protac-i

PROTAC-I targets steroid hormone receptors for ubiquitination and degradation.

I-BET762 carboxylic acid is an inhibitor of BRD4(pIC50 of 5.1).

PROTAC IRAK4 degrader-1 (compound I-210) is a Cereblon based PROTAC consisting of the PROTAC IRAK4 ligand-1, the E3 ligase ligand Pomalidomide and the PROTAC linker AM-Imidazole-PA-Boc.

Compound I-291, also known as PROTAC SMARCA2 4-degrader-30, targets the catalytic subunits of the SWI SNF complex, specifically SMARCA2 and SMARCA4. It effectively degrades SMARCA2 in A549 and MV411 cells, as well as SMARCA4 in MV411 cells, with a degradation concentration (DC50) of less than 100 nM.

PROTAC SMARCA2 4-degrader-29 (Compound I-279) serves as a degrader for the catalytic subunits SMARCA2 and SMARCA4 of the SWI SNF complex. In A549 cells, this compound effectively degrades SMARCA2 with a DC50 value of less than 100 nM, and similarly degrades SMARCA4 in MV411 cells with a DC50 under 100 nM.

PROTAC SMARCA2 degrader-6 (compound I-427) is a PROTAC molecule targeting SMARCA2, exhibiting a DC50 of less than 100 nM and a maximum degradation rate (Dmax%) of over 90% in A549 cells after 24 hours of treatment.

SMARCA2 degrader-4 (compound I-332) is a PROTAC-based degrader targeting the SMARCA2 protein, exhibiting a DC50 value of less than 100 nM in A549 cells and achieving a maximum degradation rate (Dmax%) of over 90% after a 24-hour treatment period.

PROTAC SMARCA2 4-degrader-32 (compound I-446) is a PROTAC degrader targeting both SMARCA2 and SMARCA4 proteins. In A549 cells, it shows DC50s values for the degradation of SMARCA2 4 proteins <100 nM and achieves a maximum degradation rate (Dmax%) of >90 after 24 hours of treatment.

PROTAC SMARCA2 degrader-17 (compound I-290) is a targeted PROTAC degrader for SMARCA2. It exhibits a DC50 of less than 100 nM and achieves a maximum degradation efficiency (Dmax%) of over 90% in A549 cells after 24 hours of treatment.

Compound I-431, also known as SMARCA2 4-degrader-2, is a PROTAC degrader targeting SMARCA2 and SMARCA4. In A549 cells, it degrades SMARCA2 4 proteins with DC50s values of less than 100 nM and achieves a maximum degradation rate (Dmax%) exceeding 90% after a 24-hour treatment.

Compound I-439, also known as SMARCA2 4-degrader-7, is a PROTAC degrader targeting SMARCA2 and SMARCA4. In A549 cells, it degrades SMARCA2 4 proteins with DC50s values less than 100 nM and achieves a maximum degradation rate (Dmax%) exceeding 90% after a 24-hour treatment.

SMARCA2 degrader-14 (compound I-408) is a PROTAC degrader targeting both SMARCA2 and SMARCA4. In A549 cells, it achieves degradation of SMARCA2 4 proteins with DC50s less than 100 nM and a maximal degradation rate (Dmax%) exceeding 90% after a 24-hour treatment.

PROTAC SMARCA2 4-degrader-33 (compound I-277) functions as a degrader targeting the proteins SMARCA2 and SMARCA4, exhibiting DC50s values of less than 100 nM for the degradation of SMARCA2 4 in A549 cells. After a treatment period of 24 hours, the maximum degradation rates (Dmax%) consistently exceed 90%.

PROTAC SMARCA2 degrader-16 (compound I-278) is a PROTAC targeting SMARCA2. It demonstrates degradation of the SMARCA2 protein with a DC50<100 nM in A549 cells, achieving a maximal degradation rate (Dmax%) of over 90% after 24 hours of treatment.

SMARCA2 degrader-13 (compound I-406) acts as a PROTAC degrader targeting SMARCA2. It exhibits a DC50 of less than 100 nM for the degradation of SMARCA2 protein in A549 cells, achieving a maximum degradation rate (Dmax%) of over 90% after 24 hours of treatment.

PROTACBRD4-DCAF1 degrader-1 (I-907) is a PROTAC degrader targeting BRD4-DCAF1, exhibiting a DC50 range of 10~100 nM.

PROTAC SMARCA2 degrader-9 (compound I-285) is a PROTAC degrader targeting SMARCA2. It degrades SMARCA2 protein in A549 cells with a DC50 value of less than 100 nM and achieves a maximum degradation rate (Dmax%) of over 90% after 24 hours of treatment.

SMARCA2 degrader-15 (compound I-409) is a PROTAC degrader targeting SMARCA2 and SMARCA4. In A549 cells, it achieves DC50s for SMARCA2 4 degradation of less than 100 nM, with a maximum degradation rate (Dmax%) exceeding 90% after a 24-hour treatment.

PROTAC SMARCA2 degrader-10 (compound I-507) is a targeted degrader of SMARCA2, demonstrating a DC50 of less than 100 nM in A549 cells, with a maximum degradation rate (Dmax%) exceeding 90% after 24 hours of treatment.

Compound I-430, known as SMARCA2 4-degrader-1, is a PROTAC degrader targeting SMARCA2 and SMARCA4. In A549 cells, it achieves degradation of SMARCA2 4 proteins with DC50s values under 100 nM and demonstrates a maximal degradation rate (Dmax%) exceeding 90% after a 24-hour treatment.

PROTAC SMARCA2 4-degrader-16 (compound I-337) serves as a PROTAC degrader targeting both SMARCA2 and SMARCA4 proteins, achieving DC50s values under 100 nM in A549 cells with a Dmax% exceeding 90 after 24 hours of treatment.

SMARCA2 degrader-2 (compound I-322) is a PROTAC degrader targeting SMARCA2; it achieves a DC50 of less than 100 nM for the degradation of SMARCA2 protein in A549 cells, with a maximum degradation rate (Dmax%) exceeding 90% after 24 hours of treatment.

SMARCA2 degrader-3 (compound I-323) is a PROTAC molecule designed to target and degrade the SMARCA2 protein. In A549 cells, it exhibits a degradation half-maximal concentration (DC50) of less than 100 nM and achieves a maximum degradation rate (Dmax%) greater than 90% after 24 hours of treatment.

PROTAC SMARCA2 degrader-20 (Compound I-40) is a potent degrader of PROTAC SMARCA2, showing potential for cancer research applications.