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MRP

Multidrug resistance proteins (MRPs) are members of the C family of a group of proteins named ATP-binding cassette (ABC) transporters. These ABC transporters together form the largest branch of proteins within the human body. The MRP family comprises of 13 members, of which MRP1 to MRP9 are the major transporters indicated to cause multidrug resistance in tumor cells by extruding anticancer drugs out of the cell.

  • Enalapril
    T160575847-73-3
    Enalapril is a dicarbocyl-containing peptide and angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity.
    • $30
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  • LY-402913
    T27954334970-65-9In house
    LY-402913 is a selective multidrug resistance protein (MRP1) inhibitor.
    • $117
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  • Gramicidin
    T11301405-97-6
    A group of peptide antibiotics from BACILLUS brevis. Gramicidin (Gramicidine) C or S is a cyclic, ten-amino acid polypeptide and gramicidins A, B, D are linear. Gramicidin is one of the two principal components of TYROTHRICIN.
    • $42
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  • Clarithromycin
    T143481103-11-9
    Clarithromycin (A-56268) is a Macrolide Antimicrobial. The mechanism of action of clarithromycin is as a Cytochrome P450 3A4 Inhibitor, and Cytochrome P450 3A Inhibitor, and P-Glycoprotein Inhibitor. The chemical classification of clarithromycin is Macrolides.
    • $50
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  • Fluoxetine
    T045054910-89-3
    Fluoxetine (LY-110140) is a highly specific serotonin uptake inhibitor and selective 5-hydroxytryptamine (5-HT) reuptake inhibitor. Fluoxetine has antidepressant activity.
    • $30
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  • Cyclophosphamide hydrate
    T07076055-19-2
    Cyclophosphamide hydrate is a DNA alkylating agent, an inhibitor of DNA synthesis. Cyclophosphamide hydrate has antitumor and immunosuppressive activities.
    • $33
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  • Cholesterol
    T076057-88-5
    Cholesterol (cholesteryl alcohol) is a natural product that is the major sterol in mammals and an agonist of estrogen-related receptor α (ERRα). Cholesterol is widely found in the cell membranes of animals and is also used in the synthesis of several important hormones and bile acids.
    • $45
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  • Cyclophosphamide
    T0707L50-18-0
    Cyclophosphamide is an alkylating agent used in the treatment of several forms of cancer including leukemias, lymphomas and breast cancer.
    • $35
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  • Prazosin hydrochloride
    T105019237-84-4
    Prazosin hydrochloride (Vasoflex) reduces peripheral resistance and relaxes vascular smooth muscles as a selective adrenergic alpha-1 antagonist by a mechanism not completely known. Prazosin hydrochloride is a synthetic piperazine derivative with hypotensive antiadrenergic properties, It is used in the treatment of heart failure, hypertension, pheochromocytoma, Raynaud's syndrome, prostatic hypertrophy, and urinary retention.
    • $50
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  • Perindoprilat
    T148495153-31-4
    Perindoprilat (Perindoprilate) is an angiotensin-converting enzyme inhibitor.
    • $37
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  • Benzocaine
    T092494-09-7
    Benzocaine is a surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings.
    • $42
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  • 3-(9-Chloro-3-methyl-4-oxoisoxazolo[4,3-c]quinolin-5(4H)-yl)-N-(3,4,5-trimethoxyphenyl)benzeneacetamide
    T9944246238-55-1
    3-(9-Chloro-3-methyl-4-oxoisoxazolo[4,3-c]quinolin-5(4H)-yl)-N-(3,4,5-trimethoxyphenyl)benzeneacetamide inhibits multidrug resistance protein (MRP1).
    • $117
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  • Sophoraisoflavone A
    TN2219117204-81-6
    Sophoraisoflavone A is a potential MRP inhibitor; it is also an inhibitor of germ tube growth in the AM fungus Gigaspora margarita, it strongly inhibited germ tube growth at 1.25 ug/disc. Sophoraisoflavone A shows inhibitory effects on copper-induced prot
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  • Flurbiprofen
    T02915104-49-4
    Flurbiprofen (dl-Flurbiprofen) is an anti-inflammatory analgesic and antipyretic of the phenylalkynoic acid series. It has been shown to reduce bone resorption in periodontal disease by inhibiting CARBONIC ANHYDRASE.
    • $50
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  • Ketoprofen
    T083922071-15-4
    Ketoprofen (RP-19583) is a propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic and antipyretic effects. Ketoprofen inhibits the activity of the enzymes cyclo-oxygenase I and II, resulting in a decreased formation of precursors of prostaglandins and thromboxanes. The resulting decrease in prostaglandin synthesis, by prostaglandin synthase, is responsible for the therapeutic effects of ibuprofen. Ketoprofen also causes a decrease in the formation of thromboxane A2 synthesis, by thromboxane synthase, thereby inhibiting platelet aggregation.
    • $45
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  • Perindopril erbumine
    T1484L107133-36-8
    Perindopril erbumine (S9490-3) is the tert-butylamine salt of perindopril, the ethyl ester of a non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. Upon hydrolysis, Perindopril erbumine (S9490-3) is converted to its active form perindoprilat, inhibiting ACE and the conversion of angiotensin I to angiotensin II; consequently, angiotensin II-mediated vasoconstriction and angiotensin II-stimulated aldosterone secretion from the adrenal cortex are inhibited and diuresis and natriuresis ensue.
    • $30
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  • Indican
    T19866487-60-5
    Indican (Indoxyl-β-D-glucoside) is a natural protective compound that is used to protect the liver.
    • $42
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  • Cinobufotalin
    T4A23991108-68-5
    Cinobufotalin is a main cardiac toxin in toad, it is a novel anti-HCC agent, it induces growth inhibition and apoptosis in cultured HCC cells through ceramide production. Cinobufotalin is also an effective reversal agent for the multidrug resistance of tu
    • $44
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  • Licoisoflavone A
    TN186366056-19-7
    Licoisoflavone A (Phaseoluteone) is an MRP inhibitor and inhibits lipid peroxidation with an IC50 of 7.2 μM.
    • $98
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  • Ceefourin 1
    T8596315702-40-0
    Ceefourin 1 is a highly selective multidrug resistance protein 4 (MRP4) inhibitor.
    • $36
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  • Estriol
    T157150-27-1
    Estriol (Oestriol) is a hydroxylated metabolite of ESTRADIOL or ESTRONE that has a hydroxyl group at C3, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen. During PREGNANCY, a large amount of estriol is produced by the PLACENTA.
    • $37
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  • Prednisone
    T101853-03-2
    Prednisone (Dehydrocortisone) is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.
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  • Propafenone
    T086654063-53-5
    Propafenone (Propafenonum) is only found in individuals that have used or taken this drug. It is an antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity. The drug is generally well tolerated. The electrophysiological effect of propafenone manifests itself in a reduction of upstroke velocity (Phase 0) of the monophasic action potential. In Purkinje fibers, and to a lesser extent myocardial fibers, propafenone reduces the fast inward current carried by sodium ions, which is responsible for the drugs antiarrhythmic actions. Diastolic excitability threshold is increased and effective refractory period prolonged. Propafenone reduces spontaneous automaticity and depresses triggered activity. At very high concentrations in vitro, propafenone can inhibit the slow inward current carried by calcium but this calcium antagonist effect probably does not contribute to antiarrhythmic efficacy.
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  • Reserpine
    T079150-55-5
    Reserpine (Serpalan) is an alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.
    • $36
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  • Lisinopril dihydrate
    T070683915-83-7
    Lisinopril dihydrate (MK-521) is an orally bioavailable, long-acting angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity.
    • $57
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  • PU23
    T9982817635-93-1
    PU 23 is an inhibitor of multidrug-resistant protein 4 (MRP4).
    • $34
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