linear

Xanthotoxol (Psoralen) is a biologically active linear furocoumarin, shows strong pharmacological activities as anti-inflammatory, antioxidant, 5-HT antagonistic, and neuroprotective effects.

Chitosan (MW 150000) (Deacetylated chitin) is a linear polysaccharide made up of randomly distributed β-(1-4)-linked D-glucosamine (deacetylated unit) and N-acetyl-D-glucosamine.

Lycopene (ψ,ψ-Carotene) is a linear, unsaturated hydrocarbon carotenoid, the major red pigment in fruits such as tomatoes, pink grapefruit, apricots, red oranges, watermelon, rosehips, and guava. As a class, carotenoids are pigment compounds found in photosynthetic organisms (plants, algae, and some types of fungus), and are chemically characterized by a large polyene chain containing 35-40 carbon atoms; some carotenoid polyene chains are terminated by two 6-carbon rings. In animals, carotenoids such as lycopene may possess antioxidant properties which may retard aging and many degenerative diseases. As an essential nutrient, lycopene is required in the animal diet.

Glutaric acid is a simple five-carbon linear dicarboxylic acid. Glutaric acid is naturally produced in the body during the metabolism of some amino acids, including lysine and tryptophan

Heparan sulfate is a natural product, a linear polysaccharide. Heparan sulfate occurs as a proteoglycan (HSPG) that is tightly attached to cell surface or extracellular matrix proteins.

L-Diguluronic acid, a linear polysaccharide copolymer consisting of two L-guluronic acid (G) units, serves as a precursor for Alginate[1], a categorically unbranched polyanionic polysaccharide. Alginate finds application in the development of antifungal agent delivery carriers[2].

Maltooctaose is a low molecular weight carbohydrate obtained by starch hydrolysis. It is composed of a group of linear α(1-4)-linked D-glucose polymers and trace amounts of (1-6)-linked glucose condensed with a degree of polymerization of 8.

Phycocyanobilin (PCB), a linear open-chain tetrapyrrole chromophore, is a bilirubin analog with anti-inflammatory and antioxidant activity for the study of neurological disorders such as Alzheimer's disease.

Nostosin G, a linear peptide, comprises three subunits: 4-hydroxyphenyllactic acid (Hpla), homotyrosine (Hty), and argininal. It exhibits a potent trypsin inhibitory effect, demonstrated by an IC 50 value of 0.1 μM [1].

Cecropin A TFA, a linear 37-residue antimicrobial polypeptide derived from Hyalaphora cecropia pupae, exhibits anti-bacterial, anti-inflammatory [1], and anti-cancer activities [2].

Dermatan sulphate sodium (Chondroitin sulfate B sodium salt) is a linear sulfated polysaccharide, a glycosaminoglycan component of several important proteoglycans, and an activating ligand for the kinase of mesenchymal lymphoma. Dermatan sulphate sodium is an anticoagulant, inhibiting thrombus Dermatan sulphate sodium is an anticoagulant that inhibits thrombosis.

(-)-Marmesinin (Ammijin) is a linear furanocoumarin isolated from Aegle marmelos, with antioxidant and neuroprotective activities, which can be used in research on myocardial injury.

Gallinamide A TFA is a peptide that exhibits linear deposition and serves as a potent inhibitor of cathepsin L (CatL) with an IC50 of 17.6 pM. It inhibits SARS-CoV-2 infection by targeting CatL (EC50: 28 nM) and also inhibits Plasmodium falciparum with an IC50 of 50 nM [1] [2].

Graveolone belongs to the class of organic compounds known as linear pyranocoumarins. Graveolone can be found in dill, herbs and spices, and parsley.

Nocarnickelamides B (Compound 2) is a linear peptide and an inhibitor of ROCK1 2. It exhibits dual inhibitory activity against ROCK1 and ROCK2, with IC50 values of 14.9 μM and 21.9 μM, respectively. This compound binds to the ATP binding site and inhibits ROCK-mediated cytoskeletal contraction markers, such as myosin light chain activation. Nocarnickelamides B can be utilized in glaucoma research.

Tasiamide B is a linear peptide and Cathepsin D inhibitor discovered in the marine cyanobacterium Symploca sp. This compound serves as an excellent template for the development of aspartic protease inhibitors. Tasiamide B effectively targets skin cancer through its strong interaction with the protein HSP90.