bronchitis

Moxifloxacin hydrochloride (BAY12-8039 HCl) is a fourth generation fluoroquinolone with expanded activity against gram-positive bacteria as well as atypical pathogens. Moxifloxacin has been linked to mild ALT elevations during therapy and to rare instances of idiosyncratic acute liver injury with symptoms and jaundice.

Doxofylline (Doxophylline) is a methylxanthine derivative with the presence of a dioxolane group in position 7. As a drug used in the treatment of asthma, doxofylline has shown similar efficacy to theophylline but with significantly fewer side effects in animal and human studies.

Lomefloxacin hydrochloride (Okacyn) inhibits DNA gyrase, a type II topoisomerase involved in the induction or relaxation of supercoiling during DNA replication. This inhibition leads to a decrease in DNA synthesis during bacterial replication, resulting in cell growth inhibition and eventually cell lysis. Lomefloxacin Hydrochloride is the hydrochloride salt form of lomefloxacin, a synthetic broad-spectrum fluoroquinolone with antibacterial activity.

ASM-024, a potent nicotinic receptor agonist, is a small molecule synthetic piperazine compound that promotes different targets and signaling pathways of β2-adrenergic receptors mediating smooth muscle relaxation, and is a potential compound for the treatment of asthma and chronic obstructive bronchitis with anti-inflammatory activity.

Midesteine (MR-889) is a small molecule neutrophil elastase inhibitor used in the treatment of bronchitis, asthma and chronic lung disease.

Sulfalene (SMP2), a long-acting sulfonamide antibiotic, is used for the therapy of chronic bronchitis, urinary tract infections, and malaria.

Diphylline (Diprophylline) is a xanthine derivative. Diphylline exerts bronchodilator effects and to a lesser extent vasodilator and diuretic properties. Diphylline probably acts as a competitive inhibitor of phosphodiesterase which leads to an increase in intracellular cAMP. This results in relaxation of bronchial smooth muscle and other smooth muscles. Diphylline may also antagonize adenosinereceptors. Diphylline is used in the treatment of acute bronchial asthma, chronic bronchitis and emphysema.

Terpin hydrate, a cis-form hydrate, is derived from sources such as oil of turpentine, oregano, thyme, and eucalyptus. It is used as an insect repellent and expectorant. Terpin hydrate(cis-Terpin hydrate) is commonly used to loosen mucus and ease congestion in patients presenting with acute or chronic bronchitis, and related pulmonary conditions. It was popular in the United States since the late nineteenth century, but was removed from marketed medications in the 1990s after the U.S. Food and Drug Administration (FDA) stated that based on the evidence currently available, there are inadequate data to establish general recognition of the safety and effectiveness of these ingredients . Elixirs of terpin hydrate are still available with a prescription but must be prepared by a compounding pharmacy.

Dirithromycin (LY237216) is a macrolide glycopeptide antibiotic. It is used to treat many different types of bacterial infections, such as bronchitis, pneumonia, tonsillitis, and even skin infections.

Cefaclor monohydrate (Cefaclorum) is a beta-lactam, second-generation cephalosporin antibiotic with bactericidal activity.

Pidotimod is a synthetic dipeptide with immunomodulatory properties.

Ipratropium Bromide (Sch 1000) is a synthetic anticholinergic agent that is used as an inhalant for treatment of acute bronchospasm due to chronic bronchitis and emphysema.

2,3-Pentanedione is a food additive that also occurs naturally as a fermentation product in beer, wine and yogurt and is released during the roasting of coffee beans. Inhalation of 2,3-Pentanedione is thought to be the cause of severe respiratory disease in humans, including occlusive bronchitis.

(-)-β-pinene (Nopinene) is inhibit infectious bronchitis virus (IBV) with an IC50 of 1.32 mM,with antimicrobial activity

Sodium Houttuyfonate (Houttuynin sodium bisulfite), the active compound of the Houttuynia plant, is mainly used for treating purulent skin infections, respiratory tract infections, including pneumonia in elderly patients, and chronic bronchitis.

Nodakenin ((+)-Marmesinin) is a compound with anti-allergic and anti-inflammatory activities.

Decarboxy Moxifloxacin is a decarboxylated compound of moxifloxacin. Moxifloxacin is an oral active 8-methoxyquinolone antibiotic used in acute bacterial sinusitis, chronic bronchitis, acute bacterial deterioration, and community-acquired pneumonia.

Guacetisal is extracted from the esterification reaction of acetylsalicylic acid with guaiacol which can be used for research on the treatment of chronic bronchitis.

GW 766994 is a specific and oral chemokine receptor-3 (CCR3) antagonist. It has the potential for asthma and eosinophilic bronchitis treatment.

Spirofylline is an agent of bronchodilator, has the potential for asthma and bronchitis and emphysema treatment.

Lomefloxacin (SC47111A) is a synthetic broad-spectrum fluoroquinolone with antibacterial activity.

IA-Alkyne (Iodoacetamide-alkyne) is a TRP channel (TRPC) agonist. IA-Alkyne can be used to develop an isotopically tagged probe for quantitative cysteine-reactivity profiling. It also has the potential for the study of respiratory infection.

Guaimesal is a chemical compound primarily studied for the treatment of exacerbated chronic bronchitis.

Sudexanox, a flavonoid derivative, is utilized in the treatment of allergies, atopic asthma, and asthmatic bronchitis. In preclinical studies, Sudexanox has demonstrated potent activity in an IgE-induced passive cutaneous anaphylaxis model in rats.