T0107 |
Halcinonide
|
3093-35-4
|
99.94%
|
|
Halcinonide (Halciderm), a high-efficiency corticosteroid, is served as an anti-inflammatory agent used in topical preparations.
|
T12109 |
MRT-83
|
1263131-92-5
|
99.92%
|
|
MRT-83 is a potent Smo antagonist.
|
T1926 |
Sonidegib
|
956697-53-3
|
99.91%
|
|
Sonidegib (Erismodegib), a Smoothened (Smo) antagonist, inhibits Hedgehog (Hh) signaling with IC50 of 1.3 nM (mouse) and 2.5 nM (human), respectively.
|
T15727 |
Sonidegib diphosphate
|
1218778-77-8
|
99.86%
|
|
Sonidegib diphosphate (LDE225 diphosphate) is an effective and selective Smo antagonist (IC50: 1.3 nM and 2.5 nM for mouse and human Smo in a binding assay, resp...
|
T2450 |
SANT-1
|
304909-07-7
|
99.84%
|
|
SANT-1 directly binds to Smoothened (Smo) receptor (Kd: 1.2 nM) and inhibits Smo agonist effects (IC50: 20 nM).
|
T2299 |
BMS-833923
|
1059734-66-5
|
99.61%
|
|
BMS-833923 (XL-139), an orally bioavailable Smoothened antagonist, inhibits BODIPY cyclopamine binding to SMO in a dose-dependent manner (IC50: 21 nM).
|
T3363 |
Jervine
|
469-59-0
|
99.57%
|
|
The biological activity of Jervine (Jerwiny) is mediated via its interaction with the 7 passes transmembrane protein Smoothened. Jervine binds with and inhibits ...
|
T64351 |
GI-560192
|
301326-41-0
|
99.44%
|
|
GI-560192 (RL-0070933) is a potent smo cilial modulator with an EC50 value of 0.02 µM. GI-560192 modulates the translocation and/or accumulation of smoothened to...
|
T10085 |
20(S)-Hydroxycholesterol
|
516-72-3
|
99.25%
|
|
20(S)-Hydroxycholesterol (20α-Hydroxycholesterol) is an allosteric activator of the oncoprotein smoothened (Smo).
|
T5465 |
PF-5274857
|
1373615-35-0
|
98.99%
|
|
PF-5274857 (PF-5274857 free base) is an effective and selective hedgehog signaling pathway inhibitor (IC50: 5.8 nM and a Ki: 4.6 nM). PF-5274857 is a potentially...
|
T6891 |
MK-4101
|
935273-79-3
|
98.91%
|
|
MK-4101, an effective inhibitor of the Hedgehog pathway, has anti-tumor activity through the induction of extensive apoptosis and inhibition of proliferation in ...
|
T14188 |
ALLO-2
|
1357350-60-7
|
98.67%
|
|
ALLO-2 is a Inhibitor of Drug-Resistant Smo Mutant.It inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM.
|
T24159 |
IHR-1
|
548779-60-8
|
98.6%
|
|
IHR-1 is a Potent Smo antagonist (IC50 = 7.6 nM). Selectively inhibits Hedgehog signaling over Wnt and Notch signaling pathways. Blocks Smo accumulation in prima...
|
T11838 |
LEQ506
|
1204975-42-7
|
98.53%
|
|
LEQ506 is a Smo inhibitor with IC50s of 2 nM and 4 nM for hSmo and mSmo, respectively.
|
T1779 |
SAG
|
912545-86-9
|
98.16%
|
|
SAG (Smoothened Agonist) is a potent Smo receptor agonist and activates the Hedgehog signaling pathway.
|
T1810 |
Purmorphamine
|
483367-10-8
|
98.11%
|
|
Purmorphamine (Shh Signaling Antagonist VI), which directly binds and activates Smoothened, blocks BODIPY-cyclopamine binding to Smo. It also is an inducer of os...
|
T6514 |
Glasdegib
|
1095173-27-5
|
98%
|
|
Glasdegib (PF-04449913) (PF-04449913) is a potent, and orally bioavailable Smoothened (Smo) inhibitor with IC50 of 5 nM. Phase 2.
|
T2250 |
DY131
|
95167-41-2
|
96.72%
|
|
DY131 (DY-131) is a novel selective agonist of ERRβ and ERRγ.
|
T60738 |
JNJ-1289
|
792898-18-1
|
98%
|
|
JNJ-1289 is a selective, potent, and competitive inhibitor of human spermine oxidase (hSMOX) with an IC50 value of 50 nM.JNJ-1289 has potential anticancer and an...
|
T2825 |
Cyclopamine
|
4449-51-8
|
98%
|
|
Cyclopamine (11-Deoxojervine), a Smoothened (Smo) antagonist (IC50: 46 nM in TM3Hh12 cells), belongs to the group of steroidal jerveratrum alkaloids.
|