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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T24727 | ROR Modulator I | ROR-Modulator-I,RORModulatorI | |
ROR Modulator I is the first potent inverse agonist of the retinoid-related orphan receptor. It also has dual selectivity for RORβ and RORγt. | |||
T12750 | ROR agonist-1 | Others | |
ROR agonist-1 is a potent and orally bioavailable the retinoic acid receptor-related orphan receptor C2 (RORC2) inverse agonist(inhibition of IL-17A production from human primary TH 17 cells with a pIC50 of 7.5). | |||
T4050 | GSK2981278 | ROR gama modulator 1 | ROR |
GSK2981278 (ROR gama modulator 1) is a highly potent and selective inverse agonist of retinoic acid receptor-related orphan receptor gamma (ROR gamma). | |||
T39250 | Bevurogant | ROR | |
Bevurogant is an antagonist of RORγt receptor and can be used in studies about the treatment of chronic inflammatory diseases. | |||
TQ0007 | Cintirorgon | LYC-55716 | ROR |
Cintirorgon (LYC-55716) is a selective, oral agonist of RORγ. Cintirorgon modulates gene expression of RORγ expressing T lymphocyte immune cells. | |||
T5163 | SR1001 | ROR | |
SR 1001 is an inverse agonist for RORα/RORγ (Kis: 172/111 nM). | |||
T4670 | SR0987 | ROR | |
SR0987 is a RORγt agonist, | |||
T4594 | SR1078 | SR 1078 | ROR |
SR1078 is an agonist of retinoic acid receptor-related orphan receptor (ROR)α/γ. | |||
T7388 | GSK805 | ROR | |
GSK805 is a potent, orally bioavailable retinoid-related orphan receptor gamma t (RORγt) inverse agonist that interacts with the receptor's putative ligand binding domain without exerting significant effects on DNA bindi... | |||
T9635 | Cedirogant | ABBV-157 | ROR |
Cedirogant (ABBV-157) is an orally active retinoid-related orphan receptor-γt(RORγt) inverse agonist that is used for psoriasis study. | |||
T16832 | S18-000003 | ROR | |
S18-000003 is an effective orally bioavailable retinoic acid receptor-related orphan receptor-gamma-t inhibitor (IC50: 29 nM). S18-000003 inhibits IL-17 production. | |||
T12753 | RORγt Inverse agonist 6 | ROR | |
RORγt Inverse agonist 6 is an agonist of RORγt inverse. RORγt Inverse agonist 6 can be used in research on Th17-driven autoimmune diseases. | |||
T9623 | RORγt inverse agonist 13 | ROR | |
RORγt inverse agonist 13 (Compound 3i) is a potent, orally active and selective RORγt inverse agonist (IC50=63.8 nM), with improved drug-like properties[1]. | |||
T14369 | AZD-0284 | ROR | |
AZD-0284 is an inverse agonist of the nuclear receptor RORγ. In development for the treatment of plaque psoriasis vulgaris and respiratory tract disorders[1]. | |||
T5160 | SR3335 | ML 176 | ROR |
SR3335 (ML 176) is a selective inverse agonist of RORα, competitively inhibiting the binding of 25-hydroxycholesterol to the ligand binding domain (Ki: 220 nM). | |||
T6690 | T0901317 | Apoptosis , FXR , Liver X Receptor , ROR | |
T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively; it inhibits nuclear factor/κB (NF/κB). | |||
T67943 | RORγ inverse agonist 1 | ||
RORγ inverse agonist 1 has anti-inflammatory activity and can be used to treat rheumatism and psoriasis. | |||
T5520L | Cetrorelix diacetate | NS-75A,SB-075 acetate,SB-075 diacetate,Cetrorelix acetate,NS-75A diacetate | GNRH Receptor |
Cetrorelix diacetate (NS-75A) is is a gonadotropin-releasing hormone antagonist. It works by blocking the action of GnRH upon the pituitary, thus rapidly suppressing the production and action of luteinizing hormone (LH) ... | |||
T5520 | Cetrorelix Acetate | Cetrorelix | GNRH Receptor |
Cetrorelix Acetate is gonadotropin-releasing hormone (GnRH) receptor antagonist with an IC50 of 1.21 nM. | |||
T9040 | Aurora kinase inhibitor-2 | IUN-70219,Aurora Kinase Inhibitor II | Aurora Kinase |
Aurora kinase inhibitor-2 (IUN-70219) is a cell-permeable anilinoquinazoline that inhibit the activity of Aurora A (IC50 = 0.39 M). | |||
T12010 | Aurora B inhibitor 1 | Aurora Kinase | |
Aurora B inhibitor 1 is an Aurora B (Aurora-1) inhibitor (Ki <0.010 uM) with potential anticancer activity for cancer research. | |||
T61093 | MicroRNA-21-IN-2 | Others | |
MicroRNA-21-IN-2 is a potential miR-21 inhibitor with an AC50 value of 3.29 μM. MicroRNA-21-IN-2 can be used to study cancer. | |||
T5524 | Aurora kinase inhibitor-3 | Aurora Kinase Inhibitor III | Aurora Kinase |
Aurora kinase inhibitor-3 (Aurora Kinase Inhibitor III) is a potent inhibitor of Aurora A kinase (IC50 = 42 nM).1 It is selective for Aurora A over BMX, BTK, IGF-1R, c-Src, TRKB, SYK, and EGFR. | |||
T18977 | Dihydrorhodamine 123 | DHR 123 | Others |
Dihydrorhodamine 123 (DHR 123) is a fluorescent probe (λex=488 nm, λem=525 nm). | |||
T11013L1 | Dextrorotation nimorazole phosphate ester TFA | Others | |
Dextrorotation nimorazole phosphate ester TFA is an anti-anaerobic and anti-parasitic agent. | |||
TQ0007L | Cintirorgon sodium | LYC-55716 sodium salt,LYC 55716,LYC55716 | |
Cintirorgon (LYC-55716) is an orally active RORgamma agonist with potential immunomodulatory and antineoplastic activities. LYC-55716 selectively binds to the RORg, and binds to ROR response elements, enhancing the funct... | |||
T64145 | RORγt/DHODH-IN-1 | ||
RORγt/DHODH-IN-1 (compound (R)-14d) is a potent, orally active dual inhibitor of RORγt (IC50: 0.083 μM) and DHODH (IC50: 0.172 μM), which exhibits significant in vivo anti-inflammatory effects. | |||
T63609 | RORγt modulator 3 | ||
RORγt modulator 3 is a modulator of retinol-related orphan receptor γt (RORγt) and can be used to study RORγt-mediated diseases such as pain, COPD, inflammation, asthma, colitis, multiple sclerosis, rheumatoid arthritis,... | |||
T64146 | RORγt/DHODH-IN-3 | ||
RORγt/DHODH-IN-3 (compound (S)-14d) is a potent, orally active dual inhibitor of RORγt (IC50: 0.098 μM) and DHODH (IC50: 0.432 μM).RORγt/DHODH-IN-1 has significant in vivo anti-inflammatory effects. | |||
T62647 | Aurora A inhibitor 2 | ||
Aurora A inhibitor 2 (Compound 16h) is a potent inhibitor of Aurora A kinase (IC50: 21.94 nM). | |||
T63853 | Aurora kinase inhibitor-10 | ||
Aurora kinase inhibitor-10 is an orally active Aurora B inhibitor (IC50: 8 nM) that exhibits antitumour effects. | |||
T72252 | RORγt inverse agonist 14 | ROR | |
RORγt inverse agonist 14 (8e) is a potent, selective, and orally active compound with an EC50 of 2.5 nM, exhibiting anti-inflammatory activity. It is employed in researching rheumatoid arthritis and psoriasis [1]. | |||
T70309 | Dicetrorelix pamoate | ||
Dicetrorelix pamoate is a synthetic decapeptide with gonadotropin-releasing hormone (GnRH) antagonistic activity. GnRH induces the production and release of luteinizing hormone (LH) and follicle stimulating hormone (FSH)... | |||
T63124 | RORγt modulator 4 | ||
RORγt modulator 4 is a RORγt modulator that regulates IL-17A production activity in cells derived from mouse spleen. | |||
T79470 | RORγt inverse agonist 31 | ROR | |
RORγt inverse agonist 31 (14g) is a potent antagonist of the retinoic acid receptor-related orphan receptor γt (RORγt), exhibiting an inhibitory concentration (IC50) of 0.428 μM. It has demonstrated efficacy in mitigatin... | |||
T39363 | 2,4-Difluororesorcinol | ||
2,4-Difluororesorcinol is a fluorinated building block. | |||
T125443 | Physarorubinic acid A | ||
Physarorubinic acid A is a useful organic compound for research related to life sciences and the catalog number is T125443. | |||
T68765 | Spirorenone | ||
Spirorenone is an androstadienone derivative as a highly effective aldosterone antagonist. Spirorenone is 8.6 times as potent as spironolactone, but showed a lower affinity for the mineralocorticoid receptors. In phase I... | |||
T25300 | Dehydrorotenone | ||
Dehydrorotenone is a retinoid of Tephrosia egregia and has great antioxidant activity. | |||
T63436 | Aurora A inhibitor 1 | ||
Aurora A inhibitor 1 is a potent and selective Aurora A inhibitor. Aurora A is associated with cancers of multiple histological origins and may exhibit oncogenic activity when overexpressed. aurora A inhibitor 1 exhibits... | |||
T10412 | Aurora inhibitor 1 | Aurora Kinase | |
Aurora inhibitor 1 is a potent Aurora inhibitor (IC50: ≤ 4 nM and ≤13 nM for Aurora A and Aurora B kinase). | |||
T62484 | Aurora Kinases-IN-2 | ||
Aurora Kinases-IN-2 (compound 12Aj) is a potent inhibitor of Aurora kinases, acting on Aurora A (IC50: 90 nM) and Aurora B (IC50: 152 nM). Aurora Kinases-IN-2 can be used in cancer research. | |||
T72254 | RORγt inverse agonist 26 | ||
RORγt inverse agonist 26, a potent reverse agonist of RORγt, effectively modulates Th17 cell differentiation and suppresses IL-17 production. This compound shows promising potential for researching inflammation and autoi... | |||
T12755 | RORγt Inverse agonist 2 | Others | |
RORγt Inverse agonist 2 is a selective, orally active inverse agonist of RORγt(EC50 of 119 nM). | |||
T63678 | RORγt modulator 2 | ||
RORγt modulator 2 is a modulator of retinol-related orphan receptor γt (RORyt) (IC50<50 nM) and can be used in the study of RORγt-mediated diseases such as pain, inflammation, asthma, rheumatoid arthritis, COPD, multiple... | |||
T12752 | RORγt Inverse agonist 3 | Others | |
RORγt Inverse agonist 3 is a potent, selective and orally active inverse agonist of RORγ(EC50s of 0.22 μM and 0.15 μM for hRORγ and RORγt (human IL-17 cells), respectively). | |||
T40043 | RORγt Inverse agonist 10 | ||
RORγt Inverse agonist 10 is a highly potent and orally bioavailable compound that acts as an antagonist for the retinoic acid receptor-related orphan nuclear receptor gamma t (RORγt). With an IC50 of 51 nM, it effectivel... | |||
T64140 | RORγt agonist 2 | ||
RORγt agonist 2 is a potent agonist of RORγt. RORγt agonist 2 induces Th17 cell differentiation, increases levels of pro-inflammatory cytokines and thus enhances lymphocyte cytotoxicity. rorγt agonist 2 exhibits an inhib... | |||
T131596 | Dihydrorobustic deoxybenzoin | ||
Dihydrorobustic deoxybenzoin is a useful organic compound for research related to life sciences and the catalog number is T131596. | |||
T82931 | Aurora A inhibitor 3 | Aurora Kinase | |
Aurora A Inhibitor 3 (Compound 5h) effectively inhibits Aurora-A kinase, exhibiting an IC50 of 0.78 μM, and demonstrates cytotoxicity against MCF-7 and MDA-MB-231 cell lines with GI50 values of 0.12 μM and 0.63 μM, respe... |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T3S1251 | Neoruscogenin | ROR | |
1. Neoruscogenin represents a universal pharmacological tool for RORα research due to its specific selectivity profile versus other nuclear receptors. | |||
T2834 | Nobiletin | Hexamethoxyflavone | Apoptosis , MMP , Reactive Oxygen Species , ROR , Autophagy |
Nobiletin (Hexamethoxyflavone) is a natural polymethoxylated flavone isolated from citrus peels with anti-inflammatory and anti-tumor activities. Nobiletin is practically insoluble (in water) and an extremely weak acidic... | |||
T1079 | Metronidazole | Flagyl,Metronidazol,Anagiardil | Apoptosis , NADPH , Hydrogenase , Antibacterial , Antibiotic , Parasite , Antifection |
Metronidazole (Metronidazol) is a synthetic nitroimidazole derivative with antiprotozoal and antibacterial activities. | |||
T13502 | 3-Oxo-5β-cholanoic acid | Dehydrolithocholic acid | ROR |
3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid) (Dehydrolithocholic acid) is a bile acid metabolite and inhibits the differentiation of TH17 cells by directly binding to the key transcription factor RORγt (Kd: 1.13 μM)... | |||
T37009 | Oxychlororaphine | phenazine-1-carboxamide | Antibacterial |
Oxychlororaphine (phenazine-1-carboxamide) inhibits strongly the growth of Streptomyces sp. 441. | |||
T4912 | Jatrorrhizine chloride | Yatrorhizine chloride,Neprotine chloride | Others , 5-HT Receptor , OCT , Antibacterial , AChE |
Jatrorrhizine chloride (Neprotine chloride) is a potent and orally active uptake-2 transporter inhibitor. It exhibits a critical neuroprotective role in H2O2-induced apoptosis via inhibition of the MAPK pathway in HT22 h... | |||
T3840 | Dihydroresveratrol | 3,4',5-Trihydroxybibenzyl | Estrogen Receptor/ERR , Others |
Dihydroresveratrol (3,4',5-Trihydroxybibenzyl) is a major metabolite of resveratrol that is produced by animal-associated bacteria, including the gut microbiota. Dihydroresveratrol and dihydroresveratrol monosulfate are ... | |||
T3933 | Jatrorrhizine | Yatrorizine,neprotin | MAO , 5-HT Receptor , Antibacterial , AChE |
Jatrorrhizine (neprotin) is a protoberberine alkaloid isolated from Enantia chlorantha (Annonaceae) and other species. It was found to have antimicrobial and antifungal activity. It binds and noncompetitively inhibits mo... | |||
T2986 | Jatrorrhizine hydrochloride | Others | |
Jatrorrhizine hydrochloride is extracted from berberidis, radix. | |||
TN1586 | Dihydrorotenone | Apoptosis , Mitochondrial Metabolism | |
Dihydrorotenone is a potent mitochondrial inhibitor and probably induces Parkinsonian syndrome. | |||
T34389 | Rorifone | 10-(Methylsulfonyl)decanenitrile | |
Rorifone is a biochemical. | |||
TN6425 | Saprorthoquinone | ||
Saprorthoquinone is a natural product from Salvia prionitis. | |||
TN1360 | Afrormosine | Others | |
Afrormosine is a natural product | |||
T75436 | Jatrorrhizine hydroxide | ||
Jatrorrhizine hydroxide, an alkaloid derived from Coptis chinensis, exhibits a range of biological activities including neuroprotective, antimicrobial, antiplasmodial, and antioxidant properties [1]. It acts as a potent ... | |||
TN2147 | Retrorsine | P450 , OCT | |
Retrorsine selectively inhibits hepatocyte proliferation and following liver injury evokes small hepatocyte-like progenitor cells. Retrorsine can be used for the research of hepatocellular injury. | |||
TN3864 | Dihydroresveratrol 3-O-glucoside | Others | |
Dihydroresveratrol 3-O-glucoside is a natural product fonud in the leaves of Camellia sinensis var. assamica (J.W. Mast.) Kitam. | |||
T80004 | Tetrahydrorhombifoline | ||
Tetrahydrorhombifoline, a quinolizidine alkaloid found in the aerial parts of Genista vuralii A. Duran & H. Dural (Fabaceae), exhibits antibacterial and antifungal activities as evidenced by the extract from G. vuralii [... | |||
T41264 | Roridin L2 | ||
Roridin L2 is a natural product for research related to life sciences. The catalog number is T41264 and the CAS number is 85124-22-7. | |||
TMA0600 | Dihydrorobinetin | Others | |
(+)-Dihydrorobinetin is reported as a chemical marker of vinegars aged in acacia wood and can be used for authenticity purposes. | |||
T32198 | Retrorsine N-oxide | Isatidine | |
Isatidine is a pyrrolizidine alkaoid. |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPK-00572 | ROR1 Protein, Canine, Recombinant (His) | Canine | HEK293 |
ROR1 (Receptor tyrosine kinase-like orphan receptor 1), also known as neurotrophic tyrosine kinase receptor-related 1 (NTRKR1), is a member of the ROR family within receptor tyrosine kinases (RTK) superfamily. Two ROR ... | |||
TMPK-00413 | ROR1 Protein, Human/Cynomolgus/Rhesus macaque, Recombinant (His & Avi) | Human,Cynomolgus,Rhesus macaque | HEK293 |
ROR1 (Receptor tyrosine kinase-like orphan receptor 1), also known as neurotrophic tyrosine kinase receptor-related 1 (NTRKR1), is a member of the ROR family within receptor tyrosine kinases (RTK) superfamily. Two ROR ... | |||
TMPK-00577 | ROR2 Protein, Human, Recombinant (His & Avi) | Human | HEK293 |
ROR2 (Receptor Tyrosine Kinase-like Orphan Receptor 2) is a member of the ROR family of receptor tyrosine kinases and is important for skeletal development, including bone and cartilage formation, as well as for the deve... | |||
TMPK-00579 | ROR2 Protein, Human, Recombinant (hFc) | Human | HEK293 |
ROR2 (Receptor Tyrosine Kinase-like Orphan Receptor 2) is a member of the ROR family of receptor tyrosine kinases and is important for skeletal development, including bone and cartilage formation, as well as for the deve... | |||
TMPK-00578 | ROR2 Protein, Human, Recombinant (aa 34-403, His & Avi), Biotinylated | Human | HEK293 |
ROR2 (Receptor Tyrosine Kinase-like Orphan Receptor 2) is a member of the ROR family of receptor tyrosine kinases and is important for skeletal development, including bone and cartilage formation, as well as for the deve... | |||
TMPK-00566 | ROR2 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 |
ROR2 (Receptor Tyrosine Kinase-like Orphan Receptor 2) is a member of the ROR family of receptor tyrosine kinases and is important for skeletal development, including bone and cartilage formation, as well as for the deve... | |||
TMPY-04649 | ROR1 Protein, Human, Recombinant (His) | Human | HEK293 |
ROR1 Protein, Human, Recombinant (His) is expressed in HEK293 with His tag. The predicted molecular weight is 43.4 kDa. Accession number: Q01973 | |||
TMPY-05394 | ROR2 Protein, Human, Recombinant (His) | Human | HEK293 |
ROR2 Protein, Human, Recombinant (His) is expressed in HEK293 with His tag. The predicted molecular weight is 42.8 kDa. Accession number: Q01974 | |||
TMPH-01791 | RORA Protein, Human, Recombinant (His) | Human | E. coli |
Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of embryonic development, cellular d... | |||
TMPH-01792 | RORC Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of cellular differentiation, immunit... | |||
TMPH-00498 | Prorelaxin Protein, Canine, Recombinant (His) | Canine | E. coli |
Prorelaxin Protein, Canine, Recombinant (His) is expressed in E. coli. | |||
TMPY-06508 | ROR1 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 |
ROR1 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 with hFc tag. The predicted molecular weight is 68.53 kDa. Accession number: NP_038873.2 | |||
TMPY-06825 | ROR1 Protein, Human, Recombinant (hFc & Avi), Biotinylated | Human | HEK293 |
ROR1 Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 with AVI and hFc tag. The predicted molecular weight is 70.53 kDa. Accession number: NP_005003.2 | |||
TMPY-06850 | ROR2 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
ROR2 Protein, Mouse, Recombinant (His) is expressed in HEK293 with His tag. The predicted molecular weight is 42.64 kDa. Accession number: Q9Z138 | |||
TMPY-04068 | ROR1 Protein, Human, Recombinant (hFc) | Human | HEK293 |
ROR1 Protein, Human, Recombinant (hFc) is expressed in HEK293 with hFc tag. The predicted molecular weight is 69 kDa. Accession number: Q01973 | |||
TMPY-05603 | ROR1 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 |
ROR1 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 with His and AVI tag. The predicted molecular weight is 45.2 kDa. Accession number: Q01973 | |||
TMPY-04428 | ROR1 Protein, Human, Recombinant (aa 453-783, His & GST) | Human | Baculovirus-Insect Cells |
ROR1 Protein, Human, Recombinant (aa 453-783, His & GST) is expressed in Baculovirus-Insect Cells with His and GST tag. The predicted molecular weight is 65.3 kDa. Accession number: AAA60275.1 | |||
TMPY-04986 | ROR1 Protein, Human, Recombinant, Biotinylated | Human | HEK293 |
ROR1 Protein, Human, Recombinant, Biotinylated is expressed in HEK293. The predicted molecular weight is 42.8 kDa. Accession number: Q01973 | |||
TMPY-05639 | ROR2 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 |
ROR2 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 with His and AVI tag. The predicted molecular weight is 44.6 kDa. Accession number: Q01974 | |||
TMPY-06103 | ROR1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
ROR1 Protein, Mouse, Recombinant (His) is expressed in HEK293 with His tag. The predicted molecular weight is 43.3 kDa. Accession number: Q9Z139 | |||
TMPH-01241 | TOP1 Protein, Human, Recombinant (His & Myc) | Human | Baculovirus |
Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via tran... |