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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T62978 | HIV-IN-3 | ||
HIV-IN-3 (Compound 22a) is a potent inhibitor of HIV (IC50: 1.5 μM). HIV-IN-3 has potential for the study of HIV-related diseases. | |||
T0682 | Lamivudine | GR109714X,BCH-189 | HIV Protease , Reverse Transcriptase |
Lamivudine (BCH-189) is a reverse transcriptase inhibitor and ZALCITABINE analog in which a sulfur atom replaces the 3' carbon of the pentose ring. It is used to treat HIV disease. | |||
T0028 | Gamibetal | 3-Hydroxy-GABA,4-Amino-3-hydroxybutyric Acid | HIV Protease |
Gamibetal (4-Amino-3-hydroxybutyric Acid) is used as a chiral reagent in the synthesis of antiepileptic and hypotensive drug GABOB and analogues. Also used in the preparation of HIV-1 inhibitors derived from Betulinic Ac... | |||
T14313 | Apricitabine | AVX754,SPD754 | HIV Protease , DNA/RNA Synthesis |
Apricitabine (SPD754) is a highly selective and orally active HIV-1 reverse transcriptase inhibitor (Ki=0.08 μM), the (-) enantiomer of 2′-deoxy-3′-oxy-4′-thiocytidine (dOTC) . Apricitabine inhibits DNA polymerase α, β a... | |||
T6S2391 | L-Chicoric Acid | (-)-Chicoric acid,trans-Caffeoyltartaric acid,Chicoric acid,dicaffeoyltartaric acid | Others , HIV Protease |
L-Chicoric Acid (trans-Caffeoyltartaric acid) has been shown to inhibit hyaluronidase and HIV-1 integrase, and to possess phagoeytosis stimulatory activity in vitro and in vivo and antiviral acitivy. L-Chicoric acid may ... | |||
T5429 | Theaflavin 3,3'-digallate | 8-Gingerol,TFDG | Virus Protease , Antioxidant , HIV Protease , HSV |
Theaflavin 3,3'-digallate (8-Gingerol) , a major polyphenol found in black tea, is an inducer of oxidative stress which has anti-inflammatory and cancer chemopreventive actions, it reduces tumor angiogenesis by downregul... | |||
TQ0174 | Mavorixafor | AMD-070 | CXCR |
Mavorixafor (AMD-070) is an effective and selective antagonist of CXCR4, with an IC50 value of 13 nM against CXCR4 125I-SDF binding. Mavorixafor inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells (IC... | |||
T4S0797 | Berberine | Berberin,Umbellatine | Reactive Oxygen Species , Topoisomerase , Endogenous Metabolite , Antibacterial , Antibiotic , Autophagy |
1. Berberine (Umbellatine) is a potent oral hypoglycemic agent with beneficial effects on lipid metabolism. 2. Berberine may as a broad-spectrum anti-microbial medicine, a complementary therapeutic agent for HIV/AIDS. 3.... | |||
T29393 | 3'-Deoxy-4-thiothymidine | Thymidine, 3'-deoxy-4-thio-,Ddthds | |
3'-Deoxy-4-thiothymidine can moderately active in protecting HIV-induced cytopathogenicity of MT-2 and CEM cells. | |||
T78551 | Glycolithocholic acid 3-sulfate disodium | Glycolithocholate sulfate disodium,SLCG disodium,Sulfolithocholylglycine disodium | |
Glycolithocholic acid 3-sulfate (disodium) demonstrates inhibitory effects on in vitro HIV-1 replication and has potential applications in HIV infection and gallbladder disease research [1] [2]. | |||
T10986 | DDX3-IN-1 | Others | |
DDX3-IN-1 is a DEAD-box polypeptide 3 (DDX3) inhibitor with CC50 of 50 and 36 μM for HIV and HCV, respectively. Antiviral activity. | |||
TN2951 | 3-(hydroxymethyl)cyclopentanone | CCR | |
3-Hydroxymethylcyclopentanone is a precursor to synthesize methyl epijasmonate. 3-Hydroxymethylcyclopentanone compounds, which are useful as intermediates in the preparation of HIV chemokine CCR-5 receptor antagonists. | |||
T72203 | Reverse transcriptase-IN-3 | ||
Reverse transcriptase-IN-3, a pyrimidine-5-carboxamide derivative, functions as an inhibitor of HIV-1, demonstrating potent activity against both wild-type and mutant strains of HIV-1. | |||
T72162 | HIV-1 integrase inhibitor 10 | ||
HIV-1 Integrase Inhibitor 10, an orally active allosteric integrase inhibitor (ALLINI), effectively inhibits the NLRepRluc virus's viral outgrowth in MT-2 cells, exhibiting EC50 values of 3-5 nM. This compound is utilize... | |||
T73758 | Glycolithocholic acid 3-sulfate | ||
Glycolithocholic acid 3-sulfate (SLCG), a cholic acid derivative and glycolithocholic acid metabolite, effectively inhibits HIV-1 replication in vitro. This compound holds potential for researching HIV infection and gall... | |||
T78950 | HIV-1 protease-IN-8 | HIV Protease | |
HIV-1 protease-IN-8 (compound 34b) is a potent inhibitor of the HIV-1 protease enzyme, exhibiting an IC50 of 0.32 nM. It demonstrates IC50 values of 0.29 μM for the wild-type HIV-1 (HIV-1 NL4-3) and 1.90 μM against a dru... | |||
T78737 | NNRTIs-IN-3 | HIV Protease | |
NNRTIs-IN-3 (compound 8) is an HIV-1 non-nucleoside reverse transcriptase inhibitor, displaying potent efficacy with an EC50 value of 0.01 µM [1]. | |||
T80621 | Semzuvolimab | UB421 | |
Semzuvolimab, a murine IgG1κ antibody, targets the p55 T-cell surface antigen T4/Leu-3 (CD4). It has demonstrated capabilities to neutralize HIV infection and may inhibit HIV in patients on stable highly active antiretro... | |||
T60342 | HIV-1 inhibitor-47 | ||
HIV-1 inhibitor-47 is a compound that effectively inhibits HIV-1 by preventing the vif-dependent degradation of human APOBEC3G. It has a notable inhibition effect, with an IC50 value of 14.33 μM. Additionally, HIV-1 inhi... | |||
T77141 | Pegaldesleukin | ||
Pegaldesleukin, a conjugate of polyethylene glycol and interleukin-2 (PEG-IL2), exhibits antiviral activity with potential applications in managing HIV. It may delay the progression of HIV infection by preserving the imm... |