Licochalcone D may be a potential drug for human melanoma treatment by inhibiting proliferation, inducing apoptosis via the mitochondrial pathway and blocking cell migration and invasion. Licochalcone D has cardioprotective potential against myocardial is
Echinatin (Retrochalcone) is extracted from licorice and is a natural chalcone. Echinatin has a wide range of biological activities including hepatoprotective, anti-inflammatory, anti-bacterial infections, and attenuates lung damage.
Gossypin has antidiabetic, antioxdiant, anticonvulsant, anti-allergic, antiinflammatory, antinociceptive, cytotoxic and antibacterial activities; it inhibits the NF-kappaB activation pathway, which may explain its role in the suppression of inflammation,
1. Licochalcone B (LCB) inhibits the proliferation of human malignant bladder cancer cell lines (T24 and EJ) in vitro and antitumor activity in vivo in MB49 (murine bladder cancer cell line) tumor model. 2. LCB and Licochalcone D(LCD) significantly reduce
2'-O-Methylisoliquiritigenin, a compound synthesized by enzymes specifically induced in NR.2'-O-Methylisoliquiritigenin, isolated from the Arachis species, up-regulates 5-HT, NE, DA and GABA pathways, but does not put a very significant effect on ne NE pathway.
Semilicoisoflavone B, an isoflavone extracted from Kohlrabi, has anticancer activity and induces apoptosis in oral cancer cells by inducing ROS production and down-regulating MAPK and Ras Raf MEK signaling.
Magnesium isoglycyrrhizinate hydrate (18α-Glycyrrhizic acid Magnesium hydrate) is an active ingredient derived from licorice with anti-inflammatory properties. It lowers alanine and aspartate aminotransferase activities and can be used in HIV-1 infection research.
Licoflavonol is a flavonoid compound that can be extracted from licorice. It is an inhibitor of Salmonella Typhimurium serotype 3 secretion system and suppresses the secretion of Abeta by inhibiting β-site APP cleaving enzyme 1 (BACE1) transcription.
Isoangustone A is a natural product that inhibits PI3K, MKK4, and MKK7 through ATP competition, suppresses the expression of G1 phase regulatory proteins, inhibits the phosphorylation of Akt, GSK-3β, and JNK1/2, and inhibits the proliferation of human melanoma cells and tumour growth in xenograft mouse models.
Quercitrin hydrate is a natural flavonoid glycoside with multiple activities, including anti-inflammatory, antioxidant, anticancer, neuroprotective, and cardiovascular protective effects, and inhibits aldose reductase.
Licoisoflavone B is an isoflavonoid from Glycyrrhiza uralensis Fisch.Licoisoflavone B inhibits lipid peroxidation and inhibits human cytochrome P450 enzymes (CYP2C8 and CYP2C9).
Glyasperin D is a flavonoid compound extracted from the root of Glycyrrhiza uralensis, which has potential antimicrobial activity against Helicobacter pylori.