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Cat No. | Product Name | Synonyms | Targets |
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T13457 | (Z)-9-Propenyladenine | (Z)-Mutagenic Impurity of Tenofovir Disoproxil | Others |
(Z)-9-Propenyladenine is a mutagenic impurity in tenofovir disoproxil fumarate. | |||
T12127 | 9-Propenyladenine | Mutagenic Impurity of Tenofovir Disoproxil,Tenofovir Impurity 2 | Others |
9-Propenyladenine is a mutagenic impurity in tenofovir disoproxil fumarate. | |||
T5363 | Tempo | 2,2,6,6-Tetramethylpiperidinooxy | Free radical scavengers , Reactive Oxygen Species , DNA/RNA Synthesis , Mitochondrial Metabolism |
Tempo (2,2,6,6-Tetramethylpiperidinooxy) has a wide range of applications including use as a free radical scavenger, a reagent in organic synthesis and as a structural probe in electron spin resonance spectroscopy. | |||
T20760 | Benzidine orange | DCC-1802,Polymo Orange GR,Oralith Orange PG,DCC 1802,DCC1802 | Others |
Benzidine orange (DCC-1802) shows mutagenic and carcinogenic activity. | |||
T15611 | JH-RE-06 | DNA/RNA Synthesis | |
JH-RE-06 disrupts mutagenic translesion synthesis (TLS) by preventing the recruitment of mutagenic POLζ. JH-RE-06 is an effective REV1-REV7 interface inhibitor (IC50=0.78 μM; Kd=0.42 μM), which targets REV1 that interact... | |||
T68110 | Moxnidazole | ||
Moxnidazole, a 5-nitroimidazole, is mutagenic in microbial assays and in Drosophila, inducing genetic alterations in mouse somatic cells. | |||
T9049 | Difurazon hydrochloride | Others | |
Difurazon hydrochloride is a mutagenic drug . Difurazon hydrochloride may has been used to treat bacillary dysentery. It is an antibacterial growth promoter in animal feeds. | |||
T4169 | N-Nitroso-N-methylurea | 1-Methyl-1-nitrosourea,N-Methyl-N-nitrosourea,Methylnitrosourea | Others , DNA Alkylator/Crosslinker |
N-Nitroso-N-methylurea (Methylnitrosourea) is a nitrosourea compound with alkylating, carcinogenic, and mutagenic properties. | |||
T19859 | Nicosulfuron | Milagro,Accent,Motivell | Others |
Nicosulfuron (Milagro) is a pesticide that works by inhibiting the acetolactate synthase enzyme. Nicosulfuron has not been found to induce mutagenic or carcinogenic effects. Nicosulfuron is a herbicide to protect corn cr... | |||
T1488 | Procarbazine hydrochloride | NSC-77213 HCl,Procarbazine HCl | DNA Alkylator/Crosslinker , DNA/RNA Synthesis |
Procarbazine hydrochloride (NSC-77213 HCl) is the hydrochloride salt of a methylhydrazine derivative with antineoplastic and mutagenic activities. Although the exact mode of cytotoxicity has not been elucidated, procarba... | |||
T37514 | Hydroxy Dimetridazole | Drug Metabolite | |
Dimetridazole is a nitroimidazole-based compound with antibacterial and anticoccidial activity. It was once widely used in the treatment of parasitic infections in poultry, cattle, swine and farmed fish until suspected t... | |||
T33623 | Necatorin | Necatorine | |
Necatorin is a mutagenic compound from edible mushroom Lactarius necator. | |||
T71210 | S7958 | ||
S7958 is a is a TAS2R8 antagonist. It was found to be non-mutagenic in vitro. | |||
T31601 | Eclanamine maleate | U-48753E,U48,753E,U-48,753E,U48753E,U 48,753E | |
Eclanamine was discovered to be slightly mutagenic in the AS52 assay, and a potential agent which was subjected to a battery of short-term assays for genetic activity. | |||
T71422 | S6821 | ||
S6821 is a TAS2R8 antagonist. S6821 was not found to be mutagenic or clastogenic in vitro, and did not induce micronuclei in bone marrow polychromatic erythrocytes in vivo. | |||
T28894 | SZV558 | SZV 558,SZV-558 | |
SZV558 is a potent inhibitor of both human and rodent MAO-B. SZV558 is safe in high doses with no hERG and mutagenic activities and demonstrated neuroprotection in an in vivo chronic model of PD. | |||
T23797 | Bis(diazoacetyl)butane | 1,4-Bis-diazoacetylbutane,Supermutagen,1,4-Bis(diazoacetyl)butane,DAB (mutagen) | |
Bis(diazoacetyl)butane is a mutagen and traditionally related to radio-mimetic chemical mutagens due to the similarity of appearance of mutagenic action of this mutagen and physical mutagens. It also has anti-tumor and c... | |||
T40933 | Bromochloroacetonitrile | ||
Bromochloroacetonitrile is a chemical compound that is formed as a by-product during the chlorine disinfection process of water that contains natural organic material. This compound exhibits direct mutagenic activity and... | |||
T63236 | AZD4625 | ||
AZD4625 (Compound 21) is a selective, potent, orally active, covalent and mutagenic mutant GTPaseKRASG12C inhibitor. | |||
T9233 | Metronidazole acetic acid | Antibacterial , Antibiotic , Parasite | |
Metronidazole acetic acid is a metabolite of Metronidazole with mutagenic activity in bacteria. Metronidazole is a nitroimidazole antibiotic, amebicide, and antiprotozoal agent used particularly for protozoa and anaerob... | |||
T78460 | 1-Methylpyrene | ||
1-Methylpyrene, a pervasive environmental pollutant and carcinogen in rodents, exhibits mutagenic activity through the sequential activation by multiple CYP and sulfotransferase (SULT) enzymes, leading to chromosomal los... | |||
T74622 | Antibacterial agent 109 | ||
Antibacterial agent 109 (Compound C-2) is a potent antibacterial agent against both gram-positive and gram negative bacteria, and non-mutagenic. Antibacterial agent 109 inhibits protein synthesis by blocking the extensio... | |||
T36235 | 5-Chlorouracil | ||
5-Chlorouracil is a chlorinated derivative of the pyrimidine nucleoside base uracil . In vivo, it is converted into chlorodeoxyuridine, which is mutagenic and genotoxic.1 Uracil is chlorinated at the 5 position in a cell... |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T19412 | Macrozamin | Others | |
Macrozamin has carcinogenic, mutagenic, teratogenic and neurotoxic properties.Macrozamin is a natural product isolated from Cycads. | |||
T2895 | Lupeol | Fagarasterol,Monogynol B,Clerodol,(3β,13ξ)-Lup-20(29)-en-3-ol,Farganasterol | Apoptosis , Androgen Receptor , Akt |
Lupeol (Monogynol B) is a novel androgen receptor inhibitor with anti-inflammatory and antioxidant activity. | |||
TN1683 | Gentisin | DNA/RNA Synthesis | |
Gentisin is a novel inhibitor of vascular smooth muscle cells (VSMC) proliferation with an IC50 value of 7.84 μM. Gentisin has mutagenic activity. | |||
T2863 | P-Coumaric acid | para-Coumaric Acid,4-Hydroxycinnamic acid,trans-4-Hydroxycinnamic acid,Trans-p-Coumaric acid,4-Coumaric acid,P-Hydroxycinnamic acid | Endogenous Metabolite , Antibiotic |
p-Coumaric acid (para-Coumaric Acid) is the abundant isomer of cinnamic acid, with antitumor and anti-mutagenic activities. | |||
TJS0405 | Lucidin | NSC 30546,Henine | Others |
1. Lucidin (NSC-30546) and its derivatives are genotoxic, it is mutagenic at the hypoxanthine-guanine phosphoribosyl transferase gene locus. | |||
T2801 | Aristolochic acid A | TR 1736,Aristolochin,Aristolochine,Aristolochic Acid I,Aristolochic Acid | Others , NF-κB |
Aristolochic acid A (TR 1736) is a compound of mutagenic, carcinogenic, and nephrotoxic compounds commonly found in the Birthwort (Aristolochiaceae) family of plants. | |||
T5746 | Dictamine | Dictamnine,Dectamine | Apoptosis , Anti-infection , Antibacterial , Antifungal |
Dictamine (Dectamine) shows anticholinesterase, anti-inflammatory, mutagenic, and has antimicrobial activity against bacteria and fungi. It has the ability to exert cytotoxicity in human cervix, colon, and oral carcinoma... | |||
T4832 | Cytosine | 6-Aminopyrimidin-2(1H)-one,4-Amino-2-hydroxypyrimidine,Cytosinimine | Endogenous Metabolite |
Cytosine (6-Aminopyrimidin-2(1H)-one) is a pyrimidine base that is a fundamental unit of nucleic acids. The deamination of cytosine alone is apparent and the nucleotide of cytosine is the prime mutagenic nucleotide in le... | |||
T19165 | 8-Hydroxyguanine | 8 Hydroxyguanine,7,8-dihydro-8-oxoguanine,2-Amino-6,8-dihydroxypurine | Endogenous Metabolite |
8-Hydroxyguanine (8 Hydroxyguanine) is the major premutagenic damage produced by reactive oxygen species. It causes G-T and A-C substitutions.8-Hydroxyguanine is a biomarker for RNA oxidation and oxidative DNA damage.8-H... | |||
TN1078 | Seneciphylline | P450 , GST | |
Seneciphylline, one of the hepatotoxic pyrolizidine alkaloids, has mutagenic activity in Drosophila and their transfer into rat milk.Seneciphylline can significantly increased the activities of epoxide hydrase and glutat... | |||
T19317 | Ethyl phenylacetate | Others | |
Ethyl phenylacetate is a “greener" solvent with low toxicity. Ethyl phenylacetate is a non-mutagenic and is a Kosher food additive. Ethyl phenylacetate gives the wines a strong honey-like character. Ethyl phenylacetate i... | |||
T7031 | Aristolochic acid B | Aristolochic Acid II | DNA |
Aristolochic acid B (Aristolochic Acid II) is one of the major components of the carcinogenic plant extract aristolochic acid, is known to be mutagenic and to form DNA adducts in vitro and in vivo, Aristolochic acid B sh... | |||
TN1711 | Gossypetin | Antioxidant , p38 MAPK , MAPK , Antibacterial | |
Gossypetin, a hexahydroxylated flavonoid extractable from Rhodiola rosea Linn. is a potent MKK3 and MKK6 inhibitor that strongly attenuates the MKK3/6-p38 signaling pathway.Gossypetin exhibits antimutagenic, antiatherosc... | |||
T4918 | DL-Glyceraldehyde | Glyceric aldehyde | Reductase |
DL-Glyceraldehyde (Glyceric aldehyde) is produced from the action of the enzyme glyceraldehyde dehydrogenase, which converts glycerol to glyceraldehyde using NADP as a cofactor. When present at sufficiently high levels, ... | |||
T2163 | Dihydrocapsaicin | CCRIS1589,6,7-Dihydrocapsaicin,8-Methyl-N-vanillylnonanamide | Others , TRP/TRPV Channel |
Dihydrocapsaicin (CCRIS1589) is isolated from Capsicum fruit. Capsaicin is the primary active component of the heat and pain-eliciting lipid soluble fraction of the Capsicum pepper. Like capsaicin, dihydrocapsaicin is an... | |||
T13544 | Altertoxin I | Dihydroalterperylenol | Others |
Altertoxin I (Dihydroalterperylenol) is a quinone-type mycotoxin produced by Alternaria alternata fungi. It is mutagenic and cytotoxic and can weakly disrupt metabolic communication. | |||
T13531 | Aflatoxicol | Aflatoxin R0 | Others |
Aflatoxin (Aflatoxin R0) is a mutagenic and carcinogenic mycotoxin derived from aflatoxin B1 through metabolic processes facilitated by Rhizopus spp. | |||
TN4346 | Jaconine | Others | |
Jaconine, jacoline,jacobine, and jacozine, the hepatotoxic alkaloids, are potentially carcinogenic, mutagenic, and teratogenic and may pose health hazards to the human consumer. | |||
TN3608 | Catalpin | Others | |
Catalpin exhibited mutagenic activity towards Salmonella typhimurium strain TA100 in the presence and absence of rat liver homogenate (S9) mix in Ames' test. |
Cat No. | Product Name | Species | Expression System |
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TMPH-00555 | LpxC Protein, E. coli, Recombinant (His) | E. coli | E. coli |
Catalyzes the hydrolytic deamination of cytosine to uracil. Is involved in the pyrimidine salvage pathway, which allows the cell to utilize cytosine for pyrimidine nucleotide synthesis. Is also able to catalyze deaminati... | |||
TMPY-02798 | NEIL1 Protein, Human, Recombinant (His) | Human | E. coli |
NEIL1 is a member of DNA glycosylases. DNA glycosylases are a family homologous to the bacterial Fpg/Nei family. They play a role in base excision repair which is the mechanism by which damaged bases in DNA are removed a... | |||
TMPY-01480 | LTC4S Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
Leukotriene C4 synthase, also known as LTC4 synthase, Leukotriene-C(4) synthase, and LTC4S, is a multi-pass membrane protein that belongs to the MAPEG family. LTC4S is detected in the lung, platelets, and the myelogenous... |