, lips, eyes, and genitals. Herpes simplex virus type 2 (HSV-2) infection is responsible for signific...
TMPJ-01451	Asprosin Protein, Human, Recombinant (His)	Human	Human Cells
	Asprosin is a protein hormone that is produced by white adipose tissue in mammals (and potentially by other tissues), which is then transported to the liver and stimulates it to release glucose into the blood stream. In ...
TMPJ-00541	CD177 Protein, Human, Recombinant (His)	Human	Human Cells
	CD177 is polymorphic and has at least two alleles: PRV1 and NB1. Human PRV1 is a Glycosyl-Phosphatidylinositol (GPI)-linked cell surface glycoprotein that belongs to the uPAR/CD59/Ly6 family of receptors. PRV1 is express...
TMPJ-00836	G6PD Protein, Human, Recombinant (His)	Human	Human Cells
	Glucose-6-Phosphate 1-Dehydrogenase (G6PD) is a cytosolic enzyme that belongs to the glucose-6-phosphate dehydrogenase family. G6PD participates in the pentose phosphate pathway that supplies reducing energy to cells by ...
TMPJ-01439	Asprosin Protein, Mouse, Recombinant (His)	Mouse	Human Cells
	Asprosin is a protein hormone that is produced by white adipose tissue in mammals (and potentially by other tissues), which is then transported to the liver and stimulates it to release glucose into the blood stream. In ...
TMPY-01865	BLMH Protein, Mouse, Recombinant (His)	Mouse	E. coli
	The papain superfamily member bleomycin hydrolase (BLMH) is a cytoplasmic cysteine peptidase that is highly conserved through evolution. The only known activity of the enzyme is metabolic inactivation of the glycopeptide...
TMPJ-01034	TIM Protein, Human, Recombinant (His)	Human	E. coli
	Triose-phosphate isomerase, also named Triose-phosphate isomerase, TPI and TIM, is an enzyme that catalyzes the reversible interconversion of the triose phosphate isomers dihydroxyacetone phosphate and D-glyceraldehyde 3...
TMPY-01820	Munc18-1/STXBP1 Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells
	Syntaxin-binding protein 1, also known as N-Sec1, Protein unc-18 homolog 1, MUNC18-1 and STXBP1, is a peripheral membrane protein that belongs to the STXBP / unc-18 / SEC1 family. STXBP1 is an evolutionally conserved neu...
TMPY-00462	EPO/Erythropoietin Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293
	Erythropoietin is a member of the EPO / TPO family. It is a secreted, glycosylated cytokine composed of four alpha helical bundles. Erythropoietin can be found in the plasma and regulates red cell production by promoting...
TMPY-02073	EPO/Erythropoietin Protein, Rat, Recombinant (His)	Rat	Baculovirus-Insect Cells
	Erythropoietin is a member of the EPO / TPO family. It is a secreted, glycosylated cytokine composed of four alpha helical bundles. Erythropoietin can be found in the plasma and regulates red cell production by promoting...
TMPY-02986	EPO/Erythropoietin Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Erythropoietin is a member of the EPO / TPO family. It is a secreted, glycosylated cytokine composed of four alpha helical bundles. Erythropoietin can be found in the plasma and regulates red cell production by promoting...
TMPY-01634	Surfactant protein D/SFTPD Protein, Rhesus, Recombinant (His)	Rhesus	HEK293
	Surfactant pulmonary-associated protein D, also known as SFTPD and SP-D, is a member of the collectin family of C-type lectins that is synthesized in many tissues including respiratory epithelial cells in the lung, and c...
TMPY-01765	Surfactant protein D/SFTPD Protein, Human, Recombinant (His)	Human	HEK293
	Surfactant pulmonary-associated protein D, also known as SFTPD and SP-D, is a member of the collectin family of C-type lectins that is synthesized in many tissues including respiratory epithelial cells in the lung, and c...
TMPY-01110	Surfactant protein D/SFTPD Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Surfactant pulmonary-associated protein D, also known as SFTPD and SP-D, is a member of the collectin family of C-type lectins that is synthesized in many tissues including respiratory epithelial cells in the lung, and c...
TMPY-00442	Serpin A1 Protein, Rat, Recombinant (His)	Rat	HEK293
	SerpinA1, also known as Alpha-1 antitrypsin (AAT), is a prototype member of the Serpin superfamily of the serine protease inhibitors. This serine protease inhibitor blocks the protease, neutrophil elastase. Alpha-1 antit...
TMPH-02963	ISG15 Protein, Mouse, Recombinant (His)	Mouse	Yeast
	Ubiquitin-like protein which plays a key role in the innate immune response to viral infection either via its conjugation to a target protein (ISGylation) or via its action as a free or unconjugated protein. ISGylation i...