T73300 |
AXL-IN-13
|
2376928-82-2
|
98%
|
|
AXL-IN-13 is a potent and orally active AXL inhibitor with an IC50 value of 1.6 nM and a Kd value of 0.26 nM.AXL-IN-13 exhibits anticancer activity, reverses TGF...
|
T3512 |
S49076 HCl
|
1265966-31-1
|
98%
|
|
S49076 is an effective inhibitor of MET, AXL/MER, and FGFR1/2/3. S49076 potently blocked cellular phosphorylation of MET, AXL, and FGFRs and inhibited downstream...
|
T12650 |
R916562
|
1037798-41-6
|
98%
|
|
R916562 is an orally active and selective Axl/VEGF-R2 inhibitor with IC50s of 136 nM and 24 nM, respectively. R916562 has anti-angiogenesis and anti-metastasis.
|
T2S0837 |
2-(Chloromethyl)-4-(4-nitrophenyl)thiazole
|
89250-26-0
|
98%
|
|
2-(Chloromethyl)-4-(4-nitrophenyl)thiazole is a natural product derived from Astragalus propinquus.2-(Chloromethyl)-4-(4-nitrophenyl)thiazole exhibits anticancer...
|
T12925 |
Sitravatinib malate
|
2244864-88-6
|
98%
|
|
Sitravatinib malate is an orally bioavailable receptor inhibitor of tyrosine kinase (RTK) (IC50s of 1.5 nM, 2 nM, 2 nM, 5 nM, 6 nM, 6 nM, 8 nM, 0.5 nM, 29 nM, 5 ...
|
T15822 |
Ly93
|
1883528-69-5
|
98%
|
|
Ly93 is a selective and orally active inhibitor of sphingomyelin synthase 2 (SMS2) (IC50: 91 nM).
|
T1968 |
UNC2250
|
1493694-70-4
|
98%
|
|
UNC2250 is an effective and specific Mer inhibitor (IC50=1.7 nM).
|
TQ0041 |
Ningetinib Tosylate
|
1394820-77-9
|
98%
|
|
Ningetinib Tosylate is an orally bioavailable tyrosine kinase inhibitor with IC50s of <1.0, 1.9 and 6.7 nM for Axl, VEGFR2, and c-Met, respectively.
|
T13074 |
TAM-IN-2
|
2135642-56-5
|
98%
|
|
TAM-IN-2 is an inhibitor of TAM.
|
T4349 |
Sitravatinib
|
1123837-84-2
|
98%
|
|
Sitravatinib (MGCD516) is an inhibitor targeting multiple RTKs involved in driving sarcoma cell growth, including c-Met, c-Kit, PDGFRα/β, PDGFR, and Axl.
|
T7007 |
UNC2025
|
1429881-91-3
|
98%
|
|
UNC-2025( IC50 of 0.74 nM and 0.8 nM) is a potent and orally bioavailable dual MER/FLT3 inhibitor. UNC-2025 is about 20-fold selectivity higher than Axl and Tyro...
|
T2629 |
UNC2881
|
1493764-08-1
|
98%
|
|
UNC2881 is a specific Mer tyrosine kinase inhibitor (IC50: 4.3 nM). It is about 83- and 58-fold higher selectivity than Axl and Tyro3, respectively.
|
T4409 |
Gilteritinib
|
1254053-43-4
|
98%
|
|
Gilteritinib is a potent inhibitor at the FMS-related tyrosine kinase 3 (FLT3) and AXL tyrosine kinase receptors (IC50 = 0.29 nM and <1 nM, respectively). In pre...
|
T4419 |
UNC2025 2HCl (1429881-91-3(free base))
|
T4419
|
98%
|
|
UNC2025 is a potent and orally bioavailable Mer/Flt3 dual inhibitor with IC50 of 0.8/0.74 nM for Mer/Flt3.
|
T2586 |
Cabozantinib
|
849217-68-1
|
98%
|
|
Cabozantinib (XL184) is a potent pan-tyrosine kinases inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt3 (IC50s: 0.035, 1.3, 4.6, 7 and 11.3 nM).
|
T4213 |
NCT-503
|
1916571-90-8
|
98%
|
|
NCT-503 is an inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH), inhibiting serine synthesis from 3-phosphoglycerate in cells.
|
T9052 |
XL092
|
2367004-54-2
|
98%
|
|
JUN04542 is an Axl Mer cMet KDR inhibitor for the treatment of Axl and Mer receptor tyrosine kinase- dependent disorders.
|
T17205 |
UNC2541
|
1612782-86-1
|
98%
|
|
UNC2541 is a potent and Mer tyrosine kinase (MerTK)-specific inhibitor. It also binds in the MerTK ATP pocket (IC50: 4.4 nM). UNC2541 inhibits phosphorylated Mer...
|
T16806 |
RU-302
|
1182129-77-6
|
98%
|
|
RU-302 is a pan inhibitor of TAM Receptor blocking the interface between the TAM Ig1 ectodomain and the Gas6 Lg domain. RU-302 effectively blocks the activation ...
|
T4426 |
CEP-40783
|
1437321-24-8
|
98%
|
|
CEP-40783 is an effective, specific and orally active AXL/c-Met inhibitor (IC50: 7/12 nM). It also inhibits MER and TYRO3 (IC50: 29/19 nM).
|