ATM/ATR

ATM serine/threonine kinase, symbol ATM, is a serine/threonine protein kinase that is recruited and activated by DNA double-strand breaks. It phosphorylates several key proteins that initiate activation of the DNA damage checkpoint, leading to cell cycle arrest, DNA repair or apoptosis. Several of these targets, including p53, CHK2, BRCA1, NBS1 and H2AX are tumor suppressors. ATR is a serine/threonine kinase and belongs to the phosphoinositide 3- kinase related protein kinases (PIKKs), particularly to ATM (ataxia telangiectasia mutated) subfamily. It functions to maintain genome integrity by stabilizing replication forks and by regulating cell cycle progression and DNA repair.

Cat. No.	Product name	CAS No.	Purity
T10396	ATM Inhibitor-1	2135639-94-8	98%
T10396	ATM Inhibitor-1 is a highly potent, selective and orally active ATM inhibito (IC50: 0.7 nM) anti-tumor activity. It shows weak activity against mTOR (IC50, 21 μM...
T10407	Gartisertib	1613191-99-3	98%
T10407	ATR inhibitor 2 is an orally active, ATP-competitive, and selective ATR inhibitor (Ki <150 pM) with antitumor activity. ATR inhibitor 2 potently inhibits ATR-dri...
T16773	Ro 90-7501	293762-45-5	98%
T16773	Ro 90-7501 is an amyloid β42 fibril assembly inhibitor (EC50: 2 μM). Ro 90-7501 inhibits ATM phosphorylation and DNA repair. Ro 90-7501 also inhibits PP5 in a TP...
T15673	KU 59403	845932-30-1	98%
T15673	KU 59403 is an effective ATM inhibitor (IC50: 3 nM, 9.1 μM, and 10 μM for ATM, DNA-PK, and PI3K, respectively).
TN1673	Garcinone C	76996-27-5	98%
TN1673	Garcinone C is a xanthone derivative extracted from Garcinia oblongifolia Champ with anti-inflammatory, astringency, and granulation-promoting activities. Garcin...
T10406	Tuvusertib	1613200-51-3	98%
T10406	Tuvusertib is an orally available ataxia telangiectasia and Rad3-related (ATR) kinase inhibitor (Ki< 1 µΜ) with selective and potentially antitumor activity.Tuvu...
T2433	NU 7026	154447-35-5	98%
T2433	NU7026 is an effective DNA-PK inhibitor (IC50: 0.23 μM, in cell-free assays), 60-fold selective for DNA-PK than PI3K and no inhibition against both ATM and ATR.
T63872	KU-60019	925701-46-8	98%
T63872	KU-60019 is a specific inhibitor of ATM kinase (IC50: 6.3 nM).
T19671	AZ31	2088113-98-6	98%
T19671	AZ31 is an ATM inhibitor with potency, high selectivity, and oral activity.AZ31 inhibits ATM enzymes, intracellular ATM, with IC50 values of <1.2 nM and 46 nM, r...
T1958	AZ20	1233339-22-4	98%
T1958	AZ20 is an effective and specific inhibitor of ATR kinase (IC50: 5 nM, in a cell-free assay), 8-fold selectivity over mTOR.
T62083	Camonsertib	2417489-10-0	98%
T62083	RP-3500 (ATR inhibitor 4) is a selective, orally active ATR kinase inhibitor (ATRi) with an IC50: 1.00 nM in biochemical assays and exhibits potent antitumour ef...
T6770	AZD0156	1821428-35-6	98%
T6770	AZD0156 , an effective and specific inhibitors of ATM kinase, is potential antineoplastic activities and chemo-/radio-sensitizing.
T5175	Azd1390	2089288-03-7	98%
T5175	AZD1390 is an exceptionally potent inhibitor of ATM in cells (IC50: 0.78 nM) with >10,000-fold selectivity over closely related members of the PIKK family of enz...
T6100	Torin 2	1223001-51-1	98%
T6100	Torin 2(IC50=0.25 nM), a specific and effective mTOR inhibitor, is the 800-fold greater specific activity for mTOR than PI3K and improves pharmacokinetic propert...
T2084	ETP-46464	1345675-02-6	98%
T2084	ETP-46464 is an effective and specific ATR inhibitor (IC50: 25 nM).
T1821	CGK733	905973-89-9	98%
T1821	CGK 733 is a potent and selective inhibitor of ATM/ATR.
T2669	Berzosertib	1232416-25-9	98%
T2669	VE-822 has been used in trials studying the treatment of Ovarian Neoplasms, Ovarian Serous Tumor, Adult Solid Neoplasm, Advanced Solid Tumor, and Advanced Solid ...
T7318	Elimusertib	1876467-74-1	98%
T7318	BAY 1895344 is a potent, highly selective and orally available ATR inhibitor with an IC50 of 7 nM.BAY 1895344 shows potent anti-tumor efficacy in monotherapy and...
T6283	Wortmannin	19545-26-7	98%
T6283	Wortmannin is the first described PI3K inhibitor with IC50 of 3 nM, with little selectivity within the PI3K family. Also blocks autophagosome formation and poten...
T2685	KU-55933	587871-26-9	98%
T2685	KU-55933 (ATM Kinase Inhibitor) is a potent and specific ATM inhibitor.