d-12

Banoxantrone-D12 is the deuterium-labeled form of Banoxantrone(T70860), a bioreductive agent that can be metabolically converted to AQ4, a stable compound with DNA affinity and topoisomerase II inhibition properties.

Topiramate-D12 is a deuterium labeled Topiramate. Topiramate (T0675) is an agent of broad-spectrum antiepileptic. Topiramate (T0675) is an antagonist of GluR5 receptor.

Banoxantrone-D12 dihydrochloride is the deuterium-labeled Banoxantrone dihydrochloride (T10459). Banoxantrone is a bioreductive agent that can be reduced to a stable, DNA-affinity compound AQ4, which is a topoisomerase II inhibitor.

3-Hydroxyoctanoic Acid-D12 is the deuterated analog of 3-Hydroxyoctanoic Acid (T9719).

C12-Sphingosine (Sphingosine (d12:1)) is a sphingosine congener with 12 carbon atoms, inducing serine palmitoyltransferase activity in a time- and concentration-dependent manner.

Anti-MERS-D12 mAb is a fully human monoclonal neutralizing antibody isolated from a recovered patient. It binds specifically to the receptor-binding domain (RBD) of the MERS-CoV spike glycoprotein with extremely high affinity, effectively blocking the interaction between the virus and the host receptor dipeptidyl peptidase 4 (DPP4). This action exerts potent neutralizing activity by preventing viral attachment and entry into host cells.

3-Keto Sphinganine (d12:0) is a short-chain analog of 3-keto sphinganine (d18:0), which typically possesses a C18 chain length. The latter is a lyso-sphingolipid synthesized through the condensation of L-serine and palmitoyl-CoA mediated by the enzyme serine palmitoyl transferase (SPT). A deficiency in Vitamin K deactivates SPT, leading to a reduced synthesis of 3-keto sphinganine among other sphingolipids. [Matreya, LLC. Catalog No. 1893]

Vancomycin-D12 trifluoroacetate is a deuterated compound of Vancomycin trifluoroacetate (TMSM-2378). Vancomycin trifluoroacetic acid has a CAS number of 1404-90-6. Vancomycin is an antibiotic used to treat serious bacterial infections by stopping the growth of bacteria.

Adenosine monophosphate-D12 dilithium is a deuterium-labeled variant of adenosine monophosphate. This compound acts as an agonist of the adenosine A1 receptor and exhibits significant antiviral activity against HSV-1 and HSV-2. Additionally, adenosine monophosphate is a crucial cellular metabolite involved in energy homeostasis and signal transduction regulation.

Benzyl benzoate-D12 is the deuterated form of Benzyl benzoate. Benzyl benzoate (T0729) (Benzoic acid benzyl ester) is used as a fragrance component in cosmetics. It can also be utilized in research related to inflammatory skin diseases associated with scabies and Demodex mites.

1,4-Diazabicyclo[2.2.2]octane-D12 is the deuterated form of 1,4-Diazabicyclo[2.2.2]octane (TMSM-0044).

2'-Deoxyadenosine-5'-monophosphate-D12 dilithium is the deuterium-labeled version of 2'-Deoxyadenosine-5'-monophosphate. This compound, a derivative of nucleic acid AMP, is a deoxyribonucleotide found in DNA. It is utilized in the study of adenosine-based interactions during DNA synthesis and damage processes.

Ethylenediaminetetraacetic acid-D12 is the deuterated form of Ethylenediaminetetraacetic acid. Ethylenediaminetetraacetic acid (T20470) (EDTA) serves as a metal chelator, binding with divalent and trivalent metal cations, including calcium. It exhibits antihypercalcemic and anticoagulant properties, reduces metal ion-catalyzed oxidative damage to proteins, and maintains a reducing environment during protein purification. EDTA is commonly used in protein purification and storage and helps minimize the formation of disulfide bonds.

4-Methylpentanoic acid-D12 is the deuterated form of 4-Methylpentanoic acid. 4-Methylpentanoic acid, also known as Isocaproic Acid, is classified as a short-chain fatty acid (SCFA).

Adenosine monophosphate-15N5,D12 dilithium is a deuterated and 15N-labeled form of Adenosine monophosphate. Acting as an agonist for the adenosine A1 receptor, it exhibits significant antiviral activity against HSV-1 and HSV-2. Adenosine monophosphate is a crucial cellular metabolite involved in regulating energy homeostasis and signal transduction.

D-Glucose-D12-1 is the deuterated form of D-Glucose. D-Glucose (T0887) (Glucose) is a monosaccharide that serves as a significant carbohydrate in biology. It functions as a sweetener in carbohydrates, is vital for general metabolism, and acts as a critical signaling molecule related to cellular metabolic status and responses to biotic and abiotic stress.

Cytidine 5′-monophosphate-D12 dilithium is the deuterated form of Cytidine 5'-monophosphate. This nucleotide, also known as 5'-Cytidylic acid, serves as a monomer in RNA. It is composed of the nucleobase cytosine, the pentose sugar ribose, and a phosphate group.

Cyclosporin A-D12 is a deuterium-labeled form of Cyclosporin A. Cyclosporin A (T0945) (Cyclosporine A) functions as an immunosuppressant by binding to cyclophilin and inhibiting protein phosphatase 2B (PP2B/calcineurin) with an IC50 value of 7 nM. It also inhibits the adhesion molecule CD11a/CD18.

Tetramethylpyrazine-D12 is a deuterated compound of Tetramethylpyrazine. Tetramethylpyrazine (T2722) has a CAS number of 1124-11-4. Tetramethylpyrazine (T2722) (ligustrazine, TMP), a natural compound isolated from Chinese herbal medicine Ligusticum wallichii (Chuan Xiong) shows anti-inflammation, antioxidant, antiplatelet, and antiapoptosis activities.

Chrysene-D12 is a deuterated compound of Chrysene. Chrysene (T14961) has a CAS number of 218-01-9. Chrysene (T14961) is a high molecular weight (HMW), polycyclic aromatic hydrocarbon (PAH).

Benzo[k]fluoranthene-D12 is a deuterated compound of Benzo[k]fluoranthene. Benzo[k]fluoranthene (TMSM-4835) has a CAS number of 207-08-9.

Perylene-D12 is a deuterated compound of Perylene. Perylene (TYD-00680) has a CAS number of 198-55-0.

Hexamidine-d12 is the deuterium-labeled version of Hexamidine. It exhibits amoebicidal activity and can be utilized in research related to Acanthamoeba keratitis (Acanthamoebakeratitis).

Abemaciclib impurity 1-d12 (6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole-d12) is the deuterium-labeled form of Abemaciclib impurity 1. Abemaciclib Impurity 1 (6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole) serves as a pharmaceutical intermediate in the synthesis of several active compounds.