amines

N-Succinimidyl-S-acetylthioacetate (SATA) is a protein modification agent that introduces thiol-groups into protein molecules and adds sulfhydryl groups in a protected form to proteins and other amine-containing molecules for later reaction with sulfhydryl reactive crosslinkers such as Sulfo-SMCC, Sulfo-MBS, etc.

Ceramide phosphoethanolamine (CPE) is an analog of sphingomyelin that contains ethanolamine rather than choline as the head group. It is the principal membrane phospholipid in invertebrates such as Drosophila, which lacks sphingomyelin. It is only produced in small amounts in mammalian cells, accounting for approximately 0.02 mol% of total phospholipids in mouse testis and brain. In Drosophila, CPE is biosynthesized by CPE synthase from ceramide and cytidine diphosphate-ethanolamine in the Golgi lumen. In mammals, it is biosynthesized by sphingomyelin synthase 2 (SMS2) in the plasma membrane and by sphingomyelin synthase-related protein (SMSr) in the endoplasmic reticulum (ER). In Drosophila, CPE has a role in glial ensheathment of axons. Disrupting CPE synthesis by depleting SMSr in vitro in mammalian cells leads to an accumulation of ER ceramides, which are then mislocalized to the mitochondria, inducing apoptosis. However, ceramide levels are not altered in transgenic mice lacking SMSr catalytic activity. CPEs (bovine) is a mixture of CPEs with variable N-acyl chain lengths.

Lysophosphatidylethanolamines (egg) are the partial hydrolysis products of phosphatidylethanolamine.

m-PEG12-NHS ester is a PEG backbone PROTAC linker commonly used in the synthesis of PROTAC molecules, and the NHS ester can covalently bind to primary amines (-NH2) on biomolecule.

Indole-3-methanamine has been detected, but not quantified in, barley, cereals, and cereal products.

N-Boc-O-tosyl hydroxylamine serves as a nitrogen source for the N-amination of aryl and alkyl amines.

Aniline is the simplest aromatic amine, characterized by an amino group attached to a phenyl ring. Aniline is an industrially significant commodity chemical, as well as a versatile starting material for fine chemical synthesis, with its main use being in the manufacture of precursors to polyurethane, dyes, and other industrial chemicals; like most volatile amines, it has a distinctive and unpleasant odor of rotten fish, it ignites readily, burning with a smoky flame characteristic of aromatic compounds. Aniline is toxic to humans upon exposure.

2,4,5-Trichlorobenzenesulfonyl chloride (TCBSC) is a versatile building block in the synthesis of various organic compounds, such as amines, alcohols, and carboxylic acids.

N-Oleoyl valine is an endogenous N-acyl amine that acts as an antagonist at the transient receptor potential vanilloid type 3 (TRPV3) receptor, which is involved in thermoregulation. N-Oleoyl valine is increased in mice following cold exposure for up to at least 16 days. Acute lung injury in mice increases the concentration of N-Oleoyl valine in lung tissue. N-acyl amines also promote mitochondrial uncoupling.

D-erythro-Sphingosine (trans-4-Sphingenine) is a protein kinase C (PKC) inhibitor. D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator

3-Pyridylacetic acid hydrochloride (3-PAA-HCl) is a high homologue of niacin. It is a decomposition product of nicotine (and other tobacco alkaloids). It can also react with amines, alcohols and carboxylic acids, and can also act as an acid in the reaction. catalyst.

Tris(2,2,2-trifluoroethyl) borate (SL 75212) is mostly used in condensation reactions. It has been shown to promote the direct formation of amides from carboxylic acids and amines as well as the formation of imines from amines or amides with carbonyl compounds.

GMBS, a heterobifunctional cross-linker, possesses an N-hydroxysuccinimide (NHS) ester at one end and a maleimide group at the other. It is commonly used in bioconjugation to link amines and sulfhydryls [thiols], forming stable amide and thioether bonds, respectively, which are useful in creating protein and peptide conjugates.

Mal-amido-PEG2-NHS ester is a noncleavable linker for antibody-drug conjugates (ADCs) that includes a maleimide group and an NHS ester, facilitating the labeling of protein primary amines (-NH2), amine-modified oligonucleotides, and other amine-containing molecules[1][2].

Mal-amido-PEG1-C2-NHS ester is a noncleavable antibody-drug conjugate (ADC) linker that incorporates a maleimide functional group and an N-hydroxysuccinimide (NHS) ester. The NHS ester offers a means to specifically modify primary amines (-NH2) present in proteins, amine-modified oligonucleotides, and other amine-containing molecules[1][2].

Mal-amido-PEG10-C2-NHS ester is a noncleavable antibody-drug conjugate (ADC) linker that consists of a maleimide group and an N-hydroxysuccinimide (NHS) ester, which enables efficient labeling of primary amines (-NH2) in proteins, amine-modified oligonucleotides, and other amine-containing molecules [1][2].

Mal-amido-PEG10-C2-NHS ester is a noncleavable ADC linker with a maleimide group and an NHS ester, used as a labeling agent for primary amines (-NH2) in proteins, amine-modified oligonucleotides, and other amine-containing molecules [1][2].

Mal-L-PA-NH-Boc is a noncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). It forms stable covalent bonds with thiols or amines on antibodies, enhancing ADC stability and targeting。

Sulfo-SMCC sodium, a widely utilized non-cleavable, hetero-bifunctional crosslinker for antibody-drug conjugates (ADCs), features both N-hydroxysuccinimide (NHS) ester and maleimide groups. These functionalities enable it to specifically react with primary amines and sulfhydryl groups, respectively.

Acetylmandelic acid, (+)- is a chiral derivatizing agent,and used for NMR determination of enantiomeric purity of α-deuterated carboxylic acids, alcohols, and amines.

Tioxacin is an orally active bactericide that demonstrates efficacy when combined with fatty amines against certain G(+) and G(-) bacteria, including Escherichia coli strains resistant to Nalidixic acid and Pseudomonas aeruginosa.

5-Norbornene-2-acetic acid succinimidyl ester plays a critical role in bioimaging due to its ester group, which reacts with compounds containing amines.

16-Aminohexadecanoic acid is an alkyl chain compound characterized by terminal carboxylic acid and amino groups. It serves as a PROTAC linker in PROTAC synthesis. The amino group (NH2) can react with carboxylic acids, activated NHS esters, and carbonyl groups (ketones, aldehydes). The terminal carboxylic acid can form stable amide bonds by reacting with primary amines of activated NHS esters.

10-Aminodecanoic acid is an alkane chain featuring terminal carboxylic acid and amino groups. This compound serves as a PROTAC linker in PROTAC synthesis and other conjugation applications. The amino group (NH2) can react with carboxylic acids, activated NHS esters, and carbonyls (ketones, aldehydes), while the terminal carboxylic acid can react with primary amines of activated NHS esters to form stable amide bonds.