rnase — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T8591	RNase L-IN-2	5-(3-hydroxyphenyl)-8-thia-4,6-diazatricyclo[7.4.0.0,2,7]trideca-1(9),2(7),5-trien-3-one	Others
	RNase L-IN-2 is an activator of RNase L with EC50 of 22 uM; shows broad-spectrum antiviral activity against diverse types of RNA viruses, including the human pathogen human parainfluenza virus type 3, with no cytotoxic a...		Others
T78345	Ribonuclease A	EC 3.1.27.5,RNase A
	Ribonuclease A (RNase A) is a potent endonuclease that removes RNA during dna and protein preparation.
T79488	RNase L-IN-1		DNA/RNA Synthesis
	RNase L-IN-1 (compound 17a) functions as an inhibitor of RNase L (Ribonuclease L), an enzyme responsible for RNA degradation to inhibit viral replication, and plays a crucial role in mediating innate immune responses and...		DNA/RNA Synthesis
T2096	Framycetin sulfate	Neomycin Sulphate B,Framycetin sulphate	Antibacterial , Antibiotic
	Framycetin sulfate (Neomycin Sulphate B) belongs to aminoglycoside class of antibiotics that contain two or more aminosugars connected by glycosidic bonds.		Antibacterial , Antibiotic
T15594	MKC8866		IRE1
	MKC8866 is a selective IRE1 RNase inhibitor (IC50: 0.29 μM in human vitro). MKC8866 inhibits IRE1 RNase in breast cancer cells leading to the decreased production of pro-tumorigenic factors and it can inhibit prostate ca...		IRE1
T6363	4μ8C	IRE1 Inhibitor III	IRE1
	4μ8C (IRE1 Inhibitor III)(IC50=76 nM) is an effective and specific IRE1 Rnase inhibitor.		IRE1
T11762L	Kira8	AMG-18	IRE1
	Kira8 (AMG-18) is a mono-selective IRE1α inhibitor that allosterically attenuates IRE1α RNase activity (IC50: 5.9 nM).		IRE1
T14847	B I09		Others , IRE1
	B I09, an IRE-1 RNase inhibitor with an IC50 of 1230 nM, inhibits splicing of XBP1 mRNA in human WaC3 cells and expression of xbp-1 in LPS-stimulated B cells. B I09 can be used to simulate the defects of XBP-1 in CLL cel...		Others , IRE1
T3654	APY29		IRE1
	APY29 is an allosteric modulator of IRE1α; inhibits IRE1α autophosphorylation (IC50 = 280 nM) and activates IRE1α RNase activity.		IRE1
T11488	GSK2850163		IRE1
	GSK2850163 is a novel inhibitor of inositol-requiring enzyme-1 alpha (IRE1α) which can inhibit RNase activity and IRE1α kinase activity (IC50s: 200 and 20 nM).		IRE1
TN6600	Kaempferol 3-O-(6''-galloyl)-beta-D-glucopyranoside		HIV Protease
	Kaempferol 3-O-(6''-galloyl)-beta-D-glucopyranoside is a glucopyranoside that inhibits HIV-2 RNase H with an IC50 of 5.19 μM.		HIV Protease
TQ0076	KIRA6		IRE1
	KIRA6 is an effective inhibitor of IRE1α RNase kinase (IC50: 0.6 μM). It can trigger an apoptotic response.		IRE1
T65118	DEPC	Diethyl pyrocarbonate	Others
	DEPC (Diethyl pyrocarbonate) is a potent and irreversible RNase inhibitor containing histidine residues.DEPC can be used to prevent RNA enzyme degradation by modifying histidine residues with carboxylation resulting in e...		Others
T9564	IRE1α kinase-IN-1		IRE1
	IRE1α kinase-IN-1 is a highly selective IRE1α (ERN1) inhibitor, with an IC50 of 77 nM. It displays 100-fold selectivity for IRE1α over the IRE1β isoform. It inhibits ER stress-induced IRE1α oligomerization and autophosph...		IRE1
T0374	Sunitinib Malate	Sutent,SU 11248 (Malate),SU 11248,Sunitinib	Apoptosis , Mitophagy , VEGFR , FLT , IRE1 , PDGFR , c-Kit , Autophagy
	Sunitinib Malate (Sunitinib) is an indolinone-based tyrosine kinase inhibitor. It blocks the tyrosine kinase activities of VEGFR2, PDGFRβ (IC50: 80/2 nM), and c-kit.
T11762	Kira8 Hydrochloride	AMG-18 Hydrochloride	Adenosine Receptor
	Kira8 Hydrochloride is a mono-selective IRE1α inhibitor that allosterically attenuates IRE1α RNase activity with an IC50 of 5.9 nM.		Adenosine Receptor
T63591	HIV-1 inhibitor-45
	HIV-1 inhibitor-45 is a potent inhibitor of HIV-1 RNase H (IC50: 0.067 μM) and has antiviral effects.
TP1803	S Tag Peptide
	S Tag Peptide is a 15 amino acid peptide derived from RNase A.
T62156	HIV-1 integrase inhibitor 9
	HIV-1 integrase inhibitor 9 (compound 8a) is a potent inhibitor of HIV-1 RNase H (IC50: 12.3 μM) and has antiviral effects.
T15664	KIRA-7		Others
	KIRA-7 is an imidazopyrazine compound. KIRA-7 has an anti-fibrotic effect. KIRA-7 binds the IRE1α kinase (IC50: 110 nM) to allosterically inhibit its RNase activity.		Others