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Search Results for " mutagenic "

Targets

23

Compounds

19

Natural Products

3

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T13457 (Z)-9-Propenyladenine (Z)-Mutagenic Impurity of Tenofovir Disoproxil Others
(Z)-9-Propenyladenine is a mutagenic impurity in tenofovir disoproxil fumarate.
T12127 9-Propenyladenine Mutagenic Impurity of Tenofovir Disoproxil,Tenofovir Impurity 2 Others
9-Propenyladenine is a mutagenic impurity in tenofovir disoproxil fumarate.
T5363 Tempo 2,2,6,6-Tetramethylpiperidinooxy Free radical scavengers , Reactive Oxygen Species , DNA/RNA Synthesis , Mitochondrial Metabolism
Tempo (2,2,6,6-Tetramethylpiperidinooxy) has a wide range of applications including use as a free radical scavenger, a reagent in organic synthesis and as a structural probe in electron spin resonance spectroscopy.
T20760 Benzidine orange DCC-1802,Polymo Orange GR,Oralith Orange PG,DCC 1802,DCC1802 Others
Benzidine orange (DCC-1802) shows mutagenic and carcinogenic activity.
T15611 JH-RE-06 DNA/RNA Synthesis
JH-RE-06 disrupts mutagenic translesion synthesis (TLS) by preventing the recruitment of mutagenic POLζ. JH-RE-06 is an effective REV1-REV7 interface inhibitor (IC50=0.78 μM; Kd=0.42 μM), which targets REV1 that interact...
T68110 Moxnidazole
Moxnidazole, a 5-nitroimidazole, is mutagenic in microbial assays and in Drosophila, inducing genetic alterations in mouse somatic cells.
T9049 Difurazon hydrochloride Others
Difurazon hydrochloride is a mutagenic drug . Difurazon hydrochloride may has been used to treat bacillary dysentery. It is an antibacterial growth promoter in animal feeds.
T4169 N-Nitroso-N-methylurea 1-Methyl-1-nitrosourea,N-Methyl-N-nitrosourea,Methylnitrosourea Others , DNA Alkylator/Crosslinker
N-Nitroso-N-methylurea (Methylnitrosourea) is a nitrosourea compound with alkylating, carcinogenic, and mutagenic properties.
T19859 Nicosulfuron Milagro,Accent,Motivell Others
Nicosulfuron (Milagro) is a pesticide that works by inhibiting the acetolactate synthase enzyme. Nicosulfuron has not been found to induce mutagenic or carcinogenic effects. Nicosulfuron is a herbicide to protect corn cr...
T1488 Procarbazine hydrochloride NSC-77213 HCl,Procarbazine HCl DNA Alkylator/Crosslinker , DNA/RNA Synthesis
Procarbazine hydrochloride (NSC-77213 HCl) is the hydrochloride salt of a methylhydrazine derivative with antineoplastic and mutagenic activities. Although the exact mode of cytotoxicity has not been elucidated, procarba...
T37514 Hydroxy Dimetridazole Drug Metabolite
Dimetridazole is a nitroimidazole-based compound with antibacterial and anticoccidial activity. It was once widely used in the treatment of parasitic infections in poultry, cattle, swine and farmed fish until suspected t...
T33623 Necatorin Necatorine
Necatorin is a mutagenic compound from edible mushroom Lactarius necator.
T71210 S7958
S7958 is a is a TAS2R8 antagonist. It was found to be non-mutagenic in vitro.
T31601 Eclanamine maleate U-48753E,U48,753E,U-48,753E,U48753E,U 48,753E
Eclanamine was discovered to be slightly mutagenic in the AS52 assay, and a potential agent which was subjected to a battery of short-term assays for genetic activity.
T71422 S6821
S6821 is a TAS2R8 antagonist. S6821 was not found to be mutagenic or clastogenic in vitro, and did not induce micronuclei in bone marrow polychromatic erythrocytes in vivo.
T28894 SZV558 SZV 558,SZV-558
SZV558 is a potent inhibitor of both human and rodent MAO-B. SZV558 is safe in high doses with no hERG and mutagenic activities and demonstrated neuroprotection in an in vivo chronic model of PD.
T23797 Bis(diazoacetyl)butane 1,4-Bis-diazoacetylbutane,Supermutagen,1,4-Bis(diazoacetyl)butane,DAB (mutagen)
Bis(diazoacetyl)butane is a mutagen and traditionally related to radio-mimetic chemical mutagens due to the similarity of appearance of mutagenic action of this mutagen and physical mutagens. It also has anti-tumor and c...
T40933 Bromochloroacetonitrile
Bromochloroacetonitrile is a chemical compound that is formed as a by-product during the chlorine disinfection process of water that contains natural organic material. This compound exhibits direct mutagenic activity and...
T63236 AZD4625
AZD4625 (Compound 21) is a selective, potent, orally active, covalent and mutagenic mutant GTPaseKRASG12C inhibitor.
T9233 Metronidazole acetic acid Antibacterial , Antibiotic , Parasite
Metronidazole acetic acid is a metabolite of Metronidazole with mutagenic activity in bacteria. Metronidazole is a nitroimidazole antibiotic, amebicide, and antiprotozoal agent used particularly for protozoa and anaerob...
T78460 1-Methylpyrene
1-Methylpyrene, a pervasive environmental pollutant and carcinogen in rodents, exhibits mutagenic activity through the sequential activation by multiple CYP and sulfotransferase (SULT) enzymes, leading to chromosomal los...
T74622 Antibacterial agent 109
Antibacterial agent 109 (Compound C-2) is a potent antibacterial agent against both gram-positive and gram negative bacteria, and non-mutagenic. Antibacterial agent 109 inhibits protein synthesis by blocking the extensio...
T36235 5-Chlorouracil
5-Chlorouracil is a chlorinated derivative of the pyrimidine nucleoside base uracil . In vivo, it is converted into chlorodeoxyuridine, which is mutagenic and genotoxic.1 Uracil is chlorinated at the 5 position in a cell...

Compounds

(Z)-9-Propenyladenine
T13457
Synonym: (Z)-Mutagenic Impurity of Tenofovir Disoproxil
Target: Others
9-Propenyladenine
T12127
Synonym: Mutagenic Impurity of Tenofovir Disoproxil,Tenofovir Impurity 2
Target: Others
Tempo
T5363
Synonym: 2,2,6,6-Tetramethylpiperidinooxy
Target: Free radical scavengers, Reactive Oxygen Species, DNA/RNA Synthesis, Mitochondrial Metabolism
Benzidine orange
T20760
Synonym: DCC-1802,Polymo Orange GR,Oralith Orange PG,DCC 1802,DCC1802
Target: Others
JH-RE-06
T15611
Synonym:
Target: DNA/RNA Synthesis
Moxnidazole
T68110
Synonym:
Target:
Difurazon hydrochloride
T9049
Synonym:
Target: Others
N-Nitroso-N-methylurea
T4169
Synonym: 1-Methyl-1-nitrosourea,N-Methyl-N-nitrosourea,Methylnitrosourea
Target: Others, DNA Alkylator/Crosslinker
Nicosulfuron
T19859
Synonym: Milagro,Accent,Motivell
Target: Others
Procarbazine hydrochloride
T1488
Synonym: NSC-77213 HCl,Procarbazine HCl
Target: DNA Alkylator/Crosslinker, DNA/RNA Synthesis
Hydroxy Dimetridazole
T37514
Synonym:
Target: Drug Metabolite
Necatorin
T33623
Synonym: Necatorine
Target:
S7958
T71210
Synonym:
Target:
Eclanamine maleate
T31601
Synonym: U-48753E,U48,753E,U-48,753E,U48753E,U 48,753E
Target:
S6821
T71422
Synonym:
Target:
SZV558
T28894
Synonym: SZV 558,SZV-558
Target:
Bis(diazoacetyl)butane
T23797
Synonym: 1,4-Bis-diazoacetylbutane,Supermutagen,1,4-Bis(diazoacetyl)butane,DAB (mutagen)
Target:
Bromochloroacetonitrile
T40933
Synonym:
Target:
AZD4625
T63236
Synonym:
Target:
Metronidazole acetic acid
T9233
Synonym:
Target: Antibacterial, Antibiotic, Parasite
1-Methylpyrene
T78460
Synonym:
Target:
Antibacterial agent 109
T74622
Synonym:
Target:
5-Chlorouracil
T36235
Synonym:
Target:
Cat No. Product Name Synonyms Targets
T19412 Macrozamin Others
Macrozamin has carcinogenic, mutagenic, teratogenic and neurotoxic properties.Macrozamin is a natural product isolated from Cycads.
T2895 Lupeol Fagarasterol,Monogynol B,Clerodol,(3β,13ξ)-Lup-20(29)-en-3-ol,Farganasterol Apoptosis , Androgen Receptor , Akt
Lupeol (Monogynol B) is a novel androgen receptor inhibitor with anti-inflammatory and antioxidant activity.
TN1683 Gentisin DNA/RNA Synthesis
Gentisin is a novel inhibitor of vascular smooth muscle cells (VSMC) proliferation with an IC50 value of 7.84 μM. Gentisin has mutagenic activity.
T2863 P-Coumaric acid para-Coumaric Acid,4-Hydroxycinnamic acid,trans-4-Hydroxycinnamic acid,Trans-p-Coumaric acid,4-Coumaric acid,P-Hydroxycinnamic acid Endogenous Metabolite , Antibiotic
p-Coumaric acid (para-Coumaric Acid) is the abundant isomer of cinnamic acid, with antitumor and anti-mutagenic activities.
TJS0405 Lucidin NSC 30546,Henine Others
1. Lucidin (NSC-30546) and its derivatives are genotoxic, it is mutagenic at the hypoxanthine-guanine phosphoribosyl transferase gene locus.
T2801 Aristolochic acid A TR 1736,Aristolochin,Aristolochine,Aristolochic Acid I,Aristolochic Acid Others , NF-κB
Aristolochic acid A (TR 1736) is a compound of mutagenic, carcinogenic, and nephrotoxic compounds commonly found in the Birthwort (Aristolochiaceae) family of plants.
T5746 Dictamine Dictamnine,Dectamine Apoptosis , Anti-infection , Antibacterial , Antifungal
Dictamine (Dectamine) shows anticholinesterase, anti-inflammatory, mutagenic, and has antimicrobial activity against bacteria and fungi. It has the ability to exert cytotoxicity in human cervix, colon, and oral carcinoma...
T4832 Cytosine 6-Aminopyrimidin-2(1H)-one,4-Amino-2-hydroxypyrimidine,Cytosinimine Endogenous Metabolite
Cytosine (6-Aminopyrimidin-2(1H)-one) is a pyrimidine base that is a fundamental unit of nucleic acids. The deamination of cytosine alone is apparent and the nucleotide of cytosine is the prime mutagenic nucleotide in le...
T19165 8-Hydroxyguanine 8 Hydroxyguanine,7,8-dihydro-8-oxoguanine,2-Amino-6,8-dihydroxypurine Endogenous Metabolite
8-Hydroxyguanine (8 Hydroxyguanine) is the major premutagenic damage produced by reactive oxygen species. It causes G-T and A-C substitutions.8-Hydroxyguanine is a biomarker for RNA oxidation and oxidative DNA damage.8-H...
TN1078 Seneciphylline P450 , GST
Seneciphylline, one of the hepatotoxic pyrolizidine alkaloids, has mutagenic activity in Drosophila and their transfer into rat milk.Seneciphylline can significantly increased the activities of epoxide hydrase and glutat...
T19317 Ethyl phenylacetate Others
Ethyl phenylacetate is a “greener" solvent with low toxicity. Ethyl phenylacetate is a non-mutagenic and is a Kosher food additive. Ethyl phenylacetate gives the wines a strong honey-like character. Ethyl phenylacetate i...
T7031 Aristolochic acid B Aristolochic Acid II DNA
Aristolochic acid B (Aristolochic Acid II) is one of the major components of the carcinogenic plant extract aristolochic acid, is known to be mutagenic and to form DNA adducts in vitro and in vivo, Aristolochic acid B sh...
TN1711 Gossypetin Antioxidant , p38 MAPK , MAPK , Antibacterial
Gossypetin, a hexahydroxylated flavonoid extractable from Rhodiola rosea Linn. is a potent MKK3 and MKK6 inhibitor that strongly attenuates the MKK3/6-p38 signaling pathway.Gossypetin exhibits antimutagenic, antiatherosc...
T4918 DL-Glyceraldehyde Glyceric aldehyde Reductase
DL-Glyceraldehyde (Glyceric aldehyde) is produced from the action of the enzyme glyceraldehyde dehydrogenase, which converts glycerol to glyceraldehyde using NADP as a cofactor. When present at sufficiently high levels, ...
T2163 Dihydrocapsaicin CCRIS1589,6,7-Dihydrocapsaicin,8-Methyl-N-vanillylnonanamide Others , TRP/TRPV Channel
Dihydrocapsaicin (CCRIS1589) is isolated from Capsicum fruit. Capsaicin is the primary active component of the heat and pain-eliciting lipid soluble fraction of the Capsicum pepper. Like capsaicin, dihydrocapsaicin is an...
T13544 Altertoxin I Dihydroalterperylenol Others
Altertoxin I (Dihydroalterperylenol) is a quinone-type mycotoxin produced by Alternaria alternata fungi. It is mutagenic and cytotoxic and can weakly disrupt metabolic communication.
T13531 Aflatoxicol Aflatoxin R0 Others
Aflatoxin (Aflatoxin R0) is a mutagenic and carcinogenic mycotoxin derived from aflatoxin B1 through metabolic processes facilitated by Rhizopus spp.
TN4346 Jaconine Others
Jaconine, jacoline,jacobine, and jacozine, the hepatotoxic alkaloids, are potentially carcinogenic, mutagenic, and teratogenic and may pose health hazards to the human consumer.
TN3608 Catalpin Others
Catalpin exhibited mutagenic activity towards Salmonella typhimurium strain TA100 in the presence and absence of rat liver homogenate (S9) mix in Ames' test.

Natural Products

Macrozamin
T19412
Synonym:
Target: Others
Lupeol
T2895
Synonym: Fagarasterol,Monogynol B,Clerodol,(3β,13ξ)-Lup-20(29)-en-3-ol,Farganasterol
Target: Apoptosis, Androgen Receptor, Akt
Gentisin
TN1683
Synonym:
Target: DNA/RNA Synthesis
p-Coumaric acid
T2863
Synonym: para-Coumaric Acid,4-Hydroxycinnamic acid,trans-4-Hydroxycinnamic acid,Trans-p-Coumaric acid,4-Coumaric acid,P-Hydroxycinnamic acid
Target: Endogenous Metabolite, Antibiotic
Lucidin
TJS0405
Synonym: NSC 30546,Henine
Target: Others
Aristolochic acid A
T2801
Synonym: TR 1736,Aristolochin,Aristolochine,Aristolochic Acid I,Aristolochic Acid
Target: Others, NF-κB
Dictamine
T5746
Synonym: Dictamnine,Dectamine
Target: Apoptosis, Anti-infection, Antibacterial, Antifungal
Cytosine
T4832
Synonym: 6-Aminopyrimidin-2(1H)-one,4-Amino-2-hydroxypyrimidine,Cytosinimine
Target: Endogenous Metabolite
8-Hydroxyguanine
T19165
Synonym: 8 Hydroxyguanine,7,8-dihydro-8-oxoguanine,2-Amino-6,8-dihydroxypurine
Target: Endogenous Metabolite
Seneciphylline
TN1078
Synonym:
Target: P450, GST
Ethyl phenylacetate
T19317
Synonym:
Target: Others
Aristolochic acid B
T7031
Synonym: Aristolochic Acid II
Target: DNA
Gossypetin
TN1711
Synonym:
Target: Antioxidant, p38 MAPK, MAPK, Antibacterial
DL-Glyceraldehyde
T4918
Synonym: Glyceric aldehyde
Target: Reductase
Dihydrocapsaicin
T2163
Synonym: CCRIS1589,6,7-Dihydrocapsaicin,8-Methyl-N-vanillylnonanamide
Target: Others, TRP/TRPV Channel
Altertoxin I
T13544
Synonym: Dihydroalterperylenol
Target: Others
Aflatoxicol
T13531
Synonym: Aflatoxin R0
Target: Others
Jaconine
TN4346
Synonym:
Target: Others
Catalpin
TN3608
Synonym:
Target: Others

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPH-00555 LpxC Protein, E. coli, Recombinant (His) E. coli E. coli
Catalyzes the hydrolytic deamination of cytosine to uracil. Is involved in the pyrimidine salvage pathway, which allows the cell to utilize cytosine for pyrimidine nucleotide synthesis. Is also able to catalyze deaminati...
TMPY-02798 NEIL1 Protein, Human, Recombinant (His) Human E. coli
NEIL1 is a member of DNA glycosylases. DNA glycosylases are a family homologous to the bacterial Fpg/Nei family. They play a role in base excision repair which is the mechanism by which damaged bases in DNA are removed a...
TMPY-01480 LTC4S Protein, Human, Recombinant (His) Human Baculovirus-Insect Cells
Leukotriene C4 synthase, also known as LTC4 synthase, Leukotriene-C(4) synthase, and LTC4S, is a multi-pass membrane protein that belongs to the MAPEG family. LTC4S is detected in the lung, platelets, and the myelogenous...
TargetMol