Smo

Smoothened (Smo), a class Frizzled G protein-coupled receptor (class F GPCR), transduces the Hedgehog (Hh) signal across the cell membrane. The Hh signaling pathway includes both canonical and noncanonical pathways. The canonical Hh pathway functions through major Hh molecules such as Hh ligands, PTCH, Smo, and GLI, whereas the noncanonical Hh pathway involves the activation of Smo or GLI through other pathways. The Hh signaling cascade is initiated by the binding of the Hh protein ligand to its cellular membrane receptor, Patched (PTCH), which relieves PTCH-mediated repression of the seven-transmembrane (7TM) protein Smo. Activated Smo transduces the signal to the GLI family of transcription factors, which translocate to the nucleus to regulate numerous gene products involved in tissue patterning and cell differentiation.

Cat. No.	Product name	CAS No.	Purity
T3460	HhAntag	496794-70-8	98%
T3460	HhAntag is a small molecule inhibitor of GLI1-mediated transcription, an essential down-stream element of the Hedgehog (Hh) pathway with the anti-tumor activity....
T6514	Glasdegib	1095173-27-5	98%
T6514	Glasdegib (PF-04449913) is a potent, and orally bioavailable Smoothened (Smo) inhibitor with IC50 of 5 nM. Phase 2.
T11838	LEQ506	1204975-42-7	98%
T11838	LEQ506 is a Smo inhibitor with IC50s of 2 nM and 4 nM for hSmo and mSmo, respectively.
T9531	MRT-14	1263131-83-4	98%
T9531	MRT-14 is a potent Smo antagonist and can be used in several types of cancers linked to abnormal Hh signaling studies.
T24159	IHR-1	548779-60-8	98%
T24159	IHR-1 is a Potent Smo antagonist (IC50 = 7.6 nM). Selectively inhibits Hedgehog signaling over Wnt and Notch signaling pathways. Blocks Smo accumulation in prima...
T2250	DY131	95167-41-2	98%
T2250	DY131 is a novel selective agonist of ERRβ and ERRγ.
T14188	ALLO-2	1357350-60-7	98%
T14188	ALLO-2 is a Inhibitor of Drug-Resistant Smo Mutant.It inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM.
T2666	Taladegib	1258861-20-9	98%
T2666	Taladegib is an orally bioavailable small molecule antagonist of the Hedgehog (Hh)-ligand cell surface receptor smoothened (Smo) with potential antineoplastic ac...
T1779	SAG	912545-86-9	98%
T1779	SAG is a potent Smo receptor agonist and activates the Hedgehog signaling pathway.
T6891	MK-4101	935273-79-3	98%
T6891	MK-4101, an effective inhibitor of the Hedgehog pathway, has anti-tumor activity through the induction of extensive apoptosis and inhibition of proliferation in ...
T5465	PF-5274857	1373615-35-0	98%
T5465	PF-5274857 is an effective and selective hedgehog signaling pathway inhibitor (IC50: 5.8 nM and a Ki: 4.6 nM). PF-5274857 is a potentially attractive clinical ca...
T10085	20(S)-Hydroxycholesterol	516-72-3	98%
T10085	20(S)-Hydroxycholesterol is an allosteric activator of the oncoprotein smoothened (Smo).
T64351	GI-560192	301326-41-0	98%
T64351	GI-560192 is a potent smo cilial modulator with an EC50 value of 0.02 µM. GI-560192 modulates the translocation and/or accumulation of smoothened to the primary ...
T1810	Purmorphamine	483367-10-8	98%
T1810	Purmorphamine, which directly binds and activates Smoothened, blocks BODIPY-cyclopamine binding to Smo. It also is an inducer of osteoblast differentiation.
T3363	Jervine	469-59-0	98%
T3363	The biological activity of Jervine is mediated via its interaction with the 7 passes transmembrane protein Smoothened. Jervine binds with and inhibits smoothened...
T2825	Cyclopamine	4449-51-8	98%
T2825	Cyclopamine, a Smoothened (Smo) antagonist (IC50: 46 nM in TM3Hh12 cells), belongs to the group of steroidal jerveratrum alkaloids.
T2299	BMS-833923	1059734-66-5	98%
T2299	BMS-833923, an orally bioavailable Smoothened antagonist, inhibits BODIPY cyclopamine binding to SMO in a dose-dependent manner (IC50: 21 nM).
T2450	SANT-1	304909-07-7	98%
T2450	SANT-1 directly binds to Smoothened (Smo) receptor (Kd: 1.2 nM) and inhibits Smo agonist effects (IC50: 20 nM).
T15727	Sonidegib diphosphate	1218778-77-8	98%
T15727	Erismodegib diphosphate is an effective and selective Smo antagonist (IC50: 1.3 nM and 2.5 nM for mouse and human Smo in a binding assay, respectively).
T12109	MRT-83	1263131-92-5	98%
T12109	MRT-83 is a potent Smo antagonist.