T14847 |
B I09
|
1607803-67-7
|
98%
|
|
B I09, an IRE-1 RNase inhibitor with an IC50 of 1230 nM, inhibits splicing of XBP1 mRNA in human WaC3 cells and expression of xbp-1 in LPS-stimulated B cells. B ...
|
TQ0101 |
MKC3946
|
1093119-54-0
|
98%
|
|
MKC3946 is an effective and soluble IRE1α inhibitor which triggered modest growth inhibition in multiple myeloma cell lines.
|
T9564 |
IRE1α kinase-IN-1
|
2328097-41-0
|
98%
|
|
IRE1α kinase-IN-1 is a highly selective IRE1α (ERN1) inhibitor, with an IC50 of 77 nM. It displays 100-fold selectivity for IRE1α over the IRE1β isoform. It inhi...
|
T6681 |
STF-083010
|
307543-71-1
|
98%
|
|
STF-083010 is a selective inhibitor of the IRE1α endonuclease.
|
T6363 |
4μ8C
|
14003-96-4
|
98%
|
|
4μ8C(IC50=76 nM) is an effective and specific IRE1 Rnase inhibitor.
|
T11488 |
GSK2850163
|
2121989-91-9
|
98%
|
|
GSK2850163 is a novel inhibitor of inositol-requiring enzyme-1 alpha (IRE1α) which can inhibit RNase activity and IRE1α kinase activity (IC50s: 200 and 20 nM).
|
T9848 |
GSK2850163 (S enantiomer)
|
2309519-81-9
|
98%
|
|
GSK2850163 (S enantiomer) is the inactive enantiomer of GSK2850163. GSK2850163 is an novel inhibitor of inositol-requiring enzyme-1 alpha (IRE1a).
|
T0374L |
Sunitinib
|
557795-19-4
|
98%
|
|
Sunitinib, a multi-targeted RTK inhibitor, is targeting PDGFRβ and VEGFR2 (Flk-1) with IC50 of 2 nM and 80 nM and also inhibits c-Kit.
|
T0374 |
Sunitinib Malate
|
341031-54-7
|
98%
|
|
Sunitinib is an indolinone-based tyrosine kinase inhibitor. It blocks the tyrosine kinase activities of VEGFR2, PDGFRβ (IC50: 80/2 nM), and c-kit.
|
T17143 |
Toyocamycin
|
606-58-6
|
98%
|
|
Toyocamycin is an adenosine analog produced by Actinomycete, acts as an XBP1 inhibitor, inhibits IRE1α-induced ATP-dependent XBP1 mRNA cleavage (IC50: 80 nM). To...
|
T11762L |
Kira8
|
1630086-20-2
|
98%
|
|
Kira8 is a mono-selective IRE1α inhibitor that allosterically attenuates IRE1α RNase activity (IC50: 5.9 nM).
|
T9349 |
IXA4
|
1185329-96-7
|
98%
|
|
IXA4 is a highly selective, nontoxic activator of IRE1/XBP1s and reduces APP secretion by activating IRE1. IXA4-stimulated IRE1 activation also enhanced pancreat...
|
T3654 |
APY29
|
1216665-49-4
|
98%
|
|
APY29 is an allosteric modulator of IRE1α; inhibits IRE1α autophosphorylation (IC50 = 280 nM) and activates IRE1α RNase activity.
|
TQ0076 |
KIRA6
|
1589527-65-0
|
98%
|
|
KIRA6 is an effective inhibitor of IRE1α RNase kinase (IC50: 0.6 µM). It can trigger an apoptotic response.
|
T12071 |
MKC9989
|
1338934-20-5
|
98%
|
|
MKC9989 is an inhibitor of Hydroxy aryl aldehydes (HAA). MKC9989 also inhibits IRE1α with an IC50 of 0.23 to 44 μM.
|
T7483 |
6-Bromo-2-hydroxy-3-methoxybenzaldehyde
|
20035-41-0
|
98%
|
|
6-Bromo-2-hydroxy-3-methoxybenzaldehyde is an inhibitor of IRE-1α (IC50 : 0.08 μM).
|
T15594 |
MKC8866
|
1338934-59-0
|
98%
|
|
MKC8866 is a selective IRE1 RNase inhibitor (IC50: 0.29 μM in human vitro). MKC8866 inhibits IRE1 RNase in breast cancer cells leading to the decreased productio...
|