ldha — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T3175	LDHA-IN-4	AZ 33,AZ-33,LDHA Inhibitor,AZ33	Dehydrogenase
	LDHA-IN-4 (AZ33) is an LDHA inhibitor. Binding affinity to 6-His-tagged human LDHA (2 to 322 amino acid residue) expressed in Escherichia coli BL21 (DE3) cells by SPR analysis with an active value of 0.093 μM.		Dehydrogenase
T39805	LDHA-IN-3	PSTMB,1-(phenylseleno)-4-(trifluoromethyl) benzene	Dehydrogenase
	LDHA-IN-3 (1-(phenylseleno)-4-(trifluoromethyl) benzene) is a potent non-competitive lactate dehydrogenase (LDHA) inhibitor with an IC50 value of 145.2 nM.LDHA-IN-3 is a selenobenzene compound that can be used in cancer ...		Dehydrogenase
T15362	FX-11	LDHA Inhibitor FX11	Dehydrogenase
	FX-11 (LDHA Inhibitor FX11) is A potent, selective and competitive specific inhibitor of lactate dehydrogenase A (LDHA) with a Ki of 8 μM. FX-11 can activate PKM2 (pyruvate kinase M2). FX-11 can reduce ATP levels, induce...		Dehydrogenase
T73222	LDHA-IN-5
	LDHA-IN-5 is a novel and potent inhibitor targeting both glycolate oxidase (GO) and lactate dehydrogenase A (LDHA), designed for the treatment of primary hyperoxaluria.
T60995	LDHA/PDKs-IN-2
	LDHA/PDKs-IN-2 (compound 20k) is a potent LDHA and PDKs dual inhibitor with IC50 values of 0.7 and 1.6 μM, respectively. LDHA/PDKs-IN-2 increases oxygen consumption as well as decreases the lactate formation. LDHA/PDKs-I...
T61339	LDHA/PDKs-IN-1
	LDHA/PDKs-IN-1 (compound 20e) is a highly effective dual inhibitor of PDKs and LDHA, displaying IC50 values of 0.8 μM and 0.15 μM, respectively. It significantly suppresses A549 cell proliferation (EC50 = 13.2 μM), reduc...
T15435	GSK2837808A		Dehydrogenase
	GSK2837808A is a potent and selective inhibitor of lactate dehydrogenase A (LDHA) (IC50s: 1.9 and 14 nM for LDHA and LDHB, respectively).		Dehydrogenase
T4295	(R)-GNE-140	GNE-140	Dehydrogenase
	(R)-GNE-140 (GNE-140) is an effective LDHA/LDHB inhibitor (IC50s: 3/5 nM) and is 18-fold more potent than S enantiomer.		Dehydrogenase
T11829	LDH-IN-1		Dehydrogenase
	LDH-IN-1 is a pyrazole-based human lactate dehydrogenase (LDH) inhibitor(IC50s of 32 and 27 nM for LDHA and LDHB, respectively).		Dehydrogenase
T19831	Sodium Oxamate	oxamate sodium,Oxamic acid sodium salt,Aminooxoacetic acid sodium salt,SO	Apoptosis , Dehydrogenase , CDK
	Sodium Oxamate (Oxamic acid sodium salt) is an LDH inhibitor that specifically inhibits LDHA. Sodium Oxamate has antitumor activity and induces cell cycle arrest and apoptosis.		Apoptosis , Dehydrogenase , CDK
T22336	Galloflavin		Dehydrogenase
	Galloflavin inhibits both the A and B isoforms of lactate dehydrogenase with Ki of 5.46 µM and 15.06 µM, respectively. Galloflavin is also a potential anticancer agent.		Dehydrogenase
T24530	NHI-2	NHI 2
	NHI-2 is an inhibitor of LDHA that acts by reducing lactate production in HeLa cells.
T27421	GNE-140 racemic	GNE-140,GNE 140,GNE140
	GNE-140 racemic is a potent lactate dehydrogenase (LDHA) inhibitor.
T13450L	GNE-140 racemate	GNE-140 (racemate)	Others
	GNE-140 is a potent inhibitor of lactate dehydrogenase A (LDHA). GNE-140 is a racemate mixture of (R)-GNE-140 and (S)-GNE-140.		Others
T79874	CHK-336
	CHK-336 (Example 1), an orally active LDHA inhibitor (IC50 <1 nM), suppresses lactate production in mouse hepatocytes and is applicable in hyperoxaluria research [1].
T79204	Anticancer agent 122
	Anticancer agent 122, a potent inhibitor of human lactate dehydrogenase A (h LDHA), exhibits significant anticancer activities, rendering it suitable for use in cancer research [1].
T81747	MS6105		PROTACs
	MS6105 is a chimeric LDH protein hydrolysis-targeted PROTAC that degrades LDHA and LDHB efficiently, with its activity contingent on both time and the ubiquitin-proteasome system, exhibiting anticancer properties [1]. Ad...		PROTACs

Compounds

LDHA-IN-4

T3175

Synonym: AZ 33,AZ-33,LDHA Inhibitor,AZ33

Target: Dehydrogenase

LDHA-IN-3

T39805

Synonym: PSTMB,1-(phenylseleno)-4-(trifluoromethyl) benzene

Target: Dehydrogenase

FX-11

T15362

Synonym: LDHA Inhibitor FX11

Target: Dehydrogenase

Target: Dehydrogenase

(R)-GNE-140

T4295

Synonym: GNE-140

Target: Dehydrogenase

LDH-IN-1

T11829

Synonym:

Target: Dehydrogenase

Sodium Oxamate

T19831

Synonym: oxamate sodium,Oxamic acid sodium salt,Aminooxoacetic acid sodium salt,SO

Target: Apoptosis, Dehydrogenase, CDK

Galloflavin

T22336

Synonym:

Target: Dehydrogenase

Synonym: GNE-140,GNE 140,GNE140

Target:

GNE-140 racemate

T13450L

Synonym: GNE-140 (racemate)

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPJ-00724	LDHA Protein, Human, Recombinant (His)	Human	E. coli
	L-Lactate Dehydrogenase A Chain (LDHA) is an enzyme that catalyzes the conversion of L-lactate and NAD+ to pyruvate and NADH in the final step of anaerobic glycolysis. LDHA contains an N-terminal coenzyme binding region,...
TMPY-04241	LDHA Protein, Rat, Recombinant (His)	Rat	E. coli
	LDHA Protein, Rat, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 38.7 kDa and the accession number is B5DEN4.
TMPY-00010	LDHA Protein, Mouse, Recombinant (His)	Mouse	E. coli
	LDHA Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 36.5 kDa and the accession number is P06151.