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PAI-1

Plasminogen activator inhibitor-1 (PAI-1) also known as endothelial plasminogen activator inhibitor or serpin E1 is a protein that in humans is encoded by the SERPINE1 gene. Elevated PAI-1 is a risk factor for thrombosis and atherosclerosis,PAI-1 is a serine protease inhibitor (serpin) that functions as the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), the activators of plasminogen and hence fibrinolysis (the physiological breakdown of blood clots). It is a serine protease inhibitor (serpin) protein (SERPINE1).The other PAI, plasminogen activator inhibitor-2 (PAI-2) is secreted by the placenta and only present in significant amounts during pregnancy. In addition, protease nexin acts as an inhibitor of tPA and urokinase. PAI-1, however, is the main inhibitor of the plasminogen activators.

  • TM5441
    T42541190221-43-2
    TM5441 is an orally bioavailable inhibitor of plasminogen activator inhibitor 1 (PAI-1).
    • $34
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  • Toddalolactone
    T4S0592483-90-9
    Toddalolactone ((+)-Toddalolactone) is an anti-inflammatory and analgesic.
    • $100
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  • TM5007
    T8962342595-05-5
    TM5007 is a poent inhibitor of plasminogen activator inhibitor-1 (PAI-1; IC50 of 29 uM).
    • $148
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  • GW-6604
    T9947452342-37-9In house
    GW-6604 is an ALK5 inhibitor and shows clear antifibrotic effects resulting in liver function improvement.
    • $30
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  • AZ3976
    T237641418747-15-5
    AZ3976 is an inhibitor of PAI-1 with an IC50 of 16 μM in a plasma clot lysis assay. AZ3976 displays profibrinolytic activities.
    • $39
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  • Upamostat
    T13257590368-25-5
    Upamostat is an inhibitor of a serine protease and is a urokinase plasminogen activator (uPA) inhibitor.
    • $97
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  • Loureirin B
    T3876119425-90-0
    Loureirin B can downregulate the expression of fibrosis-related molecules by regulating MMPs and TIMPs levels, inhibit scar fibroblast proliferation and suppress TGF-β1-induced fibrosis, during which TGF-β1/Smad2/3 pathway is likely involved.
    • $64
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  • Angstrom6
    T26629220334-14-5
    Angstrom6 (A-6 peptide) is an 8 amino acid peptide derived from single chain urokinase fibrinogen activator (scuPA) that interferes with the uPA/uPAR cascade and abrogates the downstream effects.Angstrom6 has antitumor activity and inhibits tumor cell migration, invasion, and metastasis by binding to CD44 and modulating CD44-mediated cell signaling.
    • $49
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  • Aleplasinin
    T29856481629-87-2
    Aleplasinin (PAZ 417) is a selective and orally active inhibitor of Plasminogen activator inhibitor-1(PAI-1) and a key negative regulator of the fibrinolytic system. Aleplasinin can be used in Alzheimer's disease studies.
    • $125
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  • Tiplaxtinin
    T2030393105-53-8
    Tiplaxtinin (Tiplasinin)(PAI-039) is a selective and orally efficacious inhibitor of plasminogen activator inhibitor-1 (PAI-1) with IC50 of 2.7 uM.
    • $37
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  • UK-371804
    T3442256477-09-5
    UK-371804 is an effective and specific uPA inhibitor. It was selected as a candidate for further preClinicalal evaluation for the treatment of chronic dermal ulcers.
    • $44
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  • TM5275 sodium
    T42551103926-82-4
    TM5275 sodium (TM5275 sodium salt) is an inhibitor of plasminogen activator inhibitor 1 (PAI-1).
    • $40
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