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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T10889 | CRTh2 antagonist 2 | GPR | |
CRTh2 antagonist 2 is a selective and potent CRTH2 antagonist, IC50≤10 nM. CRTh2 antagonist 2 can be used to study the direction of androgenic alopecia. | |||
T10084 | CRTh2 antagonist 1 | GPR | |
CRTh2 antagonist 1 is a CRTh2 antagonist (IC50: 89 nM). | |||
T10890 | CRTh2 antagonist 3 | Others | |
CRTh2 antagonist 3 is a powerful chemokine receptor homologous molecule expressed on Th2 cell (CRTh2) antagonists. CRTh2 antagonist 3 enhanced the activity of PDK1 on short peptide substrates with EC50 of 2 μM and Kd of ... | |||
T10891 | CRTH2-IN-1 | Ramatroban analog | P450 |
CRTH2-IN-1 is a selective prostaglandin D2 receptor DP2 (CRTH2) antagonist, a Ramatroban analog, with an IC50 of 6 nM in the human DP2 binding assay. | |||
T17232 | Vidupiprant | AMG 853 | Prostaglandin Receptor |
Vidupiprant (AMG 853) is an effective dual antagonist of CRTH2 and prostanoid D receptor with IC50s of 8 nM and 35 nM in human plasma. Vidupiprant can be used in studies about the treatment of asthma. | |||
T14565 | BI-671800 | AP-761,Cmpd A | GPR , Prostaglandin Receptor |
BI-671800 (AP-761) is a highly specific and potent antagonist of chemoattractant receptor-homologous molecule on Th2 cells (DP2/CRTH2). With IC50 values of 4.5 nM and 3.7 nM for PGD2 binding to CRTH2 in hCRTH2 and mCRTH2... | |||
T3520 | Setipiprant | KYTH-105,ACT-129968 | GPR , Prostaglandin Receptor |
Setipiprant (ACT-129968) is an orally available, selective CRTH2 antagonist (IC50: 6.0 nM). CRTH2 is a G protein-coupled receptor for prostaglandin (PGD2). PGD2 is produced by the mast cells and is a key mediator in vari... | |||
T14211 | AMG-009 | Others | |
AMG-009 is a prostaglandin D2 antagonist. For CRTH2 and DP receptors, the IC50s are 3 nM and 12 nM, respectively. | |||
T10691 | CAY10595 | GPR | |
CAY10595 is an antagonist of the CRTh2 (DP2) receptor with a Ki of 10 nM. | |||
T3965 | Fevipiprant | QAW039,NVP-QAW039 | GPR , Prostaglandin Receptor |
Fevipiprant (NVP-QAW039) is a selective, potent, reversible competitive CRTh2 antagonist. | |||
T7359 | CAY10471 Racemate | TM30089 Racemate | GPR , Prostaglandin Receptor |
CAY10471 Racemate (TM30089 Racemate) is a potent, highly selective CRTH2/DP 2 receptor antagonist. CAY10471 Racemate binds to the human CRTH2/DP2, DP1, and TP receptors( Ki values of 0.6, 1200, and >10,000 nM,respectivel... | |||
T6399 | AZD1981 | GPR , Prostaglandin Receptor | |
AZD1981 is an effective and specific CRTh2 (DP2) receptor antagonist (IC50: 4 nM), showing >1000-fold selectivity over more than 340 other enzymes and receptors, including DP1. AZD1981 has been used in trials studying th... | |||
T77601 | (2-{[2-(2-fluorophenoxy)ethyl]sulfanyl}-1H-benzimidazol-1-yl)acetic acid | GPR | |
(2-{[2-(2-fluorophenoxy)ethyl]sulfanyl}-1H-benzimidazol-1-yl)acetic acid is a prostaglandin-like CRTH2 antagonist with an IC50 < 10 μM, which can be used in studies of rhinitis, COPD, rheumatoid arthritis, eczema and con... | |||
T2396 | Ramatroban | BAY u3405 | GPR , Prostaglandin Receptor , PPAR |
Ramatroban (BAY u3405) (BAY u3405) is a thromboxane A(2) (TxA(2)) antagonist marketed for allergic rhinitis. It has been used in trials studying the treatment of Asthma. | |||
T3306 | PF-04418948 | PF 04418948,PF04418948 | Prostaglandin Receptor |
PF-04418948 is a potent EP2 receptor antagonist (IC50 = 16 nM for human EP2 receptors). Displays over 2000-fold selectivity for EP2 receptors over EP1, EP3, EP4, DP1 amd CRTH2 receptors; exhibits <30% binding at a divers... | |||
TQ0051 | MK-7246 | GPR | |
MK-7246 is a potent and specific CRTH2 antagonist (Ki: 2.5 nM). | |||
T16097 | MK-8318 | Others | |
MK-8318 is an effective and selective antagonist of the CRTh2 receptor (Ki: 5.0 nM). | |||
T15828 | L 888607 | Others | |
L 888607 is an effective and selective CRTH2 agonist (Ki: 0.8 nM). | |||
T28925 | TASP0376377 | TASP-0376377,TASP 0376377 | |
TASP0376377 is a potent antagonist of CRTH2. | |||
T28927 | TASP0412098 | TASP 0412098,TASP-0412098 | |
TASP0412098 is a potent, selective CRTH2 antagonist with oral activity. |