Search Result

Search Results for " immunosuppression "

Targets

Apoptosis DNA/RNA Synthesis Antibacterial Antibiotic HSV

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T1454	Acyclovir	Aciclovir,Acycloguanosine	Apoptosis , DNA/RNA Synthesis , Antibacterial , Antibiotic , HSV
	Acyclovir (Aciclovir) is a synthetic analog of the purine nucleoside, guanosine, with potent antiviral activity against herpes simplex viruses type 1 and 2, varicella-zoster virus and other viruses of the herpesvirus fam...
T3189	B7/CD28 interaction inhibitor 1	CTLA-4 inhibitor	Others
	B7/CD28 interaction inhibitor 1 (CTLA-4 inhibitor) is a potent CTLA-4 inhibitor.		Others
T8875	CD73-IN-3	EX-A4254,LY-3475070	CD73
	CD73-IN-3 (LY-3475070) is a potent and selective CD73 inhibitor with an IC50 of 28 nM, and its use alone or in combination with pembrolizumab is currently being tested in patients with advanced cancer.		CD73
T27695	JTE-607	JTE-607 dihydrochloride,JTE-607 HCl	Cysteine Protease
	JTE-607 is a cytokine production inhibitor. JTE-607 induces apoptosis accompanied by an increase in p21waf1/cip1 in acute myelogenous leukemia cells.		Cysteine Protease
T22430	SRX3207		Others , PI3K , Syk
	SRX3207 is an inhibitor of Syk and PI3K and relieves tumor immunosuppression.		Others , PI3K , Syk
T7776	ADH-503	GB1275	Complement System
	ADH-503 (GB1275) is a potent agonist of the integrin CD11b to mitigate myeloid cell immunosuppression.		Complement System
T10824	Cis-Urocanic acid	cis-UCA,(Z)-Imidazole-4-acrylic acid,(Z)-Urocanic acid,(E)-Urocanic acid,(Z)-3-(1H-Imidazol-5-yl)acrylic acid	5-HT Receptor
	cis-Urocanic acid ((E)-Urocanic acid) is a 5-HT2A receptor agonist (Kd: 4.6 nM). It is an immune modulator that induces immunosuppression by binding to the 5-HT2A receptor.		5-HT Receptor
T6543	Indoximod	NLG-8189,Indoximod (NLG-8189）,1-Methyl-D-tryptophan	Indoleamine 2,3-Dioxygenase (IDO)
	Indoximod (Indoximod (NLG-8189)) is a methylated tryptophan with immune checkpoint inhibitory activity. Indoximod inhibits the enzyme indoleamine 2, 3-dioxygenase (IDO), which degrades the essential amino acid tryptophan...		Indoleamine 2,3-Dioxygenase (IDO)
T71938	MNF
	MNF, also known as 3,4-MNF, is an antagonist of the aryl hydrocarbon receptor (AhR). MNF reduces UVR-mediated immunosuppression and induces Tregs in murine contact hypersensitivity (CHS).
T69648	Inupadenant HCl
	Inupadenant, also known as EOS-850, is a highly selective small molecule antagonist of the adenosine A2a receptor, in the adenosine triphosphate adenosine pathway, a key driver of immunosuppression in the tumor microenv...
T30508	BMS-243117	UNII-MBE6KWV0QI,CHEMBL67237,MBE6KWV0QI
	BMS-243117 is an effective selective LCK inhibitor with good cell activity (IC(50)=1.1 microM) and inhibition of T cell proliferation, which has great potential for therapeutic immunosuppression and the treatment of dise...
T80726	Ziralimumab	ABX-RB2
	Ziralimumab (ABX-RB2), an anti-human CD147/BSG monoclonal antibody, is employed for immunosuppression [1].
T63956	OP-5244 sodium
	OP-5244 sodium is a potent, orally active inhibitor of CD73 (IC50: 0.25 nM). OP-5244 sodium has shown potential for cancer research by blocking adenosine production and thereby reversing immunosuppression.
T40211	EIF4E-IN-1	eIF4E-IN-1
	eIF4E-IN-1 (WO2021003194A1, compound Y), is a highly effective inhibitor of eIF4E, a key protein involved in immunosuppression. By targeting immune checkpoint proteins such as PD-1, PD-L1, LAG3, TIM3, and IDO, eIF4E-IN-1...
T12240	Nor-NOHA acetate	Nω-Hydroxy-nor-L-arginine acetate	Apoptosis , Arginase
	nor-NOHA acetate (Nω-Hydroxy-nor-L-arginine acetate) is a reversible inhibitor of arginase, with anti-leukemic activity, effective in endothelial dysfunction, immunosuppression, and metabolism.		Apoptosis , Arginase
T64239	Belatacept
	Belatacept (BMS 224818) is a selective blocker of T-cell costimulation. Belatacept binds CD 80/86 ligands and thus exhibits an inhibitory effect on CD-28-mediated T-cell costimulation. Belatacept can be used to study org...
T61053	CD73-IN-11
	CD73-IN-11 is able to used for tumor-related diseases medicament preparing. CD73-IN-11 is an effective CD73 inhibitor. CD73 can catalyze the production of adenosine from extracellular 5'-phosphate adenosine (5'-AMP) whic...
T61000	CD73-IN-10
	CD73-IN-10 can be used in preparing tumor-related diseases medicament. CD73-IN-10 is a potent CD73 inhibitor that can catalyze the adenosine production from extracellular 5'-phosphate adenosine (5'-AMP). Adenosine induce...
T82609	Dargistotug	M-6223
	Dargistotug (M-6223) is a fully human IgG1 monoclonal antibody that targets TIGIT (T cell immune receptor with Ig domain and ITIM), an inhibitory immune checkpoint responsible for NK cell depletion and diminished cytokin...
T79653	VISTA-IN-2		Autophagy
	VISTA-IN-2 (Compound 1) is a V-domain Ig suppressor of T-cell activation (VISTA) inhibitor that promotes the degradation of VISTA in cells via autophagy, reverses VISTA-related immunosuppression, and fortifies the antitu...		Autophagy
T79319	OATD-02		Arginase
	OATD-02 is an orally active, competitive, reversible, noncovalent inhibitor with slow offset kinetics that targets both Arginase1 and 2, exhibiting inhibitory concentrations (IC50) of 20 nM (hARG1), 39 nM (hARG2), 39 nM ...		Arginase

Compounds

Acyclovir

T1454

Synonym: Aciclovir,Acycloguanosine

Target: Apoptosis, DNA/RNA Synthesis, Antibacterial, Antibiotic, HSV

B7/CD28 interaction inhibitor 1

T3189

Synonym: CTLA-4 inhibitor

Target: Others

CD73-IN-3

T8875

Synonym: EX-A4254,LY-3475070

Target: CD73

JTE-607

T27695

Synonym: JTE-607 dihydrochloride,JTE-607 HCl

Target: Cysteine Protease

SRX3207

T22430

Synonym:

Target: Others, PI3K, Syk

ADH-503

T7776

Synonym: GB1275

Target: Complement System

cis-Urocanic acid

T10824

Synonym: cis-UCA,(Z)-Imidazole-4-acrylic acid,(Z)-Urocanic acid,(E)-Urocanic acid,(Z)-3-(1H-Imidazol-5-yl)acrylic acid

Target: 5-HT Receptor

Indoximod

T6543

Synonym: NLG-8189,Indoximod (NLG-8189）,1-Methyl-D-tryptophan

Target: Indoleamine 2,3-Dioxygenase (IDO)

Synonym: UNII-MBE6KWV0QI,CHEMBL67237,MBE6KWV0QI

Synonym: Nω-Hydroxy-nor-L-arginine acetate

Target: Apoptosis, Arginase

Cat No.	Product Name	Synonyms	Targets
T2210	Genipin	(+)-Genipin	Others , Autophagy
	Genipin ((+)-Genipin), an active aglycone derived from an iridoid glycoside called geniposide, is found in the fruit of Gardenia jasminoides Ellis.		Others , Autophagy
T0948L	Corticosterone	17-Deoxycortisol,11β,21-Dihydroxyprogesterone,Kendall's compound B,Corticosterone (From plants)	Glucocorticoid Receptor , Endogenous Metabolite
	Corticosterone (Kendall's compound B) is an adrenocortical steroid with salocorticoid and glucocorticoid activity that is orally active. Corticosterone is involved in the regulation of energy, immune responses, and stres...		Glucocorticoid Receptor , Endogenous Metabolite
T2729	Scoparone	Escoparone,Scoparon,Aesculetin dimethyl ether,6,7-dimethoxycoumarin,6,7-Dimethylesculetin	Others
	Scoparone (Aesculetin dimethyl ether) can be found in a number of food items such as sweet orange, wild celery, mandarin orange (clementine, tangerine), and lemon. It is found in the Chinese herb Artemisia scoparia and h...		Others
TJS1779	Protosappanin A	PTA	NADPH-oxidase , IL Receptor , IκB/IKK , TNF , NF-κB , TLR , ROS , COX , HIV Protease , JAK , NO Synthase , STAT
	Protosappanin A (PTA) has anti-oxidative/nitrative activities on brain immune and neuroinflammation through regulation of CD14/TLR4-dependent IKK/IÎºB/NF-ÎºB inflammation signal pathway; it exerts anti-neuroinflammatory ...

Natural Products

Genipin

T2210

Synonym: (+)-Genipin

Target: Others, Autophagy

Corticosterone

T0948L

Synonym: 17-Deoxycortisol,11β,21-Dihydroxyprogesterone,Kendall's compound B,Corticosterone (From plants)

Target: Glucocorticoid Receptor, Endogenous Metabolite

Scoparone

T2729

Synonym: Escoparone,Scoparon,Aesculetin dimethyl ether,6,7-dimethoxycoumarin,6,7-Dimethylesculetin

Target: NADPH-oxidase, IL Receptor, IκB/IKK, TNF, NF-κB, TLR, ROS, COX, HIV Protease, JAK, NO Synthase, STAT

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-05838	CD52 Protein, Cynomolgus, Recombinant (hFc)	Cynomolgus	HEK293
	CD52 / CDW52 is a small glycosylphosphatidylinositol (GPI) anchored glycoprotein. It has a mature peptide comprising only 12 amino acids and is abundantly expressed on human lymphocytes. From the clinical point of view t...
TMPY-03001	CD52 Protein, Rat, Recombinant (hFc)	Rat	HEK293
	CD52 / CDW52 is a small glycosylphosphatidylinositol (GPI) anchored glycoprotein. It has a mature peptide comprising only 12 amino acids and is abundantly expressed on human lymphocytes. From the clinical point of view t...
TMPY-03413	PPIL2 Protein, Human, Recombinant (aa 280-457, His)	Human	E. coli
	PPIL2, is an enzyme that belongs to the cyclophilin family. The cyclophilins are peptidylprolyl isomerases and are highly conserved ubiquitous. They play an important role in protein folding, immunosuppression by cyclosp...
TMPY-04488	CD52 Protein, Human, Recombinant (hFc)	Human	HEK293
	CD52 / CDW52 is a small glycosylphosphatidylinositol (GPI) anchored glycoprotein. It has a mature peptide comprising only 12 amino acids and is abundantly expressed on human lymphocytes. From the clinical point of view t...
TMPY-05609	CD52 Protein, Human, Recombinant (hFc & Avi), Biotinylated	Human	HEK293
	CD52 / CDW52 is a small glycosylphosphatidylinositol (GPI) anchored glycoprotein. It has a mature peptide comprising only 12 amino acids and is abundantly expressed on human lymphocytes. From the clinical point of view t...
TMPY-00222	CD52 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
	CD52 / CDW52 is a small glycosylphosphatidylinositol (GPI) anchored glycoprotein. It has a mature peptide comprising only 12 amino acids and is abundantly expressed on human lymphocytes. From the clinical point of view t...
TMPJ-01068	FKBP25/FKBP3 Protein, Human, Recombinant (His)	Human	E. coli
	FKBP25 contains 1 PPIase FKBP-type domain, belongs to the FKBP-type PPIase family. FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell prolif...
TMPY-03285	PPIL1 Protein, Human, Recombinant (His)	Human	E. coli
	PPIL1 is a member of the cyclophilin family. Cyclophilins are well conserved and ubiquitous. Members of cyclophilin family take a significant part in protein folding, immunosuppression by cyclosporin A, and infection of ...
TMPY-05314	TGF beta 2 Protein, Mouse, Recombinant (His), Biotinylated	Mouse	HEK293
	TGF beta 2 (Transforming growth factor beta 2), an extracellular glycosylated protein, which belongs to the TGF-beta family. TGF-beta regulates key mechanisms of tumor development, namely immunosuppression, metastasis, a...
TMPY-00231	TGF beta 2 Protein, Canine, Recombinant (His)	Canine	HEK293
	TGF beta 2 (Transforming growth factor beta 2), an extracellular glycosylated protein, which belongs to the TGF-beta family. TGF-beta regulates key mechanisms of tumor development, namely immunosuppression, metastasis, a...
TMPY-00413	TGF beta 2 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	TGF beta 2 (Transforming growth factor beta 2), an extracellular glycosylated protein, which belongs to the TGF-beta family. TGF-beta regulates key mechanisms of tumor development, namely immunosuppression, metastasis, a...
TMPY-04577	TGF beta 2 Protein, Rhesus, Recombinant (His)	Rhesus	HEK293
	TGF beta 2 (Transforming growth factor beta 2), an extracellular glycosylated protein, which belongs to the TGF-beta family. TGF-beta regulates key mechanisms of tumor development, namely immunosuppression, metastasis, a...