SGLT

Sodium-dependent glucose cotransporters (or sodium-glucose linked transporter, SGLT) are a family of glucose transporter found in the intestinal mucosa (enterocytes) of the small intestine (SGLT1) and the proximal tubule of the nephron (SGLT2 in PCT and SGLT1 in PST). They contribute to renal glucose reabsorption. In the kidneys, 100% of the filtered glucose in the glomerulus has to be reabsorbed along the nephron (98% in PCT, via SGLT2). If the plasma glucose concentration is too high (hyperglycemia), glucose is excreted in urine (glucosuria) because SGLT are saturated with the filtered glucose. Glucose is never secreted by a healthy nephron.

Cat. No.	Product name	CAS No.	Purity
T68174	Sergliflozin A	360775-96-8	98%
T68174	Sergliflozin A is a selective SGLT2 inhibitor that induces diabetes in a dose-dependent manner. It reduces hyperglycemia.
T12893	SGLT inhibitor-1	2247314-23-2	98%
T12893	SGLT inhibitor-1 is a potentsodium glucose co-transporter proteins (SGLTs) dual inhibitor(hSGLT1 and hSGLT2 with IC50s of 43 nM and 9 nM, respectively).
T12892	SGL5213	1240305-17-2	98%
T12892	SGL5213 is an oral active and low-absorbable inhibitor of sodium-dependent glucose cotransporter 1 (SGLT1)(hSGLT1 and hSGLT2 with IC50 values of 29 nM and 20 nM ...
T15752	Licogliflozin	1291094-73-9	98%
T15752	Licogliflozin is an inhibitor of sodium-glucose cotransporter (SGLT1 and SGLT2).
TN4784	Picraline	2671-32-1	98%
TN4784	A series of a hydroxy substituted derivatives 21-28 at C-17 of the Picraline-type alkaloids have been derived as having potent SGLT inhibitory activity.
T15807	LY2794193	2173037-97-1	98%
T15807	LY2794193 is a highly effective and selective agonist of the mGlu3 receptor (hmGlu3 Ki=0.927 nM,EC50=0.47 nM; hmGlu2 Ki=412 nM,EC50=47.5 nM).
T11671	IRAK inhibitor 4 trans	T11671	98%
T11671	IRAK inhibitor 4 is a compound that functions as an inhibitor of interleukin-1 receptor-associated kinase 4 (IRAK4). It specifically targets and inhibits the act...
T15505	HSK0935	1638851-44-1	98%
T15505	HSK0935 is a highly selective and orally available SGLT2 inhibitor (IC50: 1.3 nM). It has antihyperglycemic activities.
TN4399	Kushenol C	99119-73-0	98%
TN4399	Kushenol C is a good 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenger, and it exhibits inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2)....
T17221	Velagliflozin	946525-65-1	98%
T17221	Velagliflozin is an orally available inhibitor of sodium-glucose cotransporter 2.
T2385	Ipragliflozin	761423-87-4	98%
T2385	Ipragliflozin is under investigation in Type 2 Diabetes and Diabetes Mellitus, Type 2.
T1782L	Canagliflozin hemihydrate	928672-86-0	98%
T1782L	Canagliflozin hemihydrate is a drug of the gliflozin class or subtype 2 sodium-glucose transport inhibitors used for the treatment of type 2 diabetes. SGLT2 is r...
T1766	Empagliflozin	864070-44-0	98%
T1766	Empagliflozin is a Sodium-Glucose Cotransporter 2 Inhibitor. The mechanism of action of empagliflozin is as a Sodium-Glucose Transporter 2 Inhibitor.
TN1856	Leachianone A	97938-31-3	98%
TN1856	Leachianone A is a potential antitoxic agent, it shows inhibitory effects on cadmium- Induced cytotoxicity.
T2389	Dapagliflozin	461432-26-8	98%
T2389	Dapagliflozin is a selective sodium-glucose co-transporter subtype 2 (SGLT2) inhibitor with antihyperglycemic activity.
T2922	Phlorizin	60-81-1	98%
T2922	Phlorizin is a non-selective SGLT inhibitor found in apple, for hSGLT1( Ki=300 nM) and hSGLT2( Ki=39 nM) .
T9590	T-1095	209746-59-8	98%
T9590	T-1095 is an inhibitor of renal glucose reabsorption and the expression of Na+-glucose cotransporters (SGLTs) and facilitative glucose transporter 2 (GLUT2).
T4460	Dapagliflozin ((2S)-1,2-propanediol, hydrate)	960404-48-2	98%
T4460	Dapagliflozin (2S)-1, 2-propanediol, hydrate is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2). It is in developm...
T3547	Sotagliflozin	1018899-04-1	98%
T3547	LX-4211 is an orally bioavailable inhibitor of the sodium-glucose co-transporter subtype 1 (SGLT1) and 2 (SGLT2), with potential antihyperglycemic activity.
T34286	Remogliflozin etabonate	442201-24-3	98%
T34286	Remogliflozin etabonate is a prodrug of regaliflozin and an inhibitor SGLT2 with Ki values of 1.95, 2.14, 8.57, and 43.1μM for hSGLT2, rSGLT2, rSGLT1, and hSGLT1...