presynaptic — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T8118	Bekanamycin	Kanamycin B	Antibacterial , Antibiotic
	Bekanamycin (Kanamycin B) is an aminoglycoside antibiotic.		Antibacterial , Antibiotic
TQ0084	Lumateperone Tosylate	ITI-007	Dopamine Receptor , 5-HT Receptor
	lumateperone Tosylate (ITI-007) is a 5-HT2A receptor antagonist (Ki: 0.54 nM), a SERT blocker (Ki: 61 nM), a partial agonist of presynaptic D2 receptors and an antagonist of postsynaptic D2 receptors (Ki: 32 nM).		Dopamine Receptor , 5-HT Receptor
T21069	Lumateperone	ITI 722,ITI722,ITI-007,ITI007	5-HT Receptor
	Lumateperone (ITI 722) is a 5HT2A receptor antagonist and a dopamine receptor phosphoprotein modulator (DPPM).		5-HT Receptor
T3280	Clodronate disodium tetrahydrate	clodronic acid disodium tetrahydrate,Disodium clodronate tetrahydrate,Clastoban,Clodronate disodium	IL Receptor , TNF
	Clodronate disodium tetrahydrate (Clastoban) inhibits bone resorption and soft tissue calcification.		IL Receptor , TNF
T7386	Bretylium tosylate		Others
	Bretylium tosylate is an inhibitor of the presynaptic release of vasoconstrictor neurotransmitters, a available antiarrhythmic drug for ventricular arrhythmias.		Others
T4S1876	3-Deoxyaconitine		Sodium Channel
	3- Deoxyaconitine is a derivative of Aconitine (A189875), which activates tetrodotoxin-sensitive Na+ channels, inducing presynaptic depolarization, thus blocking the nerve action potential which, in turn, blocks the rele...		Sodium Channel
T21766	ML352
	ML352, a noncompetitive inhibitor of the presynaptic choline transporter (CHT), exhibits K i values of 92 nM in HEK293 cells with human CHT expression and 166 nM in mouse forebrain synaptosomes [1].
T1540	Doxepin hydrochloride	Toruan,Doxepin HCl,Aponal,Novoxapin	P450 , Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor , AChR , Norepinephrine , Histamine Receptor
	Doxepin hydrochloride (Aponal) is a dibenzoxepin tricyclic compound. It displays a range of pharmacological actions including maintaining adrenergic innervation. Its mechanism of action is not fully understood, but it ap...
T22530	6-Chloromelatonin		Melatonin Receptor , Dopamine Receptor
	6-Chloromelatonin is a potent melatonin receptor agonist, a 5-methoxyindole compound that competes for the same presynaptic melatonin receptor sites in the rabbit retina and inhibits the calcium-dependent release of [3H]...		Melatonin Receptor , Dopamine Receptor
T7218	Endomorphin 2		Opioid Receptor
	Endomorphins-2 (EM-2) could decrease both the frequency and amplitude of the sEPSC of the motoneurons in lamina IX, which was reversed by the MOR antagonist CTOP. EM-2-IR fibers originated from primary afferent fibers f...		Opioid Receptor
T0869	Atomoxetine hydrochloride	Tomoxetine hydrochloride,(R)-Tomoxetine hydrochloride,LY 139603,Atomoxetine HCl,LY 139603 HCl	Dopamine Receptor , 5-HT Receptor , Norepinephrine
	Atomoxetine hydrochloride (LY 139603) is the hydrochloride salt of atomoxetine, a phenoxy-3-propylamine derivative and selective non-stimulant, norepinephrine reuptake inhibitor with cognitive-enhancing activity. Althou...		Dopamine Receptor , 5-HT Receptor , Norepinephrine
T8270	Deserpidine	Harmonyl	RAAS
	Deserpidine (Harmonyl) is only found in individuals that have used or taken this drug. It is an ester alkaloid drug isolated from Rauwolfia canescens (family Apocynaceae) with antipsychotic and antihypertensive propertie...		RAAS
T12118	MSOP		GluR
	MSOP is a selective antagonist of group III metabotropic glutamate receptor (KD of 51 μM for the L-AP4-sensitive presynaptic mGluR).		GluR
T10779	CGP 25454A		Others
	CGP 25454A is a novel and selective antagonist of the presynaptic dopamine autoreceptor.		Others
T23662	Aganodine	Aganodin
	Aganodine is a guanidine that activates presynaptic imidazoline receptors. Aganodine inhibits the presynaptic release of norepinephrine through its agonism at imidazoline receptors.
T71439	Opc 4392
	Opc 4392 is an agonist of presynaptic dopamine D(2) receptor.
T24462	Mezilamine
	Mezilamine is an antagonist of dopamine. It also blocks presynaptic but stimulating postsynaptic alpha-adrenoceptors.
T68767	Mezilamine HCl
	Mezilamine HCl is a dopamine antagonist, blocking presynaptic but stimulating postsynaptic alpha-adrenoceptors.
T38975	WAY-100135 dihydrochloride
	WAY-100135 dihydrochloride is a potent and selective antagonist of both presynaptic and postsynaptic 5-HT 1A receptors, exhibiting an IC 50 value of 34 nM specifically at the rat hippocampal 5-HT 1A receptor. This compou...
T40541	α-Synuclein (61-75)
	α-Synuclein (61-75) is a peptide fragment derived from the larger protein α-Synuclein. α-Synuclein is predominantly found in presynaptic nerve terminals and is considered to be a biomarker candidate for Parkinson's disea...