L-Arginine (L-Arg) is a substrate of endothelial nitric oxide synthase (eNOS). L-Arginine is transported to vascular smooth muscle cells via a family of cationic amino acid transporters and is metabolized to nitric oxide, polyamines, or L-proline. L-Arginine is a potent vasodilator and can be used to induce experimental acute pancreatitis.
Soyasaponin Ba may represent viable candidates for effective vaccine adjuvants due to their higher and lower or non-haemolytic effects.Soyasaponins Ab and Bb prevent scopolamine-induced memory impairment in mice without the inhibition of acetylcholinester
Dihydrodaidzein ((±)-Dihydrodaidzein)-producing bacteria might lead to clarification of some of the mechanisms regulating the production of equol by fecal microbiota.
(-)-(S)-Equol (4',7-Dihydroxyisoflavan) is an orally bioavailable, non-steroidal estrogen naturally produced by the metabolism of the isoflavonoid daidzein by human intestinal microflora, with potential chemoprotective and estrogen receptor (ER) modulating activities. S-equol preferentially binds to and activates the beta isoform of ER in certain target tissues, while having an antagonistic effect in other tissues. This modulates the expression of ER-responsive genes in a tissue-specific manner. This agent may increase bone mineral density, affect vasomotor symptoms, and may decrease the proliferation rate of susceptible cancer cells. In addition, this agent interferes with the activity of enzymes involved in steroid biosynthesis. S-equol inhibits dihydrotestosterone (DHT) production and may inhibit the proliferation of androgen-driven prostate cancer. S-equol is the biologically active enantiomer while R-equol is essentially inactive and has a weak affinity for alpha-ER.
Soyasaponin Ab may represent a viable candidate for effective vaccine adjuvant, TLR4 receptor dependent pathway may be involved in immune stimulatory effects of soyasaponin Ab.
Desmethylglycitein (6,7,4'-Trihydroxyisoflavone) , is a novel inhibitor of PKCα in suppressing solar UV-induced matrix metalloproteinase 1, which has antioxidant, and anti-cancer activities.
Coumarin is a chemical compound/poison found in many plants, notably in high concentration in the tonka bean, woodruff, and bison grass. It has clinical value as the precursor for several anticoagulants, notably warfarin.
Phytohemagglutinin P (PHA-P) is a naturally occurring lectin, the protein form of PHA.PHA is a selective T-cell mitogen that binds T-cell receptors and enhances HIV-1 replication.
DL-Tryptophan ((±)-Tryptophan) containing dipeptides are interesting ingredients for functional foods as a natural prevention for hypertension with reduced side effects due to its selective inhibition of the C-domain. Low thalamic Tryptophan uptake appears to be a strong, independent predictor of long survival in patients with previous glioma treatment.
6-Hydroxycoumarin (6-hydroxychromen-2-one) exhibits cytotoxicity against human HL60, HCT116, COLO205 cells with activity value of 35 uM, 42 uM, 37 respectively. 6-Hydroxycoumarin is a human CA9, CA12 inhibitor.
Ethyl coumarin-3-carboxylate, a coumarin derivative, serves as a pseudo-template for the synthesis of Molecularly Imprinted Polymers (MIPs) that specifically recognize aflatoxins.
7-Amino-4-(trifluoromethyl)coumarin (Coumarin 151) is a 5-Hydroxytryptamine Receptor Subtype 1E (HTR1E) antagonist, a Galanin Receptor 2 (GALR2) antagonist, and a hydroxysteroid (17-beta) dehydrogenase 4 (HSD17B4) inhibitor with an activity value of 21 µM.
L-α-lysophosphatidylinositol sodium is an endogenous ligand of GPR55 and an endogenous cannabinoid neurotransmitter that is involved in controlling cell survival and tumor progression.
Isoformononetin (IFN) is a methoxy isoflavone present in human dietary supplements that exhibits immune-protective effects by preventing neuroinflammation in a streptozotocin-induced rat model through inhibition of the NLRP3 ASC IL-1 axis activation.
3-Hydroxylicochalcone A is a naturally occurring chalcone derivative. chalcone derivatives usually inhibit murine 11β-hydroxysteroid dehydrogenase 2 (11β-HSD2), e.g., Licochalcone A is the most potent of them all (IC50=15.6 μM).