joining

ART558 is a potent, selective, low molecular weight, allosteric DNA polymerase activity of Polθ inhibitor (IC50=7.9 nM). ART558 can be used for the research of cancer.

DCZ0415 induces antimyeloma activity in vitro, in vivo and in primary cells of drug-resistant myeloma patients. DCZ0415 is a potent TRIP13 inhibitor that can impair the repair of non-homologous end junctions and inhibit NF-κB activity.

Fmoc-PEG12-NHS ester, a PEG-based linker for PROTACs, facilitates the joining of two essential ligands, crucial for the formation of PROTAC molecules, and enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

PU-H71 HCl (Zelavespib HCl) is a novel Hsp90 inhibitor, a novel purine-based analog, and a radiosensitizer that may be a promising agent for CIRT. PU-H71 HCL shows antitumor activity in many preclinical models of malignancy. PU-H71 HCL has an inhibitory effect on the protein expression levels of Rad51 and Ku70, which may be associated with the double chain break repair in the homologous recombination pathway and non-homologous end-joining pathway.

DMNB (6-Nitroveratraldehyde) is DNA-dependent protein kinase (DNA-PK) inhibitor with IC50 of 15 μM, an enzyme involved in the non-homologous end-joining (NHEJ) pathway of double-stranded DNA break (DSB) repair in human cells.

PFM01 is an inhibitor of MRE11 endonuclease. PFM01 can regulate double-strand break repair (DSBR) by nonhomologous end-joining (NHEJ) versus homologous recombination (HR).

Acid-C2-PEG3-NHS ester is a PEG-based linker for PROTACs, joining two essential ligands crucial for PROTAC formation, enabling selective protein degradation via the ubiquitin-proteasome system within cells.

Acid-PEG2-C2-Boc is a PEG-based linker for PROTACs, joining two essential ligands crucial for forming PROTAC molecules, enabling selective protein degradation through the ubiquitin-proteasome system within cells.

Acid-PEG5-TEMPO is a PEG-based linker for PROTACs, joining two essential ligands crucial for PROTAC molecule formation, and facilitates selective protein degradation using the ubiquitin-proteasome system within cells.

Ald-Ph-PEG2-NH-Boc is a PEG-based linker for PROTACs, joining two essential ligands crucial for forming PROTAC molecules. This linker facilitates selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Ald-Ph-PEG4-Boc is a PEG-based linker for PROTACs, joining two essential ligands crucial for forming PROTAC molecules, and enabling selective protein degradation by leveraging the [ubiquitin-proteasome] system within cells.

Alkyne-PEG4-maleimide is a PEG-based linker for PROTACs, joining two essential ligands to form PROTAC molecules and enabling selective protein degradation via the ubiquitin-proteasome system within cells.

Amino-PEG5-Boc is a PEG-based linker for PROTACs, crucial for joining two essential ligands and enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Amino-PEG5-CH2COOH is a PEG-based linker for PROTACs, joining two essential ligands to form PROTAC molecules and enabling selective protein degradation via the ubiquitin-proteasome system within cells (PROTACs) [ubiquitin-proteasome system].

Amino-PEG9-amine is a PEG-based linker used in PROTACs, joining two essential ligands to facilitate the formation of PROTAC molecules and enabling selective protein degradation via the ubiquitin-proteasome system within cells.

Amino-PEG9-Boc is a PEG-based linker for PROTACs, essential for joining two ligands in PROTAC molecules and enabling selective protein degradation via the ubiquitin-proteasome system within cells.

Aminooxy-PEG3-acid is a PEG-based linker for PROTACs, joining two essential ligands crucial for forming PROTAC molecules. This linker facilitates selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Aminooxy-PEG7-methane is a PEG-based linker for PROTACs, joining two essential ligands to facilitate selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

APN-C3-PEG4-alkyne is a PEG-based linker for PROTACs, joining two essential ligands critical for forming PROTAC molecules, and enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Azide-PEG3-C1-Ala is a PEG-based linker for PROTACs, joining two essential ligands to form PROTAC molecules, and enabling selective protein degradation through the ubiquitin-proteasome system within cells.

Azide-PEG6-Tos is a PEG-based linker for PROTACs, joining two essential ligands crucial for PROTAC molecule formation, and enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Azido-PEG1-C2-acid is a PEG-based linker for PROTACs, joining two essential ligands crucial for forming PROTAC molecules, thereby enabling selective protein degradation via the ubiquitin-proteasome system [within cells].

Azido-PEG1-NHS ester is a PEG-based linker for PROTACs, enabling the formation of PROTAC molecules by joining two essential ligands and facilitating selective protein degradation through the ubiquitin-proteasome system within cells.

Azido-PEG10-acid is a PEG-based linker for PROTACs, joining two essential ligands crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.