suppressive — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T3382	Wilforlide A	Abruslactone A,3-Epiabruslactone A,Regelide	Tyrosinase
	Wilforlide A (3-Epiabruslactone A) is a natural product, separated from the ethanolic extract of tripterygium wilfordii. High-dose wilforlide A has obvious anti-inflammatory effect, but has no significant immune suppress...		Tyrosinase
T1473	Trilostane	Win 24540	Dehydrogenase
	Trilostane (Win 24540) is a synthetic derivative of androstane with adrenocortical suppressive properties. Trilostane reversibly inhibits 3 beta-hydroxysteroid dehydrogenase delta 5-4 isomerase in the adrenal cortex.		Dehydrogenase
TN1560	Dehydroeffusol	5-Ethenyl-1-Methylphenanthrene-2,7-Diol,Dehydro Effusol	MMP , ERK , GPR , Others
	Dehydroeffusol (Dehydro Effusol) possesses anti-cancer, anxiolytic and sedative properties. Dehydroeffusol inhibits gastric cancer cell growth and tumorigenicity by selectively inducing tumor-suppressive endoplasmic reti...		MMP , ERK , GPR , Others
T30808	CG500354	CG-500354,CG 500354
	CG500354 plays a tumor suppressive role through the cAMP/CREB signaling pathway and is a novel inducer of neural differentiation and growth arrest in primary HUMAN GBM derived cells.
T81947	Laxiflorin B-4		ERK
	Laxiflorin B-4, a derivative of Laxiflorin B, demonstrates increased affinity for ERK1/2 and enhanced tumor-suppressive effects [1].		ERK
T74010	(Rac)-Mono(3,5,5-trimethylhexyl) phthalate
	(Rac)-Mono(3,5,5-trimethylhexyl) phthalate, a significant metabolite of widely utilized phthalate plasticizers, exhibits an immuno-suppressive effect [1].
T39342	4-Maleimidosalicylic acid
	4-Maleimidosalicylic acid is a polar maleimide compound that does not exhibit suppressive effects on IL-2 production in JURKAT T cells.
TN2181	Sarmentosin		Others
	Sarmentosin significantly lowers the SGPT level of patients suffering from chronic viral hepatitis, and shows a suppressive effect on cell-mediated immune responses in mice. It shows a good effect in lowering serum gluta...		Others
TN3482	Bakkenolide B		NOS , COX
	Bakkenolide B has suppressive properties for allergic and inflammatory responses and may be utilized as a potent agent for the treatment of asthma.		NOS , COX
TN3125	5-Methoxycanthin-6-one		Others
	5-Methoxycanthin-6-one displays moderate cytotoxic activity against the human prostate cancer cell PC-3 line, with IC50 values ranging from 13.5-15.4 uM versus doxorubicine with IC50 = 1.5 uM. It also exhibits a clear su...		Others
T78291	Tregalizumab	BT-061
	Tregalizumab, a humanized IgG1-type monoclonal antibody targeting CD4, selectively activates regulatory T cells (Tregs) with suppressive functions in vitro and has potential applications in researching autoimmune disease...
T4134L	OTS514	OTS514 HCl,OTS514 Hydrochloride,OTS-514,OTS 514	Apoptosis , TOPK
	OTS514 (OTS514 Hydrochloride) is a potent TOPK inhibitor. OTS514 exhibits a growth-suppressive effect on small cell lung cancer. OTS514 effectively suppressed the growth of SCLC cell lines (IC50: 0.4 ~ 42.6 nM). Treatmen...		Apoptosis , TOPK
T64004	DX3-234
	DX3-234 is an inhibitor of oxidative phosphorylation (OXPHOS). In a Pan02 homozygous model of pancreatic cancer, DX3-234 exhibits significant tumour suppressive activity.
T81555	Pancreastatin (33-49), porcine
	Pancreastatin (33-49), porcine, a peptide fragment derived from the porcine pancreas, exerts insulin-suppressive effects in vitro and augments the glucose priming effect [1] [2].
T72909	D-(+)-Sorbose
	D-(+)-Sorbose, the active enantiomer of D-Sorbose, inhibits disaccharidase activity and demonstrates suppressive effects on postprandial blood glucose and insulin levels in rats. Its role as a sweetener may aid in preven...
TP1557	Urocortin II, human TFA
	Human urocortin (hUcn) II is a new member of the corticotropin-releasing-factor (CRF) family. It selectively binds to the CRF2 receptor. Human urocortin II exhibits mild motor-suppressive effects and delayed anxiolytic-l...
T80966	Topsalysin	PRX-302
	Topsalysin, a prostate-specific antigen (PSA)-activated protoxin, comprises a synthetic proaerolysin fusion protein targeting human prostate-specific antigen. This compound has demonstrated tumor-suppressive effects in a...
T82711	CKS-17
	CKS-17, a synthetic retroviral envelope peptide, embodies conserved amino acid sequences found in the transmembrane envelope proteins of various animal and human retroviruses. This immunomodulatory epitope exerts suppres...
T73508	FLDP-5
	FLDP-5, a blood-brain barrier (BBB) penetrant curcuminoid analogue, induces the production of Reactive Oxygen Species (ROS), DNA damage, and cell cycle S phase arrest. It demonstrates significant tumor-suppressive effect...
T35460	β-Endorphin (rat)
	β-Endorphin (β-EP) is an endogenous opioid neuropeptide with diverse biological activities. It is produced via piomelanocortin cleavage in the pituitary gland, hypothalamus, and in lymphocytes, then migrates to its sites...