T78711 |
A011
|
|
98%
|
|
A011, a potent and selective ataxia-telangiectasia mutated (ATM) inhibitor, exhibits an IC50 of 1.0 nM and triggers apoptosis as well as G2/M phase cell cycle ar...
|
T78959 |
ATR-IN-23
|
2923800-62-6
|
98%
|
|
ATR-IN-23 (Compound 34), a potent and selective ATR inhibitor, exhibits an IC50 of 1.5 nM, has demonstrated antiproliferative effects on LoVo cells, and induces ...
|
T79031 |
ATR-IN-21
|
2905312-17-4
|
98%
|
|
ATR-IN-21, also known as compound 60, is a potent inhibitor of ATR, exhibiting an IC50 of less than 1000 nM [1].
|
T79033 |
ATR-IN-22
|
2905312-07-2
|
98%
|
|
ATR-IN-22 (Compound 34), an orally active ATR inhibitor, exhibits potent anti-proliferative effects on MIAPaCa-2 cells with an IC50 value of less than 1 μM and d...
|
T79058 |
ATR-IN-24
|
2370889-43-1
|
98%
|
|
ATR-IN-24 (Compound 1) is an ATR inhibitor with demonstrated anticancer activity [1].
|
T79121 |
ATR-IN-29
|
2761193-67-1
|
98%
|
|
ATR-IN-29, a potent, orally active inhibitor of ATR kinase, exhibits an IC50 of 1 nM and demonstrates antiproliferative activity [1].
|
T79305 |
ATM Inhibitor-8
|
|
98%
|
|
ATM Inhibitor-8 (Compound 10r) is a potent, selective, and orally active inhibitor of ATM, exhibiting anti-tumor activity [1], characterized by an IC50 value of ...
|
T79306 |
ATM Inhibitor-9
|
|
98%
|
|
ATM Inhibitor-9 (Compd 7a) is a potent inhibitor of ATM kinase, exhibiting an IC50 value of 5 nM, and is utilized in cancer research [1].
|
T15673 |
KU 59403
|
845932-30-1
|
98%
|
|
KU 59403 is an effective ATM inhibitor (IC50: 3 nM, 9.1 μM, and 10 μM for ATM, DNA-PK, and PI3K, respectively).
|
T10407 |
Gartisertib
|
1613191-99-3
|
98%
|
|
ATR inhibitor 2 is an orally active, ATP-competitive, and selective ATR inhibitor (Ki <150 pM) with antitumor activity. ATR inhibitor 2 potently inhibits ATR-dri...
|
T10396 |
ATM Inhibitor-1
|
2135639-94-8
|
98%
|
|
ATM Inhibitor-1 is a highly potent, selective and orally active ATM inhibito (IC50: 0.7 nM) anti-tumor activity. It shows weak activity against mTOR (IC50, 21 μM...
|
T4443 |
AZ32
|
2288709-96-4
|
99.94%
|
|
AZ32 is an orally bioavailable and blood-brain barrier-penetrating ATM inhibitor with an IC50 of <6.2 nM for ATM enzyme, and an IC50 of 0.31 μM for ATM in cell.
|
T10468 |
Elimusertib hydrochloride(1876467-74-1 free base)
|
T10468
|
99.86%
|
|
Elimusertib hydrochloride(1876467-74-1 free base) (BAY-1895344 hydrochloride) is a effective, orally available and selective ATR inhibitor with anti-tumor activi...
|
T6612 |
NU6027
|
220036-08-8
|
99.85%
|
|
NU6027 is a potent ATR/CDK inhibitor, inhibits CDK1/2, ATR and DNA-PK with Ki of 2.5 μM/1.3 μM, 0.4 μM and 2.2 μM, enter cells more readily than the 6-aminopurin...
|
T6261 |
CP-466722
|
1080622-86-1
|
99.85%
|
|
CP-466722, an effective and reversible ATM inhibitor, does not inhibit ATR and PI3K or PIKK family members in cells.
|
T2616 |
PIK-93
|
593960-11-3
|
99.83%
|
|
PIK-93 is the first potent, synthetic PI4K inhibitor with IC50 of 19 nM; inhibits PI3Kα with IC50 of 39 nM.
|
T2685 |
KU-55933
|
587871-26-9
|
99.80%
|
|
KU-55933 (ATM Kinase Inhibitor) is a potent and specific ATM inhibitor.
|
T3338 |
Ceralasertib
|
1352226-88-0
|
99.76%
|
|
Ceralasertib (AZD6738) is an orally active, and selective ATR kinase inhibitor with IC50 of 1 nM.
|
T4251 |
GJ103 sodium salt
|
1459687-96-7
|
99.75%
|
|
GJ103 sodium salt is an active analog of GJ072, a read-through compound. It has been shown to reduce the surface tension of aqueous solutions, which makes it eas...
|
T7318 |
Elimusertib
|
1876467-74-1
|
99.72%
|
|
Elimusertib (BAY-1895344) is a potent, highly selective and orally available ATR inhibitor with an IC50 of 7 nM.Elimusertib shows potent anti-tumor efficacy in m...
|