T27830 |
Lifarizine
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RS-87476 |
Calcium Channel
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Lifarizine 是一种钙钠通道拮抗剂, 在简化的大鼠双血管闭塞存活模型中显示出神经保护活性。 |
T24873 |
TGX-115
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TGX 115 |
PI3K
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TGX-115是一种细胞渗透性和有效的PI 3-K 异构体p110β/p110δ抑制剂(对p110β IC50值为 0.13 μM, 对p110δ值为0.63 μM),是一种调节血小板粘附过程的酶,可抑制磷酸肌苷(PI)3-激酶,可用来治疗... |
T4330 |
CaCCinh-A01
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Chloride channel
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CaCCinh-A01 是钙激活氯离子通道和TMEM16A 抑制剂,IC50值分别为 10 和 2.1 μM。 |
T11994 |
Melagatran
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Thrombin
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Melagatran, a direct and orally active thrombin inhibitor, specifically inhibits thrombin without affecting other enzyme... |
T28414 |
Piclozotan
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SUN-4057 |
5-HT Receptor
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Piclozotan (anhydrous) 是一种 5-HT1A 受体激动剂,在短暂的大脑中动脉闭塞(t-MCAO)模型中表现出显着的神经保护活性,可以改善晚期帕金森病患者的运动并发症。 |
T1476 |
Pramipexole
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普拉克索,SND 919 |
Dopamine Receptor
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Pramipexole 是能够透过血脑屏障的 D2 型多巴胺受体的选择性激动剂,对 D2 型受体、D2、D3、D4亚型受体的Ki 分别为 2.2 nM、3.9 nM、0.5 nM、1.3 nM。它可用于研究帕金森综合症和腿多动综合征。 |
T70540 |
Pinokalant
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LOE-908 |
SARS-CoV
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TRP/TRPV Channel
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Pinokalant 是一种新型非选性阳离子通道抑制剂。Pinokalant 在体内实验中可显著减少皮质梗死体积,可改善缺血半影区的代谢和电生理状态,可减少大鼠大脑中动脉闭塞后急性期磁共振图像上的病变大小。Pinokalant是一种潜在的S... |
T23146 |
PHA 568487 free base
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PHA 568487 |
AChR
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PHA 568487 free base 是一种选择性的 α7 烟碱乙酰胆碱受体激动剂,可用于减缓神经炎症。 |
T6951 |
Pramipexole dihydrochloride hydrate
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普拉克索盐酸盐水合物,普拉克索,Mirapex,Pramipexole 2HCl Monohydrate |
Dopamine Receptor
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Pramipexole 2HCl Monohydratee 是选择性的,具有血脑屏障 (BBB) 渗透性的 D2 型多巴胺受体激动剂,对 D2 型受体、D2、D3、D4亚型受体的 Ki 分别为 2.2 nM、3.9 nM、0.5 nM、1.... |
T38063 |
N-Acetyl lysyltyrosylcysteine amide
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N-Acetyl lysyltyrosylcysteine amide is a potent, reversible, specific, and non-toxic tripeptide inhibitor of myeloperoxi... |
T2163 |
Dihydrocapsaicin
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二氢辣椒素,CCRIS1589,8-Methyl-N-vanillylnonanamide,6,7-Dihydrocapsaicin |
Others
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TRP/TRPV Channel
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Dihydrocapsaicin 是一种天然来源的辣椒素,是TRPV1的选择性激动剂,同时可以增加 p-Akt 水平。它可以增强低温诱导的神经保护。 |
T35689 |
MTP 131 acetate
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Others
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MTP 131 acetate 是一种小的线粒体靶向四肽。 |
T27897 |
LY 215490
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LY215490,LY-215490 |
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LY 215490 is a selective, competitive and systemically active antagonist of AMPA receptor. LY 215490 has neuroprotective... |
T27351 |
Fostedil
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KB-944,KB 944,KB944,A 53986,BRN 3626546,A-53986 |
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Fostedil is a calcium channel antagonist. KB-944 increased regional segment function in normal and ischemic regions and ... |
T16902 |
SMND-309
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Others
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SMND-309 is a metabolite of salvianolic acid B. It also shows neuroprotective effects in cultured neurons and in permane... |
T68814 |
GZN39838
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GZN39838, also known as 6beta-Acetoxy-7alpha-hydroxyroyleanone is a natural blocker of Kv1.2 channels, not involving dir... |
T41029 |
Streptokinase
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Streptokinase is a bacterial protein that acts as a plasminogen activator, commonly employed in the investigation of blo... |
T76987 |
Tarcocimab
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Tarcocimab (OG1953) 是一种人源化抗VEGFA 单克隆抗体 (IgG1 型)。Tarcocimab 可用于视网膜静脉阻塞 (RVO) 和湿性老年性黄斑变性 (AMD) 的研究。 |
T35463 |
(±)14(15)-EET
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(±)14(15)-EET,(±)14,15-EpETrE,(±)14,15-EET |
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(±)14(15)-EET is a metabolite of arachidonic acid that is formed via epoxidation of arachidonic acid by cytochrome P450.... |
T36570 |
KUS121
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KUS121 is a valosin-containing protein (VCP) modulator that inhibits VCP ATPase activity (IC50= 330 nM).1It inhibits cel... |