pa 1

Pediocin PA-1, a broad-spectrum lactic acid bacterial bacteriocin, inhibits the activity of foodborne pathogens including Listeria monocytogenes and Gram-positive bacteria, and can be utilized as a food biopreservative [1].

Pediocin PA 1 TFA is a broad-spectrum bacteriocin produced by lactic acid bacteria, inhibiting the activity of foodborne pathogens such as Listeria monocytogenes and other Gram-positive bacteria. It has applications as a biopreservative in food products.

PA1 2HCl is a blocker of photoswitchable epithelial sodium channel (ENaC). PA1 2HCl enables the optical control of ENaC channels, in particular the δβγ isoform, by switching between blue and green light, or by turning on and off blue light.

PA3552-IN-1 is an antibiotic adjuvant that can reduce the expression of PA3552 and restore the sensitivity of MDR Pseudomonas aeruginosa DK2 strain to Polymyxin B.

IK1 inhibitor PA-6 (PA-6) is a selective and potent inhibitor of IK1 (KIR2.x ion-channel-carried inward rectifier current) with an IC50 of 12-15 nM for human and mouse KIR2.x currents.

(+)-JQ1 PA, a derivative of the Bromodomain and extra-terminal (BET) inhibitor JQ1, exhibits an IC50 of 10.4 nM.

1-Arachidonoyl-2-hydroxy-sn-glycero-3-PA is a phospholipid that contains arachidonic acid at the sn-1 position, serving as a precursor to 1-Monoarachidin. It binds with the LPA2/EDG4 receptor and can inhibit the secretion of TNF-α and IL-6 induced by LPS in wild-type dendritic cells but does not affect Lpa2-/- dendritic cells. Additionally, it reduces the differentiation of HT-29 human colon cancer cells into goblet cells in the presence of sodium butyrate.

1-Myristyl-2-hydroxy-sn-glycero-3-PA (1-Myristyl LPA) is a derivative of lysophosphatidic acid. In HEL cells, 1-Myristyl-2-hydroxy-sn-glycero-3-PA can elevate intracellular calcium levels.

1-Arachidonoyl-2-hydroxy-sn-glycero-3-PA (sodium) [1-Arachidonoyl-sn-glycerol 3-phosphate (sodium)] is a phospholipid containing arachidonic acid at the sn-1 position. It binds to the LPA2/EDG4 receptor with an EC50 of 10 nM and is present in the rat brain, representing 37% of arachidonic acid lysophosphatidic acid species. This compound serves as a precursor to 1-arachidonoyl-sn-glycerol and inhibits the secretion of TNF-α and IL-6 from dendritic cells stimulated by wild-type LPS. Additionally, 1-arachidonoyl-2-hydroxy-sn-glycero-3-PA (sodium) can suppress the differentiation of HT-29 colon cancer cells into goblet cells in the presence of sodium butyrate.

1-Palmitoyl-2-oleoyl-sn-glycero-3-PA (1,2-POPA) is a phospholipid featuring a palmitic acid (16:0) chain that is saturated and an oleic acid (18:1) chain that is monounsaturated, positioned at the sn-1 and sn-2 locations, respectively. This compound is utilized in creating micelles, liposomes, and various artificial membrane forms.

1-Palmitoyl-D9-2-hydroxy-sn-glycero-3-PA is compound, an analog of LPA with palmitic acid at the sn-1 position, activates reporter gene expression in PC12 cells fitted with human lysophosphatidic acid receptor 4 (LPA4) at 0.01 to 10 µM concentrations. Additionally, 1-palmitoyl LPA prompts aggregation in isolated human platelets within the 12-300 µM range, a process reversible by prostaglandin E1 (PGE1), theophylline, or EDTA. It also interacts with calcium and magnesium to boost the efficacy of ampicillin, piperacillin, and ceftazidime against P. aeruginosa strains from cystic fibrosis patients.

1,2-Dioleoyl-sn-glycero-3-PA (ammonium salt) is a phospholipid characterized by the incorporation of the long-chain fatty acid oleic acid at the sn-1 and sn-2 positions. It is utilized in the synthesis of artificial membranes such as liposomes.

18:1-12:0 Biotin PA ammonium is a biotinylated phosphatidic acid capable of coupling with streptavidin.

1,2-Dioleoyl-sn-glycero-3-PA (ammonium) is a phospholipid. With excellent biocompatibility and notable amphiphilic properties, phospholipids serve as the principal and suitable dosage forms or excipients in drug formulations, enabling enhanced therapeutic efficacy. 1,2-Dioleoyl-sn-glycero-3-PA (ammonium) is applicable in drug delivery research.

PIC1 PA, a peptide consisting of 15 amino acids, serves as an effective analog of PIC1 that inhibits complement activation mediated by the classical pathway. Functionally, PIC1 PA interferes with the interaction between the C1s-C1r-C1r-C1s/MASPs and the collagen-like region (CLR) of C1q/MBL. It specifically binds to the CLR of C1q, with an average equilibrium dissociation constant (KD) of 33.3 nM when binding purified C1q.

PIC1 PATFA is the trifluoroacetate form of PIC1 PA. PIC1 PA TFA is a peptide composed of 15 amino acids and serves as an effective PIC1 analog capable of inhibiting complement activation mediated by the classical pathway.

(D)-PPA 1 TFA, a hydrolysis-resistant D-peptide antagonist, is a potent PD-1/PD-L1 inhibitor with an affinity for PD-1 of 0.51 μM, demonstrating efficacy both in vitro and in vivo [1].

Cyclophosphamide is an alkylating agent type of anti-tumor drug, and its main target is DNA. Cyclophosphamide inhibits the proliferation of tumor cells by undergoing alkylation reactions with DNA, interfering with the replication and transcription processes of DNA.

Taltobulin trifluoroacetate is a synthetic analogue of the tripeptide hemiasterlin, is a potent agent of antimicrotubule that circumvents P-glycoprotein-mediated resistance in vitro and in vivo.

CINPA1 (CINPA 1) is a selective inhibitor of constitutive androstane receptor (CAR) with an IC50 of 70 nM for CAR-mediated transcription. CINPA1 can be used in studies about CAR function.

JT010 is an effective agonist of TRPA1 (EC50 = 0.65 nM).

LPA1 receptor antagonist 1(LPA1 R antagonist 1) is a selective and potent lysophosphatidic acid (LPA1) receptor antagonist (IC50 : 25 nM) for the study of idiopathic pulmonary fibrosis.

AP-18 is a potent and selective TRPA1 inhibitor. AP-18 inhibits activation of TRPA1 induced by 50 μM Cinnamaldehyde with an IC50 of 3.1 μM and 4.5 μM for human and mouse TRPA1, respectively. AP-18 could reverse complete Freund's adjuvant (CFA)-induced mechanical hyperalgesia in mice. AP-18 could attenuate Yo-Pro uptake induced by 30 μM AITC in a concentration-dependent manner (IC50= 10.3 μM).

AMG-0347 (UNII-CD7L9290QR) is a small molecule inhibitor targeting TRPA1(transient receptor potential ankyrin 1) ion channels, a receptor found in sensory neurons and involved in the detection of pain and environmental stimuli. AMG-0347 acts by blocking the function of TRPA1 and has analgesic effects.