m-18

C22:1 1-Deoxyceramide (m18:1/22:1) [C22:1(13Z) 1-Deoxyceramide] is a type of deoxyceramide lipid that lacks the 1-hydroxyl group, making it a variant of ceramide. It has potential neurotoxicity and is involved in mitochondrial stress and cell death signaling. This compound can be utilized in studies of sphingolipid metabolism abnormalities related to neurodegenerative diseases.

1-Deoxyceramide (m18:1/20:0) is a type of ceramide. Its levels increase in the dorsal root ganglia of mice treated with Docetaxel.

Abemaciclib metabolite M18 (LSN3106729) is a potent cyclin-dependent kinase (CDK) inhibitor with antitumor properties. It has been incorporated alongside a cereblon (CRBN) ligand to develop a proteolysis-targeting chimera (PROTAC) that selectively degrades CDK4/6 [1] [2].

C24:1 1-Deoxyceramide (m18:1/24:1(15Z)) is a lipid molecule that can be used in life science related research. The CAS number of C24:1 1-Deoxyceramide (m18:1/24:1(15Z)) is 1246298-58-7.

C12 1-Deoxyceramide (m18:1/12:0) is a lipid molecule that can be used in life science related research. The CAS number of C12 1-Deoxyceramide (m18:1/12:0) is 1246298-54-3.

C16 1-Deoxyceramide (m18:1/16:0) is a lipid molecule that can be used in life science related research. The CAS number of C16 1-Deoxyceramide (m18:1/16:0) is 1246298-56-5.

C24:1 dihydro 1-Deoxyceramide (m18:0/24:1) is a lipid molecule that can be used in life science related research. The CAS number of C24:1 dihydro 1-Deoxyceramide (m18:0/24:1) is 1246298-60-1.

1-Deoxysphingosine (m18:1(14Z)) is an unconventional sphingolipid featuring a (14Z) double bond at the n-4 position, synthesized when serine palmitoyltransferase combines palmitoyl-CoA with alanine, not serine, during sphingolipid production. Unlike typical sphingolipids, it lacks the essential C1-hydroxyl group for standard degradation but undergoes metabolism by cytochrome P450 (CYP) subfamilies CYP4A and CYP4F in MEF cells.

C24:1 1-Deoxyceramide (m18:1(14Z)/24:1) (C24:1 Ceramide (m18:1/24:1)) is an analogue of ceramide.

C6 Dihydro 1-deoxyceramide (m18:0/6:0) (C6 Dihydro ceramide (m18:0/6:0)) is an analogue of ceramide.

C6 1-Deoxyceramide (m18:1/6:0) (C6:0 Ceramide (m18:1/6:0)) is a non-typical short-chain ceramide.

C22 1-Deoxyceramide (m18:1(14Z)/22:0) (also referred to as C22 Ceramide (m18:1/22:0); Cer(m18:1/22:0)) is a long-chain neuroceramide that includes 1-Deoxysphingosine (m18:1(14Z)).

C6 1-Deoxyceramide (m18:1(14Z)/6:0) (Ceramide (m18:1(14Z)/6:0)) is a type of short-chain ceramide that includes 1-Deoxysphingosine (m18:1(14Z)).

OM-189 is a selective inhibitor of synthetic thrombin.

LM-189 is a G protein α subunit I (Gαi)-biased agonist and serves as a Gαi-biased ligand for the β2-adrenergic receptor (β2AR). It stabilizes a specific conformation in TM6 and enhances the dynamics of ICL2. LM-189 is useful for developing Gαi-biased β2AR agonists.

LM-189 free base is a G protein α subunit I (Gαi)-biased agonist and acts as a Gαi-biased ligand for the β2-adrenergic receptor (β2AR). It stabilizes a particular conformation in TM6 and enhances the dynamics of ICL2. LM-189 free base is useful for the development of Gαi-biased β2AR agonists.

PPM-18 (NSC 73233) is a potent anti-inflammatory agent that inhibits the expression of nitric oxide synthase, and also acts as an effective inhibitor of iNOS expression by blocking the binding of NF-κB to the promoter⁽¹⁾. As a vitamin K analog, this compound can also induce autophagy and apoptosis in bladder cancer cells through the ROS and AMPK signaling pathways⁽²⁾.

CFM-184 is an orally active factor IXa inhibitor with hFIXa IC50 = 4.9 nM.

SMM-189 is a potent and selective CB2 inverse agonist.

ZM-181037 is an ATP-sensitive potassium channel-blocker and a eukalemic diuretic.

RTICBM-189 is a potent, brain-penetrant allosteric modulator of the cannabinoid type-1 (CB1) receptor with a pIC50 of 7.54 in the Ca2+ mobilization assay, and exhibits pIC50s of 5.29 for hCB1 and 6.25 for mCB1.

M 18 is a bioactive chemical.

Fulvestrant (ZM 182780) is an estrogen receptor (ER) antagonist (IC50=9.4 nM) and an agonist of GPR30. Fulvestrant has antitumor activity, inhibiting cell proliferation and inducing apoptosis and autophagy.

Tivicilovir (AM188) is a hepatitis B virus inhibitor. tiviclovir is a guanine-related acyclic 2'-deoxyguanine analogue with anti-herpesvirus activity.