T15807 |
LY2794193
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LY2794193 is a highly effective and selective agonist of the mGlu3 receptor (hmGlu3 Ki=0.927 nM,EC50=0.47 nM; hmGlu2 Ki=412 nM,EC50=47.5 nM).
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T1782 |
Canagliflozin
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Canagliflozin, a sodium-glucose transporter 2( SGLT2) and P-Glycoprotein inhibitor, is used in type 2 diabetes.
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T4460 |
Dapagliflozin ((2S)-1,2-propanediol, hydrate)
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Dapagliflozin (2S)-1, 2-propanediol, hydrate is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2). It is in developm...
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T15505 |
HSK0935
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HSK0935 is a highly selective and orally available SGLT2 inhibitor (IC50: 1.3 nM). It has antihyperglycemic activities.
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T2922 |
Phlorizin
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Phlorizin is a non-selective SGLT inhibitor found in apple, for hSGLT1( Ki=300 nM) and hSGLT2( Ki=39 nM) .
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T12893 |
SGLT inhibitor-1
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SGLT inhibitor-1 is a potentsodium glucose co-transporter proteins (SGLTs) dual inhibitor(hSGLT1 and hSGLT2 with IC50s of 43 nM and 9 nM, respectively).
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T9590 |
T-1095
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T-1095 is an inhibitor of renal glucose reabsorption and the expression of Na+-glucose cotransporters (SGLTs) and facilitative glucose transporter 2 (GLUT2).
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T2385 |
Ipragliflozin
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Ipragliflozin is under investigation in Type 2 Diabetes and Diabetes Mellitus, Type 2.
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T16083 |
Mizagliflozin
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Mizagliflozin is a sodium-glucose transporter inhibitor( Ki of 27 nM for human SGLT1). Mizagliflozin displays 303-fold selectivity over SGLT2. Mizagliflozin is u...
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T15752 |
Licogliflozin
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Licogliflozin is an inhibitor of sodium-glucose cotransporter (SGLT1 and SGLT2).
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T38843 |
Enavogliflozin
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Enavogliflozin is an orally available small molecule and sodium glucose transporter 2 inhibitor.
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T4999 |
Ertugliflozin
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PF-04971729 (Ertugliflozin) is a potent and selective inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2).
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T2389 |
Dapagliflozin
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Dapagliflozin is a selective sodium-glucose co-transporter subtype 2 (SGLT2) inhibitor with antihyperglycemic activity.
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T15656 |
KGA-2727
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KGA-2727 is a potent and selective SGLT1 inhibitor, with Kis of 97.4 nM and 43.5 nM for human and rat SGLT1, respectively. The selectivity ratios (Ki for SGLT2/K...
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T2S0731 |
Trilobatin
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Trilobatin has anti-oxidant effect, can increase superoxide dismutase (SOD) activity.Trilobatin has anti-inflammatory effect, it potentially inhibits the lipopol...
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T11671 |
IRAK inhibitor 4 trans
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IRAK inhibitor 4 is an interleukin-1 receptor associated kinase 4 (IRAK4) inhibitor. IRAK inhibitor 4 (trans) is the trans form of IRAK inhibitor 4.
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TN4784 |
Picraline
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A series of a hydroxy substituted derivatives 21-28 at C-17 of the Picraline-type alkaloids have been derived as having potent SGLT inhibitory activity.
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T2924 |
Phloretin
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Phloretin is a well-known inhibitor of eukaryotic urea transporters, blocks VacA-mediated urea and ion transport. Phloretin is a dihydrochalcone, a type of natur...
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T17221 |
Velagliflozin
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Velagliflozin is an orally available inhibitor of sodium-glucose cotransporter 2.
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T7217 |
Bexagliflozin
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EGT1442 is a potent, selective sodium glucose co-transporter 2 (SGLT2) inhibitor with IC50 values of 5.6 µM and 2 nM for human SGLT1 and SGLT2, respectively
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T1766 |
Empagliflozin
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Empagliflozin is a Sodium-Glucose Cotransporter 2 Inhibitor. The mechanism of action of empagliflozin is as a Sodium-Glucose Transporter 2 Inhibitor.
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T12892 |
SGL5213
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SGL5213 is an oral active and low-absorbable inhibitor of sodium-dependent glucose cotransporter 1 (SGLT1)(hSGLT1 and hSGLT2 with IC50 values of 29 nM and 20 nM ...
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TN1856 |
Leachianone A
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Leachianone A is a potential antitoxic agent, it shows inhibitory effects on cadmium- Induced cytotoxicity.
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TN4399 |
Kushenol C
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Kushenol C is a good 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenger, and it exhibits inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2)....
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T5016 |
Tofogliflozin (hydrate)
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Tofogliflozin hydrate is a potent and highly specific inhibitor of SGLT2(IC50 of 2.9 nM and Ki values of 2.9 nM, 14.9 nM, and 6.4 nM for human, rat, and mouse SG...
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T3547 |
Sotagliflozin
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LX-4211 is an orally bioavailable inhibitor of the sodium-glucose co-transporter subtype 1 (SGLT1) and 2 (SGLT2), with potential antihyperglycemic activity.
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