55
23
1
1
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T21640 | Talinolol | Adrenergic Receptor | |
(±)-Talinolol is a selective β1 adrenoceptor antagonist well known for its cardioprotective and antihypertensive activity. | |||
T1940 | BTB06584 | RAAS , ATPase | |
BTB06584 is an IF1-dependent, selective inhibitor of the mitochondrial F1 Fo-ATPase. BTB06584 is a novel acetohydroxyacid synthase(AHAS) inhibitor, a promising drug target against Mycobacterium tuberculosis (MTB). | |||
T24109 | GSK329 | GSK 329,GSK-329 | Others |
GSK329 is an effective and selective inhibitor of TNNI3 Interacting Kinase (TNNI3K). GSK329 exhibits positive cardioprotective outcomes in the model of ischemia/reperfusion cardiac injury. | |||
T21919 | UCF 101 | Apoptosis | |
UCF 101 is a specific inhibitor of HtrA2 and reduces apoptosis in PC12 cells. | |||
T9714 | Atpenin A5 | Potassium Channel | |
Atpenin A5 is a potent and highly specific complex II inhibitor (IC50 ~10 nM). Atpenin A5 is also an effective mKATP channel agonist and cardioprotective agent[1]. | |||
T0075 | Nicorandil | SG-75 | Potassium Channel |
Nicorandil (SG-75)(Ikorel) acts by relaxing the smooth muscle of the blood vessels, especially those of the venous system. It undertakes this through two methods. Firstly, by activating potassium channels, and secondly b... | |||
T12478L | Pinacidil | S 1230,P 1134,S-1230,P-1134,P1134 | Potassium Channel |
Pinacidil (P 1134) is a guanidine that opens potassium channels and directly dilates peripheral blood vessels in small arteries, lowering blood pressure and peripheral resistance and producing fluid retention. | |||
T19335 | Danegaptide Hydrochloride | GAP-134 (Hydrochloride),ZP 1609 Hydrochloride | Gap Junction Protein |
Danegaptide Hydrochloride (GAP-134 (Hydrochloride)) (GAP-134 Hydrochloride) is a selective modifier of the gap junction protein. | |||
T25859 | Necrostatin-7 | Necrostatin 7,Necrostatin7,Nec 7,Nec-7,Nec7 | Apoptosis |
Necrostatin-7 (Necrostatin 7) is an inhibitor of necrotic apoptosis with cardioprotective effects, inhibits RANK-NFATc1 signaling, and attenuates macrophage differentiation into osteoblasts. | |||
T37807 | JTV 519 fumarate | ||
Ryanodine receptor (RyR) inhibitor; stabilizes RyR2 in a closed conformation. Exhibits antiarrhythmic and cardioprotective properties in vivo. Hunt et al (2007) K201 (JTV519) suppresses spontaneous Ca2+ release and [3H]r... | |||
T10874 | CP-060 | Calcium Channel | |
CP-060 is a potent Ca2+ antagonist and inhibits Ca2+ overload with antioxidant and cardioprotective activities. | |||
T8493 | Ingliforib | GPi 296,CP 368296 | Phosphorylase |
Ingliforib (CP 368296) is a novel glycogen phosphorylase inhibitor,has antihyperglycemic and cardioprotective properties. | |||
T6454 | CORM-3 | CORM3 | Others , NF-κB , NOD-like Receptor (NLR) |
CORM-3 is a carbon monoxide-releasing molecule with anti-inflammatory and cardioprotective activity. | |||
T68077 | Furnidipine | ||
Furnidipine significantly reduced AoD and AF and had antiarrhythmic and cardioprotective effects at low doses in a rat model. | |||
T7845 | BTZO-1 | Apoptosis | |
BTZO-1 is an antioxidant response element (ARE) activator with cardioprotective activity. | |||
T75098 | HIF-PHD-IN-3 | Reactive Oxygen Species | |
HIF-PHD-IN-3 is a potent hiPSC-CM cardioprotective scaffold with potential inhibitory effects on HIF-PHD, regulates heme oxygenase-1, and can be used to study anaemia. | |||
T16812 | RWJ-67657 | JNJ 3026582 | p38 MAPK |
RWJ-67657 (JNJ 3026582) is an orally active and selective p38α and p38β MAPK inhibitor (IC50s: 1 and 11 μM, respectively). RWJ-67657 shows no activity at p38γ and p38δ and shows a cardioprotective effect. | |||
T16420 | P-1075 | Potassium Channel | |
P-1075 opens mitochondrial K(ATP) channels and generates reactive oxygen species causing cardioprotection of rabbit hearts. P-1075 is an effective activator of sulfonylurea receptor 2-associated ATP-sensitive potassium c... | |||
T37379 | Protectin D1 | Neuroprotectin D1,NPD1 | Akt , PI3K |
Protectin D1 (Neuroprotectin D1) is a neuroprotectin produced by neuronal cells and is a potential cardioprotective agent.Protectin D1 attenuates myocardial ischemia/reperfusion injury and inhibits imiquimod-induced psor... | |||
T24270 | KS370G | KS-370-G,KS 370 G,Caffeic Acid Phenethyl Amide | |
KS370G (Caffeic Acid Phenethyl Amide) inhibits UUO-induced renal fibrosis marker expression. KS370G is an orally active hypoglycemic and cardioprotective agent that reduces collagen deposition in obstructed kidneys and s... | |||
T14506 | BAY 60-6583 | Others , Adenosine Receptor | |
BAY 60-6583 is a potent, high-affinity adenosine A2B receptor agonist (EC50 = 3 nM) with affinity for A2B receptors that exceeds that for A1, A2A, and A3 receptors.BAY 60-6583 is cardioprotective in a model of myocardial... | |||
T36569 | KR-32568 | Sodium Channel | |
KR-32568 is a sodium/hydrogen exchanger 1 (NHE-1) inhibitor (IC50: 230 nM). KR-32568 exhibits potent cardioprotective effects. When used at a concentration of 10 μM, it restored cardiac systolic function in an isolated i... | |||
T26842 | Bms 188107 | Bms188107,Bms-188107 | |
Bms 188107 is a calcium antagonist, it has cardioprotective effects. | |||
T69097 | ARD-353 | ||
ARD-353 is a nonpeptide delta receptor agonist with cardioprotective effects. | |||
T28656 | Sabiporide | BIIB 722CL | |
Sabiporide is a NHE-1 inhibitor and a cardioprotective agent. | |||
T30487 | BMS 180448 | BMS-180448,BMS180448 | |
BMS 180448 is a prototype mitochondrial ATP-sensitive K+ (Mitok (ATP)) channel opener with cardioprotective and vasodilating properties. | |||
T11732 | JTV-519 hemifumarate | K201 hemifumarate | MELK |
JTV-519 hemifumarate,Antiarrhythmic and cardioprotective properties. is a Ca2+-dependent blocker of sarcoplasmic reticulum Ca2+-stimulated ATPase (SERCA) and a partial agonist of ryanodine receptors in striated muscle. | |||
T12708 | Resveratrol analog 1 | Others | |
Resveratrol analog 1 is an analog of Resveratrol. Resveratrol is a natural polyphenolic phytoalexin with possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. | |||
T12709 | Resveratrol analog 2 | Others | |
Resveratrol analog 2 is an analog of Resveratrol. Resveratrol is a natural polyphenolic phytoalexin with possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. | |||
T37252 | Chitoheptaose heptahydrochloride | ||
Chitoheptaose heptahydrochloride is a chitosan oligosaccharide with antioxidant, anti-inflammatory, antiapoptotic, and cardioprotective properties. It effectively promotes the growth and photosynthesis parameters of whea... | |||
T11731 | JTV-519 free base | K201 free base | FLT |
JTV-519 free base (K201 free base), recognized for its antiarrhythmic and cardioprotective properties, functions as a Ca2+-dependent blocker of sarcoplasmic reticulum Ca2+-stimulated ATPase (SERCA) and serves as a partia... | |||
T31191L | Dagapamil | Dagapamilum | |
Dagapamil hydrochloride is a calcium-channel blocker. Dagapamil hydrochloride is claimed to have antihypertensive, antiarrhythmic, cardioprotective, antiallergic and platelet aggregation-inhibiting action in animal model... | |||
T31191 | Dagapamil hydrochloride | ||
Dagapamil hydrochloride is a calcium-channel blocker. Dagapamil hydrochloride is claimed to have antihypertensive, antiarrhythmic, cardioprotective, antiallergic and platelet aggregation-inhibiting action in animal model... | |||
T28400 | Phenoprolamine Hydrochloride | phenoprolamine,DDPH | |
Phenoprolamine Hydrochloride is an adrenergic α1 receptor antagonist with potent antihypertensive, neuroprotective and cardioprotective effects. Phenoprolamine Hydrochloride inhibits CYP2D and CYP3A activities and down-r... | |||
T61540 | F15845 | ||
F 15845 is a potent and persistent blocker of the sodium current. It possesses cardioprotective properties and exhibits both anti-ischemic activity and short- and long-term cardioprotection following myocardial infarctio... | |||
T78092 | UCL-TRO-1938 | PI3K | |
UCL-TRO-1938, a potent allosteric activator of PI3Kα, exhibits an EC50 of approximately 60 μM. This compound promotes cell proliferation and possesses both cardioprotective and neural regeneration effects [1]. | |||
T80070 | PKCβII Peptide Inhibitor I | PKC | |
PKCβII Peptide Inhibitor I, a specific PKCβII inhibitor, exhibits cardioprotective properties in a rat cardiac ischemia/reperfusion injury model and mitigates vascular endothelial dysfunction [1]. | |||
T62288 | AD013 | ||
AD013 is a dual cACE and NEP inhibitor. AD013 is a C-domain selective ACE inhibitor of lenopril-tryptophan synthesis. AD013 has the potential to provide potent anti-hypertensive and cardioprotective effects. | |||
T63160 | AD011 | ||
AD011 is a dual cACE/NEP inhibitor. AD011 was synthesized via the previously reported C-domain selective ACE inhibitor lenopril-tryptophan. AD011 shows potential to provide potent anti-hypertensive and cardioprotective e... | |||
T76191 | GLP-1(28-36)amide TFA | ||
GLP-1(28-36)amide TFA, a C-terminal nonapeptide derived from GLP-1 cleavage by neutral endopeptidase (NEP), acts as an antioxidant targeting mitochondria. It inhibits mitochondrial permeability transition (MPT), exhibiti... | |||
T11731L | JTV-519 Formate | JTV-519 Formate (145903-06-6 Free base) | Others , Calcium Channel |
JTV-519 Formate is a Ca2+-dependent blocker of sarcoplasmic reticulum Ca2+-stimulated ATPase (SERCA). JTV-519 Formate is also a partial agonist of ryanodine receptors in striated muscle. JTV-519 Formate exhibits antiarrh... | |||
T62831 | AD012 | ||
AD012 is a dual inhibitor of cACE/NEP. AD012 utilises the previously reported C-domain selective ACE inhibitor lenopril-tryptophan synthesis. AD012 has the potential to provide potent anti-hypertensive and cardioprotecti... | |||
T60276 | Cyclocreatine phosphate | ||
Cyclocreatine phosphate is an anti-tumor agent. Cyclocreatine phosphate(CCrP) is the proposed active form of cyclocreatine (CCr), a substrate analogue of creatine kinase. Cyclocreatine and its water-soluble derivative, c... | |||
T37297 | Ru360 | ||
Ru360, an oxygen-bridged dinuclear ruthenium amine complex, is a selective mitochondrial calcium uptake inhibitor. Ru360 potently inhibits Ca2+ uptake into mitochondria with an IC50 of 0.184 nM. Ru360 binds to mitochondr... | |||
TP1965 | Parstatin(human) | Parstatin (human) | |
Cell-permeable peptide cleaved from protease-activated receptor 1 (PAR1) upon receptor activation. Attenuates endothelial cell migration and proliferation (IC50 ~ 3 μM), and induces cell cycle arrest. Promotes activation... | |||
TP1966 | Parstatin(mouse) | Parstatin (mouse) | |
Cell-permeable peptide cleaved from protease-activated receptor 1 (PAR1) upon receptor activation. Attenuates endothelial cell migration and proliferation (IC50 ~ 20 μM), and induces cell cycle arrest. Promotes activatio... | |||
T71910 | Racemic rasagiline | ||
Racemic rasagiline, also known as AGN-1135, is a Monoamine Oxidase type-B inhibitor (MAOI). However, application of this drug can lead to fatal hypertensive crisis in patients who consume tyramine-rich foods. TVP-102... | |||
T68499 | F15845 HBr | ||
F 15845 is a blocker of the persistent sodium current prevents consequences of hypoxia in rat femoral artery. F15845 has been shown to selectively inhibit the persistent sodium current of Nav1.5[1] exerting cardioprotect... | |||
T37496 | Alamandine | ||
Alamandine can be formed from angiotensin A by action of ACE-2 or directly from angiotensin-(1-7) by decarboxylation of its aspartate residue. The angiotensin A analog produces effects resembling those of Ang II (1-7). H... | |||
T60713 | TK-129 | ||
TK-129 is an orally active, potent inhibitor of KDM5B with IC 50 of 44 nM that is low-toxicity. TK-129 shows cardioprotective effects by inhibiting KDM5B and blocking the KDM5B -associated Wnt pathway. TK-129 can be used... |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T3809 | Liriope muscari baily saponins C | Others | |
Liriope muscari baily saponins C has an anti-thrombotic activity due to down-regulation of the increased mRNA expression levels of TF and IL-6. | |||
TN2144 | Resveratroloside | P450 , NO Synthase | |
Resveratroloside has cardioprotective effect, it exhibits α±-glucosidase inhibitory activity, it also can inhibit hydroxylation of testosterone by CYP3A4. | |||
T2763 | Panaxadiol | 20(R)-Panaxadiol | Others , HIF/HIF Prolyl-Hydroxylase |
Panaxadiol (20(R)-Panaxadiol) is a novel antitumor agent extracted from the Chinese medical herb Panax ginseng. | |||
TN1982 | Neoglycyrol | Others | |
Neoglycyrol shows some cardioprotective effects . | |||
T3885 | ROSIRIDIN | 6'-O-Deacetylrosiridoside C,(-)-Rosiridin | Others , Monoamine Oxidase |
Rosiridin (6'-O-Deacetylrosiridoside C) has cardioprotective activity. | |||
T5S0833 | Astragaloside III | Antioxidant | |
Astragaloside III has cardioprotective effects as well as causing improvement in cognitive function. It can be used in the prevention of cardio-cerebral vascular diseases. It also is antioxidant. | |||
T3735 | Tetrahydrocurcumin | Sabiwhite,Tetrahydrodiferuloylmethane,HZIV 81-2,Tetrahydro Curcumin | P450 , Endogenous Metabolite , Autophagy |
Tetrahydrocurcumin (HZIV 81-2), a major metabolite of curcumin, has strong antioxidant and cardioprotective properties. | |||
T6S1101 | Astragalin | Kaempferol 3-D-glucoside,Kaempferol 3-O-glucoside,kaempferol-3-glucoside,3-Glucosylkaempferol,Astragaline,Kaempferol 3-β-D-glucopyranoside | Apoptosis , NF-κB |
Astragalin (Kaempferol 3-O-glucoside) is a biologically active natural flavonoid. It has a variety of pharmacological properties, including antioxidant, anti-inflammatory, anti-cancer, neuroprotective, and cardioprotecti... | |||
TQ0207 | Sulforaphane | Apoptosis , Nrf2 , HDAC | |
Sulforaphane is derived from the consumption of cruciferous vegetables, such as broccoli. It has shown anticancer and cardioprotective activities. | |||
TN1182 | 11-Keto-beta-boswellic acid | 11-Keto-beta-boswellic acid | Leukotriene Receptor , NF-κB , Lipoxygenase |
11-Keto-beta-boswellic acid, a novel Nrf2 activator, and a selective 5-lipoxygenase (5-LOX) inhibitor; it exerts dose dependent cardioprotective effect manifested by dose-dependent reduction in serum lactate dehydrogenas... | |||
TN1065 | Hirsutine | Apoptosis | |
Hirsutine induces apoptosis and is a potent Dengue virus inhibitor exhibiting low cytotoxicity.Hirsutine has anticancer, cardioprotective, anti-hypertensive and anti-arrhythmic activities, it also has vasodilatation acti... | |||
T4518 | Licochalcone D | ERK , NF-κB | |
Licochalcone D may be a potential drug for human melanoma treatment by inhibiting proliferation, inducing apoptosis via the mitochondrial pathway and blocking cell migration and invasion. Licochalcone D has cardioprotect... | |||
T4749 | Squalene | Nikko Squalane EX,Super Squalene,AddaVax,all-trans-Squalene,trans-Squalene,Spinacene | Reactive Oxygen Species , Endogenous Metabolite , Antifungal |
Squalene (AddaVax) is a natural organic compound originally obtained for commercial purposes primarily from shark liver oil, though there are botanical sources as well, including rice bran, wheat germ, and olives. All hi... | |||
TN1969 | N-(p-Coumaroyl) serotonin | PDGFR | |
N-(p-Coumaroyl) Serotonin is a polyphenol isolated from the seeds of safflower. N-(p-Coumaroyl) serotonin has antioxidant, cardioprotective effects after ischemia and antitumor activity, it may be beneficial in improving... | |||
T3S1553 | Trans-Cinnamaldehyde | Cinnamaldehyde,Cinnamic aldehyde,Cinnamal,Phenylacrolein | COX , Endogenous Metabolite |
1. trans-Cinnamaldehyde (Phenylacrolein) exhibits excellent anti-inflammatory activities and antidepressant-like effects in stressed mid-aged rats as a COX-2 inhibitor. 2. Cinnamic aldehyde induces apoptosis of CML cells... | |||
T40586 | Neophytadiene | ||
Neophytadiene, a diterpene discovered in Turbinaria ornate, showcases desirable bioactive properties including anti-inflammatory, antioxidant, and cardioprotective effects. | |||
TN1642 | Ferruginol | BCL , PARP , Caspase | |
Ferruginol has anti-plasmodial, leishmanicidal, anti-ulcerogenic, cardioprotective, anticancer, anti-oxidative and anti-inflammatory activities, it can induce apoptosis in non-small cell lung cancer (NSCLC) cells. | |||
TN1412 | Astringin | trans-Astringin | IL Receptor , Others |
Astringinin is a potent antiarrhythmic agent with cardioprotective activity in ischemic and ischemic-reperfused rat heart, the beneficial effects of astringinin in the ischemic and ischemic-reperfused hearts may be corre... | |||
T75531 | Ladanetin-6-O-β-D-glucopyranoside | ||
Ladanetin-6-O-β-D-glucopyranoside, an active flavonoid, exhibits antioxidative effects and has potential for research into cardioprotective effects [1]. | |||
TN1431 | Baohuoside VII | Others | |
Baohuoside aglycone possesses cardioprotective effect in prevention of ischemia/ reperfusion injury and reduce the myocardial infraction, the mechnism is due to the reduction of the injury of free radicals. Baohuoside VI... | |||
T77201 | Rutin trihydrate | ||
Rutin (Rutoside) trihydrate, a natural flavonoid glycoside, exhibits multifaceted therapeutic properties, including antioxidant, anti-inflammatory, anti-diabetic, and anti-carcinogenic activities. Additionally, it has de... | |||
T81956 | Ladanetin-6-O-β-(6′′-O-acetyl)glucoside | ||
Ladanetin-6-O-β-(6′′-O-acetyl)glucoside, a flavonoid extracted from Dracocephalum tanguticum whole plants, exhibits antioxidant properties and cardioprotective effects, mitigating Doxorubicin-induced toxicity in H9c2 cel... | |||
T8291 | 2-Carene | Others | |
2-Carene is a naturally occurring bicyclic monoterpene found in many essential oils such as pine, cedar and cypress. It has been found to have anti-inflammatory, antifungal and antibacterial activities, as well as antiox... |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-00734 | KNG1 Protein, Human, Recombinant (His) | Human | Human Cells |
Kininogen-1 is a secreted protein which contains three cystatin domains. There are two alternatively spliced forms, designated as the high molecular weight (HMW) and low MW (LMW) forms. Kininogen-1 plays a critical role ... |
Cat No. | Product Name | ||
---|---|---|---|
L6100 | Polyphenolic Natural Product Library | 640 compounds | |
A unique collection of 640 natural polyphenolic compounds for high throughput screening (HTS) and high content screening (HCS); |