larvae

piperitone is a natural compound from Piper nigrum L

Hexythiazox is a mite growth regulator and a thiazolidine based acaricide that has long-lasting effects against many kinds of mites and is applied at any stage of the plant growth from budding to fruiting.

Retene (NSC-26317) is widely present in recent and ancient sediments, and compounds can be extracted from fir forest soils, humic coals, terrestrial petroleum hydrocarbon source rocks, and deep-sea sediments.Retene is produced by dehydrogenation of pine acids during petrogenesis.

Cyromazine (CGA-72662) is an ectoparasiticide. Insect growth regulator. Specific activity against dipterous larvae. Cyromazine is a fda approved for use in livestock.

Triflumuron is an insecticide belonging to the group of so-called insect growth regulators. It inhibits the synthesis of chitin by the insect larvae, causing the die.

1-Tridecanol (tridecan-1-ol) is found in plants damaged by larvae.

ALPHA-PINENE ((-)-Alpha-Pinene) is a bicyclic monoterpene found in pine trees and other plants, including Cannabis with diverse biological activities [1]. It reduces the growth of a panel of seven Gram-positive bacteria, seven Gram-negative bacteria, and eight yeast strains with MIC values of 0.75-1.29, 1.05-1.59, and 0.7-1.17%, respectively [2]. It has insecticidal activity against C. molestus larvae with LC50 values ranging from 47 to 49 mg/L.3 ALPHA-PINENE (100 μg/ml) induces apoptosis, increases anion superoxide production and DNA fragmentation, and activates caspase-3 in B16/F10 melanoma cells [4]. In a B16/F10 mouse xenograft model, ALPHA-PINENE(100 ml of a 10 mg/ml solution) reduces the number of metastatic lung nodules by approximately 7-fold. ALPHA-PINENE(8.6 mg/L, aerosol) also increases the time spent in the open arms of the elevated plus maze by approximately 2-fold in mice, indicating anxiolytic-like activity [5].

(E)-β-Farnesene (trans-β-Farnesene) is a sesquiterpene hydrocarbon found in Phlomis aurea Decne, serving as the primary component of many aphid alarm pheromones that disrupt feeding. It also impairs the development and survival of Chilo suppressalis larvae by disrupting their hormone balance.

N-Chloroacetyl-3,5-bis(trifluoromethyl)aniline (KM1954) is an insecticide, it is most active against 1st stage Ae. aegypti larvae with LC50 values of 125μM.

Oleoyl proline is an N-acyl amine that can be detected in bovine brain extracts and D. melanogaster larvae using mass spectrometry. In a preclinical model of pain, mice lacking fatty acid amide hydrolase (FAAH KO) had decreased N-oleoyl proline levels in

Temephos (Temefos) is a cholinesterase inhibitor. Temephos is an organothiophosphate insecticide, used in the therapy of water infested with disease-carrying insects including midges, mosquitoes, and black fly larvae.

Perfluoroheptanesulfonic acid (1-Perfluoroheptanesulfonic acid; Perfluoroheptanesulphonic acid) is a perfluoroalkyl substance (PFAS). This compound has been detected in landfill leachate and has been shown to induce deformities in zebrafish larvae (EC50=168.1 μM). Exposure to PFHpS in fetuses can lead to reduced birth weight.

Triazophos is a non-systemic pesticide that acts as an acetylcholinesterase (AChE) inhibitor, forming a covalent and irreversible bond with the acetylcholine binding site. This action blocks the hydrolysis of acetylcholine, leading to increased excitability. It is effective against a wide range of soil insects and mites, including aphids, thrips, midges, beetles, lepidopteran larvae, mole crickets, and red spiders. Triazophos is suitable for use on various crops such as ornamental plants, cotton, rice, corn, soybeans, oil palm, olives, and coffee.

Fibrostat (Compound 5n) is a selective HDAC6 inhibitor that exerts antifibrotic effects by hindering HDAC6 activity, with an IC50 value of 63 nM for HDAC6. It exhibits superior selectivity over HDAC1, HDAC3, HDAC5, HDAC8, HDAC10, and HDAC11. Fibrostat effectively reduces the expression of fibrosis markers, fibronectin and collagen 1, in fibroblasts. It shows no toxicity in rat perfused heart and zebrafish larvae studies. Fibrostat holds promise for research on fibrosis-related diseases.

Compound 3i, a 5-HT2C agonist-4, acts as an agonist for the 5-HT2C receptor with an EC50 of 5.7 nM. It is capable of reducing locomotor activity in zebrafish larvae.

Insecticidal agent 20 (Compound 17) is an insecticide that binds to AChBP. It demonstrates effective insecticidal activity against mosquito larvae (LC50: 1.57 ppm) and pupae (LC50: 4.17 ppm).

Etofenprox is an orally active non-ester pyrethroid insecticide. It is toxic to various pests including Diptera, with mild effects on mammals and fish. This compound promotes liver tumor formation in rats and increases microsomal ROS levels. It is suitable for agricultural pest control and malaria-related research.

SDH-IN-24 (Compound 51) is an inhibitor of succinate dehydrogenase (SDH) with an LC50 of 6.9 mg/L against second-stage larvae of Bursaphelenchus xylophilus and an IC50 of 15.0 μM against SDH. It exerts nematicidal activity by disrupting nematode energy metabolism, inhibiting movement, feeding, reproduction, inducing oxidative stress, reducing protein content, and impairing antioxidant capability. SDH-IN-24 is applicable for research in nematode control.

Insecticidal agent 21 (Compound 6) is an insecticide targeting Culex pipiens larvae with an LC50 of 0.4 μg/mL. It achieves multi-target neurotoxicity by inhibiting acetylcholinesterase (AChE) and simultaneously targeting other neural receptors, including nicotinic acetylcholine receptors (nAChR), voltage-gated sodium channels (VGSC), and γ-aminobutyric acid receptors (GABAAR). Insecticidal agent 21 shows potent insecticidal activity and can be utilized in the development of new insecticides to combat mosquito resistance to conventional agents.

Steroid sulfatase-IN-9 (compound 54E) is a steroid sulfatase inhibitor with an inhibition rate of 87.03% at 10 μM. It shows no toxic effects on zebrafish larvae.

Spinosyn Daglycone (A-83543D aglycone) is an aglycone form of the insecticide Spinosyn D. Unlike Spinosyn D, Spinosyn Daglycone is not harmful to neonate larvae of H. virescens (tobacco budworm) with an LC50 of greater than 64 ppm.

MC3935 (Compound 19) is an LSD1 inhibitor with an IC50 of 0.52 μM for the LSD1-CoREST enzyme complex. It shows significant antischistosomal activity against newly transformed schistosomula (NTS) and adult Schistosoma mansoni, although its onset of action is delayed against larvae. MC3935 exhibits no significant toxicity to human cells and is useful for schistosomiasis research.

Cycloprothrin (GH414; NK-8116) is an insecticidal pesticide composed of two stereoisomers: (1R, alphaR)-Cycloprothrin and (R)-Cycloprothrin. The (1R, alphaR)-Cycloprothrin is approximately 6 times more effective against Mythimna separata larvae and 4 times more effective against Aphis medicaginis larvae than the (R)-Cycloprothrin.

LSD1-IN-44 (Compound 19) is an LSD1 inhibitor with an IC50 of 0.02 μM for the LSD1-CoREST enzyme complex. It exhibits significant antischistosomal activity against newly transformed schistosomula (NTS) and adult Schistosoma mansoni, though its effect on larvae shows some delay. LSD1-IN-44 demonstrates no notable toxicity to human cells and is applicable for schistosomiasis research.