Epoxide Hydrolase

Epoxide hydrolases (EH's), also known as epoxide hydratases, are enzymes that metabolize compounds that contain an epoxide residue; they convert this residue to two hydroxyl residues through an epoxide hydrolysis reaction to form diol products. Several enzymes possess EH activity. Microsomal epoxide hydrolase (epoxide hydrolase 1, EH1, or mEH), soluble epoxide hydrolase (sEH, epoxide hydrolase 2, EH2, or cytoplasmic epoxide hydrolase), and the more recently discovered but not as yet well defined functionally, epoxide hydrolase 3 (EH3) and epoxide hydrolase 4 (EH4) are structurally closely related isozymes. Other enzymes with epoxide hydrolase activity include leukotriene A4 hydrolase, Cholesterol-5,6-oxide hydrolase, MEST (gene) (Peg1/MEST), and Hepoxilin-epoxide hydrolase. The hydrolases are distinguished from each other by their substrate preferences and, directly related to this, their functions.

Cat. No.	Product name	CAS No.	Purity
T63536	Dual FAAH/sEH-IN-1	2756099-59-7	98%
T63536	Dual FAAH/sEH-IN-1 (compound 3) is a high affinity dual inhibitor of FAAH (fatty acid amide hydrolase) and sEH (soluble epoxide hydrolase), with IC50 values of 7...
T21859	ARM1	68729-05-5	98%
T21859	ARM1 is a potent inhibitor of aminopeptidase and epoxide hydrolase. The IC50 values are 7.61 µM for aminopeptidase and 12.4 µM for epoxide hydrolase.
T10900	CUDA	479413-68-8	98%
T10900	CUDA is an effective soluble cyclohydrolase inhibitor with IC50 of 11.1 nM and 112 nM for mouse sEH and human sEH, respectively. CUDA selectively increases the a...
TN1438	Beta-Amyrin acetate	1616-93-9	98%
TN1438	beta-Amyrin acetate inhibits HMG-CoA Reductase (HMGCR) and sEH activity with IC50 of 3.4 μM. beta-Amyrin acetate has anti-inflammatory, antifungal, antioxidant, ...
T14315	AR-9281	913548-29-5
T14315	AR9281 is a potent and selective inhibitor of soluble epoxide hydrolase (s-EH) potentially for the treatment of hypertension and type 2 diabetes
T11147	EC5026	1809885-32-2	96.6%
T11147	EC5026 has the potential to relieve pain by stabilizing natural analgesic and anti-inflammatory mediators.
T14557	BI-1935	940954-41-6	97.55%
T14557	BI-1935 is an inhibitor of soluble epoxide hydrolase (sEH). For diseases related to cardiovascular disease.
T7199	TPPU	1222780-33-7	98%
T7199	TPPU is a potent inhibitor of both human and mouse sEH (IC50 of 3.7 and 2.8 nM, respectively)
T7898	AUDA	479413-70-2	98%
T7898	AUDA is an inhibitor of sEH(IC50 values of 18 and 69 nM for the mouse and human enzymes, respectively)
T8315	1-Cyclohexyl-3-dodecyl urea	402939-18-8	98%
T8315	1-Cyclohexyl-3-dodecyl urea is a highly selective soluble epoxide hydrolase (sEH) inhibitor.
T12580	PTUPB	1287761-01-6	99.15%
T12580	PTUPB is a potent and dual inhibitor of sEH and COX-2 enzymes(IC50 of 0.9 nM and 1.26 μM, respectively).
T8844	Diflapolin	724453-98-9	99.23%
T8844	Diflapolin is a highly active dual 5-lipoxygenase-activating protein (FLAP)/soluble epoxide hydrolase (sEH) inhibitor with marked anti-inflammatory efficacy and ...
T17158	Trans-AUCB	885012-33-9	99.27%
T17158	trans-AUCB is an effective and selective soluble epoxide hydrolase inhibitor (IC50s: 1.3 nM, 8 nM, 8 nM for hsEH, mouse sEH and rat sEH, respectively).
T15430	GSK2256294A	1142090-23-0	99.27%
T15430	GSK2256294A is potent, selective inhibitor of recombinant human, rat and mouse sEH with IC50 of 27 pM, 61 pM and 189 pM, respectively.
T17196	UC-1728	948304-40-3	99.88%
T17196	UC-1728 is an effective rabbit soluble epoxide hydrolase inhibitor (IC50: 2 nM on rabbit liver).
T2716	1,3-Diphenylurea	102-07-8	99.93%
T2716	1, 3-Diphenylurea is involved with Epoxide hydrolase activity.
T23044	N,N'-Dicyclohexylurea	2387-23-7	98%
T23044	soluble epoxide hydrolase (sEH) inhibitor
T0355	Valpromide	2430-27-5	98%
T0355	Valpromide is a carboxamide derivative of valproic acid, used in the treatment of epilepsy and some affective disorders.