dca

AlbA-DCA, a conjugate of Albiziabioside A and a dichloroacetate acid subunit, markedly increases intracellular ROS, alleviates lactic acid accumulation in the tumor microenvironment, selectively kills cancer cells, and induces apoptosis.

CL2A-SN-38 is a drug-linker conjugate composed of a potent a DNA Topoisomerase I inhibitor SN-38 and a linker CL2A to make antibody drug conjugate (ADC).. CL2A-SN-38 is composed of a potent a DNA Topoisomerase I inhibitor SN-38 and a linker CL2A to make antibody drug conjugate (ADC). CL2A-SN-38 provides significant and specific antitumor effects against a range of human solid tumor types. CL2A is a noncleavable complicated PEG8- and triazole-containing PABC-peptide-mc linker. CL2A is cleavable through pH sensitivity, giving rise to bystander effect, and binds the antibody at a cysteine residue via a disulfide bond. .

Deoxycholic acid (Cholanoic Acid) is a bile acid formed by bacterial action from cholate. It is usually conjugated with glycine or taurine. Deoxycholic acid acts as a detergent to solubilize fats for intestinal absorption, is reabsorbed itself, and is used as a choleretic and detergent.

Sodium dichloroacetate (BCA) , a specific inhibitor of pyruvate dehydrogenase kinase (PDK) with IC50 values of 183 and 80 μM for PDK2 and PDK4 respectively, has been shown to derepress a mitochondrial potassium-ion channel axis, trigger apoptosis in cancer cells, and inhibit tumor growth.

22-Hydroxy docosanoic acid, a hydroxylated fatty acid identified within the suberin component of silver birch (B. pendula) outer bark, along with the leaves, roots, and wood of Q. ilex from Cala Violina and Colognole, Italy. [Matreya, LLC. Catalog No. 1818]

1β-Hydroxydeoxycholic acid (1β-OH-DCA), recognized as a secondary bile acid, serves as a biomarker for CYP3A. This compound is metabolized from deoxycholic acid specifically by CYP3A4 and CYP3A7 through recombinant human CYP450 enzymes [1].

DCA-RMR1 is a cross-linking agent. It induces the bicyclization of natural peptides via N-terminal Cys-Cys cross-linking. DCA-RMR1 is synthesized by derivatizing RMR1 with 1,3-dichloroacetone (DCA).

Honokiol DCA is an inhibitor of DRP1 phosphorylation. Honokiol DCA stimulates a phenotype suggestive of respiration through mitochondrial normalization and demonstrating activity in Vemurafenib-resistant melanoma in vivo.

LDCA is a double-hit metabolic regulator that exhibits potent anti-proliferative activity. lDCA competitively inhibits LDH-A enzyme activity, alters mitochondrial hyperpolarization and simultaneously subverts apoptosis. lDCA has a pronounced effect in cancer cells and does not show toxicity.

Mito-SilylDCA, a mitochondrial-targeted pyruvate dehydrogenase kinase (PDK1) inhibitor, possesses a thiamine pyrophosphate (TPP) moiety for PDK1 targeting within the mitochondrial network, several dichloroacetate (DCA) groups for effective PDK1 inhibition, a polyethylene glycol linker, and a silyl group [1].

DCAF1 Ligand 1 (compound I-653) serves as the target protein ligand for PROTA CBRD4-DCAF1 degrader-1, exhibiting a DC50 value of 10~100 nM.

PROTACBRD4-DCAF1 degrader-1 (I-907) is a PROTAC degrader targeting BRD4-DCAF1, exhibiting a DC50 range of 10~100 nM.

DCAF11 ligand 1 acts as a ligand for the E3 ubiquitin ligase DCAF11, and it is used in the synthesis of the PROTAC degrader FF2039.

DCAF15 ligand-1 (compound 9) is a ligand for the E3 ligase DCAF15, suitable for synthesizing PROTACs such as IBG1.

DCAI is an inhibitor of nucleotide exchange and nucleotide release acting by binding to the pocket adjacent to the Ras-SOS interface.

DCAT Maleate is an inhibitor of N-methyl transferases (NMT). DCAT Maleate methylate non-methylated pre-neurotoxins to prevent the formation of Parkinson's syndrome neurotoxins.

DCAI hydrochloride is an inhibitor of nucleotide exchange and nucleotide release, by binding to the pocket adjacent to the Ras-SOS interface.

DCAF1 Binder 1 selectively targets the CRL4 DCAF1 E3 ligase complex as a ligand, playing a role in targeted protein degradation (TPD) [1].

DCAF1 Binder 2, an E3 ligase ligand, is implicated in BRD9, kinase, and selective Bruton's tyrosine kinase (BTK) degradation.

DCAP is a potent broad-spectrum antibiotic lead derived from natural products. It exerts bactericidal effects by specifically inducing bacterial membrane permeabilization and irreversible loss of membrane potential, demonstrating excellent in vitro activity against resistant Gram-positive bacteria.

Anti-Mouse MAdCAM-1 Antibody (MECA-367) is a rat-derived IgG2a, κ antibody inhibitor targeting mouse MAdCAM-1.

N-Methyllindcarpine is a natural product of Lindera, Lauraceae. The catalog number is TN6015 and the CAS number is 14028-97-8. N-Methyllindcarpine can be used as a reference standard.

AdCaPy is a catalyst for MHC II antigen loading, which accelerates the loading process of peptide antigens onto MHC II. AdCaPy serves as a valuable molecular tool for enhancing immune response.

(-)-Epigallocatechin Gallate (EGCG) is a phenolic antioxidant polyphenol flavonoid found in plants such as green and black tea, which inhibits telomerase and DNA methyltransferase, blocks the activation of EGF receptors and HER-2 receptors, inhibits cellular oxidation, and prevents free radical damage to cells.