T4636 |
Protein kinase inhibitors 1
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1365986-44-2
|
98%
|
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Protein kinase inhibitors 1 is a novel inhibitor of HIPK2 with an IC50 of 74 nM and Kd of 9.5 nM.
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T11133 |
DYRKs-IN-2
|
1386980-04-6
|
98%
|
|
DYRKs-IN-2 has antitumor activity. DYRKs-IN-2 is a potent DYRKs inhibitor with IC50s of 30.6 nM and 12.8 nM for DYRK1B and DYRK1A, respectively.
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T11132 |
DYRKs-IN-1
|
1387090-01-8
|
98%
|
|
DYRKs-IN-1 has antitumor activity. DYRKs-IN-1 is a potent DYRKs (Dual-specificity tyrosine-phosphorylation-regulated kinases) inhibitor with IC50s of 9 nM and 5 ...
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T24152 |
HTH-01-091
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2000209-42-5
|
98%
|
|
HTH-01-091 is a potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor (IC50: 10.5 nM).HTH-01-091 inhibits PIM1/2/3, RIPK2, DYRK3, smMLCK...
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T40187 |
GNF2133
|
2561414-56-8
|
98%
|
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GNF2133 is an effective and selective inhibitor of DYRK1A with IC50s of 6.2 nM. GNF2133 can be used in studies about type 1 diabetes.
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T14980 |
CLK-IN-T3
|
2109805-56-1
|
98%
|
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CLK-IN-T3 is an inhibitor of CLK1, CLK2, and CLK3 with IC50s of 0.67, 15, and 110 nM. CLK-IN-T3 exhibits anti-cancer activity.
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T11447 |
GNF4877
|
2041073-22-5
|
98%
|
|
GNF4877 is a potent DYRK1A and GSK3β inhibitor (IC50s: 6 nM and 16 nM). It leads to blockade of nuclear factor of activated T-cells (NFATc) nuclear export and in...
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T15579 |
INDY
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1169755-45-6
|
98%
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INDY is an ATP-competitive inhibitor of Dyrk1A and Dyrk1B with IC50s of 0.24 μM and 0.23 μM and a Ki of 0.18 μM for Dyrk1A ATP pocket, respectively.
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T15204 |
EHT 1610
|
1425945-60-3
|
98%
|
|
EHT 1610 is a potent inhibitor of DYRK, with an IC50 of 0.36 nM and 0.59 nM for DYRK1A and DYRK1B, respectively. EHT 1610 has an inhibitory effect on leukemia, r...
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T10827 |
CK2/ERK8-IN-1
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1085822-09-8
|
98%
|
|
CK2/ERK8-IN-1 is a dual inhibitor of casein kinase 2 (CK2) (Ki: 0.25 µM) and ERK8 (IC50s: 0.50 μM) with pro-apoptotic efficacy. CK2/ERK8-IN-1 also binds to PIM1,...
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T2670 |
ML167
|
1285702-20-6
|
98%
|
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ML167 is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor.
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TQ0111 |
LDN-192960
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184582-62-5
|
98%
|
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LDN-192960 is a potent inhibitor of Haspin and DYRK2 (IC50s: 10 nM and 48 nM).
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T2811 |
Harmine hydrochloride
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343-27-1
|
98%
|
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Harmine hydrochloride is extracted from Peganum Harmala Genus.
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T15422 |
GSK-626616
|
1025821-33-3
|
98%
|
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GSK-626616 is a potent and orally bioavailable DYRK3 inhibitor (IC50: 0.7 nM). It inhibits other members of the DYRK family with similar potency. GSK-626616 is a...
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T6257 |
AZ191
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1594092-37-1
|
98%
|
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AZ191(IC50 of 17 nM) is an effective and specific DYRK1B inhibitor. The specificity of AZ191 for DYRK1B is about 5- and 110-fold greater over DYRK1A and DYRK2, r...
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T61360 |
ARN25068
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2649882-80-2
|
98%
|
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ARN25068 is a potent inhibitor of GSK-3β, FYN, and DYRK1A protein kinases, exerting its activity in the sub-micromolar range. This compound effectively addresses...
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T2431 |
ID-8
|
147591-46-6
|
98%
|
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ID-8, a DYRK inhibitor, sustains embryonic stem cell self-renewal in long-term culture.
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T22012 |
7BIO
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916440-85-2
|
98%
|
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7-bromoindirubin-3'-oxime (7BIO) is a caspase independent nonapoptotic cell death inducer. 7BIO is an inhibitor of FLT3, DYRK1A, DYRK2, Aurora B and Aurora C kin...
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T1711 |
Harmine
|
442-51-3
|
98%
|
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Harmine is an alkaloid isolated from seeds of Peganum harmala.
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T11960 |
MBM-55
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2083622-09-5
|
98%
|
|
MBM-55 is an effective inhibitor of NIMA related kinase 2 (NEK2) with an IC50 of 1 nM. MBM-55 effectively inhibits the proliferation of cancer cells by inducing...
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