CGRP Receptor

CGRP receptor is found in myelinated A-fibers axon which is required for ligand specificity and function of the receptor. The CGRP receptor has three subunits: receptor activity-modifying protein 1 (RAMP1), calcitonin-like receptor (CLR) and receptor component protein (RCP).[17] The complex central receptor is the G protein-coupled receptor calcitonin receptor-like receptor (CALCRL) which is necessary for CGRP and adrenomedullin (AM receptors). For function CGRP, CALCRL must coincide with RAMP1 where the ligand-binding domain of CGRP is located.

Cat. No.	Product name	CAS No.	Purity
TP1040	Calcitonin (salmon)	47931-85-1	98%
TP1040	Calcitonin salmon, a calcium regulating hormone, is used to treat osteoporosis in women who are at least 5 years past menopause.
T6590	MK-3207 Hydrochloride	957116-20-0	98%
T6590	MK-3207 is a potent CGRP receptor antagonist with IC50 and Kiof 0.12 nM and 0.022 nM, highly selective versus human AM1, AM2, CTR, and AMY3. Phase 2.
TP1257L	Adrenomedullin (AM) (22-52), human acetate		98%
TP1257L	Adrenomedullin (AM) (22-52), human acetate is an antagonist of calcitonin generelated peptide receptor in the hindlimb vascular bed of the cat and an adrenomedul...
T16107	ML230	1776055-05-0	98%
T16107	ML230 is a selective ATP-binding cassette (ABC) transporter ABCG2 inhibitor. It 36-fold selective for ABCG2 over ABCB1 (EC50s: 0.13 μM and 4.65 μM, respectively)...
T8682	Vazegepant hydrochloride	1414976-20-7	98%
T8682	Vazegepant is the first intranasal gepant for the acute treatment of migraine and has announced a positive phase II/III study.
TP2167	β-CGRP, human acetate	TP2167	98%
TP2167	β-CGRP, human acetate is one of calcitonin peptides and acts via the complex of receptor-activity-modifying protein (RAMP) and calcitonin-receptor-like receptor ...
TP1040L	Calcitonin（salmon） Acetate(47931-85-1(free base))	TP1040L	98%
TP1040L	Calcitonin（salmon） Acetate, a calcium regulating hormone, is used to treat osteoporosis in women who are at least 5 years past menopause.
T12293L	Olcegepant	204697-65-4	98%
T12293L	Olcegepant is an effective and selective non-peptide calcitonin gene-related peptide 1 (CGRP1) receptor antagonist (IC50 of 0.03 nM and Ki of 14.4 pM for human C...
T13453	CGRP antagonist 1	1123757-49-2	98%
T13453	CGRP antagonist 1 is a potent CGRP receptor antagonist with Ki values of 35 nM and IC50 values of 57 nM, respectively.CGRP antagonist 1 can be used for the study...
T17194	Ubrogepant	1374248-77-7	98%
T17194	Ubrogepant is a novel oral calcitonin gene-related peptide receptor antagonist in development for acute treatment of migraine.
TP1134L	HCGRP-(8-37) acetate	TP1134L	98%
TP1134L	HCGRP-(8-37) acetate is a human calcitonin gene-related peptide (hCGRP) fragment acetate and also an antagonist of CGRP receptor.
T4610	Rimegepant	1289023-67-1	98%
T4610	BMS-927711 is a highly potent, oral calcitonin gene-related peptide (CGRP) receptor antagonist with a Ki value of 0.027 nM.