cos-7 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T10979	DCPIB		Potassium Channel , Chloride channel
	DCPIB, a known specific and potent inhibitor of volume-regulated anion channels (VRAC),DCPIB displayed superior selectivity toward TRESK with an IC50 of 0.14 μM, demonstrating at least 100-fold higher affinity over TREK1...		Potassium Channel , Chloride channel
T16420	P-1075		Potassium Channel
	P-1075 opens mitochondrial K(ATP) channels and generates reactive oxygen species causing cardioprotection of rabbit hearts. P-1075 is an effective activator of sulfonylurea receptor 2-associated ATP-sensitive potassium c...		Potassium Channel
T8851	I3MT-3	HMPSNE	Hippo pathway
	I3MT-3 (HMPSNE) (HMPSNE) is a potent, selective and cell membrane permeability inhibitor of 3-mercaptopyruvate sulfur transferase (3MST), which targets the persulfated cysteine residues located at the active site of 3MST...		Hippo pathway
T19840	GSK-F1	PI4KA inhibitor-F1	PI4K
	GSK-F1 (PI4KA inhibitor-F1) is a novel potent PI4KA inhibitor.		PI4K
T67951	JB061		Myosin
	JB061 is a nonmuscle myosin inhibitor, demonstrating selective inhibitory activity with IC50 values of 4.4 μM (Cardiac muscle myosin), 9.1 μM (Skeletal muscle myosin), and >100 μM (Smooth muscle myosin II). It exhibits l...		Myosin
T0386L	Ropivacaine	LEA-103 HCl	Potassium Channel , Sodium Channel
	Ropivacaine (LEA-103 HCl) is a local anaesthetic drug belonging to the amino amide group.		Potassium Channel , Sodium Channel
T37526	2-Oleoylglycerol	2-Oleoyl Glycerol,2-OG,2-Monoolein	GPR
	2-Oleoylglycerol is a lipid found in palm kernel, sunflower seed and rice bran.2-Oleoylglycerol acts as a GPR119 agonist with neuroprotective effects and induces secretion of glucagon-like peptide 1 (GLP-1).2-Oleoylglyce...		GPR
T6645	Ropivacaine hydrochloride monohydrate	Ropivacaine HCl,Ropivacaine HCl monohydrate,LEA 103,LEA-103 HCl	Potassium Channel , Sodium Channel
	Ropivacaine hydrochloride monohydrate (LEA-103 HCl) is an anaesthetic agent and blocks impulse conduction in nerve fibres through inhibiting sodium ion influx reversibly.		Potassium Channel , Sodium Channel
TP2021	[Pro3]-GIP (Rat)
	High affinity rat GIP receptor partial agonist (Kd = 13 nM). Increases cAMP accumulation in COS-7 cells transfected with rat GIP receptor, while also acting as a competitive antagonist of GIP.
T61475	Ropivacaine mesylate
	Ropivacaine mesylate, a long-acting amide local anaesthetic, is used for spinal block and effectively mitigates neuropathic pain. It achieves analgesia by reversibly inhibiting sodium ion influx in nerve fibers, thus blo...
T37092	20-HEPE
	20-HEPE is a metabolite of eicosapentaenoic acid that is formed via ω-oxidation of EPA by cytochrome P450 (CYP) ω-oxidases, including human CYP4F3B. It activates peroxisome proliferator-activated receptor α (PPARα) in CO...
T37167	Reduced Haloperidol
	Reduced haloperidol is an active metabolite of haloperidol . It is formed via reduction of haloperidol by ketone reductase. Reduced haloperidol inhibits radioligand binding to sigma-1 and dopamine D2 receptors (Kis = 1.4...
T28235	OMDM169	OMDM 169,OMDM-169
	OMDM169 is a potent and selective MAGL inhibitor. OMDM169 could enhances 2-AG levels and of exerts analgesic activity via indirect activation of cannabinoid receptors. OMDM169 exhibited 0.13 microM
T38220	11-cis Retinol
	11-cisRetinol is an isomer of vitamin A . It is formed from vitamin A,viaatrans-retinyl ester intermediate, by the enzyme RPE65 in the retinal pigment epithelium and then converted to 11-cis retinal as part of the visual...
T36555	Tyr-α-CGRP (human) (trifluoroacetate salt)
	Tyr-α-CGRP is an N-terminal extended tyrosinated analogue of α-calcitonin gene-related peptide . It binds to amylin receptors AMY1 and AMY3 in COS-7 cells expressing the human receptors (IC50s = 141 and 1.86 nM, respecti...
T36232	20-carboxy Arachidonic Acid
	20-carboxy Arachidonic acid (20-COOH-AA) is the major metabolite of 20-HETE that is produced in renal tubular epithelial, endothelial, and microvascular smooth muscle cell cultures. This ω-oxidation conversion can take p...
T83733	TIP39 (human, bovine) TFA	Tuberoinfundibular Peptide of 39 Residues
	TIP39, a neuropeptide and an agonist for the parathyroid hormone receptor type 2 (PTH2R), effectively increases cAMP levels in COS-7 cells featuring recombinant PTH2R from humans or rats (EC50s = 0.5 and 0.8 nM, respecti...
T37413	Calcitonin (salmon) (trifluoroacetate salt)
	Calcitonin is a peptide hormone that lowers blood calcium level and inhibits bone resorption. It belongs to the calcitonin family of peptides, which also includes amylin , calcitonin gene-related peptide , and adrenomedu...
T36639	Donecopride (fumarate hydrate)
	Donecopride is a partial agonist of the serotonin (5-HT) receptor subtype 5-HT4E(Ki= 8.5 nM) and an inhibitor of acetylcholinesterase (AChE; IC50= 16 nM).1It is selective for AChE over butyrylcholinesterase (BChE; IC50= ...