Home Tools
Log in
Cart

MRP

Multidrug resistance proteins (MRPs) are members of the C family of a group of proteins named ATP-binding cassette (ABC) transporters. These ABC transporters together form the largest branch of proteins within the human body. The MRP family comprises of 13 members, of which MRP1 to MRP9 are the major transporters indicated to cause multidrug resistance in tumor cells by extruding anticancer drugs out of the cell.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T1018 Prednisone 53-03-2 99.69%
Prednisone
Prednisone (Dehydrocortisone) is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.
TN2219 Sophoraisoflavone A 117204-81-6 98%
Sophoraisoflavone A
Sophoraisoflavone A is a potential MRP inhibitor; it is also an inhibitor of germ tube growth in the AM fungus Gigaspora margarita, it strongly inhibited germ tu...
T0924 Benzocaine 94-09-7 99.97%
Benzocaine
Benzocaine is a surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings.
T4A2399 Cinobufotalin 1108-68-5 99.94%
Cinobufotalin
Cinobufotalin is a main cardiac toxin in toad, it is a novel anti-HCC agent, it induces growth inhibition and apoptosis in cultured HCC cells through ceramide pr...
T0760 Cholesterol 57-88-5 99.94%
Cholesterol
Cholesterol (cholesteryl alcohol) is a natural product that is the major sterol in mammals and an agonist of estrogen-related receptor α (ERRα). Cholesterol is w...
T1434 Clarithromycin 81103-11-9 99.89%
Clarithromycin
Clarithromycin (A-56268) is a Macrolide Antimicrobial. The mechanism of action of clarithromycin is as a Cytochrome P450 3A4 Inhibitor, and Cytochrome P450 3A In...
T1050 Prazosin hydrochloride 19237-84-4 99.87%
Prazosin hydrochloride
Prazosin hydrochloride (Vasoflex) reduces peripheral resistance and relaxes vascular smooth muscles as a selective adrenergic alpha-1 antagonist by a mechanism n...
T0706 Lisinopril dihydrate 83915-83-7 99.87%
Lisinopril dihydrate
Lisinopril dihydrate (MK-521) is an orally bioavailable, long-acting angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity.
T1484L Perindopril erbumine 107133-36-8 99.8%
Perindopril erbumine
Perindopril erbumine (S9490-3) is the tert-butylamine salt of perindopril, the ethyl ester of a non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor with...
TN1863 Licoisoflavone A 66056-19-7 99.71%
Licoisoflavone A
Licoisoflavone A (Phaseoluteone) is an MRP inhibitor and inhibits lipid peroxidation with an IC50 of 7.2 μM.
T0866 Propafenone 54063-53-5 99.69%
Propafenone
Propafenone (Propafenonum) is only found in individuals that have used or taken this drug. It is an antiarrhythmia agent that is particularly effective in ventri...
T0450 Fluoxetine 54910-89-3 99.65%
Fluoxetine
Fluoxetine (LY-110140) is a highly specific serotonin uptake inhibitor and selective 5-hydroxytryptamine (5-HT) reuptake inhibitor. Fluoxetine has antidepressant...
T0707 Cyclophosphamide hydrate 6055-19-2 99.65%
Cyclophosphamide hydrate
Cyclophosphamide hydrate is a DNA alkylating agent, an inhibitor of DNA synthesis. Cyclophosphamide hydrate has antitumor and immunosuppressive activities.
T9944 3-(9-Chloro-3-methyl-4-oxoisoxazolo[4,3-c]quinolin-5(4H)-yl)-N-(3,4,5-trimethoxyphenyl)benzeneacetamide 246238-55-1 99.62%
3-(9-Chloro-3-methyl-4-oxoisoxazolo[4,3-c]quinolin-5(4H)-yl)-N-(3,4,5-trimethoxyphenyl)benzeneacetamide
3-(9-Chloro-3-methyl-4-oxoisoxazolo[4,3-c]quinolin-5(4H)-yl)-N-(3,4,5-trimethoxyphenyl)benzeneacetamide inhibits multidrug resistance protein (MRP1).
T0791 Reserpine 50-55-5 99.6%
Reserpine
Reserpine (Serpalan) is an alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage ves...
T1484 Perindoprilat 95153-31-4 99.48%
Perindoprilat
Perindoprilat (Perindoprilate) is an angiotensin-converting enzyme inhibitor.
T1605 Enalapril 75847-73-3 99.47%
Enalapril
Enalapril is a dicarbocyl-containing peptide and angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity.
T8596 Ceefourin 1 315702-40-0 98.4%
Ceefourin 1
Ceefourin 1 is a highly selective multidrug resistance protein 4 (MRP4) inhibitor.
T0707L Cyclophosphamide 50-18-0 98.26%
Cyclophosphamide
Cyclophosphamide is an alkylating agent used in the treatment of several forms of cancer including leukemias, lymphomas and breast cancer.
T0291 Flurbiprofen 5104-49-4 98%
Flurbiprofen
Flurbiprofen (dl-Flurbiprofen) is an anti-inflammatory analgesic and antipyretic of the phenylalkynoic acid series. It has been shown to reduce bone resorption i...
Prednisone
T1018
Prednisone (Dehydrocortisone) is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.
Sophoraisoflavone A
TN2219
Sophoraisoflavone A is a potential MRP inhibitor; it is also an inhibitor of germ tube growth in the AM fungus Gigaspora margarita, it strongly inhibited germ tu...
Benzocaine
T0924
Benzocaine is a surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings.
Cinobufotalin
T4A2399
Cinobufotalin is a main cardiac toxin in toad, it is a novel anti-HCC agent, it induces growth inhibition and apoptosis in cultured HCC cells through ceramide pr...
Cholesterol
T0760
Cholesterol (cholesteryl alcohol) is a natural product that is the major sterol in mammals and an agonist of estrogen-related receptor α (ERRα). Cholesterol is w...
Clarithromycin
T1434
Clarithromycin (A-56268) is a Macrolide Antimicrobial. The mechanism of action of clarithromycin is as a Cytochrome P450 3A4 Inhibitor, and Cytochrome P450 3A In...
Prazosin hydrochloride
T1050
Prazosin hydrochloride (Vasoflex) reduces peripheral resistance and relaxes vascular smooth muscles as a selective adrenergic alpha-1 antagonist by a mechanism n...
Lisinopril dihydrate
T0706
Lisinopril dihydrate (MK-521) is an orally bioavailable, long-acting angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity.
Perindopril erbumine
T1484L
Perindopril erbumine (S9490-3) is the tert-butylamine salt of perindopril, the ethyl ester of a non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor with...
Licoisoflavone A
TN1863
Licoisoflavone A (Phaseoluteone) is an MRP inhibitor and inhibits lipid peroxidation with an IC50 of 7.2 μM.
Propafenone
T0866
Propafenone (Propafenonum) is only found in individuals that have used or taken this drug. It is an antiarrhythmia agent that is particularly effective in ventri...
Fluoxetine
T0450
Fluoxetine (LY-110140) is a highly specific serotonin uptake inhibitor and selective 5-hydroxytryptamine (5-HT) reuptake inhibitor. Fluoxetine has antidepressant...
Cyclophosphamide hydrate
T0707
Cyclophosphamide hydrate is a DNA alkylating agent, an inhibitor of DNA synthesis. Cyclophosphamide hydrate has antitumor and immunosuppressive activities.
3-(9-Chloro-3-methyl-4-oxoisoxazolo[4,3-c]quinolin-5(4H)-yl)-N-(3,4,5-trimethoxyphenyl)benzeneacetamide
T9944
3-(9-Chloro-3-methyl-4-oxoisoxazolo[4,3-c]quinolin-5(4H)-yl)-N-(3,4,5-trimethoxyphenyl)benzeneacetamide inhibits multidrug resistance protein (MRP1).
Reserpine
T0791
Reserpine (Serpalan) is an alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage ves...
Perindoprilat
T1484
Perindoprilat (Perindoprilate) is an angiotensin-converting enzyme inhibitor.
Enalapril
T1605
Enalapril is a dicarbocyl-containing peptide and angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity.
Ceefourin 1
T8596
Ceefourin 1 is a highly selective multidrug resistance protein 4 (MRP4) inhibitor.
Cyclophosphamide
T0707L
Cyclophosphamide is an alkylating agent used in the treatment of several forms of cancer including leukemias, lymphomas and breast cancer.
Flurbiprofen
T0291
Flurbiprofen (dl-Flurbiprofen) is an anti-inflammatory analgesic and antipyretic of the phenylalkynoic acid series. It has been shown to reduce bone resorption i...
1 2
TargetMol