T15822 |
Ly93
|
1883528-69-5
|
98%
|
|
Ly93 is a selective and orally active inhibitor of sphingomyelin synthase 2 (SMS2) (IC50: 91 nM).
|
T3512 |
S49076 HCl
|
1265966-31-1
|
98%
|
|
S49076 is an effective inhibitor of MET, AXL/MER, and FGFR1/2/3. S49076 potently blocked cellular phosphorylation of MET, AXL, and FGFRs and inhibited downstream...
|
T12925 |
Sitravatinib malate
|
2244864-88-6
|
98%
|
|
Sitravatinib malate is an orally bioavailable receptor inhibitor of tyrosine kinase (RTK) (IC50s of 1.5 nM, 2 nM, 2 nM, 5 nM, 6 nM, 6 nM, 8 nM, 0.5 nM, 29 nM, 5 ...
|
T12650 |
R916562
|
1037798-41-6
|
98%
|
|
R916562 is an orally active and selective Axl/VEGF-R2 inhibitor with IC50s of 136 nM and 24 nM, respectively. R916562 has anti-angiogenesis and anti-metastasis.
|
T21302L |
UNC 569 hydrochloride
|
|
98%
|
|
UNC 569 hydrochloride is a reversible and ATP-competitive inhibitor of Mer with an IC50 of 2.9 nM and a Ki of 4.3 nM. UNC 569 hydrochloride inhibits Axl and Tyro...
|
T21302L |
UNC 569 hydrochloride
|
|
98%
|
|
UNC 569 hydrochloride is a reversible and ATP-competitive inhibitor of Mer with an IC50 of 2.9 nM and a Ki of 4.3 nM. UNC 569 hydrochloride inhibits Axl and Tyro...
|
T5164 |
Cabozantinib hydrochloride
|
1817759-42-4
|
98%
|
|
Cabozantinib (XL184) is a potent pan-tyrosine kinases inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt4 (IC50s: 0.035, 1.3, 4.6, 7 and 6 nM).
|
T3274 |
S49076
|
1265965-22-7
|
98%
|
|
S49076 is a novel, potent inhibitor of MET, AXL/MER, and FGFR1/2/3, blocking cellular phosphorylation of MET, AXL, and FGFRs.
|
T6907 |
NPS-1034
|
1221713-92-3
|
98%
|
|
NPS-1034 is a dual Met/Axl inhibitor with IC50 of 48 nM and 10.3 nM, respectively.
|
T7379 |
2-D08
|
144707-18-6
|
98%
|
|
2-D08 is a synthetic flavone that inhibits sumoylation, also inhibits Axl with an IC50 of 0.49 nM.2-D08 showed anti-aggregatory and neuroprotective effect.
|
T6120 |
Pralatrexate
|
146464-95-1
|
98%
|
|
Pralatrexate is a folate analogue inhibitor of dihydrofolate reductase (DHFR) exhibiting high affinity for reduced folate carrier-1 (RFC-1) with antineoplastic a...
|
T8327 |
ONO-7475
|
1646839-59-9
|
98%
|
|
ONO-7475 is an inhibitor with high specificity for anexelekto and MER tyrosine kinase
|
T1797 |
Cabozantinib S-malate
|
1140909-48-3
|
98%
|
|
Cabozantinib S-malate is the s-malate salt form of cabozantinib, an orally bioavailable, small molecule receptor tyrosine kinase (RTK) inhibitor with potential a...
|
T7425 |
RU-301
|
1110873-99-8
|
98%
|
|
RU-301 is a novel pan-tam inhibitor
|
T6982 |
SGI-7079
|
1239875-86-5
|
98%
|
|
SGI-7079 is a new selective Axl inhibitor. SGI-7079 can be a dose-dependent manner inhibited growth of tumors. It is also a potential therapeutic target for EGFR...
|
T9123 |
DS-1205
|
1855860-24-0
|
98%
|
|
DS-1205 is a potent and selective inhibitor of AXL kinase, with an IC50 of 1.3 nM. DS-1205 also inhibits MER, MET, and TRKA, with IC50s of 63, 104, and 407 nM, r...
|
T21302 |
UNC569
|
1350547-65-7
|
98%
|
|
Lesinurad is a selective inhibitor of URAT1, a transporter in the kidney that regulates uric acid excretion from the body. It is also a selective uric acid re-ab...
|
T2620 |
G-749
|
1457983-28-6
|
98%
|
|
G-749, a new-type FLT3 inhibitor, exhibits effective and sustained inhibition of the FLT3 wild type and mutants.
|
T73300 |
AXL-IN-13
|
2376928-82-2
|
98%
|
|
AXL-IN-13 is a potent and orally active AXL inhibitor with an IC50 value of 1.6 nM and a Kd value of 0.26 nM.AXL-IN-13 exhibits anticancer activity, reverses TGF...
|
T16806 |
RU-302
|
1182129-77-6
|
98%
|
|
RU-302 is a pan inhibitor of TAM Receptor blocking the interface between the TAM Ig1 ectodomain and the Gas6 Lg domain. RU-302 effectively blocks the activation ...
|