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PLK

Polo-like kinase (PLK) is a highly conserved serine/threonine protein kinase with a highly homologous serine/threonine kinase domain at its N-terminus, which regulates PLK activity and subcellular dynamics at the C-terminus and targeted polo-box domain (PBD). There are many PLK family members, and there are four subtypes in the human body, namely PLK1, PLK2, PLK3, and PLK4, which play important roles in the regulation of various phases of the cell cycle.
Cat. No. Product name CAS No. Purity Chemical Structure
TN3247 7-O-Prenylscopoletin 13544-37-1 98%
7-O-Prenylscopoletin and cedrelopsin show high antiproliferative activities against cancer cell lines.
T16559 Poloxime 17302-61-3 98%
Poloxime is a hydrolysis product of poloxin and is a non-ATP-competitive Plk1 inhibitor. It also has moderate Plk1 inhibitory activity.
T2634 Ro3280 1062243-51-9 98%
Ro3280 is an effective, specific inhibitor of PLK1(IC50=3, Kd=0.09 nM).
T2704 MLN0905 1228960-69-7 98%
MLN0905 is an effective PLK1 inhibitor(IC50=2 nM).
T16750 Rigosertib 592542-59-1 98%
Rigosertib is a selective and non-ATP-competitive inhibitor of PLK1 (IC50: 9 nM). Rigosertib is a multi-kinase inhibitor and a selective anti-cancer agent, which...
T10215 AAPK-25 2247919-28-2 98%
AAPK-25 is a potent and selective Aurora/PLK dual inhibitor with anti-tumor activity, which can cause mitotic delay and arrest cells in prometaphase, followed by...
T7200 TAK-960 1137868-52-0 98%
TAK-960 is an orally bioavailable, selective inhibitor of Plks with IC50 values of 0.8, 16.9, and 50.2 nM for Plk1, Plk2, and Plk3, respectively.
T6173 BI 2536 755038-02-9 98%
BI2536 is an effective Plk1 inhibitor (IC50: 0.83 nM). It has 4- and 11-fold greater selectivity than Plk2 and Plk3.
T22288 (1E)-CFI-400437 dihydrochloride 1247000-76-5 98%
CFI-400437 dihydrochloride is a selective and potent polo-like kinase 4 (PLK4) inhibitor.
T7384 CFI-400945 free base 1338806-73-7 98%
CFI-400945 is an potent, selective and orally active inhibitor of polo-like kinase 4(PLK4; Ki value of 0.26 nM).
T19664 ON1231320 1312471-39-8 98%
ON1231320 is a Polo-like kinase 2 (PLK2) inhibitor.
T14927 Centrinone 1798871-30-3 98%
Centrinone (LCR-263) is a reversible inhibitor of polo-like kinase 4 (PLK4; Ki:0.16 nM).
T3643 HMN-176 173529-10-7 98%
HMN-176 is a stilbene derivative which inhibits mitosis, interfering with polo-like kinase-1 (plk1).
T2271 SBE13 Hydrochloride 1052532-15-6 98%
SBE13 hydrochloride is an effective and specific PLK1 inhibitor (IC50: 0.2 nM); no inhibition om Aurora A kinase, Plk2/3.
T6338 PHA-680632 398493-79-3 98%
PHA-680632 is potent inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 27 nM, 135 nM and 120 nM, respectively. It has 10- to 200-fold higher IC50 for FGF...
T0973 Pyridoxine 65-23-6 98%
Pyridoxine is the 4-methanol form of vitamin B6 and is converted to pyridoxal 5-phosphate in the body. Although pyridoxine and vitamin B6 are still frequently us...
T16560 Poloxin 321688-88-4 98%
Poloxin is a non-ATP competitive Polo-like Kinase 1 inhibitor. It targets the polo-box domain (IC50: appr 4.8 μM).
T2438 HMN-214 173529-46-9 98%
HMN-214(IVX214) is a potent PLK1 inhibitor with an average IC50 of 0.12 μM.
T5818 Rigosertib sodium 592542-60-4 98%
Rigosertib, a non-ATP-competitive inhibitor of PLK1(IC50=9 nM), exhibits 30-fold higher specificity activity over Plk2 and no effect on Plk3.
T17008 TC-S 7005 1082739-92-1 98%
TC-S 7005 is an effective inhibitor of Polo-like kinases (IC50s: 214 nM, 4 nM and 24 nM for Plk1, Plk2, and Plk3).
7-O-Prenylscopoletin
TN3247
7-O-Prenylscopoletin and cedrelopsin show high antiproliferative activities against cancer cell lines.
Poloxime
T16559
Poloxime is a hydrolysis product of poloxin and is a non-ATP-competitive Plk1 inhibitor. It also has moderate Plk1 inhibitory activity.
Ro3280
T2634
Ro3280 is an effective, specific inhibitor of PLK1(IC50=3, Kd=0.09 nM).
MLN0905
T2704
MLN0905 is an effective PLK1 inhibitor(IC50=2 nM).
Rigosertib
T16750
Rigosertib is a selective and non-ATP-competitive inhibitor of PLK1 (IC50: 9 nM). Rigosertib is a multi-kinase inhibitor and a selective anti-cancer agent, which...
AAPK-25
T10215
AAPK-25 is a potent and selective Aurora/PLK dual inhibitor with anti-tumor activity, which can cause mitotic delay and arrest cells in prometaphase, followed by...
TAK-960
T7200
TAK-960 is an orally bioavailable, selective inhibitor of Plks with IC50 values of 0.8, 16.9, and 50.2 nM for Plk1, Plk2, and Plk3, respectively.
BI 2536
T6173
BI2536 is an effective Plk1 inhibitor (IC50: 0.83 nM). It has 4- and 11-fold greater selectivity than Plk2 and Plk3.
(1E)-CFI-400437 dihydrochloride
T22288
CFI-400437 dihydrochloride is a selective and potent polo-like kinase 4 (PLK4) inhibitor.
CFI-400945 free base
T7384
CFI-400945 is an potent, selective and orally active inhibitor of polo-like kinase 4(PLK4; Ki value of 0.26 nM).
ON1231320
T19664
ON1231320 is a Polo-like kinase 2 (PLK2) inhibitor.
Centrinone
T14927
Centrinone (LCR-263) is a reversible inhibitor of polo-like kinase 4 (PLK4; Ki:0.16 nM).
HMN-176
T3643
HMN-176 is a stilbene derivative which inhibits mitosis, interfering with polo-like kinase-1 (plk1).
SBE13 Hydrochloride
T2271
SBE13 hydrochloride is an effective and specific PLK1 inhibitor (IC50: 0.2 nM); no inhibition om Aurora A kinase, Plk2/3.
PHA-680632
T6338
PHA-680632 is potent inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 27 nM, 135 nM and 120 nM, respectively. It has 10- to 200-fold higher IC50 for FGF...
Pyridoxine
T0973
Pyridoxine is the 4-methanol form of vitamin B6 and is converted to pyridoxal 5-phosphate in the body. Although pyridoxine and vitamin B6 are still frequently us...
Poloxin
T16560
Poloxin is a non-ATP competitive Polo-like Kinase 1 inhibitor. It targets the polo-box domain (IC50: appr 4.8 μM).
HMN-214
T2438
HMN-214(IVX214) is a potent PLK1 inhibitor with an average IC50 of 0.12 μM.
Rigosertib sodium
T5818
Rigosertib, a non-ATP-competitive inhibitor of PLK1(IC50=9 nM), exhibits 30-fold higher specificity activity over Plk2 and no effect on Plk3.
TC-S 7005
T17008
TC-S 7005 is an effective inhibitor of Polo-like kinases (IC50s: 214 nM, 4 nM and 24 nM for Plk1, Plk2, and Plk3).
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