Home Tools
Log in
Cart
Cell Cycle/Checkpoint DYRK

DYRK

Dual-specificity tyrosine phosphorylation-regulated kinases (DYRKs) are conserved serine/threonine kinases. DYRKs have been implicated in cell survival, proliferation and differentiation, and in the pathology of Down Syndrome and Alzheimer's disease.
Cat No. product name
T15579 INDY INDY is a ATP-competitive inhibitor of Dyrk1A and Dyrk1B (IC50s: 0.24 μM and 0.23 μM). INDY sharply causes the self-renewal capacity of normal and tumorigenic...
T11447 GNF4877 GNF4877 is a potent DYRK1A and GSK3β inhibitor (IC50s: 6 nM and 16 nM). It leads to blockade of nuclear factor of activated T-cells (NFATc) nuclear export ...
T11133 DYRKs-IN-2 DYRKs-IN-2 has antitumor activity. DYRKs-IN-2 is a potent DYRKs inhibitor with IC50s of 30.6 nM and 12.8 nM for DYRK1B and DYRK1A, respectively.
T11132 DYRKs-IN-1 DYRKs-IN-1 has antitumor activity. DYRKs-IN-1 is a potent DYRKs (Dual-specificity tyrosine-phosphorylation-regulated kinases) inhibitor with IC50s of 9 nM and 5...
T14364 AZ-Dyrk1B-33 AZ-Dyrk1B-33 is a potent and selective Dyrk1B kinase inhibitor. With an IC50 of 7 nM[1].
TQ0111 LDN-192960 LDN-192960 is a potent inhibitor of Haspin and DYRK2 (IC50s: 10 nM and 48 nM).
T2811 Harmine hydrochloride Harmine hydrochloride is extracted from Peganum Harmala Genus.
T6257 AZ191 AZ191(IC50 of 17 nM) is an effective and specific DYRK1B inhibitor. The specificity of AZ191 for DYRK1B is about 5- and 110-fold greater over DYRK1A and DYRK...
T2431 ID8 ID-8, a DYRK inhibitor, sustains embryonic stem cell self-renewal in long-term culture.
T2670 ML167 ML167 is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor.
INDY
T15579CAS 1169755-45-6
INDY is a ATP-competitive inhibitor of Dyrk1A and Dyrk1B (IC50s: 0.24 μM and 0.23 μM). INDY sharply causes the self-renewal capacity of normal and tumorigenic...
GNF4877
T11447CAS 2041073-22-5
GNF4877 is a potent DYRK1A and GSK3β inhibitor (IC50s: 6 nM and 16 nM). It leads to blockade of nuclear factor of activated T-cells (NFATc) nuclear export ...
DYRKs-IN-2
T11133CAS 1386980-04-6
DYRKs-IN-2 has antitumor activity. DYRKs-IN-2 is a potent DYRKs inhibitor with IC50s of 30.6 nM and 12.8 nM for DYRK1B and DYRK1A, respectively.
DYRKs-IN-1
T11132CAS 1387090-01-8
DYRKs-IN-1 has antitumor activity. DYRKs-IN-1 is a potent DYRKs (Dual-specificity tyrosine-phosphorylation-regulated kinases) inhibitor with IC50s of 9 nM and 5...
AZ-Dyrk1B-33
T14364CAS 1679330-37-0
AZ-Dyrk1B-33 is a potent and selective Dyrk1B kinase inhibitor. With an IC50 of 7 nM[1].
LDN-192960
TQ0111CAS 184582-62-5
LDN-192960 is a potent inhibitor of Haspin and DYRK2 (IC50s: 10 nM and 48 nM).
Harmine hydrochloride
T2811CAS 343-27-1
Harmine hydrochloride is extracted from Peganum Harmala Genus.
AZ191
T6257CAS 1594092-37-1
AZ191(IC50 of 17 nM) is an effective and specific DYRK1B inhibitor. The specificity of AZ191 for DYRK1B is about 5- and 110-fold greater over DYRK1A and DYRK...
ID8
T2431CAS 147591-46-6
ID-8, a DYRK inhibitor, sustains embryonic stem cell self-renewal in long-term culture.
ML167
T2670CAS 1285702-20-6
ML167 is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor.