glucose-stimulated — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T1286	Vincamine	Angiopac,Oxybral,Devincan,Novicet,Equipur,Perval	GPR , Others
	Vincamine (Perval) is a major alkaloid of Vinca minor L., Apocynaceae. It has been used therapeutically as a vasodilator and antihypertensive agent, particularly in cerebrovascular disorders.		GPR , Others
T2755	Rhoifolin	Apigenin-7-O-rhamnoglucoside,Apigenin 7-O-neohesperidoside,Rhoifoloside	Others , p38 MAPK , NF-κB , transporter , IGF-1R , Autophagy
	Rhoifolin (Apigenin 7-O-neohesperidoside) is extracted from Turpinia arguya Seem dried leaves.
T33412	MitoPQ	MitoParaquat	Glucokinase , transporter
	MitoPQ (MitoParaquat) is a mitochondria-targeted small molecule compound that selectively enhances mitochondrial superoxide and hydrogen peroxide levels and inhibits insulin-stimulated glucose uptake and translocation of...		Glucokinase , transporter
T13867	RH01386		Others
	RH01386 is a small molecule that can prevent ER stress-induced β cell dysfunction and death, and inhibits proapoptotic gene expression,has the potential for type 2 diabetes treatment. RH01386 restores ER stress-impaired ...		Others
T3S0381	Chrysophanol 8-O-glucoside		Serine Protease
	Chrysophanol 8-O-glucoside and chrysophanol have mild cytotoxicity and anti-diabetic properties and can play metabolic roles in the insulin-stimulated glucose transport pathway		Serine Protease
T17177	TUG-424	TUG424	Others
	TUG-424 significantly enhances glucose-stimulated insulin secretion at 100 nM. TUG-424 is a potent and selective free fatty acid receptor 1 agonist (EC50: 32 nM).		Others
T12853	SBI-477		Others
	SBI-477 is a chemical probe stimulated insulin signaling by deactivating the transcription factor MondoA. SBI-477 coordinately inhibits triacylglyceride (TAG) synthesis and enhances basal glucose uptake in human skeletal...		Others
TWO2727	Propane-1,2,3-triyl tripalmitate	Palmitic Triglyceride,Tripalmitin,Tripalmitoylglycerol,Glycerol Tripalmitate	Others , Endogenous Metabolite
	Propane-1,2,3-triyl tripalmitate (Glycerol Tripalmitate) is a triacylglycerol found in dietary fats. Tripalmitin increases body weight and plasma LDL levels and reduces hepatic LDL receptor mRNA levels in hamsters fed a ...		Others , Endogenous Metabolite
TP2258	HNGF6A		Others
	increases glucose stimulated insulin secretion and glucose metabolism		Others
T70113	ATM-1001
	ATM-1001 is an inhibitor of the cancer-associated tropomyosin 3.1 (Tpm3.1), suppressing glucose-stimulated insulin secretion (GSIS) from the pancreatic islets.
T17094	Tifenazoxide	NN414	Others
	Tifenazoxide is an effective and SUR1/Kir6.2 selective KATP channels opener. Tifenazoxide has an anti-diabetic effect, can inhibit glucose-stimulated insulin release in vitro and in vivo.		Others
TP2020	[Pro3]-GIP (Mouse)
	GIP receptor antagonist (IC50 = 2.6μM). Inhibits GIP-stimulated insulin release from pancreatic β cells in vitro. In ob/ob mice, blocks the effects of GIP on insulin release and plasma glucose levels. Also improves intra...
T62836	Hit 1
	Hit 1 is an activator of insulin-degrading enzymes (IDE) (EC50: 5.5 μM) and reduces glucose-stimulated insulin secretion.
T71251	DS-1558
	DS-1558 is a potent and orally available GPR40 agonist.DS-1558 was found to have potent glucose lowering effects during an oral glucose tolerance test in ZDF rats. DS-1558 significantly and dose-dependently improved hyp...
TP2033	[Des-His1,Glu9]-Glucagon amide	des-His1-[Glu9]-Glucagon (1-29) amide
	Glucagon receptor antagonist (pA2 = 7.2 for inhibition of glucagon-induced adenylyl cyclase activation in rat liver membranes); displays no agonist activity. Enhances glucose-stimulated pancreatic insulin release in vitr...
T75833	HNGF6A TFA
	HNGF6A TFA, a humanin analogue, enhances glucose-stimulated insulin secretion and glucose metabolism, offering potential for diabetes research. It also inhibits ROS (Reactive Oxygen Species) production under oxidative st...
T76326	[Des-His1,Glu9] Glucagon
	[Des-His1,Glu9] Glucagon, a powerful antagonist of the glucagon receptor system, plays a crucial role in enhancing the glucose-stimulated insulin release from pancreatic islet cells. This compound is utilized in diabetes...
T80766	Xenin-8 TFA
	Xenin-8 TFA, a C-terminal octapeptide derived from the 25-amino acid peptide Xenin belonging to the neurotensin/xenopsin family, is biologically active. It enhances basal insulin secretion and amplifies glucose-stimulate...
T35604	Osteocalcin (1-49) (human) (trifluoroacetate salt)
	Osteocalcin (1-49) is a non-collagenous peptide that is secreted by osteoblasts and odontoblasts and comprises 1-2% of the total protein in bone. Secretion of osteocalcin (1-49) is stimulated by 1,25-dihydroxy vitamin D ...
T64553	GLP-1(7-37) TFA salt
	The truncated glucagon-like peptides GLP-1(7-37) is naturally occurring peptide product of the preproglucagon gene that are synthesized primarily in the intestine and acts as incretin that are released from the intestine...