Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty

TAM Receptor

The TAM receptors—Tyro3, Axl, and Mer—comprise a unique family of receptor tyrosine kinases,Their regulatory roles are prominent in the mature immune, reproductive, hematopoietic, vascular, and nervous systems. The TAMs and their ligands—Gas6 and Protein S—are essential for the efficient phagocytosis of apoptotic cells and membranes in these tissues.

  • Bemcentinib
    T62691037624-75-1
    Bemcentinib (R428) is a selective inhibitor of Axl (IC50: 14 nM) and has been investigated for the treatment of NSCLC.
    • $34
    In Stock
    Size
    QTY
    TargetMol | Inhibitor Hot
    TargetMol | Citations Cited
  • Gilteritinib
    T44091254053-43-4
    Gilteritinib (ASP2215) is a potent inhibitor of FMS-related tyrosine kinase 3 (FLT3) and AXL tyrosine kinase receptors (IC50 = 0.29 nM and <1 nM, respectively). In preclinical studies, gilteritinib demonstrated strong antileukemic and antitumor effects. Gilteritinib is currently in several Phase 3 clinical trials for acute myeloid leukemia.
    • $34
    In Stock
    Size
    QTY
    TargetMol | Inhibitor Hot
    TargetMol | Citations Cited
  • Tepotinib
    T61211100598-32-0
    Tepotinib (EMD-1214063) is a c-MET tyrosine kinase inhibitor (IC50=3 nM) that is selective, orally active, and ATP-competitive. Tepotinib has antitumor effect and is used in the treatment of non-small cell lung cancer.
    • $43
    In Stock
    Size
    QTY
    TargetMol | Inhibitor Hot
    TargetMol | Citations Cited
  • 2-D08
    T7379144707-18-6
    2-D08 is a synthetic flavone that inhibits sumoylation, also inhibits Axl with an IC50 of 0.49 nM.2-D08 showed anti-aggregatory and neuroprotective effect.
    • $52
    In Stock
    Size
    QTY
    TargetMol | Citations Cited
  • Cabozantinib
    T2586849217-68-1
    Cabozantinib (XL184) is a multi-targeted tyrosine kinase receptor inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt3 (IC50=0.035 1.3 4.6 7 11.3 nM). Cabozantinib exhibits both antitumor and antiangiogenic activity.
    • $39
    In Stock
    Size
    QTY
    TargetMol | Citations Cited
  • NCT-503
    T42131916571-90-8
    NCT-503 is a phosphoglycerate dehydrogenase (PHGDH) inhibitor (IC50=2.5 µM) with no activity against other dehydrogenases. NCT-503 has antitumor activity and inhibits the growth of PHGDH-dependent tumors.
    • $35
    In Stock
    Size
    QTY
    TargetMol | Inhibitor Hot
    TargetMol | Citations Cited
  • UNC2025
    T70071429881-91-3
    UNC2025 (mrx-6313)(IC50 of 0.74 nM and 0.8 nM) is a potent and orally bioavailable dual MER FLT3 inhibitor. UNC-2025 is about 20-fold selectivity higher than Axl and Tyro3.
    • $33
    In Stock
    Size
    QTY
  • Pralatrexate
    T6120146464-95-1
    Pralatrexate (10-Propargyl-10-deazaaminopterin) is a folate analogue inhibitor of dihydrofolate reductase (DHFR) exhibiting high affinity for reduced folate carrier-1 (RFC-1) with antineoplastic and immunosuppressive activities.
    • $30
    In Stock
    Size
    QTY
  • Sitravatinib
    T43491123837-84-2
    Sitravatinib (MGCD516) is an inhibitor targeting multiple RTKs involved in driving sarcoma cell growth, including c-Met, c-Kit, PDGFRα β, PDGFR, and Axl.
    • $47
    In Stock
    Size
    QTY
    TargetMol | Citations Cited
  • Astragalus Polysacharin
    T2S0837
    2-(Chloromethyl)-4-(4-nitrophenyl)thiazole, a natural product derived from Astragalus propinquus, exhibits anticancer activity and has been shown to be effective in hepatocellular carcinoma (HCC) by inhibiting the M2 polarization of tumor-associated macrophages (TAM).
    • $31
    In Stock
    Size
    QTY
  • AXL-IN-13
    T733002376928-82-2In house
    AXL-IN-13 is a potent and orally active AXL inhibitor with an IC50 of 1.6 nM and a Kd of 0.26 nM. It exhibits anticancer activity, reverses TGF-β1-induced epithelial-mesenchymal transition (EMT), and inhibits cancer cell migration and invasion.
    • $79
    In Stock
    Size
    QTY
  • DS-1205
    T91231855860-24-0
    DS-1205 is a potent and selective inhibitor of AXL kinase, with an IC50 of 1.3 nM. DS-1205 also inhibits MER, MET, and TRKA, with IC50s of 63, 104, and 407 nM, respectively. DS-1205 can inhibit cell migration in vitro and tumor growth in vivo[1].
    • $108
    In Stock
    Size
    QTY
  • Ningetinib
    TQ00211394820-69-9
    Ningetinib (CT-053) (CT053PTSA) is an orally bioavailable tyrosine kinase inhibitor with IC50s of <1.0, 1.9 and 6.7 nM for Axl, VEGFR2, and c-Met, respectively.
    • $42
    In Stock
    Size
    QTY
    TargetMol | Inhibitor Sale
    TargetMol | Citations Cited
  • SGI-7079
    T69821239875-86-5
    SGI-7079 is a new selective Axl inhibitor. SGI-7079 can be a dose-dependent manner inhibited growth of tumors. It is also a potential therapeutic target for EGFR inhibitor resistance.
    • $35
    In Stock
    Size
    QTY
    TargetMol | Inhibitor Sale
  • UNC569
    T213021350547-65-7
    UNC569 (UNC 569) is a selective inhibitor of URAT1, a transporter in the kidney that regulates uric acid excretion from the body. It is also a selective uric acid re-absorption inhibitor. UNC569 could normalize the amount of uric acid excreted by gout patients previously classified as under-excretors.
    • $38
    In Stock
    Size
    QTY
    TargetMol | Inhibitor Sale
  • Gilteritinib hemifumarate
    T719731254053-84-3
    Gilteritinib hemifumarate (ASP2215 hemifumarate) is a potent ATP-competitive dual FLT3 (IC50: 0.29 nM) and AXL (IC50: 0.73 nM) inhibitor for the treatment of relapsed or refractory FLT3 mutant AML.
    • $34
    In Stock
    Size
    QTY
  • UNC2025 2HCl (1429881-91-3(free base))
    T4419
    UNC2025 is a potent and orally bioavailable Mer/Flt3 dual inhibitor with IC50 of 0.8/0.74 nM for Mer/Flt3.
    • $51
    In Stock
    Size
    QTY
  • Dubermatinib
    T20051341200-45-0
    Dubermatinib (TP0903) is a potent and selective Axl kinase inhibitor.
    • $30
    In Stock
    Size
    QTY
    TargetMol | Inhibitor Sale
  • S49076
    T32741265965-22-7
    S49076 is a novel and potent inhibitor of MET, AXL MER, and FGFR1 2 3, effectively blocking cellular phosphorylation of MET, AXL, and FGFRs.
    • $39
    In Stock
    Size
    QTY
  • Cabozantinib S-malate
    T17971140909-48-3
    Cabozantinib S-malate (XL184) is the s-malate salt form of cabozantinib, an orally bioavailable, small molecule receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic activity.
    • $40
    In Stock
    Size
    QTY
    TargetMol | Inhibitor Sale
  • UNC2250
    T19681493694-70-4
    UNC2250 is an effective and specific Mer inhibitor (IC50=1.7 nM).
    • $38
    In Stock
    Size
    QTY
    TargetMol | Inhibitor Sale
  • G-749
    T26201457983-28-6
    G-749, a new-type FLT3 inhibitor, exhibits effective and sustained inhibition of the FLT3 wild type and mutants.
    • $40
    In Stock
    Size
    QTY
  • BMS 777607
    T26991025720-94-8
    BMS 777607 (BMS 817378) is a Met-related inhibitor targeting c-Met, Axl, Ron, and Tyro3 with IC50 values of 3.9 nM, 1.1 nM, 1.8 nM, and 4.3 nM, respectively. BMS-777607 has been investigated in basic science research for malignant solid tumors.
    • $32
    In Stock
    Size
    QTY
    TargetMol | Inhibitor Sale
  • NPS-1034
    T69071221713-92-3
    NPS-1034 is a dual Met Axl inhibitor with IC50 of 48 nM and 10.3 nM, respectively.
    • $32
    In Stock
    Size
    QTY
    TargetMol | Inhibitor Sale
  • ONO-7475
    T83271646839-59-9
    ONO-7475 is an inhibitor with high specificity for anexelekto and MER tyrosine kinase
    • $57
    In Stock
    Size
    QTY
    TargetMol | Inhibitor Sale
  • Cabozantinib hydrochloride
    T51641817759-42-4
    Cabozantinib hydrochloride (XL184) is a potent pan-tyrosine kinases inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt4 (IC50s: 0.035, 1.3, 4.6, 7 and 6 nM).
    • $37
    In Stock
    Size
    QTY
  • LDC1267
    T23111361030-48-9
    LDC1267 is a excellently specific TAM(Tyro3, Axl and Mer) kinase inhibitor, for Mer( IC50<5 nM), Tyro3(IC50=8 nM), and Axl(IC50=29 nM).
    • $30
    In Stock
    Size
    QTY
    TargetMol | Inhibitor Sale
  • UNC2541
    T172051612782-86-1
    UNC2541 is a potent and specific inhibitor of Mer tyrosine kinase (MerTK), binding in the MerTK ATP pocket (IC50: 4.4 nM) and inhibiting phosphorylated MerTK (pMerTK) with an EC50 of 510 nM.
    • $39
    In Stock
    Size
    QTY
    TargetMol | Inhibitor Sale
  • XL092
    T90522367004-54-2
    XL092 (JUN04542) is an Axl Mer cMet KDR inhibitor for the treatment of Axl and Mer receptor tyrosine kinase- dependent disorders.
    • $30
    In Stock
    Size
    QTY
    TargetMol | Inhibitor Sale
  • TAM-IN-2
    T130742135642-56-5
    TAM-IN-2 is an inhibitor of TAM.
    • $51
    In Stock
    Size
    QTY
    TargetMol | Inhibitor Sale
  • UNC 569 hydrochloride
    T21302L
    UNC 569 hydrochloride is a reversible and ATP-competitive inhibitor of Mer with an IC50 of 2.9 nM and a Ki of 4.3 nM. UNC 569 hydrochloride inhibits Axl and Tyro3 with IC50s of 37 nM and 48 nM, respectively. UNC 569 hydrochloride can be used in studies about acute lymphoblastic leukemia and atypical teratoid/rhabdoid tumors.
    • $30
    In Stock
    Size
    QTY
    TargetMol | Inhibitor Sale
  • RU-302
    T168061182129-77-6
    RU-302 is a pan inhibitor of TAM Receptor blocking the interface between the TAM Ig1 ectodomain and the Gas6 Lg domain. RU-302 effectively blocks the activation of Gas6-inducible AXL and suppresses lung cancer tumor growth.
    • $36
    In Stock
    Size
    QTY
    TargetMol | Inhibitor Sale
  • UNC2881
    T26291493764-08-1
    UNC2881 is a specific Mer tyrosine kinase inhibitor (IC50: 4.3 nM). It is about 83- and 58-fold higher selectivity than Axl and Tyro3, respectively.
    • $39
    In Stock
    Size
    QTY
    TargetMol | Inhibitor Sale
  • Ningetinib Tosylate
    TQ00411394820-77-9
    Ningetinib Tosylate is an orally bioavailable tyrosine kinase inhibitor with IC50s of <1.0, 1.9 and 6.7 nM for Axl, VEGFR2, and c-Met, respectively.
    • $41
    In Stock
    Size
    QTY
    TargetMol | Inhibitor Sale
  • CEP-40783
    T44261437321-24-8
    CEP-40783 (RXDX-106) is an effective, specific and orally active AXL c-Met inhibitor (IC50: 7 12 nM). It also inhibits MER and TYRO3 (IC50: 29 19 nM).
    • $43
    In Stock
    Size
    QTY
    TargetMol | Inhibitor Sale
  • Axl-IN-16
    T79969
    Axl-IN-16, a dual Axl/HIF inhibitor, promotes Flammulina velutipes fruiting body formation and suppresses hypoxia-inducible factor activity along with receptor tyrosine kinase expression [1].
    • Inquiry Price
    Size
    QTY
  • AXL-IN-15
    T790451954722-22-5
    AXL-IN-15 (cpd391) is a potent Axl inhibitor with a dissociation constant (K i) and half-maximal inhibitory concentration (IC50) of less than 1 nanomolar (nM), suitable for cancer research [1].
    • Inquiry Price
    Size
    QTY
  • Enapotamab
    T768641912423-61-0
    Enapotamab is an AXL/UFO-related antibody that can be used to synthesize antibody-drug couplings (Enapotamab Vedotin).
    • $263
    In Stock
    Size
    QTY
  • Sitravatinib malate
    T129252244864-88-6
    Sitravatinib malate is an orally bioavailable receptor inhibitor of tyrosine kinase (RTK) (IC50s of 1.5 nM, 2 nM, 2 nM, 5 nM, 6 nM, 6 nM, 8 nM, 0.5 nM, 29 nM, 5 nM, and 9 nM for Axl, MER, VEGFR3, VEGFR2, VEGFR1, KIT, FLT3, DDR2, DDR1, TRKA, TRKB, respectively.) , shows potent single-agent antitumor efficacy and enhances the activity of PD-1 blockade through promoting an antitumor immune microenvironment.
    • $1,520
    Backorder
    Size
    QTY
  • RU-301
    T74251110873-99-8
    RU-301 is a novel pan-tam inhibitor
    • $118
    In Stock
    Size
    QTY
    TargetMol | Inhibitor Sale
  • R916562
    T126501037798-41-6
    R916562 is an orally active, selective Axl VEGF-R2 inhibitor with IC50 values of 136 nM and 24 nM, respectively, demonstrating anti-angiogenesis and anti-metastasis properties.
    • $1,520
    Backorder
    Size
    QTY
  • S49076 HCl
    T35121265966-31-1
    S49076 HCl (S-49076 Hydrochloride) is an effective inhibitor of MET, AXL/MER, and FGFR1/2/3. S49076 HCl potently blocked cellular phosphorylation of MET, AXL, and FGFRs and inhibited downstream signaling in vitro and in vivo. In cell models, S49076 HCl inhibited the proliferation of MET- and FGFR2-dependent gastric cancer cells blocked MET-driven migration of lung carcinoma cells, and inhibited colony formation of hepatocarcinoma cells expressing FGFR1/2 and AXL. In tumor xenograft models, a good pharmacokinetic/pharmacodynamic relationship for MET and FGFR2 inhibition following oral administration of S49076 HCl was established and correlated well with impact on tumor growth.
    • $119
    Backorder
    Size
    QTY
  • Emactuzumab
    T767761448221-67-7
    Emactuzumab(RG 7155) is a monoclonal antibody against colony-stimulating factor-1 receptor targeting tumor-associated macrophages (TAMs) Emactuzumab has antitumor activity and inhibits activation of colony-stimulating factor 1 receptor (CSF1R) Emactuzumab has a high affinity for CSF-1R with a Ki value of 0.2 nM. Emactuzumab blocks CSF-1R dimerization and can be used to study cancers such as diffuse tenosynovial giant cell tumor (dt-GCT).
    • $328
    In Stock
    Size
    QTY
  • AXL-IN-14
    T733102947506-65-0
    AXL-IN-14 is a potent, orally active inhibitor of AXL with an IC50 of 0.8 nM that effectively suppresses Gas6 AXL-mediated cell migration and invasion, reduces the expression of p-AXL and p-AKT proteins, and demonstrates anti-tumor activity [1].
    • $1,820
    Backorder
    Size
    QTY