RNase

DEPC (Diethyl pyrocarbonate) is a potent and irreversible RNase inhibitor containing histidine residues.DEPC can be used to prevent RNA enzyme degradation by modifying histidine residues with carboxylation resulting in enzyme inactivation. DEPC showed inhibitory effect on the central chemical sensitivity of rabbits. DEPC modified His, Tyr, Ser and Thr residues.

RNase B, Bovine Pancreas, is the N-glycosylated form of bovine pancreatic ribonuclease, structurally analogous to RNase A. It assists in polypeptide chain folding and functions similarly to a molecular chaperone.

RNase A, Bovine Pancreas (Ribonuclease A) (DNase & Protease Free) is a ribonuclease and a widely used endonuclease that functions by specifically hydrolyzing cytosine or uracil residues in RNA. It is commonly employed in cell cycle analysis experiments.

RNase H2 is the primary source of RNase H activity in mammalian and human cells, crucial for maintaining genomic integrity. It is involved in the removal of ribonucleotides from yeast and mouse genomic DNA, a process essential for embryonic development.

DEPC-Treated Water is a high-temperature, high-pressure sterilised, RNase-free ultra-pure water that prevents contamination by non-specific nucleases and exonucleases, leaving RNase activity unaffected. It is primarily used in molecular biology experiments involving RNA.

The compound 2'-RIBOTAC-U recruiter-linker (Compound 9) is composed of an RNase L recruiter and a linker. It reacts via copper-catalyzed click chemistry with either 2’-azido-uridine or 5’-azidomethyl-uridine to form 2'-RIBOTAC-U and 5'-RIBOTAC-U, respectively. Notably, 2'-RIBOTAC-U exhibits activity against SARS-CoV-2.