Shopping Cart
- Remove All
Your shopping cart is currently empty
(8)
Cell Cycle/Checkpoint
Argentina
Australia
Austria
Belgium
Brazil
Bulgaria
Croatia
Cyprus
Czech
Denmark
Egypt
Estonia
Finland
France
Germany
Greece
Hong Kong
Hungary
Iceland
India
Ireland
Israel
Italy
Japan
Korea
Latvia
Lebanon
Malaysia
Malta
Morocco
Netherlands
New Zealand
Norway
Poland
Portugal
Romania
Singapore
Slovakia
Slovenia
Spain
Sweden
Switzerland
Taiwan,China
Thailand
Turkey
United Kingdom
United States
Other Countries
Select your Country or Region
Cell Cycle/CheckpointIRE1
Inositol-requiring enzyme 1 (IRE1) is a bifunctional serine/threonine kinase and endoribonuclease that is a major mediator of the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. It represents a potential therapeutic target for a number of diseases associated with endoplasmic reticulum stress. IRE1 is the only identified ER stress sensor in yeast and essential for UPR in animals and plants. As an ER transmembrane protein, IRE1 monitors ER homeostasis through an ER luminal stress-sensing domain and triggers UPR through a cytoplasmic kinase domain and an RNase domain. Upon ER stress, IRE1 RNase is activated through conformational change, autophosphorylation, and higher order oligomerization. Mammalian IRE1 initiates diverse downstream signaling of the UPR either through unconventional splicing of the transcription factor Xbp-1 or and through posttranscriptional modifications via Regulated IRE1-Dependent Decay (RIDD) of multiple substrates.
- 4μ8CT636314003-96-44μ8C (IRE1 Inhibitor III)(IC50=76 nM) is an effective and specific IRE1 Rnase inhibitor.
- $43
SizeQTY
Cited - GSK2850163 (S enantiomer)T98482309519-81-9In houseGSK2850163 (S enantiomer) is the inactive enantiomer of GSK2850163. GSK2850163 is an novel inhibitor of inositol-requiring enzyme-1 alpha (IRE1a).
- $117
SizeQTY
- B I09T148471607803-67-7In houseB I09, an IRE-1 RNase inhibitor with an IC50 of 1230 nM, inhibits splicing of XBP1 mRNA in human WaC3 cells and expression of xbp-1 in LPS-stimulated B cells. B I09 can be used to simulate the defects of XBP-1 in CLL cells., an IRE-1 RNase inhibitor with an IC50 of 1230 nM, inhibits splicing of XBP1 mRNA in human WaC3 cells and expression of xbp-1 in LPS-stimulated B cells. B I09 can be used to simulate the defects of XBP-1 in CLL cells., an IRE-1 RNase inhibitor with an IC50 of 1230 nM, inhibits splicing of XBP1 mRNA in human WaC3 cells and expression of xbp-1 in LPS-stimulated B cells. B I09 can be used to simulate the defects of XBP-1 in CLL cells.
- $44
SizeQTY - GSK2850163T114882121989-91-9In houseGSK2850163 is a novel inhibitor of inositol-requiring enzyme-1 alpha (IRE1α) which can inhibit RNase activity and IRE1α kinase activity (IC50s: 200 and 20 nM).
- $64
SizeQTY - APY29T36541216665-49-4APY29 is an allosteric modulator of IRE1α; inhibits IRE1α autophosphorylation (IC50 = 280 nM) and activates IRE1α RNase activity.
- $36
SizeQTY Cited - STF-083010T6681307543-71-1STF-083010 is a selective inhibitor of the IRE1α endonuclease.
- $47
SizeQTY Cited - KIRA6TQ00761589527-65-0KIRA6 is an effective inhibitor of IRE1α RNase kinase (IC50: 0.6 μM). It can trigger an apoptotic response.
- $39
SizeQTY Cited - SunitinibT0374L557795-19-4Sunitinib (SU 11248) is a multi-targeted receptor tyrosine kinase (RTK) inhibitor that inhibits VEGFR2 and PDGFRβ (IC50=80/2 nM). Sunitinib has antitumor activity and can be used for the treatment of kidney cancer and gastrointestinal tumors.
- $53
SizeQTY Cited - MKC9989T120711338934-20-5MKC9989 is an inhibitor of Hydroxy aryl aldehydes (HAA). MKC9989 also inhibits IRE1α with an IC50 of 0.23 to 44 μM.
- $79
SizeQTY - D-F07T843112361297-58-5D-F07 is a novel fluorescent IRE-1 RNase inhibitor and a tricyclic chromone with potential anticancer activity.
- $195
SizeQTY - IRE1α kinase-IN-1T95642328097-41-0IRE1α kinase-IN-1 is a highly selective IRE1α (ERN1) inhibitor, with an IC50 of 77 nM. It displays 100-fold selectivity for IRE1α over the IRE1β isoform. It inhibits ER stress-induced IRE1α oligomerization and autophosphorylation, and also inhibits IRE1α RNase activity (IC50=80 nM)
- $118
SizeQTY - Sunitinib MalateT0374341031-54-7Sunitinib Malate (Sunitinib) is an indolinone-based tyrosine kinase inhibitor. It blocks the tyrosine kinase activities of VEGFR2, PDGFRβ (IC50: 80/2 nM), and c-kit.
- $37
SizeQTY - 6-Bromo-2-hydroxy-3-methoxybenzaldehydeT748320035-41-06-Bromo-2-hydroxy-3-methoxybenzaldehyde (NSC-95682) is an inhibitor of IRE-1α (IC50 : 0.08 μM).
- $39
SizeQTY - ToyocamycinT17143606-58-6Toyocamycin (Vengicide) is an adenosine analog produced by Actinomycete, acts as an XBP1 inhibitor, inhibits IRE1α-induced ATP-dependent XBP1 mRNA cleavage (IC50: 80 nM). Toyocamycin induces apoptosis.
- $39
SizeQTY - IRE1α kinase-IN-9T790631338933-30-4IRE1α kinase-IN-9 (compound 2) is a potent inhibitor of IRE-1α, demonstrating an average IC50 value of less than 0.1 μM. It is suitable for research into diseases linked to the unfolded protein response or regulated IRE1-dependent decay (RIDD) [1].
- $1,520
SizeQTY - IXA6T625681021106-40-0IXA6 is a novel IRE1/XBP1s agonist with potential vasoprotective activity that activates IRE1-XBP1s signaling and XBP1s transcriptional response, which can be used to study neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease.
- $299
SizeQTY - IXA4T93491185329-96-7IXA4 is a highly selective, nontoxic activator of IRE1/XBP1s and reduces APP secretion by activating IRE1. IXA4-stimulated IRE1 activation also enhanced pancreatic function.
- $34
SizeQTY - MKC8866T155941338934-59-0MKC8866 is a selective IRE1 RNase inhibitor (IC50: 0.29 μM in human vitro). MKC8866 inhibits IRE1 RNase in breast cancer cells leading to the decreased production of pro-tumorigenic factors and it can inhibit prostate cancer (PCa) tumor growth.
- $80
SizeQTY - IRE1α kinase-IN-8T790621338933-29-1IRE1α kinase-IN-8, a benzoheterocyclecarboxaldehyde derivative, serves as a potent inhibitor of IRE-1α. This compound is utilized in research pertaining to diseases linked to the unfolded protein response and regulated IRE1-dependent decay (RIDD) [1].
- $1,520
SizeQTY - Kira8T11762L1630086-20-2Kira8 (AMG-18) is a mono-selective IRE1α inhibitor that allosterically attenuates IRE1α RNase activity (IC50: 5.9 nM).
- $89
SizeQTY - MKC3946TQ01011093119-54-0MKC3946 is an effective and soluble IRE1α inhibitor which triggered modest growth inhibition in multiple myeloma cell lines.
- $61
SizeQTY
Go to page 1
Page of 1
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.