apn

APN-C3-NH-Boc is a alkyl/ether-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

APN-C3-PEG4-alkyne is a PEG-based linker for PROTACs, joining two essential ligands critical for forming PROTAC molecules, and enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

APN-C3-PEG4-azide is a PEG-based linker for PROTACs, facilitating the conjugation of two essential ligands vital for PROTAC molecule formation. This linker supports selective protein degradation via the cell's ubiquitin-proteasome system.

APN- NH2 is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

APN-PEG4-Amine (hydrochloride) is a cleavable four-unit polyethylene glycol (PEG) linker used in the synthesis of antibody-drug conjugates (ADCs) [1].

APN-PEG4-BCN is a cleavable, four-unit polyethylene glycol (PEG) linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

APN-PEG4-DBCO is a cleavable linker for antibody-drug conjugates (ADCs), consisting of a four-unit PEG and a DBCO moiety, used in ADC synthesis[1].

APN-PEG4-PFP is a PEG-based linker for PROTACs that connects two essential ligands, facilitating the formation of PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

APN-PEG4-tetrazine, a cleavable ADC linker compound composed of four PEG units, is specifically designed for the synthesis of antibody-drug conjugates (ADCs) [1].

Bestatin (Ubenimex) competitively inhibits many aminopeptidases, including B, N and leucine aminopeptidases. Ubenimex is a microbial metabolite and dipeptide with potential immunomodulatory and antitumor activities. Aminopeptidases has been implicated in the process of cell adhesion and invasion of tumor cells. Therefore, inhibiting aminopeptidases may partially attribute to the antitumor effect of ubenimex. This agent also activates T lymphocyte, macrophage, and bone marrow stem cell as well as stimulates the release of interleukin-1 and -2, thus further enhances its antitumor activity.

Dinutuximab is a recombinant chimeric monoclonal antibody targeting GD2, with potential anti-cancer activity, used in high-risk neuroblastoma research.

Alunacedase alfa (APN-01) is a soluble angiotensin-converting enzyme 2 (hrsACE2) with antiviral activity that reduces the competitive entry of SARS-CoV-2 into cell membranes bound to ACE2. alunacedase alfa mimics ACE2 in vivo and can be used to study novel coronavirus infections, pulmonary hypertension and acute lung injury. Alunacedase alfa mimics ACE2 in vivo and can be used to study novel coronavirus infections, pulmonary hypertension and acute lung injury.

APN/AKT-IN-1 is a potent dual inhibitor of aminopeptidase N (APN) and protein kinase B (AKT), with IC50 values of 0.21 μM for APN and 0.27 μM for AKT inhibition. The compound effectively suppresses the phosphorylation of glycogen synthase kinase 3 beta (GSK3β), an intracellular substrate of AKT [1].

APN-PEG36-tetrazine, an analogue of APN-PEG4-tetrazine, serves as a cleavable polyethylene glycol (PEG) linker with 36 units, facilitating the synthesis of antibody-drug conjugates (ADCs) [1].

APN-PEG5-VC-PAB-MMAE is a component of INA03, functioning as a drug-linker conjugate in this transferrin-competitive antibody-drug conjugate targeting CD71 [1].

APNEA ((2R,3R,4S,5R)-2-[6-[2-(4-aminophenyl)ethylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol) is a non-selective agonist of adenosine A3 receptor.

Capnolactone is a useful organic compound for research related to life sciences. The catalog number is T124692 and the CAS number is 53771-63-4.

Bmapn is a synthetic cathinone that exhibits rewarding and reinforcing properties. It reduces dopamine transporter levels and increases the expression of the dopamine receptor D2 gene in the striatum.

CTSL/CAPN1-IN-1 (compound 14a) is an orally active inhibitor targeting CTSL and CAPN1, with IC50 values of 3.34 nM and 375.1 nM, respectively. It exhibits both anti-coronavirus and anti-inflammatory activities.

Capnoidine is a potential new anti-inflammatory drug lead candidate for diseases where current standard-of-care often fails and is associated with major side effects.

Bulbocapnine hydrochloride, a dopamine receptor inhibitor and an aporphine alkaloid, not only inhibits dopamine synthesis but also exhibits neuroleptic-like, anticonvulsant, and antinociceptive effects [1] [2] [3].

CTSL/CAPN1-IN-2 (Compound 14b) serves as an orally active inhibitor targeting both CTSL and CAPN1, manifesting IC50 values of 6.88 nM for CTSL and 347.6 nM for CAPN1 respectively. This compound not only displays anti-inflammatory attributes but also features favorable pharmacokinetic properties. Moreover, CTSL/CAPN1-IN-2 shows extensive antiviral effects against coronaviruses by inhibiting viral entry [1].

Zapnometinib (ATR-002) is a MEK inhibitor.

APNmAb005 is a human monoclonal antibody (mAb) that targets MAPT/Tau/PHF-tau. It can inhibit tau seeding in vitro and prevent neuronal loss in rTG4510 mice. APNmAb005 is applicable for Alzheimer's disease (AD) research.