cytoskeleton

Batabulin (T138067) is an antitumor compound that binds covalently and selectively to a subset of the β-tubulin isotypes, disrupting microtubule polymerization. This disruption affects cell morphology, induces cell-cycle arrest, and ultimately leads to apoptotic cell death.

Bohemine is a cyclin-dependent kinase inhibitor.

Tyrphostin AG957, a tyrosine kinase inhibitor with anti-BCR/ABL tyrosine kinase activity restores beta1 integrin-mediated adhesion and inhibitory signaling in chronic myelogenous leukemia hematopoietic progenitors[1].

SMIFH2 is formin homology 2 (FH2) domains inhibitor.

MLS000532223 is a selectiveRho family GTPases inhibitor(EC50 : 16 μM to 120 μM).

Azadirachtin has antifungal activity, used as an insecticide.

Estramustine phosphate sodium (Ro 21-8837/001) is an antimicrotubule chemotherapy agent; arrests prostate cancer cells in the G2/M phase of the cell cycle.

Ombrabulin hydrochloride is a synthetic, selective CA-4 phosphate ester or derivative of Ombrabulin to disrupt the tubulin cytoskeleton of endothelial cells and has antivascular effects. Ombrabulin is a tubulin polymerizing inhibitor, a member of the combretastatin A-4 compound class, which is a water-soluble tubulin depolymerizing tumor vascularizing compound.

MDK-6983 (MDK-6983) is an inhibitor of autophagy and disrupts the dynamics of actin cytoskeleton in human melanoma cells.

2,4-Dichlorophenoxyacetic acid (Hedonal) is a synthetic auxin used as a plant growth regulator and also used as a supplement in plant cell culture media. It is an active ingredient in herbicides used to disrupts the actin cytoskeleton for the control of root elongation and cell production.

Ombrabulin is a derivative of CA-4 phosphate. It is known to show antivascular effects through selective disruption of the tubulin cytoskeleton of endothelial cells.

ROCK2-IN-9 (compound 7u), a selective ROCK2 inhibitor with an IC50 value of 36.8 nM, demonstrates anticancer properties by impeding cancer cell migration and invasion. This action is achieved through the regulation of various actin cytoskeleton cellular activities. It holds potential for use in breast cancer research.

L-NBDNJ is a sugar mimic and an antivirulence agent. It disrupts the expression of proteins that regulate the assembly and organization of the host cell cytoskeleton. In cystic fibrosis (CF) lung disease infection models, L-NBDNJ exhibits both anti-inflammatory and anti-infective properties.

Denibulin is a vascular disrupting agent that reversibly inhibits microtubule assembly, disrupting the cytoskeleton of tumor vascular endothelial cells. It demonstrates tolerance and potential anti-vascular effects, making it useful for cancer research.

SM311 (Compound 10) is a potent, selective, and irreversible inhibitor of LIMK1, with an EC50 of 0.045 μM and over 30-fold selectivity for LIMK1 over LIMK2. It can inhibit cofilin phosphorylation and actin cytoskeleton regulation. SM311 shows potential for research in neurodegenerative disorders such as Fragile X Syndrome (FXS) and Alzheimer's disease, as well as in tumor invasion.

IKP-104 is a microtubule/tubulin inhibitor (IC50 = 1.31 μM) that halts cells in mitosis and the M phase by inhibiting microtubule assembly and inducing cytoskeleton microtubule depolymerization. It suppresses the growth of both murine and human tumor cell lines, exhibiting antitumor effects in mouse ascites tumor and lung cancer models. IKP-104 is applicable in research on cancers such as leukemia, lung cancer, and melanoma.

Anticanceragent 291 (Compound 2406) is an anticancer compound. It disrupts the integrity of the β-tubulin cytoskeleton and inhibits WNT/β-catenin (Wnt/β-catenin) signaling pathways. This compound significantly suppresses tumor cell invasion, migration, and colony formation. Anticanceragent 291 induces G2/M phase cell cycle arrest in EC-9706 and HT-29 cells, thereby inhibiting cell proliferation. It is used in gastrointestinal cancer research.

Tubulin polymerization-IN-86 (Compound B6) is a potent inhibitor of tubulin polymerization. It effectively hinders microtubule assembly by binding to the colchicine site on tubulin, disrupting the microtubule cytoskeleton within cells. This compound exhibits strong antiproliferative activity against various cancer cell lines, induces cell cycle arrest and apoptosis, and inhibits cell migration, invasion, and long-term survival. Furthermore, Tubulin polymerization-IN-86 has demonstrated the ability to suppress tumor growth in mice, making it a valuable agent for melanoma research.

MP265 disrupts the MreB cytoskeleton and has antiproliferative effects.

MreB Perturbing Compound A22 hydrochloride is an effective inhibitor of MreB, a bacterial actin-like protein. It disrupts cell wall assembly and causes morphological changes, used for bacterial morphogenesis and antibiotic research.

Rhizopodin is a potent natural macrolide antibiotic that effectively affects the actin cytoskeleton at nanomolar concentrations.

BIPM is a potent inhibitor of Rho-associated protein kinase 2 (ROCK2). Exposure of SH-SY5Y cells to BIPM led to significant changes in cell migration, actin stress fibers and neurite length. BIPM significantly inhibits phosphorylation of cofilin, a regula

PT-262 is a potent Rho-associated protein kinase (ROCK) inhibitor with an IC50 value of approximately 5 μM, and it induces mitochondrial membrane potential loss, enhances caspase-3 activation, and promotes apoptosis, while concurrently inhibiting ERK and CDC2 phosphorylation through a p53-independent signaling pathway, disrupting cytoskeletal organization and cell migration, and collectively exerting broad anticancer activity that makes PT-262 a valuable tool for mechanistic cancer biology and signal transduction research.

Zarilamide is inhibitor of the nuclear division in germinating zoospore cysts of Phytophthora capsici. Zarilamide destructs the microtubule cytoskeleton, resulting in a consequent inhibition of mitosis.