Leu-arg

Z-Leu-Arg-AMC, a carboxybenzoyl (Z) leucine derivative featuring a 4-methylcoumarinyl-7-amide (AMC), serves as the active site for the cysteine proteinase trypanopain-Tb in Trypanosoma brucei brucei [1].

H-Ser-Phe-Leu-Leu-Arg-OH, also known as Coagulation Factor II Receptor (1-5) or Proteinase Activated Receptor 1 (1-5), is utilized in coronary heart disease (CHD) research.

Lys-Arg-Thr-Leu-Arg-Arg (KRTLRR), a hexapeptide substrate for protein kinase C associated with the EGF receptor, facilitates the determination of enzyme activity [1].

N-Myristoyl-Lys-Arg-Thr-Leu-Arg is a protein kinase C (PKC) inhibitor (IC50 = 75 μM) that effectively inhibits IL-2 receptor induction and IL-2 production in the human leukemic cell line Jurkat [1].

Ser-parafluoroPhe-Aad-Leu-Arg-Asn-Pro-NH2 is a biologically active peptide. Structure-activity studies of the thrombin receptor-tethered ligand SFLLRNP highlighted the pivotal role of the Phe-2-phenyl group in receptor recognition, while substitution with para-fluorophenylalanine [(p-F)Phe] increased its activity.

Ac-Leu-Arg-AMC (Acetyl-Leucyl-Arginyl-7-amido-4-methylcoumarin) is a fluorogenic peptide substrate.

Lys-Arg-Thr-Leu-Arg-Arg (KRTLRR) acetate is a hexapeptide. It serves as a substrate for the EGF receptor protein kinase C and is utilized to assess the activity of protein kinase C.

H-d-Val-Leu-Arg-AFC is a bioactive peptide. (kallikrein substrate)

D-Val-Leu-Arg-pNA hydrochloride is a substrate for glandular kallikrein. It can be utilized to measure the activity of plasminogen activators and plasmin. This compound is also employed in studying fibrinolytic activity in various organisms, such as bacteria and worms.

Leucylarginine hinders antinociception induced by L-arginine.

Antho-rpamide II is a biologically active neuropeptide isolated from the sea anemone Anthopleura elegantissima.

Antho-rwamide I is an anthozoan neuropeptide.

Boc-LRR-AMC TFA is a fluorescent protease substrate used to detect the trypsin-like activity of the 26S proteasome or 20S proteasome core.

Kisspeptin-10, a neuropeptide present in the brains, ovaries, and testes of zebrafish, plays a critical role in gonadal development and steroid expression. At a concentration of 10 ng/ml, it enhances the mRNA levels for the luteinizing hormone (Lh) receptor and both progestin receptor a (Pra) and Prb in zebrafish ovarian follicles. In female goldfish, doses of 0.1 and 1 µg/g of Kisspeptin-10 elevate serum levels of luteinizing hormone, with no similar effect observed in male goldfish.

EGFR peptide, a PKC peptide substrate, mirrors an amino acid sequence from EGFR's intracellular region and serves to gauge PKC activity in primary bovine retinal endothelial cells. At a concentration of 50 µM, unlike its myristoylated counterpart, EGFR peptide does not inhibit PKC activity.

EGFR peptide (myristoylated), a synthetic peptide inhibitor of PKC (IC50 = 5 µM), corresponds to the intracellular region's amino acid sequence of EGFR. It effectively reverses doxorubicin resistance in UV-2237M (UV-2237M-ADRR) fibrosarcoma cells at a concentration of 1 µM.

Tnrnflrfamide is a SCP (small cardioactive peptide)-like peptide found in lobster neurons; exhibits FMRFamide-like immunoreactivity.

Sdrnflrfamide exhibits FMRFamide-like immunoreactivity isolated from the nervous system of the lobster Homarus americanus.

EGFR peptide (myristoylated) is a synthetic peptide with an amino acid sequence corresponding to the intracellular region of EGFR, capable of inhibiting PKC activity.

Ac-RLR-AMC (Ac-Arg-Leu-Arg-AMC) TFA serves as a fluorescent substrate for the 26S proteasome (Ex/Em: 380/440-460 nm). Upon enzymatic cleavage, AMC is released, and its fluorescence allows for the quantification of the trypsin-like activity of the 26S proteasome.

Acetyl Angiotensinogen (1-14), porcine Acetate is a peptide with the sequence AC-ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS-LEU-LEU-VAL-TYR-SER-OH. The protein encoded by the Angiotensinogen gene is known as pre-angiotensinogen or angiotensinogen precursor.

Cadherin Peptide, avian Acetate is a peptide with the sequence Leu-Arg-Ala-His-Ala-Val-Asp-Val-Asn-Gly-NH2. Cadherins are a class of type-1 transmembrane proteins.

Mc-Leu-Gly-Arg is a cleavable ether linker for antibody-drug conjugate (ADC) design.

68Ga-DOTA-NT-20.3 is an analogue of neurotensin (NTS) and acts as a ligand for 68Ga ions. In PET imaging, it demonstrates rapid tumor uptake and high contrast between tumor and background, along with fast clearance from the blood and moderate accumulation in the kidneys. Its pharmacokinetic and biodistribution properties are advantageous, producing high-quality PET images in mice with subcutaneous or orthotopic human pancreatic cancer xenografts. 68Ga-DOTA-NT-20.3 specifically binds to NTSR1 on pancreatic cancer cells and outperforms 18F-FDG in PET detection of adenocarcinoma.