ataxia — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T9989	AChE-IN-27		Others
	AChE-IN-27 is a small molecule used for high-throughput assays.		Others
T5175	Azd1390		ATM/ATR
	AZD1390 is an exceptionally potent inhibitor of ATM in cells (IC50: 0.78 nM) with >10,000-fold selectivity over closely related members of the PIKK family of enzymes.		ATM/ATR
T3338	Ceralasertib	AZD6738	ATM/ATR
	Ceralasertib (AZD6738) is an orally active, and selective ATR kinase inhibitor with IC50 of 1 nM.		ATM/ATR
T4443	AZ32		ATM/ATR
	AZ32 is an orally bioavailable and blood-brain barrier-penetrating ATM inhibitor with an IC50 of <6.2 nM for ATM enzyme, and an IC50 of 0.31 μM for ATM in cell.		ATM/ATR
T1958	AZ20		ATM/ATR , mTOR
	AZ20 is an effective and specific inhibitor of ATR kinase (IC50: 5 nM, in a cell-free assay), 8-fold selectivity over mTOR.		ATM/ATR , mTOR
T6770	AZD0156		Apoptosis , ATM/ATR
	AZD0156 , an effective and specific inhibitors of ATM kinase, is potential antineoplastic activities and chemo-/radio-sensitizing.		Apoptosis , ATM/ATR
T3032	VE-821	ATR Inhibitor IV	ATM/ATR
	VE-821 (ATR Inhibitor IV) is a selective ATP competitive inhibitor of ATR( Ki/IC50: 13/26 nM in cell-free assays).		ATM/ATR
T1821	CGK733	CGK 733	ATM/ATR
	CGK733 (CGK 733) is a potent and selective inhibitor of ATM/ATR.		ATM/ATR
T6261	CP-466722	CP 466722,CP466722	ATM/ATR
	CP-466722, an effective and reversible ATM inhibitor, does not inhibit ATR and PI3K or PIKK family members in cells.		ATM/ATR
T6612	NU6027		ATM/ATR , DNA-PK , CDK
	NU6027 is a potent ATR/CDK inhibitor, inhibits CDK1/2, ATR and DNA-PK with Ki of 2.5 μM/1.3 μM, 0.4 μM and 2.2 μM, enter cells more readily than the 6-aminopurine-based inhibitors.		ATM/ATR , DNA-PK , CDK
T2084	ETP-46464		ATM/ATR , DNA-PK , PI3K , mTOR
	ETP-46464 is an effective and specific ATR inhibitor (IC50: 25 nM).		ATM/ATR , DNA-PK , PI3K , mTOR
T9522	Rimtuzalcap	CAD-1883	Potassium Channel
	Rimtuzalcap (CAD-1883) (CAD-1883), a pioneering selective positive allosteric modulator of small-conductance calcium-activated potassium channels (SK channels), is employed in the study of movement disorders such as spin...		Potassium Channel
T8922	SRS11-92	AA9	Ferroptosis
	SRS11-92 (AA9) is a ferroptosis inhibitor and a derivative of ferrostatin-1		Ferroptosis
TN1673	Garcinone C		ATM/ATR , CDK , STAT , AChR , Antifection
	Garcinone C is a xanthone derivative extracted from Garcinia oblongifolia Champ with anti-inflammatory, astringency, and granulation-promoting activities. Garcinone C is an AChE inhibitor and has potential cytotoxic effe...		ATM/ATR , CDK , STAT , AChR , Antifection
T7318	Elimusertib	BAY-1895344	ATM/ATR
	Elimusertib (BAY-1895344) is a potent, highly selective and orally available ATR inhibitor with an IC50 of 7 nM.Elimusertib shows potent anti-tumor efficacy in monotherapy and strong combination potential with the target...		ATM/ATR
T2685	KU-55933	ATM Kinase Inhibitor	ATM/ATR , DNA-PK , PI3K , mTOR , Autophagy
	KU-55933 (ATM Kinase Inhibitor) is a potent and specific ATM inhibitor.		ATM/ATR , DNA-PK , PI3K , mTOR , Autophagy
T2S1200	Sinapine		Antioxidant , P-gp , AChE
	1. Sinapine, an alkaloid from seeds of the cruciferous species, can be used as an effective natural compound for chemo-resistance. 2. Sinapine has antioxidant and radio-protective activities.		Antioxidant , P-gp , AChE
T7122	AZD-7648		DNA-PK
	AZD-7648 is an inhibitor of DNA-dependent protein kinase (DNA-PK) with the IC50 of 0.63 nM in an enzyme assay,has anti-tumor activity.		DNA-PK
T3392	Sinapine thiocyanate		P-gp , AChE
	Sinapine Thiocyanate, is a derivative of Sinapine (S486605), an alkaloidal amine found in black mustard seeds. It is the choline ester of Sinapic Acid (S486800). It is also a phenolic-chloine conjugates, acting as anti-o...		P-gp , AChE
T19663	Triheptanoin	UX 007,IND106011,UX007,UX-007,IND 106011,IND-106011	Others
	Triheptanoin (IND 106011) is a fatty acid metabolic modulator. It potentially for the treatment of fatty acid oxidation disorders and GLUT1.		Others