a 192

A 192 is a biochemical.

MI-192 is a selective HDAC2 and HDAC3 inhibitor with IC50 values of 30 nM and 16 nM, respectively. It exhibits greater selectivity for HDAC2/3 over other HDAC isomers and induces apoptosis in myeloid leukemic cells, indicating potential therapeutic use in leukemia and as an anti-stroke agent [1] [2].

AGH-192, an efficient agonist with compound-like properties, may serve as an ideal tool compound for studying 5-HT7 receptor functions. Furthermore, its observed analgesic effects in a murine neuropathic pain model indicate its potential as a pain-relieving medication.

Antitumor agent-192 (Compound 2f) is a β-carboline antitumor compound. It induces autophagy in HCT116 cells via the ATG5/ATG7 pathway. The IC50 of Antitumor agent-192 against human tumor cell lines is below 5 μM, and it significantly inhibits tumor growth and reduces tumor weight in xenograft mouse models of colorectal cancer.

Anticanceragent 192 (compound XXI) is a steroid-based histamine H3 receptor antagonist with no affinity for muscarinic and hERG receptors. It shows considerable stability in human and rat liver microsomes. Additionally, in addiction tests conducted on rats, Anticanceragent 192 enhances cognitive levels and reduces addiction severity.

Tyrosinase (192-200), a human mouse nonapeptide, is recognizable by cytolytic T cells (CTL) on the HLA-B44 molecule and is utilized in the research of melanoma-associated cancers [1].

YLT192 is an orally active and bioavailable VEGFR2 inhibitor. It also has potent antiangiogenic activity and antitumor efficacy.

LBX192( NVP-LBX192) is a liver-targeted glucokinase activator.

ML192 (CID1434953) is a selective GPR55 ligand antagonist. ML192 is an inhibitor that inhibits β-arrestin transport, ERK1/2 phosphorylation, and PKCβII translocation.

TAT-PAK18 R192A is an inactive Tat-Pak peptide. It does not influence Rac1 translocation triggered by any tested proteins.

A-192621 is a potent, nonpeptide, orally active, and selective endothelin B (ETB) receptor antagonist with an IC50 of 4.5 nM and a Ki of 8.8 nM. A-192621 promotes apoptosis in PASMCs and elevates both arterial blood pressure and plasma ET-1 levels[1][2][3]. Its selectivity is 636-fold higher for ETB than ETA (IC50 of 4280 nM and Ki of 5600 nM).

Anti-Mesothelin Antibody (YP218) is a chimeric rabbit IgG antibody that targets human Mesothelin.

PMN310 is a monoclonal antibody targeting β-amyloid oligomers (AβO). It prevents AβO-induced memory formation loss in vivo and reduces synaptic loss and inflammation. PMN310 is applicable in Alzheimer's disease research.

Selcodebart is a humanized IgG1κ monoclonal antibody inhibitor targeting the repulsive guidance molecule C (RGMC/HFE2) and exhibits anti-anemic properties. Abdakibart is applicable to research on central nervous system disorders, such as Alzheimer's disease and stroke, as well as brain tumors and anemia.

Lenipagrusin alfa is a natural homologous tetramer variant of Sophora japonica seed lectin (1-258), in its glycosylated form as alfa. Lenipagrusin alfa exhibits antitumor properties.

BIW-8962 is a humanized anti-ganglioside GM2 antibody demonstrating ADCC/CDC activity against multiple myeloma cells. In murine xenograft models, BIW-8962 exhibits potent antitumor activity. This compound is applicable for research on cancers such as myeloma.

Gimvekibart is a humanized IgG4κ monoclonal antibody inhibitor targeting IL-4Ra/CD124. It is applicable in research related to inflammatory diseases, such as idiopathic pulmonary fibrosis (IPF).

REGN7999 is a monoclonal antibody that inhibits TMPRSS6. By suppressing TMPRSS6 activity, REGN7999 prevents HJV cleavage, enhancing BMP6-HJV signaling and increasing serum hepcidin levels. This inhibition aids in alleviating iron overload and impaired erythropoiesis in β-thalassemia mouse models. REGN7999 is applicable for research in β-thalassemia.

Anti-Human/Monkey CD16a Antibody (3G8) is a monoclonal antibody targeting human and monkey CD16a and can be used in immunological research.

Anti-Human/Mouse/Monkey PD-1 Antibody (2E5) is a monoclonal antibody targeting human, mouse and monkey PD-1 and can be used in cancer immunotherapy research.

Anti-Human CD62L Antibody (DREG-200) is a monoclonal antibody targeting human CD62L and can be used in immunological research.

Anti-Human CD86 Antibody (3D1) is a monoclonal antibody targeting human CD86 and can be used in immunological research.

ent-Kaurane-16beta,19,20-triol is a natural product for research related to life sciences. The catalog number is TN3958 and the CAS number is 167898-32-0.

TAS05567 is a potent, highly selective, and ATP-competitive Syk inhibitor (IC50: 0.37 nM), showing >70% inhibition of Syk and four other kinases [FLT3 (IC50: 10 nM), JAK2 (IC50: 4.8 nM), KDR (IC50: 600 nM), RET (IC50: 29 nM)] in a panel of 192 kinases.