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Search Results for " crth2 "

20

Compounds

Cat No. Product Name Synonyms Targets
T10889 CRTh2 antagonist 2 GPR
CRTh2 antagonist 2 is a selective and potent CRTH2 antagonist, IC50≤10 nM. CRTh2 antagonist 2 can be used to study the direction of androgenic alopecia.
T10084 CRTh2 antagonist 1 GPR
CRTh2 antagonist 1 is a CRTh2 antagonist (IC50: 89 nM).
T10890 CRTh2 antagonist 3 Others
CRTh2 antagonist 3 is a powerful chemokine receptor homologous molecule expressed on Th2 cell (CRTh2) antagonists. CRTh2 antagonist 3 enhanced the activity of PDK1 on short peptide substrates with EC50 of 2 μM and Kd of ...
T10891 CRTH2-IN-1 Ramatroban analog P450
CRTH2-IN-1 is a selective prostaglandin D2 receptor DP2 (CRTH2) antagonist, a Ramatroban analog, with an IC50 of 6 nM in the human DP2 binding assay.
T17232 Vidupiprant AMG 853 Prostaglandin Receptor
Vidupiprant (AMG 853) is an effective dual antagonist of CRTH2 and prostanoid D receptor with IC50s of 8 nM and 35 nM in human plasma. Vidupiprant can be used in studies about the treatment of asthma.
T14565 BI-671800 AP-761,Cmpd A GPR , Prostaglandin Receptor
BI-671800 (AP-761) is a highly specific and potent antagonist of chemoattractant receptor-homologous molecule on Th2 cells (DP2/CRTH2). With IC50 values of 4.5 nM and 3.7 nM for PGD2 binding to CRTH2 in hCRTH2 and mCRTH2...
T3520 Setipiprant KYTH-105,ACT-129968 GPR , Prostaglandin Receptor
Setipiprant (ACT-129968) is an orally available, selective CRTH2 antagonist (IC50: 6.0 nM). CRTH2 is a G protein-coupled receptor for prostaglandin (PGD2). PGD2 is produced by the mast cells and is a key mediator in vari...
T14211 AMG-009 Others
AMG-009 is a prostaglandin D2 antagonist. For CRTH2 and DP receptors, the IC50s are 3 nM and 12 nM, respectively.
T10691 CAY10595 GPR
CAY10595 is an antagonist of the CRTh2 (DP2) receptor with a Ki of 10 nM.
T3965 Fevipiprant QAW039,NVP-QAW039 GPR , Prostaglandin Receptor
Fevipiprant (NVP-QAW039) is a selective, potent, reversible competitive CRTh2 antagonist.
T7359 CAY10471 Racemate TM30089 Racemate GPR , Prostaglandin Receptor
CAY10471 Racemate (TM30089 Racemate) is a potent, highly selective CRTH2/DP 2 receptor antagonist. CAY10471 Racemate binds to the human CRTH2/DP2, DP1, and TP receptors( Ki values of 0.6, 1200, and >10,000 nM,respectivel...
T6399 AZD1981 GPR , Prostaglandin Receptor
AZD1981 is an effective and specific CRTh2 (DP2) receptor antagonist (IC50: 4 nM), showing >1000-fold selectivity over more than 340 other enzymes and receptors, including DP1. AZD1981 has been used in trials studying th...
T77601 (2-{[2-(2-fluorophenoxy)ethyl]sulfanyl}-1H-benzimidazol-1-yl)acetic acid GPR
(2-{[2-(2-fluorophenoxy)ethyl]sulfanyl}-1H-benzimidazol-1-yl)acetic acid is a prostaglandin-like CRTH2 antagonist with an IC50 < 10 μM, which can be used in studies of rhinitis, COPD, rheumatoid arthritis, eczema and con...
T2396 Ramatroban BAY u3405 GPR , Prostaglandin Receptor , PPAR
Ramatroban (BAY u3405) (BAY u3405) is a thromboxane A(2) (TxA(2)) antagonist marketed for allergic rhinitis. It has been used in trials studying the treatment of Asthma.
T3306 PF-04418948 PF 04418948,PF04418948 Prostaglandin Receptor
PF-04418948 is a potent EP2 receptor antagonist (IC50 = 16 nM for human EP2 receptors). Displays over 2000-fold selectivity for EP2 receptors over EP1, EP3, EP4, DP1 amd CRTH2 receptors; exhibits <30% binding at a divers...
TQ0051 MK-7246 GPR
MK-7246 is a potent and specific CRTH2 antagonist (Ki: 2.5 nM).
T16097 MK-8318 Others
MK-8318 is an effective and selective antagonist of the CRTh2 receptor (Ki: 5.0 nM).
T15828 L 888607 Others
L 888607 is an effective and selective CRTH2 agonist (Ki: 0.8 nM).
T28925 TASP0376377 TASP-0376377,TASP 0376377
TASP0376377 is a potent antagonist of CRTH2.
T28927 TASP0412098 TASP 0412098,TASP-0412098
TASP0412098 is a potent, selective CRTH2 antagonist with oral activity.
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TargetMol