TN3247 |
7-O-Prenylscopoletin
|
13544-37-1
|
98%
|
|
7-O-Prenylscopoletin and cedrelopsin show high antiproliferative activities against cancer cell lines.
|
T16559 |
Poloxime
|
17302-61-3
|
98%
|
|
Poloxime is a hydrolysis product of poloxin and is a non-ATP-competitive Plk1 inhibitor. It also has moderate Plk1 inhibitory activity.
|
T2634 |
Ro3280
|
1062243-51-9
|
98%
|
|
Ro3280 is an effective, specific inhibitor of PLK1(IC50=3, Kd=0.09 nM).
|
T2704 |
MLN0905
|
1228960-69-7
|
98%
|
|
MLN0905 is an effective PLK1 inhibitor(IC50=2 nM).
|
T16750 |
Rigosertib
|
592542-59-1
|
98%
|
|
Rigosertib is a selective and non-ATP-competitive inhibitor of PLK1 (IC50: 9 nM). Rigosertib is a multi-kinase inhibitor and a selective anti-cancer agent, which...
|
T10215 |
AAPK-25
|
2247919-28-2
|
98%
|
|
AAPK-25 is a potent and selective Aurora/PLK dual inhibitor with anti-tumor activity, which can cause mitotic delay and arrest cells in prometaphase, followed by...
|
T7200 |
TAK-960
|
1137868-52-0
|
98%
|
|
TAK-960 is an orally bioavailable, selective inhibitor of Plks with IC50 values of 0.8, 16.9, and 50.2 nM for Plk1, Plk2, and Plk3, respectively.
|
T6173 |
BI 2536
|
755038-02-9
|
98%
|
|
BI2536 is an effective Plk1 inhibitor (IC50: 0.83 nM). It has 4- and 11-fold greater selectivity than Plk2 and Plk3.
|
T22288 |
(1E)-CFI-400437 dihydrochloride
|
1247000-76-5
|
98%
|
|
CFI-400437 dihydrochloride is a selective and potent polo-like kinase 4 (PLK4) inhibitor.
|
T7384 |
CFI-400945 free base
|
1338806-73-7
|
98%
|
|
CFI-400945 is an potent, selective and orally active inhibitor of polo-like kinase 4(PLK4; Ki value of 0.26 nM).
|
T19664 |
ON1231320
|
1312471-39-8
|
98%
|
|
ON1231320 is a Polo-like kinase 2 (PLK2) inhibitor.
|
T14927 |
Centrinone
|
1798871-30-3
|
98%
|
|
Centrinone (LCR-263) is a reversible inhibitor of polo-like kinase 4 (PLK4; Ki:0.16 nM).
|
T3643 |
HMN-176
|
173529-10-7
|
98%
|
|
HMN-176 is a stilbene derivative which inhibits mitosis, interfering with polo-like kinase-1 (plk1).
|
T2271 |
SBE13 Hydrochloride
|
1052532-15-6
|
98%
|
|
SBE13 hydrochloride is an effective and specific PLK1 inhibitor (IC50: 0.2 nM); no inhibition om Aurora A kinase, Plk2/3.
|
T6338 |
PHA-680632
|
398493-79-3
|
98%
|
|
PHA-680632 is potent inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 27 nM, 135 nM and 120 nM, respectively. It has 10- to 200-fold higher IC50 for FGF...
|
T0973 |
Pyridoxine
|
65-23-6
|
98%
|
|
Pyridoxine is the 4-methanol form of vitamin B6 and is converted to pyridoxal 5-phosphate in the body. Although pyridoxine and vitamin B6 are still frequently us...
|
T16560 |
Poloxin
|
321688-88-4
|
98%
|
|
Poloxin is a non-ATP competitive Polo-like Kinase 1 inhibitor. It targets the polo-box domain (IC50: appr 4.8 μM).
|
T2438 |
HMN-214
|
173529-46-9
|
98%
|
|
HMN-214(IVX214) is a potent PLK1 inhibitor with an average IC50 of 0.12 μM.
|
T5818 |
Rigosertib sodium
|
592542-60-4
|
98%
|
|
Rigosertib, a non-ATP-competitive inhibitor of PLK1(IC50=9 nM), exhibits 30-fold higher specificity activity over Plk2 and no effect on Plk3.
|
T17008 |
TC-S 7005
|
1082739-92-1
|
98%
|
|
TC-S 7005 is an effective inhibitor of Polo-like kinases (IC50s: 214 nM, 4 nM and 24 nM for Plk1, Plk2, and Plk3).
|