iron chelator

HBED (CHELII) is an iron chelator and can be used in research on the treatment of chronic iron overload and acute iron poisoning.

Phytic acid sodium salt (Sodium phytate hydrate) is known to function as a [PO4]3- storage depot and a precursor for other inositol phosphates and pyrophosphates. It is a potent chelator of divalent and trivalent cations in vitro.

SP-420 is a novel orally active iron chelator.

L-Mimosine (Leucenol) is an antineoplastic alanine-substituted pyridine derivative isolated from Leucena glauca and acts as an iron chelator.

Dp44mT, a effective iron chelator, has selective antitumor activity.

VK-28 is a brain permeable iron chelator with neuroprotection. VK-28 inhibits basal as well as iron-induced mitochondrial lipid peroxidation.

Homobutein (3-O-Methylbutein) is a dual inhibitor of HDACs and NF-κB with IC50s of 190 and 38 μM. Homobutein is an iron chelator with anticancer, anti-inflammatory, antiparasite, and antioxidation activities.

Deferoxamine (Desferrioxamine B) is an iron chelator. Deferoxamine can be used to reduce the accumulation and deposition of iron in tissues. Deferoxamine can improve neurological dysfunction by inhibiting ferroptosis and neuroinflammation after traumatic brain injury. It has antioxidant, anti-proliferation and anti-tumor activities, and can induce the production of HIF-1α, apoptosis and autophagy in cancer cells. It can be used to treat acute iron toxicity and COVID-19 related diseases.

Deferoxamine Mesylate (DFOM) is an iron chelator and ferroptosis inhibitor. Deferoxamine Mesylate binds free iron into a stable complex and reduces iron accumulation. Deferoxamine Mesylate up-regulates HIF-1α levels and induces apoptosis.

Deferitazole (FBS 0701) is a novel and orally active, selective and high affinity iron chelator.

Deferasirox (CGP-72670) is an oral iron chelating agent used to treat chronic iron overload.

Deferiprone (Deferidone) is an Iron Chelator. The mechanism of action of deferiprone is as an Iron Chelating Activity.

Neocuproine is a copper(I) chelator that enhances the purinergic component of vasoconstriction induced by electric field stimulation, and is often used as a ligand reagent and copper ion detector.Neocuproine forms stable complexes with copper ions and can play a catalytic role in certain chemical reactions and analytical methods.Neocuproine acts as a redox-active on the iron and cobalt ligand platform for protection against oxidative damage in NSC34 cells.

CN128 hydrochloride, a CN128 derivative, is an orally active and selective iron chelator.CN128 is a novel and orally active hydroxypyridone iron chelator that can be used in the study of β-thalassemia.

CGP 65015 is an oral iron chelator that mobilizes iron deposits.

Deferasirox (Fe3+ chelate) is an orally available iron chelator with potential anticancer activity, inhibits the anti-apoptotic activity of MCL-1, and can be used to study iron overload.

Deferitrin (GT-56-252) is an iron chelator. It potentially for the treatment of thalassemia and iron overload.

Ferroptosis-IN-15 (compound 12) serves as an effective inhibitor of ferroptosis, exhibiting EC50 values of 0.76 μM and 0.67 μM in A375 cells and 786-O cells, respectively. It acts as a potential iron chelator and radical-scavenging antioxidant.

ZMC2 is a potent iron chelator and antiproliferative agent demonstrating activity as a zinc metal carrier, with increased sensitivity observed in the p53-R175H cell lines.

Dexrazoxane (ICRF-187) is an anticancer drug used to block mitosis and arrest dividing cells. It is an iron chelator and provides cardioprotection against anthracycline toxicity.

Aerobactin is a bacterial-produced iron carrier and iron chelator, a key virulence factor in many Enterobacteriaceae bacteria, widely used in biochemical research.

CGP-75254A is a novel oral iron chelator.

CGP-75254A Free Acid is a novel oral iron chelator.

Deferitazole magnesium is a potential chelator for iron overload treatment.