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Results for "

phosphoinositide 3-kinase p110α

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    22
    TargetMol | Inhibitors_Agonists
  • Recombinant Protein
    1
    TargetMol | Recombinant_Protein
  • Antibody Products
    3
    TargetMol | Antibody_Products
LY294002
SF 1101, NSC 697286, LY 294002
T2008154447-36-6
LY294002 (SF 1101) is a broad-spectrum inhibitor of PI3K, inhibiting PI3Kα, PI3Kδ, and PI3Kβ (IC50=0.5 0.57 0.97 μM). LY294002 is also an inhibitor of DNA-PK (IC50=1.4 μM) and an inhibitor of CK2 (IC50=98 nM). LY294002 activates apoptosis and autophagy.
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TargetMol | Inhibitor Hot
Alpelisib
BYL-719
T19211217486-61-7
Alpelisib (BYL-719) is a PI3Kα inhibitor (IC50=5 nM) with selective, potent, and oral activity, inhibiting PI3Kβ γ δ with low activity (IC50=250 290 1200 nM). Alpelisib demonstrates antitumor activity and specifically targets PIK3CA mutant tumors.
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TargetMol | Inhibitor Hot
buparlisib
NVP-BKM120, BKM120
T1827944396-07-0
Buparlisib (BKM120) is an orally bioavailable specific oral inhibitor of the pan-class I PI3K (IC50s: 52 166 116 nM for p110α, p110β, and p110δ).
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Pictilisib
RG7321, GDC-0941
T1994957054-30-7
Pictilisib (GDC-0941) (GDC-0941) is a potent pan inhibitor of class I catalytic subunits of PI3K (IC50s: 3 33 3 75 nM for p110α β δ γ).
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Dactolisib
NVP-BEZ235, BEZ235
T2235915019-65-7
Dactolisib (BEZ235) is an orally bioavailable inhibitor of PI3K and mTOR, with IC50 values of 4 nM for p110α, 5 nM for p110γ, 7 nM for p110δ, 75 nM for p110β, and 20.7 nM for mTOR.
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PIK-75
T2667372196-67-3
PIK-75, a DNA-PK and PI3K inhibitor, suppresses DNA-PK(IC50=2 nM), p110α(IC50=5.8 nM) and p110γ(IC50=76 nM).
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ym-201636
T6110371942-69-7
YM201636 (IC50=33 nM), a specific PIKfyve inhibitor, is less effective to p110α and insensitive to Fabl, which is yeast orthologue.
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PF-4989216
PF 4989216
T69381276553-09-3
PF-4989216 is a potent and selective PI3K inhibitor with IC50 values of 2 nM (p110α), 142 nM (p110β), 65 nM (p110γ), 1 nM (p110δ), and 110 nM (VPS34).
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Pictilisib dimethanesulfonate
GDC-0941 dimethanesulfonate, GDC-0941 2 MeSO3H salt
T11381957054-33-0
Pictilisib dimethanesulfonate (GDC-0941 2 MeSO3H salt) is a potent inhibitor of PI3Kα δ with IC50 of 3 nM, with modest selectivity against p110β (11-fold) and p110γ (25-fold).
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pi-3065
PI3065
T2083955977-50-1
PI-3065 is a novel potent and selective PI3K p110δ inhibitor.
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pik-294
PIK294
T2297900185-02-6
PIK-294 is a excellently specific p110δ inhibitor(IC50=10 nM).
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A66
T24181166227-08-2
A66 is a specific and effective p110α inhibitor(IC50=32 nM).
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TGX-221
TGX221
T2661663619-89-4
TGX-221, an effective, specific, and cell membrane permeable inhibitor of the PI3K p110β catalytic subunit, is utilized for cancer treatment.
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ETP-46321
TQ02291252594-99-2
ETP-46321 is an effective and orally bioavailable PI3Kα PI3Kδ inhibitor (Ki: 2.3 14.2 nM).
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IPI-3063
T155921425043-73-7
IPI-3063 is an effective and selective inhibitor of PI3K p110δ (IC50: 2.5 ± 1.2 nM).
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omipalisib
GSK458, GSK2126458
T18611086062-66-9
Omipalisib (GSK2126458) is a small-molecule pyridylsulfonamide inhibitor of phosphatidylinositol 3-kinase (PI3K) with potential antineoplastic activity.
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Apitolisib
RG 7422, GNE 390, GDC-0980
T19161032754-93-0
Apitolisib (RG 7422), an effective, class I PI3K inhibitor for PI3Kα(IC50=5 nM), PI3Kβ(IC50=27 nM), PI3Kδ(IC50=7 nM), PI3Kγ (IC50=14 nM), is used in trials study of solid cancers, breast cancer, prostate cancer, renal cell carcinoma, and endometrial carcinoma, among others.
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pik-93
PIK 93
T2616593960-11-3
PIK-93, the first potent synthetic PI4K inhibitor, exhibits an IC50 of 19 nM and also inhibits PI3Kα with an IC50 of 39 nM.
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serabelisib
TAK-117, MLN1117, INK1117
T31531268454-23-4
Serabelisib (INK1117) is a p110α β γ δ inhibitor (IC50: 15 4.5 1.9 13.39 μM).
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PIK-inhibitors
MDK34597
T3190371934-59-7
PIK-inhibitors (MDK34597) is a pan PI3K inhibitors, an analog of PI-103.
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6-8 weeks
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pik-293
PIK293
T3348900185-01-5
PIK-293 is a PI3K inhibitor, for PI3Kδ( IC50=0.24 μM), and less potent for PI3Kα β γ.
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PI-103
PI103, PI 103
T6143371935-74-9
PI-103 is a potent, cell-permeable, ATP-competitive inhibitor of PI3K family members (IC50s: 2 3 3 15 30 23 nM for p110α β δ γ, mTOR, and DNA-PK).
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