T3460 |
HhAntag
|
496794-70-8
|
98%
|
|
HhAntag is a small molecule inhibitor of GLI1-mediated transcription, an essential down-stream element of the Hedgehog (Hh) pathway with the anti-tumor activity....
|
T6514 |
Glasdegib
|
1095173-27-5
|
98%
|
|
Glasdegib (PF-04449913) is a potent, and orally bioavailable Smoothened (Smo) inhibitor with IC50 of 5 nM. Phase 2.
|
T11838 |
LEQ506
|
1204975-42-7
|
98%
|
|
LEQ506 is a Smo inhibitor with IC50s of 2 nM and 4 nM for hSmo and mSmo, respectively.
|
T9531 |
MRT-14
|
1263131-83-4
|
98%
|
|
MRT-14 is a potent Smo antagonist and can be used in several types of cancers linked to abnormal Hh signaling studies.
|
T24159 |
IHR-1
|
548779-60-8
|
98%
|
|
IHR-1 is a Potent Smo antagonist (IC50 = 7.6 nM). Selectively inhibits Hedgehog signaling over Wnt and Notch signaling pathways. Blocks Smo accumulation in prima...
|
T2250 |
DY131
|
95167-41-2
|
98%
|
|
DY131 is a novel selective agonist of ERRβ and ERRγ.
|
T14188 |
ALLO-2
|
1357350-60-7
|
98%
|
|
ALLO-2 is a Inhibitor of Drug-Resistant Smo Mutant.It inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM.
|
T2666 |
Taladegib
|
1258861-20-9
|
98%
|
|
Taladegib is an orally bioavailable small molecule antagonist of the Hedgehog (Hh)-ligand cell surface receptor smoothened (Smo) with potential antineoplastic ac...
|
T1779 |
SAG
|
912545-86-9
|
98%
|
|
SAG is a potent Smo receptor agonist and activates the Hedgehog signaling pathway.
|
T6891 |
MK-4101
|
935273-79-3
|
98%
|
|
MK-4101, an effective inhibitor of the Hedgehog pathway, has anti-tumor activity through the induction of extensive apoptosis and inhibition of proliferation in ...
|
T5465 |
PF-5274857
|
1373615-35-0
|
98%
|
|
PF-5274857 is an effective and selective hedgehog signaling pathway inhibitor (IC50: 5.8 nM and a Ki: 4.6 nM). PF-5274857 is a potentially attractive clinical ca...
|
T10085 |
20(S)-Hydroxycholesterol
|
516-72-3
|
98%
|
|
20(S)-Hydroxycholesterol is an allosteric activator of the oncoprotein smoothened (Smo).
|
T64351 |
GI-560192
|
301326-41-0
|
98%
|
|
GI-560192 is a potent smo cilial modulator with an EC50 value of 0.02 µM. GI-560192 modulates the translocation and/or accumulation of smoothened to the primary ...
|
T1810 |
Purmorphamine
|
483367-10-8
|
98%
|
|
Purmorphamine, which directly binds and activates Smoothened, blocks BODIPY-cyclopamine binding to Smo. It also is an inducer of osteoblast differentiation.
|
T3363 |
Jervine
|
469-59-0
|
98%
|
|
The biological activity of Jervine is mediated via its interaction with the 7 passes transmembrane protein Smoothened. Jervine binds with and inhibits smoothened...
|
T2825 |
Cyclopamine
|
4449-51-8
|
98%
|
|
Cyclopamine, a Smoothened (Smo) antagonist (IC50: 46 nM in TM3Hh12 cells), belongs to the group of steroidal jerveratrum alkaloids.
|
T2299 |
BMS-833923
|
1059734-66-5
|
98%
|
|
BMS-833923, an orally bioavailable Smoothened antagonist, inhibits BODIPY cyclopamine binding to SMO in a dose-dependent manner (IC50: 21 nM).
|
T2450 |
SANT-1
|
304909-07-7
|
98%
|
|
SANT-1 directly binds to Smoothened (Smo) receptor (Kd: 1.2 nM) and inhibits Smo agonist effects (IC50: 20 nM).
|
T15727 |
Sonidegib diphosphate
|
1218778-77-8
|
98%
|
|
Erismodegib diphosphate is an effective and selective Smo antagonist (IC50: 1.3 nM and 2.5 nM for mouse and human Smo in a binding assay, respectively).
|
T12109 |
MRT-83
|
1263131-92-5
|
98%
|
|
MRT-83 is a potent Smo antagonist.
|